Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Ganglioglioma when undergoing chemotherapy or when you determine you have a genetic risk for developing Ganglioglioma because of MUC4 and NCOR2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Ganglioglioma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Pomegranate in my diet” or “Should I reduce consumption of vegetable Radish” or “Can I take Senna and Curcumin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO GANGLIOGLIOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Ganglioglioma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR GANGLIOGLIOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Ganglioglioma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Ganglioglioma from cBioPortal. The patients enrolled in the studies for Ganglioglioma are in ages between 2 to 17 with an average age of 10. 52.9% of males and 47.1% of females were the distribution of gender in these clinical studies. From a patient sample size of 17; the top genes with mutations and other abnormalities for Ganglioglioma include genes MUC4, NCOR2, KCNC3, RUNX1 and MDC1. The occurrence frequency distribution for these genes respectively is 10.5%, 10.5%, 10.5%, 10.5% and 10.5%. These tumor genetic details of Ganglioglioma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Ganglioglioma.
Ganglioglioma is a rare type of brain tumor that affects both the nerve cells (ganglion cells) and supportive cells (glial cells) in the brain. Gangliogliomas are mostly low-grade (grade 1) tumors. It is more commonly diagnosed in children, but it can also occur in young adults less than 30 years old and has a slight preponderance in males. 85% of Gangliogliomas develop in the temporal lobe and is associated with a clinical presentation of seizure disorder. Other presenting symptoms of ganglioglioma include intracranial pressure, headache, nausea, vomiting, personality change, irritability and focal neurological deficit. The management of ganglioglioma typically involves surgery to remove the tumor, with the goal of achieving complete removal. In some cases, additional treatments such as radiation therapy may also be recommended. The recurrence rate for ganglioglioma is low, but it can occur, especially in cases where the tumor is not completely removed during surgery. Regular monitoring with imaging tests such as MRI of the brain is important to detect any potential recurrence and to ensure proper management of the condition. The outcome for patients with ganglioglioma is generally good, especially with early diagnosis and appropriate treatment. The disease-free survival rate is 97% at 7.5 years for patients with gangliogliomas. Activating mutations in BRAF (V600E) occurs in 10-60% of gangliogliomas including mutations in other well-known cancer-causing genes such as KRAS, NF1 and others. Supportive nutrition with the right foods and natural supplements can complement the treatment to improve the well-being of patients diagnosed with ganglioglioma. (Ref: https://www.futuremedicine.com/doi/10.2217/fnl-2020-0003; https://onlinelibrary.wiley.com/doi/full/10.1002/cam4.3577; )
Significance of Nutrition for Ganglioglioma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Ganglioglioma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Cranberry includes active ingredients Hyperoside, P-coumaric Acid, Vitamin C, Quercitrin, Quercetin and others. And Pomegranate contains active ingredients Apigenin, Betulinic Acid, Beta-sitosterol, Corilagin, Maslinic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Ganglioglioma, activation or inhibition of selected biochemical pathways like Cell Cycle Checkpoints, Apoptosis, MAPK Signaling, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Ganglioglioma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR GANGLIOGLIOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Ganglioglioma undergoing chemotherapy treatment
In Ganglioglioma – the genes MUC4, NCOR2, KCNC3, RUNX1 and MDC1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Ganglioglioma are Cell Cycle Checkpoints, Apoptosis, DNA Repair and others. Hydroxyurea is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle Checkpoints, Apoptosis, DNA Repair so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Hyacinth Bean or Soy Bean?
Pulses are an important part of many diets. The active ingredients contained in Hyacinth Bean are Palmitic Acid, Vitamin C, Genistein, Myristic Acid, Folic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Vitamin E, Daidzein, Ferulic Acid, Beta-sitosterol and others.
Palmitic Acid can manipulate biochemical pathways Apoptosis, DNA Repair and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MYC Signaling.
Genistein can manipulate biochemical pathways DNA Repair. Aescin has biological action on biochemical pathways Cell Cycle Checkpoints. And so on.
When treating Ganglioglioma with chemotherapy Hydroxyurea – Foods like Hyacinth Bean are recommended compared to Soy Bean. This is because the active ingredients Genistein and Aescin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Palmitic Acid and Vitamin C contained in Hyacinth Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: HYACINTH BEAN IS RECOMMENDED OVER SOY BEAN FOR GANGLIOGLIOMA ON TREATMENT WITH CHEMOTHERAPY HYDROXYUREA FOR SOME CONDITIONS.
Eat more vegetables, Arugula or Radish?
Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Vitamin A, Kaempferol, Vitamin K, Erysolin among others. While the active ingredients contained in Radish are Beta-sitosterol, Linolenic Acid, P-coumaric Acid, Vitamin C, Quercetin and others.
Vitamin A can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis. Kaempferol has biological action on biochemical pathways Cell Cycle Checkpoints.
Pelargonidin can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways P53 Signaling, Apoptosis and MYC Signaling. And so on.
When treating Ganglioglioma with chemotherapy Hydroxyurea – Foods like Arugula are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Kaempferol contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER RADISH FOR GANGLIOGLIOMA ON TREATMENT WITH CHEMOTHERAPY HYDROXYUREA FOR SOME CONDITIONS.
Eat more fruits, Pomegranate or Cranberry?
