Which Foods are Recommended for Mucinous Colorectal Adenocarcinoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Mucinous Colorectal Adenocarcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Mucinous Colorectal Adenocarcinoma because of GNAS and KDR gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Mucinous Colorectal Adenocarcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Strawberry” or “Include fruit Persimmon in my diet” or “Should I reduce consumption of vegetable Radish” or “Can I take Thunder God and Cordyceps supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MUCINOUS COLORECTAL ADENOCARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Mucinous Colorectal Adenocarcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR MUCINOUS COLORECTAL ADENOCARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Mucinous Colorectal Adenocarcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Mucinous Colorectal Adenocarcinoma from cBioPortal. The patients enrolled in the studies for Mucinous Colorectal Adenocarcinoma are in ages between 34 to 81 with an average age of 62. 50.0% of males and 50.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 60; the top genes with mutations and other abnormalities for Mucinous Colorectal Adenocarcinoma include genes APC, KRAS, GNAS, KMT2D and KDR. The occurrence frequency distribution for these genes respectively is 15.2%, 13.0%, 10.9%, 10.9% and 8.7%. These tumor genetic details of Mucinous Colorectal Adenocarcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Mucinous Colorectal Adenocarcinoma.

Significance of Nutrition for Mucinous Colorectal Adenocarcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Mucinous Colorectal Adenocarcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Strawberry includes active ingredients Ellagic Acid, Lupeol, Beta-sitosterol, Vitamin C, Linolenic Acid and others. And Persimmon contains active ingredients Lycopene, Lupeol, Betulinic Acid, Vitamin C, Quercetin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Mucinous Colorectal Adenocarcinoma, activation or inhibition of selected biochemical pathways like Amino Acid Metabolism, Nucleotide metabolism, PI3K-AKT-MTOR Signaling, Small Molecule Transport plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Mucinous Colorectal Adenocarcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MUCINOUS COLORECTAL ADENOCARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Mucinous Colorectal Adenocarcinoma undergoing chemotherapy treatment

In Mucinous Colorectal Adenocarcinoma – the genes APC, KRAS, GNAS, KMT2D and KDR have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Mucinous Colorectal Adenocarcinoma are Amino Acid Metabolism, Nucleotide metabolism, DNA Repair and others. Capecitabine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Amino Acid Metabolism, Nucleotide metabolism, DNA Repair so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Fava Bean?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Fava Bean are Daidzein, Butein, Caffeic Acid, Beta-sitosterol, Vitamin C and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, DNA Repair and MYC Signaling. Vitamin C has biological action on biochemical pathways Vitamin D Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Quercetin can manipulate biochemical pathways Nucleotide metabolism. Genistein has biological action on biochemical pathways DNA Repair. And so on.

When treating Mucinous Colorectal Adenocarcinoma with chemotherapy Capecitabine – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Quercetin and Genistein in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR MUCINOUS COLORECTAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CAPECITABINE FOR SOME CONDITIONS.

Eat more vegetables, Parsnip or Radish?

Vegetables are an important part of many diets. The active ingredients contained in Parsnip are Psoralen, Imperatorin, Gallic Acid, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Radish are Caffeic Acid, Beta-sitosterol, Vitamin C, Linolenic Acid, Salicylic Acid and others.

Imperatorin can manipulate biochemical pathways NFKB Signaling, MYC Signaling and Vitamin D Signaling. Ferulic Acid has biological action on biochemical pathways DNA Repair, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Quercetin can manipulate biochemical pathways Nucleotide metabolism. Pelargonidin has biological action on biochemical pathways MYC Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling. And so on.

When treating Mucinous Colorectal Adenocarcinoma with chemotherapy Capecitabine – Foods like Parsnip are recommended compared to Radish. This is because the active ingredients Quercetin and Pelargonidin in Radish interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Imperatorin and Ferulic Acid contained in Parsnip support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PARSNIP IS RECOMMENDED OVER RADISH FOR MUCINOUS COLORECTAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CAPECITABINE FOR SOME CONDITIONS.

Eat more fruits, Persimmon or Strawberry?

Fruits are an important part of many diets. The active ingredients contained in Persimmon are Lycopene, Lupeol, Betulinic Acid, Vitamin C, Quercetin among others. While the active ingredients contained in Strawberry are Ellagic Acid, Lupeol, Beta-sitosterol, Vitamin C, Linolenic Acid and others.

Lycopene can manipulate biochemical pathways NFKB Signaling, MYC Signaling and Vitamin D Signaling. Vitamin C has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Amino Acid Metabolism.

Fisetin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways Vitamin D Signaling and MYC Signaling. And so on.

When treating Mucinous Colorectal Adenocarcinoma with chemotherapy Capecitabine – Foods like Persimmon are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Vitamin C contained in Persimmon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PERSIMMON IS RECOMMENDED OVER STRAWBERRY FOR MUCINOUS COLORECTAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CAPECITABINE FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Cashew Nut?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Cianidanol, Oleic Acid, Delphinidin among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Gallic Acid, Vitamin C, Butyric Acid, Vitamin K and others.

