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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Embryonal Carcinoma!

Aug 4, 2023

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Introduction

Foods for Embryonal Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Embryonal Carcinoma, a type of testicular cancer, is characterized by distinct pathology outlines and the presence of embryonal carcinoma cells. This malignancy, which can also occur in the ovary in females, is known for its aggressive nature. Symptoms often include a testicular mass and discomfort, with the diagnosis confirmed through tumor markers like AFP (Alpha-fetoprotein) and hCG (Human Chorionic Gonadotropin). The ICD-10 coding system classifies embryonal carcinoma for healthcare documentation. The prognosis and survival rate of embryonal carcinoma vary, influenced by factors such as the tumor’s stage and response to treatment. Treatment typically involves a combination of surgery, chemotherapy, and radiation therapy. Embryonal carcinoma can coexist with other germ cell tumors, such as teratoma or yolk sac tumor, complicating its clinical presentation and management. Understanding the causes and early detection of embryonal carcinoma are crucial for improving outcomes and providing effective care.



For Embryonal Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Embryonal Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Embryonal Carcinoma?

For example does it matter if vegetable Radish (var.) is consumed more compared to Yellow Bell Pepper? Does it make any difference if fruit Loganberry is preferred over Bayberry? Also if similar choices are made for nuts/seeds like Chia over Chinese Chestnut and for pulses like Moth Bean over Lentils. And if what I eat matters – then how does one identify foods which are recommended for Embryonal Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Embryonal Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Embryonal Carcinoma can be characterized by a unique set of biochemical pathways - the signature pathways of Embryonal Carcinoma. Biochemical pathways like Post Translation Modification, RAS-RAF Signaling, Angiogenesis, Extracellular Matrix Remodelling are part of the signature definition of Embryonal Carcinoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Loganberry contains active ingredients Luteolin, Formononetin, Myricetin, Caffeic Acid, Allicin. And Bayberry contains active ingredients Luteolin, Formononetin, Myricetin, Caffeic Acid, Allicin and possibly others.

A common mistake made when deciding and choosing foods to eat for Embryonal Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Embryonal Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Embryonal Carcinoma?

Personalized nutrition for cancers like Embryonal Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Embryonal Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Embryonal Carcinoma

All cancers like Embryonal Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Embryonal Carcinoma. Biochemical pathways like Post Translation Modification, RAS-RAF Signaling, Angiogenesis, Extracellular Matrix Remodelling are part of the signature definition of Embryonal Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Embryonal Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Embryonal Carcinoma when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

LZTR1, NCOR1, STAT5B, SOCS1 and SDHC are the top ranked reported genes for Embryonal Carcinoma. LZTR1 is reported in 7.7 % of the representative patients across all clinical trials. And NCOR1 is reported in 3.8 %. The combined population patient data cover ages from 1 to 67. 90.2 % of the patient data are identified as men. The Embryonal Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Embryonal Carcinoma!

Food and Supplements for Embryonal Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable RADISH (VAR.) or YELLOW BELL PEPPER?

Vegetable Radish (var.) contains many active ingredients or bioactives such as Formononetin, Caffeic Acid, Allicin, Isoliquiritigenin, Curcumin. These active ingredients manipulate various biochemical pathways like Oxidative Stress, Angiogenesis and JAK-STAT Signaling and others. Radish (var.) is recommended for Embryonal Carcinoma when ongoing cancer treatment is Radiation. This is because Radish (var.) modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Yellow Bell Pepper are Quercetin, Cinnamic Acid, Luteolin, Formononetin, P-coumaric Acid. These active ingredients manipulate various biochemical pathways like DNA Repair and Heat Stress Response and others. Yellow Bell Pepper is not recommended for Embryonal Carcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE RADISH (VAR.) IS RECOMMENDED OVER YELLOW BELL PEPPER FOR Embryonal Carcinoma AND TREATMENT Radiation.

Choose Fruit BAYBERRY or LOGANBERRY?

