Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Gallbladder Adenocarcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Gallbladder Adenocarcinoma because of FAT3 and PRKDC gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Gallbladder Adenocarcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Pummelo” or “Include fruit Cherimoya in my diet” or “Should I reduce consumption of vegetable Endive” or “Can I take Thunder God and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO GALLBLADDER ADENOCARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Gallbladder Adenocarcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR GALLBLADDER ADENOCARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Gallbladder Adenocarcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Gallbladder Adenocarcinoma from cBioPortal. 36.8% of males and 63.2% of females were the distribution of gender in these clinical studies. From a patient sample size of 276; the top genes with mutations and other abnormalities for Gallbladder Adenocarcinoma include genes PIK3CA, TP53, FAT3, PRKDC and NFE2L2. The occurrence frequency distribution for these genes respectively is 11.2%, 8.6%, 7.1%, 6.1% and 5.1%. These tumor genetic details of Gallbladder Adenocarcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Gallbladder Adenocarcinoma.
Significance of Nutrition for Gallbladder Adenocarcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Gallbladder Adenocarcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Pummelo includes active ingredients Beta-sitosterol, Naringin, Vitamin C, Naringenin, Linolenic Acid and others. And Cherimoya contains active ingredients Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Gallbladder Adenocarcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Gallbladder Adenocarcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR GALLBLADDER ADENOCARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Gallbladder Adenocarcinoma undergoing chemotherapy treatment
In Gallbladder Adenocarcinoma – the genes PIK3CA, TP53, FAT3, PRKDC and NFE2L2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Gallbladder Adenocarcinoma are RAS-RAF Signaling, mRNA Splicing, Cell Cycle and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, mRNA Splicing, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Beta-sitosterol, Lupeol, Delphinidin, Kaempferol among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Genistein, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling.
Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Vitamin A has biological action on biochemical pathways Extracellular Matrix Remodelling, Notch Signaling and Focal Adhesion. And so on.
When treating Gallbladder Adenocarcinoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Vitamin A in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR GALLBLADDER ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Kohlrabi or Endive?
Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Beta-sitosterol, Brassinin, Kaempferol, Vitamin C, Indole-3-carbinol among others. While the active ingredients contained in Endive are Quercetin, Kaempferol, Vitamin C, Linolenic Acid, Oleic Acid and others.
Brassinin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and JAK-STAT Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling.
Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling, Notch Signaling and Focal Adhesion. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Gallbladder Adenocarcinoma with chemotherapy Radiation – Foods like Kohlrabi are recommended compared to Endive. This is because the active ingredients Vitamin A and Quercetin in Endive interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Brassinin and Vitamin C contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER ENDIVE FOR GALLBLADDER ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Cherimoya or Pummelo?
Fruits are an important part of many diets. The active ingredients contained in Cherimoya are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Pummelo are Beta-sitosterol, Naringin, Vitamin C, Naringenin, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Stigmasterol has biological action on biochemical pathways DNA Repair, JAK-STAT Signaling and Cell Cycle.
Naringin can manipulate biochemical pathways Oxidative Stress. Naringenin has biological action on biochemical pathways Heat Stress Response, DNA Repair and Oxidative Stress. And so on.
When treating Gallbladder Adenocarcinoma with chemotherapy Radiation – Foods like Cherimoya are recommended compared to Pummelo. This is because the active ingredients Naringin and Naringenin in Pummelo interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Stigmasterol contained in Cherimoya support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CHERIMOYA IS RECOMMENDED OVER PUMMELO FOR GALLBLADDER ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Walnut or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Walnut are Quercetin, Ellagic Acid, Myricetin, Betulinic Acid, Beta-sitosterol among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Gallic Acid, Vitamin C, Beta-carotene and others.
Ellagic Acid can manipulate biochemical pathways NFKB Signaling, Glucocorticoid Signaling and Oxidative Stress. Myricetin has biological action on biochemical pathways Microtubule Dynamics, DNA Repair and Growth Factor Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress. Gallic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Gallbladder Adenocarcinoma with chemotherapy Radiation – Foods like Walnut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Myricetin contained in Walnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: WALNUT IS RECOMMENDED OVER ACORN FOR GALLBLADDER ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Gallbladder Adenocarcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. FAT3 and PRKDC are two genes whose abnormalities are risk factors for Gallbladder Adenocarcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Gallbladder Adenocarcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Gallbladder Adenocarcinoma gene FAT3 has causative impact on biological pathways like Adherens junction. And PRKDC has a causative impact on biological pathways like DNA Repair, PI3K-AKT-MTOR Signaling and DNA Repair. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like FAT3 and PRKDC should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes FAT3 and PRKDC should be avoided.
Eat more pulses, Scarlet Bean or Chickpea?
The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Linolenic Acid, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Chickpea are Linolenic Acid, Oleic Acid, Genistein, Vitamin A, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Oleic Acid can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Gallbladder Adenocarcinoma due to abnormalities in genes FAT3 and PRKDC – Foods like Scarlet Bean are recommended compared to Chickpea. This is because the active ingredients Oleic Acid and Folic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF GALLBLADDER ADENOCARCINOMA DUE TO GENES FAT3 AND PRKDC
Eat more vegetables, Giant Butterbur or Carrot?
The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Vitamin A among others. While the active ingredients contained in Carrot are Lupeol, D-limonene, Linalool, Beta-sitosterol, Vitamin E and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Beta-carotene can manipulate biochemical pathways DNA Repair. Vitamin E has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Gallbladder Adenocarcinoma due to abnormalities in genes FAT3 and PRKDC – Foods like Giant Butterbur are recommended compared to Carrot. This is because the active ingredients Beta-carotene and Vitamin E in Carrot further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER CARROT FOR REDUCING THE GENETIC RISK OF GALLBLADDER ADENOCARCINOMA DUE TO GENES FAT3 AND PRKDC
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Cranberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Cranberry are Resveratrol, Vitamin C, Hyperoside, P-coumaric Acid, Ellagic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Resveratrol can manipulate biochemical pathways P53 Signaling. Quercitrin has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Gallbladder Adenocarcinoma due to abnormalities in genes FAT3 and PRKDC – Foods like Feijoa are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Quercitrin in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF GALLBLADDER ADENOCARCINOMA DUE TO GENES FAT3 AND PRKDC
Eat more nuts, Pecan Nut or Macadamia Nut?
The active ingredients contained in Pecan Nut are Vitamin E, Cianidanol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.
Cianidanol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Delphinidin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.
Palmitic Acid can manipulate biochemical pathways DNA Repair and Chromatin Remodeling. Lauric Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Gallbladder Adenocarcinoma due to abnormalities in genes FAT3 and PRKDC – Foods like Pecan Nut are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Cianidanol and Delphinidin contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF GALLBLADDER ADENOCARCINOMA DUE TO GENES FAT3 AND PRKDC
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Gallbladder Adenocarcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pan Origimed 2020
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- Adhesion to the extracellular matrix is positively regulated by retinoic acid in HepG2 cells.
- Stigmasterol Causes Ovarian Cancer Cell Apoptosis by Inducing Endoplasmic Reticulum and Mitochondrial Dysfunction.
- The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells.
- Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel.
- Small-molecule inhibitors of NADPH oxidase 4.
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- Anti-cancer targeting telomerase inhibitors: β-rubromycin and oleic acid.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Competitive and noncompetitive inhibition of the DNA-dependent protein kinase.
- The effect of Pasteurella haemolytica cytotoxin on bovine polymorphonuclear leukocytes can be attenuated by beta-adrenoceptor antagonists.
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- Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
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- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.