Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Lung Neuroendocrine Tumors when undergoing chemotherapy or when you determine you have a genetic risk for developing Lung Neuroendocrine Tumors because of PIK3CG and FLT4 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Lung Neuroendocrine Tumors which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Strawberry” or “Include fruit Raspberry in my diet” or “Should I reduce consumption of vegetable Jute” or “Can I take Cordyceps and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO LUNG NEUROENDOCRINE TUMORS, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Lung Neuroendocrine Tumors is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR LUNG NEUROENDOCRINE TUMORS, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Lung Neuroendocrine Tumors
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Lung Neuroendocrine Tumors from cBioPortal. The patients enrolled in the studies for Lung Neuroendocrine Tumors are in ages between 44 to 76 with an average age of 55. 54.9% of males and 45.1% of females were the distribution of gender in these clinical studies. From a patient sample size of 169; the top genes with mutations and other abnormalities for Lung Neuroendocrine Tumors include genes PIK3CG, PIK3CA, PTEN, FLT4 and MET. The occurrence frequency distribution for these genes respectively is 12.9%, 8.1%, 8.1%, 8.1% and 8.1%. These tumor genetic details of Lung Neuroendocrine Tumors are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Lung Neuroendocrine Tumors.
Significance of Nutrition for Lung Neuroendocrine Tumors
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Lung Neuroendocrine Tumors. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Strawberry includes active ingredients Ellagic Acid, Lupeol, Beta-sitosterol, Oleic Acid, Fisetin and others. And Raspberry contains active ingredients Quercetin, Ellagic Acid, Gallic Acid, Resveratrol, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Lung Neuroendocrine Tumors, activation or inhibition of selected biochemical pathways like Chromatin Remodeling, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Lung Neuroendocrine Tumors, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR LUNG NEUROENDOCRINE TUMORS – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Lung Neuroendocrine Tumors undergoing chemotherapy treatment
In Lung Neuroendocrine Tumors – the genes PIK3CG, PIK3CA, PTEN, FLT4 and MET have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Lung Neuroendocrine Tumors are Chromatin Remodeling, Growth Factor Signaling, PI3K-AKT-MTOR Signaling and others. Trabectedin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Chromatin Remodeling, Growth Factor Signaling, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Lima Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Lupeol, Beta-sitosterol, Oleic Acid, Genistein among others. While the active ingredients contained in Lima Bean are Oleic Acid, Genistein, Vitamin C, Linoleic Acid, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and Chromatin Remodeling. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and P53 Signaling.
Genistein can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and Growth Factor Signaling. And so on.
When treating Lung Neuroendocrine Tumors with chemotherapy Trabectedin – Foods like Common Pea are recommended compared to Lima Bean. This is because the active ingredients Genistein and Folic Acid in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LIMA BEAN FOR LUNG NEUROENDOCRINE TUMORS ON TREATMENT WITH CHEMOTHERAPY TRABECTEDIN FOR SOME CONDITIONS.
Eat more vegetables, Cabbage or Jute?
Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Quercetin, Benzyl Isothiocyanate, Indole-3-carbinol, Beta-sitosterol, Isorhamnetin among others. While the active ingredients contained in Jute are Quercetin, Oleic Acid, Linolenic Acid, Kaempferol, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Cell Cycle, MYC Signaling and P53 Signaling. Glucaric Acid has biological action on biochemical pathways NFKB Signaling, Apoptosis and Cell Survival.
Quercetin can manipulate biochemical pathways DNA Repair. Vitamin B3 has biological action on biochemical pathways DNA Repair. And so on.
When treating Lung Neuroendocrine Tumors with chemotherapy Trabectedin – Foods like Cabbage are recommended compared to Jute. This is because the active ingredients Quercetin and Vitamin B3 in Jute interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CABBAGE IS RECOMMENDED OVER JUTE FOR LUNG NEUROENDOCRINE TUMORS ON TREATMENT WITH CHEMOTHERAPY TRABECTEDIN FOR SOME CONDITIONS.
Eat more fruits, Raspberry or Strawberry?
Fruits are an important part of many diets. The active ingredients contained in Raspberry are Quercetin, Ellagic Acid, Gallic Acid, Resveratrol, Vitamin C among others. While the active ingredients contained in Strawberry are Ellagic Acid, Lupeol, Beta-sitosterol, Oleic Acid, Fisetin and others.
Ellagic Acid can manipulate biochemical pathways NFKB Signaling, Apoptosis and Growth Factor Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and P53 Signaling.
