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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Granulosa Cell Tumor!

Aug 4, 2023

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Introduction

Foods for Granulosa Cell Tumor should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Granulosa cell tumor, also known as granulosa cell cancer, is a rare form of ovarian cancer that originates from the granulosa cells in the ovary. Accurate diagnosis, as reflected in pathology outlines, is crucial for effective treatment planning. Radiology, including ultrasound, plays a vital role in the evaluation and monitoring of granulosa cell tumors. Granulosa cell tumors can produce inhibin, a tumor marker that can aid in the diagnosis and monitoring of the disease. Treatment options for granulosa cell tumors may include surgery, chemotherapy, and hormonal therapy, tailored to the individual patient and stage of the tumor. Prognosis for granulosa cell tumors can vary depending on various factors, such as tumor stage, age, and presence of certain genetic mutations. Understanding the management and recurrence risks associated with granulosa cell tumors is important for long-term care. By seeking appropriate medical care and adhering to treatment protocols, individuals with granulosa cell tumors can optimize their chances of successful outcomes and long-term survival.



For Granulosa Cell Tumor does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Granulosa Cell Tumor does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Granulosa Cell Tumor?

For example does it matter if vegetable New Zealand Spinach is consumed more compared to Rapini? Does it make any difference if fruit Grapefruit is preferred over Purple Mangosteen? Also if similar choices are made for nuts/seeds like Chia over Brazil Nut and for pulses like Moth Bean over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Granulosa Cell Tumor and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Granulosa Cell Tumor!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Granulosa Cell Tumor can be characterized by a unique set of biochemical pathways - the signature pathways of Granulosa Cell Tumor. Biochemical pathways like Oncogenic Histone Methylation, Epithelial to Mesenchymal Transition, TGFB Signaling, Cytokine Signaling are part of the signature definition of Granulosa Cell Tumor.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Grapefruit contains active ingredients Curcumin, Naringin, Phloretin, Beta-sitosterol, Lupeol. And Purple Mangosteen contains active ingredients Curcumin, Apigenin, Beta-sitosterol, Phloretin, Lupeol and possibly others.

A common mistake made when deciding and choosing foods to eat for Granulosa Cell Tumor – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Granulosa Cell Tumor.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Granulosa Cell Tumor?

Personalized nutrition for cancers like Granulosa Cell Tumor consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Granulosa Cell Tumor biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Granulosa Cell Tumor

All cancers like Granulosa Cell Tumor can be characterized by a unique set of biochemical pathways – the signature pathways of Granulosa Cell Tumor. Biochemical pathways like Oncogenic Histone Methylation, Epithelial to Mesenchymal Transition, TGFB Signaling, Cytokine Signaling are part of the signature definition of Granulosa Cell Tumor. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Granulosa Cell Tumor need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Granulosa Cell Tumor when taking cancer treatment Temozolomide, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

FOXL2, SMAD3, TP53, PIK3C2G and MED12 are the top ranked reported genes for Granulosa Cell Tumor. FOXL2 is reported in 20.0 % of the representative patients across all clinical trials. And SMAD3 is reported in 13.3 %. The combined population patient data cover ages from 0 to 7. 1% of the patient data are identified as men. The Granulosa Cell Tumor biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Granulosa Cell Tumor!

Food and Supplements for Granulosa Cell Tumor

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable NEW ZEALAND SPINACH or RAPINI?

Vegetable New Zealand Spinach contains many active ingredients or bioactives such as Curcumin, Apigenin, Phloretin, Beta-sitosterol, Quercetin. These active ingredients manipulate various biochemical pathways like P53 Signaling, MYC Signaling, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. New Zealand Spinach is recommended for Granulosa Cell Tumor when ongoing cancer treatment is Temozolomide. This is because New Zealand Spinach modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Temozolomide.

Some of the active ingredients or bioactives in vegetable Rapini are Curcumin, Apigenin, Beta-sitosterol, Phloretin, Lupeol. These active ingredients manipulate various biochemical pathways like TGFB Signaling and Epithelial to Mesenchymal Transition and others. Rapini is not recommended for Granulosa Cell Tumor when ongoing cancer treatment is Temozolomide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE NEW ZEALAND SPINACH IS RECOMMENDED OVER RAPINI FOR Granulosa Cell Tumor AND TREATMENT Temozolomide.

