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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Erdheim Chester Disease!

Aug 4, 2023

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Introduction

Foods for Erdheim Chester Disease should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Erdheim-Chester Disease (ECD) is a rare, non-Langerhans cell histiocytosis, often regarded as a cancer, with its cause under investigation but not generally considered hereditary or genetic. Characterized by distinctive symptoms like bone pain and neurological manifestations, ECD diagnosis involves a blend of radiological techniques, including CT and brain MRI, and thorough pathology outlines. Treatment strategies for Erdheim-Chester Disease are continually evolving, with updated information accessible through platforms like UpToDate and the Erdheim-Chester Disease Global Alliance. ECD often involves organ systems like the lungs and brain, and radiology is crucial for disease assessment and monitoring. Classified under the ICD-10 system, ECD’s management is illuminated through reviews and case studies, highlighting the importance of ongoing research and awareness in tackling this complex disease.



For Erdheim Chester Disease does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Erdheim Chester Disease does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Erdheim Chester Disease?

For example does it matter if vegetable Eggplant is consumed more compared to Chayote? Does it make any difference if fruit Sugar Apple is preferred over Arctic Blackberry? Also if similar choices are made for nuts/seeds like Black Walnut over Macadamia Nut and for pulses like Green Bean over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Erdheim Chester Disease and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Erdheim Chester Disease!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Erdheim Chester Disease can be characterized by a unique set of biochemical pathways - the signature pathways of Erdheim Chester Disease. Biochemical pathways like RAS-RAF Signaling, MAPK Signaling, Cytoskeletal Dynamics, Angiogenesis are part of the signature definition of Erdheim Chester Disease.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Sugar Apple contains active ingredients Myricetin, Lycopene, Pelargonidin, Curcumin, Cinnamaldehyde. And Arctic Blackberry contains active ingredients Ellagic Acid, Lycopene, Curcumin, Quercetin, Cinnamaldehyde and possibly others.

A common mistake made when deciding and choosing foods to eat for Erdheim Chester Disease – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Erdheim Chester Disease.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Erdheim Chester Disease?

Personalized nutrition for cancers like Erdheim Chester Disease consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Erdheim Chester Disease biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Erdheim Chester Disease

All cancers like Erdheim Chester Disease can be characterized by a unique set of biochemical pathways – the signature pathways of Erdheim Chester Disease. Biochemical pathways like RAS-RAF Signaling, MAPK Signaling, Cytoskeletal Dynamics, Angiogenesis are part of the signature definition of Erdheim Chester Disease. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Erdheim Chester Disease need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Erdheim Chester Disease when taking cancer treatment Vemurafenib, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

MAP2K1, ARAF, ARID5B, BRAF and MYCN are the top ranked reported genes for Erdheim Chester Disease. MAP2K1 is reported in 25.0 % of the representative patients across all clinical trials. And ARAF is reported in 12.5 %. The combined population patient data cover ages from to . 61.5 % of the patient data are identified as men. The Erdheim Chester Disease biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Erdheim Chester Disease!

Food and Supplements for Erdheim Chester Disease

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable EGGPLANT or CHAYOTE?

Vegetable Eggplant contains many active ingredients or bioactives such as Myricetin, Isorhamnetin, Gallic Acid, Curcumin, Quercetin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, RAS-RAF Signaling and MAPK Signaling and others. Eggplant is recommended for Erdheim Chester Disease when ongoing cancer treatment is Vemurafenib. This is because Eggplant modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Vemurafenib.

Some of the active ingredients or bioactives in vegetable Chayote are Myricetin, Pelargonidin, Curcumin, Cinnamaldehyde, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and MAPK Signaling and others. Chayote is not recommended for Erdheim Chester Disease when ongoing cancer treatment is Vemurafenib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE EGGPLANT IS RECOMMENDED OVER CHAYOTE FOR Erdheim Chester Disease AND TREATMENT Vemurafenib.

Choose Fruit ARCTIC BLACKBERRY or SUGAR APPLE?

Fruit Arctic Blackberry contains many active ingredients or bioactives such as Ellagic Acid, Lycopene, Curcumin, Quercetin, Cinnamaldehyde. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, RAS-RAF Signaling and MAPK Signaling and others. Arctic Blackberry is recommended for Erdheim Chester Disease when ongoing cancer treatment is Vemurafenib. This is because Arctic Blackberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Vemurafenib.

Some of the active ingredients or bioactives in fruit Sugar Apple are Myricetin, Lycopene, Pelargonidin, Curcumin, Cinnamaldehyde. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and others. Sugar Apple is not recommended for Erdheim Chester Disease when ongoing cancer treatment is Vemurafenib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT ARCTIC BLACKBERRY IS RECOMMENDED OVER SUGAR APPLE FOR Erdheim Chester Disease AND TREATMENT Vemurafenib.

Choose Nut BLACK WALNUT or MACADAMIA NUT?

Black Walnut contains many active ingredients or bioactives such as Myricetin, Ellagic Acid, Pelargonidin, Gallic Acid, Curcumin. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling and MAPK Signaling and others. Black Walnut is recommended for Erdheim Chester Disease when ongoing cancer treatment is Vemurafenib. This is because Black Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Vemurafenib.

Some of the active ingredients or bioactives in Macadamia Nut are Myricetin, Pelargonidin, Curcumin, Cinnamaldehyde, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and MAPK Signaling and others. Macadamia Nut is not recommended for Erdheim Chester Disease when ongoing cancer treatment is Vemurafenib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BLACK WALNUT IS RECOMMENDED OVER MACADAMIA NUT FOR Erdheim Chester Disease AND TREATMENT Vemurafenib.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Erdheim Chester Disease or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or GARLAND CHRYSANTHEMUM?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Myricetin, Lycopene, Lupeol. These active ingredients manipulate various biochemical pathways like Angiogenesis, RAS-RAF Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling and others. Giant Butterbur is recommended for risk of Erdheim Chester Disease when associated genetic risk is ARAF. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Garland Chrysanthemum are Apigenin, Curcumin, Myricetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and MAPK Signaling and others. Garland Chrysanthemum is not recommended when risk of Erdheim Chester Disease when associated genetic risk is ARAF because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER GARLAND CHRYSANTHEMUM FOR ARAF GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Myricetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Angiogenesis, RAS-RAF Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling and others. Nance is recommended for risk of Erdheim Chester Disease when associated genetic risk is ARAF. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Quercetin, Lycopene, Lupeol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and Cell Cycle Checkpoints and others. Pummelo is not recommended when risk of Erdheim Chester Disease when associated genetic risk is ARAF because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR ARAF GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or EUROPEAN CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Myricetin, Lycopene, Lupeol. These active ingredients manipulate various biochemical pathways like Angiogenesis, RAS-RAF Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling and others. Common Hazelnut is recommended for risk of Erdheim Chester Disease when associated genetic risk is ARAF. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Ellagic Acid, Curcumin, Quercetin, Myricetin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling and others. European Chestnut is not recommended when risk of Erdheim Chester Disease when associated genetic risk is ARAF because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR ARAF GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Erdheim Chester Disease. Erdheim Chester Disease patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Erdheim Chester Disease, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Eggplant contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Erdheim Chester Disease?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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