Fisetin can manipulate biochemical pathways MYC Signaling and DNA Repair. Pelargonidin has biological action on biochemical pathways NFKB Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling. And so on.
When treating Lung Neuroendocrine Tumors with chemotherapy Trabectedin – Foods like Raspberry are recommended compared to Strawberry. This is because the active ingredients Fisetin and Pelargonidin in Strawberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Vitamin C contained in Raspberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: RASPBERRY IS RECOMMENDED OVER STRAWBERRY FOR LUNG NEUROENDOCRINE TUMORS ON TREATMENT WITH CHEMOTHERAPY TRABECTEDIN FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Linolenic Acid, Cianidanol, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Ferulic Acid and others.
Vitamin E can manipulate biochemical pathways NFKB Signaling, Apoptosis and DNA Repair. Cianidanol has biological action on biochemical pathways Cell Survival, MYC Signaling and P53 Signaling.
Quercetin can manipulate biochemical pathways DNA Repair. Lecithin has biological action on biochemical pathways MYC Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Lung Neuroendocrine Tumors with chemotherapy Trabectedin – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Quercetin and Lecithin in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR LUNG NEUROENDOCRINE TUMORS ON TREATMENT WITH CHEMOTHERAPY TRABECTEDIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Lung Neuroendocrine Tumors
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. PIK3CG and FLT4 are two genes whose abnormalities are risk factors for Lung Neuroendocrine Tumors. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Lung Neuroendocrine Tumors can be used as a guide for coming up with a recommended personalized nutrition plan. For Lung Neuroendocrine Tumors gene PIK3CG has causative impact on biological pathways like Inositol Phosphate Signaling and PI3K-AKT-MTOR Signaling. And FLT4 has a causative impact on biological pathways like Angiogenesis, Hematopoiesis and Focal Adhesion. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like PIK3CG and FLT4 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes PIK3CG and FLT4 should be avoided.
Eat more pulses, Scarlet Bean or Pigeon Pea?
The active ingredients contained in Scarlet Bean are Genistein, Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Pigeon Pea are Genistein, Oleic Acid, Vitamin C, Linolenic Acid, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways Myeloid-derived Suppressor Cells, Cell Cycle and MYC Signaling. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
For genetic risk of Lung Neuroendocrine Tumors due to abnormalities in genes PIK3CG and FLT4 – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Vitamin A and Linoleic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF LUNG NEUROENDOCRINE TUMORS DUE TO GENES PIK3CG AND FLT4
Eat more vegetables, Jicama or Lotus?
The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Lotus are Quercetin, Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Myeloid-derived Suppressor Cells, Growth Factor Signaling and Cell Cycle. Beta-carotene has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Oncogenic Cancer Epigenetics.
Fisetin can manipulate biochemical pathways MYC Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
For genetic risk of Lung Neuroendocrine Tumors due to abnormalities in genes PIK3CG and FLT4 – Foods like Jicama are recommended compared to Lotus. This is because the active ingredients Fisetin and Linoleic Acid in Lotus further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER LOTUS FOR REDUCING THE GENETIC RISK OF LUNG NEUROENDOCRINE TUMORS DUE TO GENES PIK3CG AND FLT4
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Jujube or Peach?
The active ingredients contained in Jujube are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Vitamin A among others. While the active ingredients contained in Peach are Modified Citrus Pectin, Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Myeloid-derived Suppressor Cells, Growth Factor Signaling and Cell Cycle. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Fisetin can manipulate biochemical pathways MYC Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Lung Neuroendocrine Tumors due to abnormalities in genes PIK3CG and FLT4 – Foods like Jujube are recommended compared to Peach. This is because the active ingredients Fisetin and Vitamin A in Peach further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Jujube together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JUJUBE IS RECOMMENDED OVER PEACH FOR REDUCING THE GENETIC RISK OF LUNG NEUROENDOCRINE TUMORS DUE TO GENES PIK3CG AND FLT4
Eat more nuts, Almond or Brazil Nut?
The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Myeloid-derived Suppressor Cells, Cell Cycle and MYC Signaling. Vitamin E has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, Myeloid-derived Suppressor Cells and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways RAS-RAF Signaling, Cell Cycle Checkpoints and MYC Signaling. And so on.
For genetic risk of Lung Neuroendocrine Tumors due to abnormalities in genes PIK3CG and FLT4 – Foods like Almond are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF LUNG NEUROENDOCRINE TUMORS DUE TO GENES PIK3CG AND FLT4
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Lung Neuroendocrine Tumors by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
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- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Fisetin: a dietary antioxidant for health promotion.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.