Foods for Mucinous Colorectal Adenocarcinoma!

Introduction

Foods for Mucinous Colorectal Adenocarcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Mucinous adenocarcinoma of the colorectal region, a distinct subtype of colorectal cancer, is characterized by the production of mucin within the tumor cells. The pathology outlines of mucinous colorectal adenocarcinoma provide essential insights into its unique histological features, differentiating it from other types of colorectal cancers. This subtype tends to present specific symptoms, including changes in bowel habits, abdominal pain, and rectal bleeding, which are key indicators for pursuing further diagnostic tests. Colorectal mucinous adenocarcinoma requires careful evaluation, often involving a combination of imaging tests and a colorectal mucinous adenocarcinoma test, such as a biopsy, to confirm the diagnosis. The treatment approach for mucinous adenocarcinoma colorectal cancer typically involves a combination of surgery, chemotherapy, and in some cases, radiation therapy, depending on the stage of the cancer and the overall health of the patient. The management and prognosis of mucinous colorectal adenocarcinoma depend on early detection and the effectiveness of the treatment regimen, highlighting the importance of regular screening and prompt medical attention for gastrointestinal symptoms.

For Mucinous Colorectal Adenocarcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Mucinous Colorectal Adenocarcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Mucinous Colorectal Adenocarcinoma?

For example does it matter if vegetable Cauliflower is consumed more compared to Turnip? Does it make any difference if fruit Pummelo is preferred over Black Mulberry? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Broad Bean over Lima Bean. And if what I eat matters – then how does one identify foods which are recommended for Mucinous Colorectal Adenocarcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Mucinous Colorectal Adenocarcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Quercetin, Curcumin, Apigenin, Lycopene, Delphinidin. And Black Mulberry contains active ingredients Quercetin, Curcumin, Apigenin, Delphinidin, Myricetin and possibly others.

A common mistake made when deciding and choosing foods to eat for Mucinous Colorectal Adenocarcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Mucinous Colorectal Adenocarcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Mucinous Colorectal Adenocarcinoma?

Personalized nutrition for cancers like Mucinous Colorectal Adenocarcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Mucinous Colorectal Adenocarcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Mucinous Colorectal Adenocarcinoma

All cancers like Mucinous Colorectal Adenocarcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Mucinous Colorectal Adenocarcinoma. Biochemical pathways like RAS-RAF Signaling, DNA Repair, Small Molecule Transport, PI3K-AKT-MTOR Signaling are part of the signature definition of Mucinous Colorectal Adenocarcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Mucinous Colorectal Adenocarcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Mucinous Colorectal Adenocarcinoma when taking cancer treatment Cetuximab, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

APC, KRAS, GNAS, KMT2D and KDR are the top ranked reported genes for Mucinous Colorectal Adenocarcinoma. APC is reported in 15.2 % of the representative patients across all clinical trials. And KRAS is reported in 13.0 %. The combined population patient data cover ages from 34 to 81. 50.0 % of the patient data are identified as men. The Mucinous Colorectal Adenocarcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Mucinous Colorectal Adenocarcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CAULIFLOWER or TURNIP?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Delphinidin, Isoliquiritigenin, Formononetin, Phloretin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Metastasis, Carbohydrate Metabolism and Amino Acid Metabolism and others. Cauliflower is recommended for Mucinous Colorectal Adenocarcinoma when ongoing cancer treatment is Cetuximab. This is because Cauliflower modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cetuximab.

Some of the active ingredients or bioactives in vegetable Turnip are Quercetin, Ellagic Acid, Curcumin, Delphinidin, Caffeic Acid. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Extracellular Matrix Remodelling and Epithelial to Mesenchymal Transition and others. Turnip is not recommended for Mucinous Colorectal Adenocarcinoma when ongoing cancer treatment is Cetuximab because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER TURNIP FOR Mucinous Colorectal Adenocarcinoma AND TREATMENT Cetuximab.

Choose Fruit BLACK MULBERRY or PUMMELO?

Fruit Black Mulberry contains many active ingredients or bioactives such as Quercetin, Curcumin, Apigenin, Delphinidin, Myricetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Metastasis, Lipid Metabolism and Growth Factor Signaling and others. Black Mulberry is recommended for Mucinous Colorectal Adenocarcinoma when ongoing cancer treatment is Cetuximab. This is because Black Mulberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cetuximab.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Curcumin, Apigenin, Lycopene, Delphinidin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Pummelo is not recommended for Mucinous Colorectal Adenocarcinoma when ongoing cancer treatment is Cetuximab because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT BLACK MULBERRY IS RECOMMENDED OVER PUMMELO FOR Mucinous Colorectal Adenocarcinoma AND TREATMENT Cetuximab.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Lycopene, Delphinidin, Myricetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, DNA Repair, Adherens junction and Amino Acid Metabolism and others. Butternut is recommended for Mucinous Colorectal Adenocarcinoma when ongoing cancer treatment is Cetuximab. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cetuximab.

Some of the active ingredients or bioactives in European Chestnut are Quercetin, Ellagic Acid, Curcumin, Apigenin, Delphinidin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. European Chestnut is not recommended for Mucinous Colorectal Adenocarcinoma when ongoing cancer treatment is Cetuximab because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Mucinous Colorectal Adenocarcinoma AND TREATMENT Cetuximab.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Mucinous Colorectal Adenocarcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or ARROWROOT?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Delphinidin, Lupeol, Myricetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and Oxidative Stress and others. Giant Butterbur is recommended for risk of Mucinous Colorectal Adenocarcinoma when associated genetic risk is APC. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Arrowroot are Quercetin, Curcumin, Apigenin, Delphinidin, Lupeol. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and Oxidative Stress and others. Arrowroot is not recommended when risk of Mucinous Colorectal Adenocarcinoma when associated genetic risk is APC because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER ARROWROOT FOR APC GENETIC RISK OF CANCER.

Choose Fruit NANCE or LIME?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Apigenin, Delphinidin, Lupeol, Myricetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and Oxidative Stress and others. Nance is recommended for risk of Mucinous Colorectal Adenocarcinoma when associated genetic risk is APC. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Lime are Curcumin, Delphinidin, Lupeol, Caffeine, Formononetin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and others. Lime is not recommended when risk of Mucinous Colorectal Adenocarcinoma when associated genetic risk is APC because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER LIME FOR APC GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Quercetin, Curcumin, Delphinidin, Lupeol, Myricetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and Oxidative Stress and others. Common Hazelnut is recommended for risk of Mucinous Colorectal Adenocarcinoma when associated genetic risk is APC. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Ellagic Acid, Curcumin, Apigenin, Delphinidin, Lupeol. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and Oxidative Stress and others. Chestnut is not recommended when risk of Mucinous Colorectal Adenocarcinoma when associated genetic risk is APC because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR APC GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Mucinous Colorectal Adenocarcinoma. Mucinous Colorectal Adenocarcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Mucinous Colorectal Adenocarcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Cauliflower contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Mucinous Colorectal Adenocarcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Crc Dd 2022
• Pan-cancer analysis of whole genomes.
• Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel.
• α-Terpineol reduces cancer pain via modulation of oxidative stress and inhibition of iNOS.