Vitamin E can manipulate biochemical pathways NFKB Signaling, DNA Repair and MYC Signaling. Cianidanol has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Hypoxia.

Myristic Acid can manipulate biochemical pathways MYC Signaling and MAPK Signaling. Palmitic Acid has biological action on biochemical pathways NFKB Signaling, MYC Signaling and MAPK Signaling. And so on.

When treating Mucinous Colorectal Adenocarcinoma with chemotherapy Capecitabine – Foods like Pecan Nut are recommended compared to Cashew Nut. This is because the active ingredients Myristic Acid and Palmitic Acid in Cashew Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CASHEW NUT FOR MUCINOUS COLORECTAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CAPECITABINE FOR SOME CONDITIONS.

Foods for Genetic Risk of Mucinous Colorectal Adenocarcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. GNAS and KDR are two genes whose abnormalities are risk factors for Mucinous Colorectal Adenocarcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Mucinous Colorectal Adenocarcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Mucinous Colorectal Adenocarcinoma gene GNAS has causative impact on biological pathways like G-protein-coupled Receptor Signaling, Reproductive Hormone Signaling and Gonadotropin-releasing hormone. And KDR has a causative impact on biological pathways like Angiogenesis and RAS-RAF Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like GNAS and KDR should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes GNAS and KDR should be avoided.

Eat more pulses, Winged Bean or Lima Bean?

The active ingredients contained in Winged Bean are Oleic Acid, Betulinic Acid, Vitamin C, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Lima Bean are Oleic Acid, Vitamin C, Genistein, Linoleic Acid, Vitamin A and others.

Betulinic Acid can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and MAPK Signaling. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Angiogenesis and RAS-RAF Signaling.

Genistein can manipulate biochemical pathways G-protein-coupled Receptor Signaling. Linoleic Acid has biological action on biochemical pathways Extracellular Matrix Remodelling. And so on.

For genetic risk of Mucinous Colorectal Adenocarcinoma due to abnormalities in genes GNAS and KDR – Foods like Winged Bean are recommended compared to Lima Bean. This is because the active ingredients Genistein and Linoleic Acid in Lima Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER LIMA BEAN FOR REDUCING THE GENETIC RISK OF MUCINOUS COLORECTAL ADENOCARCINOMA DUE TO GENES GNAS AND KDR

Eat more vegetables, Jicama or Endive?

The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Endive are Quercetin, Oleic Acid, Vitamin C, Kaempferol, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and MAPK Signaling. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Cell Cycle Checkpoints.

Quercetin can manipulate biochemical pathways G-protein-coupled Receptor Signaling. Linoleic Acid has biological action on biochemical pathways Extracellular Matrix Remodelling. And so on.

For genetic risk of Mucinous Colorectal Adenocarcinoma due to abnormalities in genes GNAS and KDR – Foods like Jicama are recommended compared to Endive. This is because the active ingredients Quercetin and Linoleic Acid in Endive further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER ENDIVE FOR REDUCING THE GENETIC RISK OF MUCINOUS COLORECTAL ADENOCARCINOMA DUE TO GENES GNAS AND KDR

Eat more fruits, Currant or Huckleberry?

The active ingredients contained in Currant are Quercetin, Delphinidin, Myricetin, Oleic Acid, Cianidanol among others. While the active ingredients contained in Huckleberry are Resveratrol, Quercetin, Delphinidin, Vitamin C, P-coumaric Acid and others.

Delphinidin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Cianidanol has biological action on biochemical pathways Cell Cycle Checkpoints, Angiogenesis and MYC Signaling.

Quercetin can manipulate biochemical pathways G-protein-coupled Receptor Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Mucinous Colorectal Adenocarcinoma due to abnormalities in genes GNAS and KDR – Foods like Currant are recommended compared to Huckleberry. This is because the active ingredients Quercetin and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Delphinidin and Cianidanol contained in Currant together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CURRANT IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF MUCINOUS COLORECTAL ADENOCARCINOMA DUE TO GENES GNAS AND KDR

Eat more nuts, Almond or Peanut?

The active ingredients contained in Almond are Quercetin, Vitamin E, Oleic Acid, Beta-sitosterol, Linolenic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Oleic Acid, Gamma-linolenic Acid, Beta-sitosterol and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Angiogenesis. Vitamin E has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.

Quercetin can manipulate biochemical pathways G-protein-coupled Receptor Signaling. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Mucinous Colorectal Adenocarcinoma due to abnormalities in genes GNAS and KDR – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Quercetin and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF MUCINOUS COLORECTAL ADENOCARCINOMA DUE TO GENES GNAS AND KDR

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Mucinous Colorectal Adenocarcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Crc Dd 2022
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