Which Foods are Recommended for Embryonal Carcinoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Embryonal Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Embryonal Carcinoma because of LZTR1 and NCOR1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Embryonal Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Sapota” or “Include fruit Saskatoon Berry in my diet” or “Should I reduce consumption of vegetable Bell Pepper” or “Can I take Alpha Lipoic Acid and Neem Extract supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO EMBRYONAL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Embryonal Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR EMBRYONAL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Embryonal Carcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Embryonal Carcinoma from cBioPortal. The patients enrolled in the studies for Embryonal Carcinoma are in ages between 1 to 67 with an average age of 23. 90.2% of males and 9.8% of females were the distribution of gender in these clinical studies. From a patient sample size of 85; the top genes with mutations and other abnormalities for Embryonal Carcinoma include genes LZTR1, NCOR1, STAT5B, SOCS1 and SDHC. The occurrence frequency distribution for these genes respectively is 7.7%, 3.8%, 3.8%, 3.8% and 3.8%. These tumor genetic details of Embryonal Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Embryonal Carcinoma.

Significance of Nutrition for Embryonal Carcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Embryonal Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Sapota includes active ingredients Linolenic Acid, Lycopene, Beta-sitosterol, Gallic Acid, Vitamin C and others. And Saskatoon Berry contains active ingredients Quercetin, Delphinidin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Embryonal Carcinoma, activation or inhibition of selected biochemical pathways like Post Translation Modification, RAS-RAF Signaling, Angiogenesis, Extracellular Matrix Remodelling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Embryonal Carcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR EMBRYONAL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Embryonal Carcinoma undergoing chemotherapy treatment

In Embryonal Carcinoma – the genes LZTR1, NCOR1, STAT5B, SOCS1 and SDHC have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Embryonal Carcinoma are Post Translation Modification, RAS-RAF Signaling, Focal Adhesion and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Post Translation Modification, RAS-RAF Signaling, Focal Adhesion so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Scarlet Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Linolenic Acid, Kaempferol, Lupeol, Daidzein, Pelargonidin among others. While the active ingredients contained in Scarlet Bean are Linolenic Acid, Beta-sitosterol, Stigmasterol, Vitamin C, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Heat Stress Response, Oncogenic Cancer Epigenetics and Angiogenesis. Vitamin C has biological action on biochemical pathways Oxidative Stress, RAS-RAF Signaling and Angiogenesis.

Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Embryonal Carcinoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Scarlet Bean. This is because the active ingredients Genistein and Citric Acid in Scarlet Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SCARLET BEAN FOR EMBRYONAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Arrowroot or Bell Pepper?

Vegetables are an important part of many diets. The active ingredients contained in Arrowroot are Quercetin, Protocatechuic Acid, Beta-carotene, Chlorogenic Acid, Vitamin C among others. While the active ingredients contained in Bell Pepper are P-coumaric Acid, Linolenic Acid, Isorhamnetin, Vitamin E, Vitamin C and others.

Quercetin can manipulate biochemical pathways DNA Repair, JAK-STAT Signaling and Notch Signaling. Beta-carotene has biological action on biochemical pathways Angiogenesis, Oxidative Stress and DNA Repair.

Capsaicin can manipulate biochemical pathways Heat Stress Response and DNA Repair. Vitamin A has biological action on biochemical pathways Notch Signaling and Focal Adhesion. And so on.

When treating Embryonal Carcinoma with chemotherapy Radiation – Foods like Arrowroot are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Vitamin A in Bell Pepper interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Beta-carotene contained in Arrowroot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER BELL PEPPER FOR EMBRYONAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Saskatoon Berry or Sapota?

Fruits are an important part of many diets. The active ingredients contained in Saskatoon Berry are Quercetin, Delphinidin among others. While the active ingredients contained in Sapota are Linolenic Acid, Lycopene, Beta-sitosterol, Gallic Acid, Vitamin C and others.

Delphinidin can manipulate biochemical pathways Oncogenic Cancer Epigenetics, Angiogenesis and RAS-RAF Signaling. Quercetin has biological action on biochemical pathways DNA Repair, JAK-STAT Signaling and Notch Signaling.

Lycopene can manipulate biochemical pathways Oncogenic Cancer Epigenetics and Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Embryonal Carcinoma with chemotherapy Radiation – Foods like Saskatoon Berry are recommended compared to Sapota. This is because the active ingredients Lycopene and Citric Acid in Sapota interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Delphinidin and Quercetin contained in Saskatoon Berry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SASKATOON BERRY IS RECOMMENDED OVER SAPOTA FOR EMBRYONAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Almond or Pecan Nut?

Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Linolenic Acid, Vitamin B3, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Pecan Nut are Linolenic Acid, Delphinidin, Vitamin E, Cianidanol, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Heat Stress Response, Oncogenic Cancer Epigenetics and Angiogenesis. Quercetin has biological action on biochemical pathways DNA Repair, JAK-STAT Signaling and Notch Signaling.

Vitamin E can manipulate biochemical pathways Oxidative Stress. Cianidanol has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Embryonal Carcinoma with chemotherapy Radiation – Foods like Almond are recommended compared to Pecan Nut. This is because the active ingredients Vitamin E and Cianidanol in Pecan Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER PECAN NUT FOR EMBRYONAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Embryonal Carcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. LZTR1 and NCOR1 are two genes whose abnormalities are risk factors for Embryonal Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Embryonal Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Embryonal Carcinoma gene LZTR1 has causative impact on biological pathways like MAPK Signaling and RAS-RAF Signaling. And NCOR1 has a causative impact on biological pathways like Androgen Signaling, Oncogenic Cancer Epigenetics and Growth Factor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like LZTR1 and NCOR1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes LZTR1 and NCOR1 should be avoided.

