Which Foods are Recommended for Chondrosarcoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Chondrosarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Chondrosarcoma because of IDH1 and EPHA7 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Chondrosarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Apricot” or “Include fruit Mango in my diet” or “Should I reduce consumption of vegetable Chayote” or “Can I take Vitamin D3 and Guggul supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO CHONDROSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Chondrosarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR CHONDROSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Chondrosarcoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Chondrosarcoma from cBioPortal. The patients enrolled in the studies for Chondrosarcoma are in ages between 14 to 79 with an average age of 55. 66.4% of males and 33.6% of females were the distribution of gender in these clinical studies. From a patient sample size of 116; the top genes with mutations and other abnormalities for Chondrosarcoma include genes TP53, IDH1, TET2, EPHA7 and ATRX. The occurrence frequency distribution for these genes respectively is 13.5%, 13.5%, 10.8%, 5.4% and 5.4%. These tumor genetic details of Chondrosarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Chondrosarcoma.

Chondrosarcoma is a rare malignant tumor of the cartilage tissue. Cartilage is a soft connective tissue that allows movement between the bones and joints. Chondrosarcoma can grow from cancerous tissue on the bone or from benign bone tumors that have become cancerous. Chondrosarcoma can appear anywhere we have cartilage, but it most commonly is found in the pelvis, sternum, ribs, arms, and legs. Chondrosarcoma equally affects men and women and appears in adults aged 40-75 years. Approximately 600 people are diagnosed with chondrosarcoma each year. Symptoms of chondrosarcoma include fatigue, fever, and unintentional weight loss. Treatment for chondrosarcoma includes surgery and bone grafts to repair and build affected bones. Chemotherapy is not typically used to treat chondrosarcoma unless the disease is very aggressive. Chondrosarcoma has good prognosis and approximately 60%-70% patients with chondrosarcoma are alive five years after diagnosis, while 10-30% of the patients will develop distant metastasis. Supportive care with the right nutrition (foods and natural supplements) along with treatment can enhance the patient’s well-being. (Ref: Aggerholm-Pedersen N, et al, Orthop Res. Rev., 2019; https://my.clevelandclinic.org/health/diseases/22112-chondrosarcoma)

Significance of Nutrition for Chondrosarcoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Chondrosarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Apricot includes active ingredients Quercetin, Vitamin C, Beta-sitosterol, Linolenic Acid, Stigmasterol and others. And Mango contains active ingredients Vitamin C, Beta-sitosterol, Lupeol, Linolenic Acid, Gallic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Chondrosarcoma, activation or inhibition of selected biochemical pathways like Hypoxia, MAPK Signaling, Oncogenic Cancer Epigenetics, Energy Metabolism plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Chondrosarcoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR CHONDROSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Chondrosarcoma undergoing chemotherapy treatment

In Chondrosarcoma – the genes TP53, IDH1, TET2, EPHA7 and ATRX have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Chondrosarcoma are Hypoxia, MAPK Signaling, Cytoskeletal Dynamics and others. Pazopanib is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Hypoxia, MAPK Signaling, Cytoskeletal Dynamics so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Linolenic Acid, Kaempferol, Stigmasterol among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A, Genistein and others.

Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Growth Factor Signaling and EPHRIN Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and MAPK Signaling.

Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition and Cytoskeletal Dynamics. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Chondrosarcoma with chemotherapy Pazopanib – Foods like Mung Bean are recommended compared to Pigeon Pea. This is because the active ingredients Oleic Acid and Linoleic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin C contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER PIGEON PEA FOR CHONDROSARCOMA ON TREATMENT WITH CHEMOTHERAPY PAZOPANIB FOR SOME CONDITIONS.

Eat more vegetables, Arugula or Chayote?

Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Chayote are Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid, Folic Acid and others.

Kaempferol can manipulate biochemical pathways WNT Beta Catenin Signaling, MAPK Signaling and Hypoxia. Vitamin A has biological action on biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and PI3K-AKT-MTOR Signaling.

Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition and Cytoskeletal Dynamics. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Chondrosarcoma with chemotherapy Pazopanib – Foods like Arugula are recommended compared to Chayote. This is because the active ingredients Oleic Acid and Linoleic Acid in Chayote interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Kaempferol and Vitamin A contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CHAYOTE FOR CHONDROSARCOMA ON TREATMENT WITH CHEMOTHERAPY PAZOPANIB FOR SOME CONDITIONS.

Eat more fruits, Mango or Apricot?

Fruits are an important part of many diets. The active ingredients contained in Mango are Vitamin C, Beta-sitosterol, Lupeol, Linolenic Acid, Gallic Acid among others. While the active ingredients contained in Apricot are Quercetin, Vitamin C, Beta-sitosterol, Linolenic Acid, Stigmasterol and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and WNT Beta Catenin Signaling. Gallic Acid has biological action on biochemical pathways Cytoskeletal Dynamics, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Rutin can manipulate biochemical pathways WNT Beta Catenin Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition and Cytoskeletal Dynamics. And so on.

When treating Chondrosarcoma with chemotherapy Pazopanib – Foods like Mango are recommended compared to Apricot. This is because the active ingredients Rutin and Oleic Acid in Apricot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Gallic Acid contained in Mango support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MANGO IS RECOMMENDED OVER APRICOT FOR CHONDROSARCOMA ON TREATMENT WITH CHEMOTHERAPY PAZOPANIB FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Acorn are Quercetin, Vitamin C, Beta-sitosterol, Gallic Acid, Beta-carotene and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and WNT Beta Catenin Signaling. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.

Beta-carotene can manipulate biochemical pathways MAPK Signaling and Notch Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling. And so on.

When treating Chondrosarcoma with chemotherapy Pazopanib – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Folic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR CHONDROSARCOMA ON TREATMENT WITH CHEMOTHERAPY PAZOPANIB FOR SOME CONDITIONS.

Foods for Genetic Risk of Chondrosarcoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. IDH1 and EPHA7 are two genes whose abnormalities are risk factors for Chondrosarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Chondrosarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Chondrosarcoma gene IDH1 has causative impact on biological pathways like Oncogenic Cancer Epigenetics, Glutathione Metabolism and Hypoxia. And EPHA7 has a causative impact on biological pathways like . Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like IDH1 and EPHA7 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes IDH1 and EPHA7 should be avoided.

Eat more pulses, Common Pea or Soy Bean?

The active ingredients contained in Common Pea are Lupeol, Daidzein, Vitamin C, Beta-sitosterol, Oleic Acid among others. While the active ingredients contained in Soy Bean are Quercetin, Lupeol, Daidzein, Vitamin C, Vitamin E and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Chondrosarcoma due to abnormalities in genes IDH1 and EPHA7 – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF CHONDROSARCOMA DUE TO GENES IDH1 AND EPHA7

Eat more vegetables, Cassava or Chicory?

The active ingredients contained in Cassava are Vitamin C, Beta-sitosterol, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Quercetin, Lupeol, Betulinic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Luteolin can manipulate biochemical pathways MYC Signaling. Esculetin has biological action on biochemical pathways Hypoxia. And so on.

For genetic risk of Chondrosarcoma due to abnormalities in genes IDH1 and EPHA7 – Foods like Cassava are recommended compared to Chicory. This is because the active ingredients Luteolin and Esculetin in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF CHONDROSARCOMA DUE TO GENES IDH1 AND EPHA7

Eat more fruits, Feijoa or Cranberry?

The active ingredients contained in Feijoa are Vitamin C, Lycopene, Casuarinin, Folic Acid among others. While the active ingredients contained in Cranberry are Resveratrol, Ellagic Acid, Quercetin, Vitamin C, Hyperoside and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Hypoxia.

Resveratrol can manipulate biochemical pathways P53 Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Chondrosarcoma due to abnormalities in genes IDH1 and EPHA7 – Foods like Feijoa are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF CHONDROSARCOMA DUE TO GENES IDH1 AND EPHA7

Eat more nuts, Almond or Peanut?

The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin C, Vitamin E, Beta-sitosterol, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways EPHRIN Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Chondrosarcoma due to abnormalities in genes IDH1 and EPHA7 – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF CHONDROSARCOMA DUE TO GENES IDH1 AND EPHA7

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Chondrosarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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