Choose Fruit PURPLE MANGOSTEEN or GRAPEFRUIT?

Fruit Purple Mangosteen contains many active ingredients or bioactives such as Curcumin, Apigenin, Beta-sitosterol, Phloretin, Lupeol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, MYC Signaling, TGFB Signaling and PI3K-AKT-MTOR Signaling and others. Purple Mangosteen is recommended for Granulosa Cell Tumor when ongoing cancer treatment is Temozolomide. This is because Purple Mangosteen modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Temozolomide.

Some of the active ingredients or bioactives in fruit Grapefruit are Curcumin, Naringin, Phloretin, Beta-sitosterol, Lupeol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and TGFB Signaling and others. Grapefruit is not recommended for Granulosa Cell Tumor when ongoing cancer treatment is Temozolomide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT PURPLE MANGOSTEEN IS RECOMMENDED OVER GRAPEFRUIT FOR Granulosa Cell Tumor AND TREATMENT Temozolomide.

Choose Nut CHIA or BRAZIL NUT?

Chia contains many active ingredients or bioactives such as Curcumin, Apigenin, Beta-sitosterol, Phloretin, Lupeol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, MYC Signaling, TGFB Signaling and PI3K-AKT-MTOR Signaling and others. Chia is recommended for Granulosa Cell Tumor when ongoing cancer treatment is Temozolomide. This is because Chia modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Temozolomide.

Some of the active ingredients or bioactives in Brazil Nut are Curcumin, Beta-sitosterol, Phloretin, Lupeol, Eugenol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, MYC Signaling, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Brazil Nut is not recommended for Granulosa Cell Tumor when ongoing cancer treatment is Temozolomide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

CHIA IS RECOMMENDED OVER BRAZIL NUT FOR Granulosa Cell Tumor AND TREATMENT Temozolomide.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Granulosa Cell Tumor or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or YAM?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Myricetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Cytokine Signaling, TGFB Signaling and PI3K-AKT-MTOR Signaling and others. Giant Butterbur is recommended for risk of Granulosa Cell Tumor when associated genetic risk is FOXL2. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Yam are Apigenin, Curcumin, Myricetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like TGFB Signaling and others. Yam is not recommended when risk of Granulosa Cell Tumor when associated genetic risk is FOXL2 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER YAM FOR FOXL2 GENETIC RISK OF CANCER.

Choose Fruit RABBITEYE BLUEBERRY or PUMMELO?

Fruit Rabbiteye Blueberry contains many active ingredients or bioactives such as Quercetin, Linalool, Eugenol, Epicatechin, Ferulic Acid. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Growth Factor Signaling, TGFB Signaling and PI3K-AKT-MTOR Signaling and others. Rabbiteye Blueberry is recommended for risk of Granulosa Cell Tumor when associated genetic risk is FOXL2. This is because Rabbiteye Blueberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Quercetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling and TGFB Signaling and others. Pummelo is not recommended when risk of Granulosa Cell Tumor when associated genetic risk is FOXL2 because it increases the signature pathways of it.

FRUIT RABBITEYE BLUEBERRY IS RECOMMENDED OVER PUMMELO FOR FOXL2 GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or EUROPEAN CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Myricetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Cell Cycle Checkpoints, Cytokine Signaling and TGFB Signaling and others. Common Hazelnut is recommended for risk of Granulosa Cell Tumor when associated genetic risk is FOXL2. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Curcumin, Quercetin, Ellagic Acid, Myricetin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and TGFB Signaling and others. European Chestnut is not recommended when risk of Granulosa Cell Tumor when associated genetic risk is FOXL2 because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR FOXL2 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Granulosa Cell Tumor. Granulosa Cell Tumor patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Granulosa Cell Tumor, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like New Zealand Spinach contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Granulosa Cell Tumor?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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