Eat more pulses, Mung Bean or Soy Bean?

The active ingredients contained in Mung Bean are Stigmasterol, Linolenic Acid, Vitexin, Quercetin, Vitamin C among others. While the active ingredients contained in Soy Bean are Vitamin E, Lupeol, Daidzein, Stigmasterol, Linolenic Acid and others.

Stigmasterol can manipulate biochemical pathways MYC Signaling, MAPK Signaling and Cell Cycle Checkpoints. Vitexin has biological action on biochemical pathways Small Molecule Transport, Apoptosis and MYC Signaling.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and MAPK Signaling. And so on.

For genetic risk of Embryonal Carcinoma due to abnormalities in genes LZTR1 and NCOR1 – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Stigmasterol and Vitexin contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF EMBRYONAL CARCINOMA DUE TO GENES LZTR1 AND NCOR1

Eat more vegetables, Sweet Potato or Parsnip?

The active ingredients contained in Sweet Potato are Linolenic Acid, Beta-sitosterol, Quercetin, Vitamin C, Linoleic Acid among others. While the active ingredients contained in Parsnip are Linolenic Acid, Psoralen, Ferulic Acid, Quercetin, Vitamin C and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and Cell Cycle Checkpoints. Beta-sitosterol has biological action on biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints.

Imperatorin can manipulate biochemical pathways Small Molecule Transport. Folic Acid has biological action on biochemical pathways MYC Signaling, MAPK Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Embryonal Carcinoma due to abnormalities in genes LZTR1 and NCOR1 – Foods like Sweet Potato are recommended compared to Parsnip. This is because the active ingredients Imperatorin and Folic Acid in Parsnip further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Sweet Potato together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SWEET POTATO IS RECOMMENDED OVER PARSNIP FOR REDUCING THE GENETIC RISK OF EMBRYONAL CARCINOMA DUE TO GENES LZTR1 AND NCOR1

Eat more fruits, Grapefruit or Strawberry?

The active ingredients contained in Grapefruit are Naringin, Linolenic Acid, Linoleic Acid, Oleic Acid, Naringenin among others. While the active ingredients contained in Strawberry are Ellagic Acid, Lupeol, Linolenic Acid, Beta-sitosterol, Vitamin C and others.

Naringin can manipulate biochemical pathways Apoptosis, Post Translation Modification and MYC Signaling. Naringenin has biological action on biochemical pathways Extracellular Matrix Remodelling, Cell Cycle Checkpoints and MAPK Signaling.

Fisetin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Embryonal Carcinoma due to abnormalities in genes LZTR1 and NCOR1 – Foods like Grapefruit are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients Naringin and Naringenin contained in Grapefruit together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GRAPEFRUIT IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF EMBRYONAL CARCINOMA DUE TO GENES LZTR1 AND NCOR1

Eat more nuts, Pistachio or Peanut?

The active ingredients contained in Pistachio are Vitamin E, Stigmasterol, Linolenic Acid, Beta-sitosterol, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Rhamnetin, Stigmasterol, Linolenic Acid, Beta-sitosterol and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis. Stigmasterol has biological action on biochemical pathways MAPK Signaling, MYC Signaling and Cell Cycle Checkpoints.

Lecithin can manipulate biochemical pathways MYC Signaling and MAPK Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, Apoptosis and MYC Signaling. And so on.

For genetic risk of Embryonal Carcinoma due to abnormalities in genes LZTR1 and NCOR1 – Foods like Pistachio are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Stigmasterol contained in Pistachio together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF EMBRYONAL CARCINOMA DUE TO GENES LZTR1 AND NCOR1

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Embryonal Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Msk Met 2021
• Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.
• Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines.
• Genomic and Functional Approaches to Understanding Cancer Aneuploidy.
• Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.
• An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics.
• Oncogenic Signaling Pathways in The Cancer Genome Atlas.
• Microbiome analyses of blood and tissues suggest cancer diagnostic approach.
• Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.
• Landscape of Microsatellite Instability Across 39 Cancer Types.
• β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
• Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
• BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
• Identification of new potent phthalazine derivatives with VEGFR-2 and EGFR kinase inhibitory activity.
• A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
• Effects of lycopene on protein expression in human primary prostatic epithelial cells.
• β-Carotene inhibits neuroblastoma cell invasion and metastasis in vitro and in vivo by decreasing level of hypoxia-inducible factor-1α.
• Adhesion to the extracellular matrix is positively regulated by retinoic acid in HepG2 cells.
• Palm tocotrienol exerted better antioxidant activities in bone than alpha-tocopherol.
• Topical (+)-catechin emulsified gel prevents DMBA/TPA-induced squamous cell carcinoma of the skin by modulating antioxidants and inflammatory biomarkers in BALB/c mice.
• Stigmasterol isolated from marine microalgae Navicula incerta induces apoptosis in human hepatoma HepG2 cells.
• Purified vitexin compound 1, a new neolignan isolated compound, promotes PUMA-dependent apoptosis in colorectal cancer.
• The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
• Naringin induces death receptor and mitochondria-mediated apoptosis in human cervical cancer (SiHa) cells.
• Naringenin attenuates the progression of liver fibrosis via inactivation of hepatic stellate cells and profibrogenic pathways.
• Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
• Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
• Osthole or imperatorin-mediated facilitation of glutamate release is associated with a synaptic vesicle mobilization in rat hippocampal glutamatergic nerve endings.
• Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
• HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
• Fisetin: a dietary antioxidant for health promotion.