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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Chondrosarcoma!

Aug 4, 2023

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Introduction

Foods for Chondrosarcoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Chondrosarcoma is a malignant tumor that develops from cartilage cells. Cartilage is the soft connective tissue that allows movement between bone and joints. Chondrosarcoma can affect men and women equally and develops in individuals between ages of 40 and 75 years. There are several types of chondrosarcomas including clear cell chondrosarcoma, dedifferentiated chondrosarcoma and mesenchymal chondrosarcoma. Symptoms of chondrosarcoma may vary depending on the location and size of the tumor, including fatigue, fever and unintentional weight loss. The prognosis of chondrosarcoma depends on various factors, including the grade and stage of the tumor. Treatment options for chondrosarcoma may include surgery, radiation therapy, and chemotherapy, customized to individual cases.



For Chondrosarcoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Chondrosarcoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Chondrosarcoma?

For example does it matter if vegetable Cabbage is consumed more compared to Towel Gourd? Does it make any difference if fruit Longan is preferred over European Cranberry? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Gram Bean over Pigeon Pea. And if what I eat matters – then how does one identify foods which are recommended for Chondrosarcoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Chondrosarcoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Chondrosarcoma can be characterized by a unique set of biochemical pathways - the signature pathways of Chondrosarcoma. Biochemical pathways like Hypoxia, MAPK Signaling, Oncogenic Cancer Epigenetics, Energy Metabolism are part of the signature definition of Chondrosarcoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Longan contains active ingredients Curcumin, Apigenin, Lycopene, Phloretin, Daidzein. And European Cranberry contains active ingredients Curcumin, Apigenin, Ellagic Acid, Quercetin, Lycopene and possibly others.

A common mistake made when deciding and choosing foods to eat for Chondrosarcoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Chondrosarcoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Chondrosarcoma?

Personalized nutrition for cancers like Chondrosarcoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Chondrosarcoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Chondrosarcoma

All cancers like Chondrosarcoma can be characterized by a unique set of biochemical pathways – the signature pathways of Chondrosarcoma. Biochemical pathways like Hypoxia, MAPK Signaling, Oncogenic Cancer Epigenetics, Energy Metabolism are part of the signature definition of Chondrosarcoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Chondrosarcoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Chondrosarcoma when taking cancer treatment Pazopanib, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, IDH1, TET2, EPHA7 and ATRX are the top ranked reported genes for Chondrosarcoma. TP53 is reported in 13.5 % of the representative patients across all clinical trials. And IDH1 is reported in 13.5 %. The combined population patient data cover ages from 14 to 79. 66.4 % of the patient data are identified as men. The Chondrosarcoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Chondrosarcoma!

Food and Supplements for Chondrosarcoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CABBAGE or TOWEL GOURD?

Vegetable Cabbage contains many active ingredients or bioactives such as Curcumin, Apigenin, Quercetin, Benzyl Isothiocyanate, Lycopene. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Epithelial to Mesenchymal Transition and MYC Signaling and others. Cabbage is recommended for Chondrosarcoma when ongoing cancer treatment is Pazopanib. This is because Cabbage modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Pazopanib.

Some of the active ingredients or bioactives in vegetable Towel Gourd are Curcumin, Apigenin, Lycopene, Phloretin, Daidzein. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, PI3K-AKT-MTOR Signaling, Notch Signaling and MAPK Signaling and others. Towel Gourd is not recommended for Chondrosarcoma when ongoing cancer treatment is Pazopanib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CABBAGE IS RECOMMENDED OVER TOWEL GOURD FOR Chondrosarcoma AND TREATMENT Pazopanib.

Choose Fruit EUROPEAN CRANBERRY or LONGAN?

Fruit European Cranberry contains many active ingredients or bioactives such as Curcumin, Apigenin, Ellagic Acid, Quercetin, Lycopene. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, PI3K-AKT-MTOR Signaling, Epithelial to Mesenchymal Transition and Hypoxia and others. European Cranberry is recommended for Chondrosarcoma when ongoing cancer treatment is Pazopanib. This is because European Cranberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Pazopanib.

Some of the active ingredients or bioactives in fruit Longan are Curcumin, Apigenin, Lycopene, Phloretin, Daidzein. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and Epithelial to Mesenchymal Transition and others. Longan is not recommended for Chondrosarcoma when ongoing cancer treatment is Pazopanib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT EUROPEAN CRANBERRY IS RECOMMENDED OVER LONGAN FOR Chondrosarcoma AND TREATMENT Pazopanib.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Lycopene, Phloretin, Daidzein. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Epithelial to Mesenchymal Transition, MAPK Signaling and Hypoxia and others. Butternut is recommended for Chondrosarcoma when ongoing cancer treatment is Pazopanib. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Pazopanib.

Some of the active ingredients or bioactives in European Chestnut are Curcumin, Apigenin, Ellagic Acid, Quercetin, Phloretin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and Epithelial to Mesenchymal Transition and others. European Chestnut is not recommended for Chondrosarcoma when ongoing cancer treatment is Pazopanib because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Chondrosarcoma AND TREATMENT Pazopanib.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Chondrosarcoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable CALABASH or DAIKON RADISH?

Vegetable Calabash contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like EPHRIN Signaling, Cell Cycle, JAK-STAT Signaling and P53 Signaling and others. Calabash is recommended for risk of Chondrosarcoma when associated genetic risk is ATRX. This is because Calabash increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Daikon Radish are Apigenin, Curcumin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like Oxidative Stress and others. Daikon Radish is not recommended when risk of Chondrosarcoma when associated genetic risk is ATRX because it increases the signature pathways of it.

VEGETABLE CALABASH IS RECOMMENDED OVER DAIKON RADISH FOR ATRX GENETIC RISK OF CANCER.

Choose Fruit WATERMELON or EUROPEAN PLUM?

Fruit Watermelon contains many active ingredients or bioactives such as Curcumin, Lupeol, Formononetin, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Cell Cycle, JAK-STAT Signaling and Hypoxia and others. Watermelon is recommended for risk of Chondrosarcoma when associated genetic risk is ATRX. This is because Watermelon increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit European Plum are Curcumin, Lupeol, Formononetin, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Oxidative Stress, PI3K-AKT-MTOR Signaling and MAPK Signaling and others. European Plum is not recommended when risk of Chondrosarcoma when associated genetic risk is ATRX because it increases the signature pathways of it.

FRUIT WATERMELON IS RECOMMENDED OVER EUROPEAN PLUM FOR ATRX GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or BRAZIL NUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like EPHRIN Signaling, Cell Cycle, JAK-STAT Signaling and P53 Signaling and others. Common Hazelnut is recommended for risk of Chondrosarcoma when associated genetic risk is ATRX. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Brazil Nut are Curcumin, Ellagic Acid, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like Oxidative Stress, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling and others. Brazil Nut is not recommended when risk of Chondrosarcoma when associated genetic risk is ATRX because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER BRAZIL NUT FOR ATRX GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Chondrosarcoma. Chondrosarcoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Chondrosarcoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Cabbage contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Chondrosarcoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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