Fruits are an important part of many diets. The active ingredients contained in Pomegranate are Apigenin, Betulinic Acid, Beta-sitosterol, Corilagin, Maslinic Acid among others. While the active ingredients contained in Cranberry are Hyperoside, P-coumaric Acid, Vitamin C, Quercitrin, Quercetin and others.
Betulinic Acid can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Casuarinin has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling and DNA Repair. And so on.
When treating Ganglioglioma with chemotherapy Hydroxyurea – Foods like Pomegranate are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Casuarinin contained in Pomegranate support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: POMEGRANATE IS RECOMMENDED OVER CRANBERRY FOR GANGLIOGLIOMA ON TREATMENT WITH CHEMOTHERAPY HYDROXYUREA FOR SOME CONDITIONS.
Eat more nuts, Pistachio or Chestnut?
Nuts are an important part of many diets. The active ingredients contained in Pistachio are Vitamin E, Beta-sitosterol, Linolenic Acid, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Chestnut are Linolenic Acid, Vitamin C, Quercetin, Oleic Acid, Linoleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Vitamin E has biological action on biochemical pathways Apoptosis, DNA Repair and MYC Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.
When treating Ganglioglioma with chemotherapy Hydroxyurea – Foods like Pistachio are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER CHESTNUT FOR GANGLIOGLIOMA ON TREATMENT WITH CHEMOTHERAPY HYDROXYUREA FOR SOME CONDITIONS.
Foods for Genetic Risk of Ganglioglioma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. MUC4 and NCOR2 are two genes whose abnormalities are risk factors for Ganglioglioma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Ganglioglioma can be used as a guide for coming up with a recommended personalized nutrition plan. For Ganglioglioma gene MUC4 has causative impact on biological pathways like Post Translation Modification. And NCOR2 has a causative impact on biological pathways like Androgen Signaling and Oncogenic Cancer Epigenetics. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like MUC4 and NCOR2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes MUC4 and NCOR2 should be avoided.
Eat more pulses, Mung Bean or Lima Bean?
The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Oleic Acid, Vitexin, Linolenic Acid among others. While the active ingredients contained in Lima Bean are Vitamin C, Oleic Acid, Genistein, Linoleic Acid, Vitamin A and others.
Quercetin can manipulate biochemical pathways Small Molecule Transport, Apoptosis and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Linoleic Acid can manipulate biochemical pathways Extracellular Matrix Remodelling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Ganglioglioma due to abnormalities in genes MUC4 and NCOR2 – Foods like Mung Bean are recommended compared to Lima Bean. This is because the active ingredients Linoleic Acid and Folic Acid in Lima Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER LIMA BEAN FOR REDUCING THE GENETIC RISK OF GANGLIOGLIOMA DUE TO GENES MUC4 AND NCOR2
Eat more vegetables, Jicama or Parsnip?
The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Parsnip are Quercetin, Vitamin C, Bergapten, Oleic Acid, Psoralen and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-carotene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Imperatorin can manipulate biochemical pathways Small Molecule Transport. Linoleic Acid has biological action on biochemical pathways Extracellular Matrix Remodelling. And so on.
For genetic risk of Ganglioglioma due to abnormalities in genes MUC4 and NCOR2 – Foods like Jicama are recommended compared to Parsnip. This is because the active ingredients Imperatorin and Linoleic Acid in Parsnip further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER PARSNIP FOR REDUCING THE GENETIC RISK OF GANGLIOGLIOMA DUE TO GENES MUC4 AND NCOR2
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Peach?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Peach are Modified Citrus Pectin, Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.
Fisetin can manipulate biochemical pathways MYC Signaling. Linoleic Acid has biological action on biochemical pathways Extracellular Matrix Remodelling. And so on.
For genetic risk of Ganglioglioma due to abnormalities in genes MUC4 and NCOR2 – Foods like Feijoa are recommended compared to Peach. This is because the active ingredients Fisetin and Linoleic Acid in Peach further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER PEACH FOR REDUCING THE GENETIC RISK OF GANGLIOGLIOMA DUE TO GENES MUC4 AND NCOR2
Eat more nuts, Pine Nut or Peanut?
The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Beta-sitosterol, Vitamin E, Vitamin C, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Ganglioglioma due to abnormalities in genes MUC4 and NCOR2 – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Vitamin B3 in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF GANGLIOGLIOMA DUE TO GENES MUC4 AND NCOR2
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Ganglioglioma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
- Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer.
- A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress.
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- BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
- Betulinic acid induces DNA damage and apoptosis in SiHa cells.
- Induction of cell cycle arrest and apoptosis in human non-small cell lung cancer A549 cells by casuarinin from the bark of Terminalia arjuna Linn.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Transcriptional activation of the cyclin-dependent kinase inhibitor p21 by PML/RARalpha.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- Excess Linoleic Acid Increases Collagen I/III Ratio and Stiffens” the Heart Muscle Following High Fat Diets.”
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- The effect of Pasteurella haemolytica cytotoxin on bovine polymorphonuclear leukocytes can be attenuated by beta-adrenoceptor antagonists.
- Osthole or imperatorin-mediated facilitation of glutamate release is associated with a synaptic vesicle mobilization in rat hippocampal glutamatergic nerve endings.
- Research progress on the anticancer effects of vitamin K2.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Modulation of Sirt1 by resveratrol and nicotinamide alters proliferation and differentiation of pig preadipocytes.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Fisetin: a dietary antioxidant for health promotion.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.