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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Erdheim Chester Disease?

Jul 30, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Erdheim Chester Disease when undergoing chemotherapy or when you determine you have a genetic risk for developing Erdheim Chester Disease because of MAP2K1 and ARAF gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Erdheim Chester Disease which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Graviola” or “Include fruit Bilberry in my diet” or “Should I reduce consumption of vegetable Carrot” or “Can I take Agaricus Mushroom and Myricetin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ERDHEIM CHESTER DISEASE, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Erdheim Chester Disease is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR ERDHEIM CHESTER DISEASE, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Erdheim Chester Disease

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Erdheim Chester Disease from cBioPortal. 61.5% of males and 38.5% of females were the distribution of gender in these clinical studies. From a patient sample size of 16; the top genes with mutations and other abnormalities for Erdheim Chester Disease include genes MAP2K1, ARAF, ARID5B, BRAF and MYCN. The occurrence frequency distribution for these genes respectively is 25.0%, 12.5%, 12.5%, 12.5% and 12.5%. These tumor genetic details of Erdheim Chester Disease are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Erdheim Chester Disease.

Significance of Nutrition for Erdheim Chester Disease

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Erdheim Chester Disease. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Graviola includes active ingredients Myricetin, Lycopene, Gallic Acid, Quercetin, Caffeic Acid and others. And Bilberry contains active ingredients Myricetin, Gallic Acid, Quercetin, Caffeic Acid, Delphinidin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Erdheim Chester Disease, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, MAPK Signaling, Cytoskeletal Dynamics, Angiogenesis plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Erdheim Chester Disease, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Erdheim Chester Disease, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, MAPK Signaling, Cytoskeletal Dynamics, Angiogenesis plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ERDHEIM CHESTER DISEASE – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Erdheim Chester Disease undergoing chemotherapy treatment

In Erdheim Chester Disease – the genes MAP2K1, ARAF, ARID5B, BRAF and MYCN have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Erdheim Chester Disease are RAS-RAF Signaling, MAPK Signaling and others. Vemurafenib is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, MAPK Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Lentils or Hyacinth Bean?

Pulses are an important part of many diets. The active ingredients contained in Lentils are Ellagic Acid, Isoliquiritigenin, Linolenic Acid, Vitamin C, Linoleic Acid among others. While the active ingredients contained in Hyacinth Bean are Vitamin C, Palmitic Acid, Genistein, Myristic Acid, Folic Acid and others.

Ellagic Acid can manipulate biochemical pathways MAPK Signaling and RAS-RAF Signaling. Isoliquiritigenin has biological action on biochemical pathways WNT Beta Catenin Signaling and MAPK Signaling.

Palmitic Acid can manipulate biochemical pathways WNT Beta Catenin Signaling and MAPK Signaling. Myristic Acid has biological action on biochemical pathways RAS-RAF Signaling and MAPK Signaling. And so on.

When treating Erdheim Chester Disease with chemotherapy Vemurafenib – Foods like Lentils are recommended compared to Hyacinth Bean. This is because the active ingredients Palmitic Acid and Myristic Acid in Hyacinth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Isoliquiritigenin contained in Lentils support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: LENTILS IS RECOMMENDED OVER HYACINTH BEAN FOR ERDHEIM CHESTER DISEASE ON TREATMENT WITH CHEMOTHERAPY VEMURAFENIB FOR SOME CONDITIONS.

Eat more vegetables, Burdock or Carrot?

Vegetables are an important part of many diets. The active ingredients contained in Burdock are Arctigenin, Caffeic Acid, Linolenic Acid, Lupeol, Dehydrocostus Lactone among others. While the active ingredients contained in Carrot are D-limonene, Lycopene, Caffeic Acid, Quercetin, Linolenic Acid and others.

Caffeic Acid can manipulate biochemical pathways MAPK Signaling and RAS-RAF Signaling. Chlorogenic Acid has biological action on biochemical pathways MAPK Signaling.

Beta-carotene can manipulate biochemical pathways MAPK Signaling. Luteolin has biological action on biochemical pathways WNT Beta Catenin Signaling. And so on.

When treating Erdheim Chester Disease with chemotherapy Vemurafenib – Foods like Burdock are recommended compared to Carrot. This is because the active ingredients Beta-carotene and Luteolin in Carrot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Caffeic Acid and Chlorogenic Acid contained in Burdock support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: BURDOCK IS RECOMMENDED OVER CARROT FOR ERDHEIM CHESTER DISEASE ON TREATMENT WITH CHEMOTHERAPY VEMURAFENIB FOR SOME CONDITIONS.

Which Foods are Recommended for Erdheim Chester Disease?

Eat more fruits, Bilberry or Graviola?

Fruits are an important part of many diets. The active ingredients contained in Bilberry are Myricetin, Gallic Acid, Quercetin, Caffeic Acid, Delphinidin among others. While the active ingredients contained in Graviola are Myricetin, Lycopene, Gallic Acid, Quercetin, Caffeic Acid and others.

Delphinidin can manipulate biochemical pathways MAPK Signaling and RAS-RAF Signaling. Chlorogenic Acid has biological action on biochemical pathways MAPK Signaling.

Fisetin can manipulate biochemical pathways WNT Beta Catenin Signaling. Vitexin has biological action on biochemical pathways WNT Beta Catenin Signaling. And so on.