Fruit Bayberry contains many active ingredients or bioactives such as Luteolin, Formononetin, Myricetin, Caffeic Acid, Allicin. These active ingredients manipulate various biochemical pathways like Oxidative Stress, Angiogenesis, Oncogenic Cancer Epigenetics and RAS-RAF Signaling and others. Bayberry is recommended for Embryonal Carcinoma when ongoing cancer treatment is Radiation. This is because Bayberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Loganberry are Luteolin, Formononetin, Myricetin, Caffeic Acid, Allicin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and Heat Stress Response and others. Loganberry is not recommended for Embryonal Carcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT BAYBERRY IS RECOMMENDED OVER LOGANBERRY FOR Embryonal Carcinoma AND TREATMENT Radiation.

Choose Nut CHIA or CHINESE CHESTNUT?

Chia contains many active ingredients or bioactives such as Luteolin, Formononetin, Myricetin, Caffeic Acid, Allicin. These active ingredients manipulate various biochemical pathways like Oxidative Stress, RAS-RAF Signaling, JAK-STAT Signaling and Oncogenic Cancer Epigenetics and others. Chia is recommended for Embryonal Carcinoma when ongoing cancer treatment is Radiation. This is because Chia modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in Chinese Chestnut are Luteolin, Formononetin, Myricetin, Caffeic Acid, Allicin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and Heat Stress Response and others. Chinese Chestnut is not recommended for Embryonal Carcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

CHIA IS RECOMMENDED OVER CHINESE CHESTNUT FOR Embryonal Carcinoma AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Embryonal Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable THISTLE or CARDOON?

Vegetable Thistle contains many active ingredients or bioactives such as Curcumin, Apigenin, Silibinin, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, JAK-STAT Signaling, Apoptosis and Reproductive Hormone Signaling and others. Thistle is recommended for risk of Embryonal Carcinoma when associated genetic risk is LZTR1. This is because Thistle increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Cardoon are Curcumin, Apigenin, Formononetin, Stigmasterol, Lupeol. These active ingredients manipulate various biochemical pathways like Small Molecule Transport and Oxidative Stress and others. Cardoon is not recommended when risk of Embryonal Carcinoma when associated genetic risk is LZTR1 because it increases the signature pathways of it.

VEGETABLE THISTLE IS RECOMMENDED OVER CARDOON FOR LZTR1 GENETIC RISK OF CANCER.

Choose Fruit BOG BILBERRY or GRAPEFRUIT?

Fruit Bog Bilberry contains many active ingredients or bioactives such as Quercetin, Curcumin, Apigenin, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, JAK-STAT Signaling, Carbohydrate Metabolism and Cytokine Signaling and others. Bog Bilberry is recommended for risk of Embryonal Carcinoma when associated genetic risk is LZTR1. This is because Bog Bilberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Grapefruit are Curcumin, Formononetin, Stigmasterol, Lupeol, Naringin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and others. Grapefruit is not recommended when risk of Embryonal Carcinoma when associated genetic risk is LZTR1 because it increases the signature pathways of it.

FRUIT BOG BILBERRY IS RECOMMENDED OVER GRAPEFRUIT FOR LZTR1 GENETIC RISK OF CANCER.

Choose Nut ALMOND or HICKORY NUT?

Almond contains many active ingredients or bioactives such as Curcumin, Formononetin, Stigmasterol, Lupeol, Melatonin. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, JAK-STAT Signaling and Reproductive Hormone Signaling and others. Almond is recommended for risk of Embryonal Carcinoma when associated genetic risk is LZTR1. This is because Almond increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Hickory Nut are Curcumin, Apigenin, Formononetin, Stigmasterol, Lupeol. These active ingredients manipulate various biochemical pathways like Small Molecule Transport and Oxidative Stress and others. Hickory Nut is not recommended when risk of Embryonal Carcinoma when associated genetic risk is LZTR1 because it increases the signature pathways of it.

ALMOND IS RECOMMENDED OVER HICKORY NUT FOR LZTR1 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Embryonal Carcinoma. Embryonal Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Embryonal Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Radish (var.) contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Embryonal Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

Some of the active ingredients or bioactives in Hickory Nut are Curcumin, Apigenin, Formononetin, Stigmasterol, Lupeol. These active ingredients manipulate various biochemical pathways like Small Molecule Transport and Oxidative Stress and others. Hickory Nut is not recommended when risk of Embryonal Carcinoma when associated genetic risk is LZTR1 because it increases the signature pathways of it.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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