When treating Erdheim Chester Disease with chemotherapy Vemurafenib – Foods like Bilberry are recommended compared to Graviola. This is because the active ingredients Fisetin and Vitexin in Graviola interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Delphinidin and Chlorogenic Acid contained in Bilberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: BILBERRY IS RECOMMENDED OVER GRAVIOLA FOR ERDHEIM CHESTER DISEASE ON TREATMENT WITH CHEMOTHERAPY VEMURAFENIB FOR SOME CONDITIONS.

Eat more nuts, Chestnut or Cashew Nut?

Nuts are an important part of many diets. The active ingredients contained in Chestnut are Ellagic Acid, Gallic Acid, Quercetin, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Cashew Nut are Gallic Acid, Vitamin C, Beta-sitosterol, Palmitic Acid, Lauric Acid and others.

Ellagic Acid can manipulate biochemical pathways MAPK Signaling and RAS-RAF Signaling. Gallic Acid has biological action on biochemical pathways MAPK Signaling.

Palmitic Acid can manipulate biochemical pathways WNT Beta Catenin Signaling and MAPK Signaling. Lauric Acid has biological action on biochemical pathways MAPK Signaling. And so on.

When treating Erdheim Chester Disease with chemotherapy Vemurafenib – Foods like Chestnut are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Cashew Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Gallic Acid contained in Chestnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CHESTNUT IS RECOMMENDED OVER CASHEW NUT FOR ERDHEIM CHESTER DISEASE ON TREATMENT WITH CHEMOTHERAPY VEMURAFENIB FOR SOME CONDITIONS.

Foods for Genetic Risk of Erdheim Chester Disease

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. MAP2K1 and ARAF are two genes whose abnormalities are risk factors for Erdheim Chester Disease. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Erdheim Chester Disease can be used as a guide for coming up with a recommended personalized nutrition plan. For Erdheim Chester Disease gene MAP2K1 has causative impact on biological pathways like Angiogenesis, RAS-RAF Signaling and cGMP Signaling. And ARAF has a causative impact on biological pathways like MAPK Signaling, RAS-RAF Signaling and Cytoskeletal Dynamics. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like MAP2K1 and ARAF should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes MAP2K1 and ARAF should be avoided.

Eat more pulses, Mung Bean or Moth Bean?

The active ingredients contained in Mung Bean are Kaempferol, Quercetin, Vitamin C, Glucaric Acid, Oleic Acid among others. While the active ingredients contained in Moth Bean are Oleic Acid, Linolenic Acid, Beta-sitosterol, Stigmasterol, Linoleic Acid and others.

Kaempferol can manipulate biochemical pathways MAPK Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and MAPK Signaling.

Folic Acid can manipulate biochemical pathways MAPK Signaling, MYC Signaling and RAS-RAF Signaling. And so on.

For genetic risk of Erdheim Chester Disease due to abnormalities in genes MAP2K1 and ARAF – Foods like Mung Bean are recommended compared to Moth Bean. This is because the active ingredients Folic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Kaempferol and Quercetin contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF ERDHEIM CHESTER DISEASE DUE TO GENES MAP2K1 AND ARAF

Eat more vegetables, Cassava or Endive?

The active ingredients contained in Cassava are Vitamin C, Oleic Acid, Linolenic Acid, Beta-sitosterol, Linoleic Acid among others. While the active ingredients contained in Endive are Kaempferol, Quercetin, Vitamin C, Oleic Acid, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways MAPK Signaling, RAS-RAF Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and MYC Signaling.

Folic Acid can manipulate biochemical pathways MAPK Signaling, MYC Signaling and RAS-RAF Signaling. And so on.

For genetic risk of Erdheim Chester Disease due to abnormalities in genes MAP2K1 and ARAF – Foods like Cassava are recommended compared to Endive. This is because the active ingredients Folic Acid in Endive further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER ENDIVE FOR REDUCING THE GENETIC RISK OF ERDHEIM CHESTER DISEASE DUE TO GENES MAP2K1 AND ARAF

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Orange or Huckleberry?

The active ingredients contained in Orange are D-limonene, Modified Citrus Pectin, Linalool, Vitamin C, Glucaric Acid among others. While the active ingredients contained in Huckleberry are Quercetin, Resveratrol, Caffeic Acid, Pelargonidin, Vitamin C and others.

D-limonene can manipulate biochemical pathways MAPK Signaling, MYC Signaling and RAS-RAF Signaling. Vitamin C has biological action on biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and MAPK Signaling.

Pelargonidin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Ferulic Acid has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Erdheim Chester Disease due to abnormalities in genes MAP2K1 and ARAF – Foods like Orange are recommended compared to Huckleberry. This is because the active ingredients Pelargonidin and Ferulic Acid in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ORANGE IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF ERDHEIM CHESTER DISEASE DUE TO GENES MAP2K1 AND ARAF

Eat more nuts, Pistachio or Brazil Nut?

The active ingredients contained in Pistachio are Resveratrol, Vitamin E, Oleic Acid, Linolenic Acid, Beta-sitosterol among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling. Resveratrol has biological action on biochemical pathways DNA Repair, RAS-RAF Signaling and MYC Signaling.

Lecithin can manipulate biochemical pathways MAPK Signaling, MYC Signaling and RAS-RAF Signaling. Vitamin E has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Erdheim Chester Disease due to abnormalities in genes MAP2K1 and ARAF – Foods like Pistachio are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Vitamin E in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Resveratrol contained in Pistachio together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF ERDHEIM CHESTER DISEASE DUE TO GENES MAP2K1 AND ARAF


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Erdheim Chester Disease by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

sample-report


References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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