Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Granulosa Cell Tumor when undergoing chemotherapy or when you determine you have a genetic risk for developing Granulosa Cell Tumor because of FOXL2 and SMAD3 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Granulosa Cell Tumor which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Pomegranate in my diet” or “Should I reduce consumption of vegetable Swede” or “Can I take Alpha Lipoic Acid and Theaflavin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO GRANULOSA CELL TUMOR, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Granulosa Cell Tumor is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR GRANULOSA CELL TUMOR, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Granulosa Cell Tumor
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Granulosa Cell Tumor from cBioPortal. 7.1% of males and 92.9% of females were the distribution of gender in these clinical studies. From a patient sample size of 17; the top genes with mutations and other abnormalities for Granulosa Cell Tumor include genes FOXL2, SMAD3, TP53, PIK3C2G and MED12. The occurrence frequency distribution for these genes respectively is 20.0%, 13.3%, 6.7%, 6.7% and 6.7%. These tumor genetic details of Granulosa Cell Tumor are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Granulosa Cell Tumor.
Significance of Nutrition for Granulosa Cell Tumor
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Granulosa Cell Tumor. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Cranberry includes active ingredients Quercetin, Vitamin C, Ellagic Acid, Caffeic Acid, Hyperoside and others. And Pomegranate contains active ingredients Betulinic Acid, Corilagin, Beta-sitosterol, Apigenin, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Granulosa Cell Tumor, activation or inhibition of selected biochemical pathways like Oncogenic Histone Methylation, Adherens junction, TGFB Signaling, Cytokine Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Granulosa Cell Tumor, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR GRANULOSA CELL TUMOR – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Granulosa Cell Tumor undergoing chemotherapy treatment
In Granulosa Cell Tumor – the genes FOXL2, SMAD3, TP53, PIK3C2G and MED12 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Granulosa Cell Tumor are Oncogenic Histone Methylation, Adherens junction, Epithelial to Mesenchymal Transition and others. Temozolomide is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Oncogenic Histone Methylation, Adherens junction, Epithelial to Mesenchymal Transition so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Chickpea?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Beta-sitosterol, Lupeol, Daidzein, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Chickpea are Linolenic Acid, Oleic Acid, Vitamin A, Genistein, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and MYC Signaling. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, P53 Signaling and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
When treating Granulosa Cell Tumor with chemotherapy Temozolomide – Foods like Common Pea are recommended compared to Chickpea. This is because the active ingredients Vitamin A and Oleic Acid in Chickpea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER CHICKPEA FOR GRANULOSA CELL TUMOR ON TREATMENT WITH CHEMOTHERAPY TEMOZOLOMIDE FOR SOME CONDITIONS.
Eat more vegetables, Cucumber or Swede?
Vegetables are an important part of many diets. The active ingredients contained in Cucumber are Beta-sitosterol, Lupeol, Cucurbitacin E, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Swede are Lycopene, Linolenic Acid, Oleic Acid, Linoleic Acid, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and MYC Signaling. Lupeol has biological action on biochemical pathways WNT Beta Catenin Signaling, P53 Signaling and PI3K-AKT-MTOR Signaling.
Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways TGFB Signaling and Epithelial to Mesenchymal Transition. And so on.
When treating Granulosa Cell Tumor with chemotherapy Temozolomide – Foods like Cucumber are recommended compared to Swede. This is because the active ingredients Oleic Acid and Linoleic Acid in Swede interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Lupeol contained in Cucumber support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CUCUMBER IS RECOMMENDED OVER SWEDE FOR GRANULOSA CELL TUMOR ON TREATMENT WITH CHEMOTHERAPY TEMOZOLOMIDE FOR SOME CONDITIONS.
Eat more fruits, Pomegranate or Cranberry?
Fruits are an important part of many diets. The active ingredients contained in Pomegranate are Betulinic Acid, Corilagin, Beta-sitosterol, Apigenin, Vitamin C among others. While the active ingredients contained in Cranberry are Quercetin, Vitamin C, Ellagic Acid, Caffeic Acid, Hyperoside and others.
Betulinic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and MYC Signaling. Gallic Acid has biological action on biochemical pathways TGFB Signaling, PI3K-AKT-MTOR Signaling and Epithelial to Mesenchymal Transition.
Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. Caffeic Acid has biological action on biochemical pathways TGFB Signaling. And so on.
When treating Granulosa Cell Tumor with chemotherapy Temozolomide – Foods like Pomegranate are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Caffeic Acid in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Gallic Acid contained in Pomegranate support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: POMEGRANATE IS RECOMMENDED OVER CRANBERRY FOR GRANULOSA CELL TUMOR ON TREATMENT WITH CHEMOTHERAPY TEMOZOLOMIDE FOR SOME CONDITIONS.
Eat more nuts, Almond or Chestnut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Beta-sitosterol, Quercetin, Vitamin E, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Chestnut are Quercetin, Vitamin C, Linolenic Acid, Ellagic Acid, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and MYC Signaling. Quercetin has biological action on biochemical pathways TGFB Signaling, WNT Beta Catenin Signaling and P53 Signaling.
Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Granulosa Cell Tumor with chemotherapy Temozolomide – Foods like Almond are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Vitamin A in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER CHESTNUT FOR GRANULOSA CELL TUMOR ON TREATMENT WITH CHEMOTHERAPY TEMOZOLOMIDE FOR SOME CONDITIONS.
Foods for Genetic Risk of Granulosa Cell Tumor
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. FOXL2 and SMAD3 are two genes whose abnormalities are risk factors for Granulosa Cell Tumor. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Granulosa Cell Tumor can be used as a guide for coming up with a recommended personalized nutrition plan. For Granulosa Cell Tumor gene FOXL2 has causative impact on biological pathways like Post Translation Modification. And SMAD3 has a causative impact on biological pathways like TGFB Signaling, Androgen Signaling and Cell Cycle Checkpoints. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like FOXL2 and SMAD3 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes FOXL2 and SMAD3 should be avoided.
Eat more pulses, Scarlet Bean or Yellow Wax Bean?
The active ingredients contained in Scarlet Bean are Vitamin C, Beta-sitosterol, Liquiritigenin, Oleic Acid, Genistein among others. While the active ingredients contained in Yellow Wax Bean are Vitamin C, Butyric Acid, Cianidanol, Vitamin A, Ferulic Acid and others.
Vitamin C can manipulate biochemical pathways Oncogenic Cancer Epigenetics, Suppressive Histone Methylation and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways Cytokine Signaling, Hypoxia and Oncogenic Cancer Epigenetics.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Palmitic Acid has biological action on biochemical pathways Cytokine Signaling, Oncogenic Cancer Epigenetics and mRNA Splicing. And so on.
For genetic risk of Granulosa Cell Tumor due to abnormalities in genes FOXL2 and SMAD3 – Foods like Scarlet Bean are recommended compared to Yellow Wax Bean. This is because the active ingredients Vitamin A and Palmitic Acid in Yellow Wax Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER YELLOW WAX BEAN FOR REDUCING THE GENETIC RISK OF GRANULOSA CELL TUMOR DUE TO GENES FOXL2 AND SMAD3
Eat more vegetables, Jicama or Yardlong Bean?
The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Vitamin A, Folic Acid, Beta-carotene among others. While the active ingredients contained in Yardlong Bean are Vitamin C, Oleic Acid, Linolenic Acid, Vitamin A, Linoleic Acid and others.
Vitamin C can manipulate biochemical pathways Oncogenic Cancer Epigenetics, Suppressive Histone Methylation and PI3K-AKT-MTOR Signaling. Vitamin B3 has biological action on biochemical pathways Hypoxia and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Granulosa Cell Tumor due to abnormalities in genes FOXL2 and SMAD3 – Foods like Jicama are recommended compared to Yardlong Bean. This is because the active ingredients Vitamin A and Folic Acid in Yardlong Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER YARDLONG BEAN FOR REDUCING THE GENETIC RISK OF GRANULOSA CELL TUMOR DUE TO GENES FOXL2 AND SMAD3
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Currant or Muskmelon?
The active ingredients contained in Currant are Quercetin, Vitamin C, Beta-sitosterol, Gamma-linolenic Acid, Caffeic Acid among others. While the active ingredients contained in Muskmelon are Vitamin C, Isoliquiritigenin, Lupeol, Oleic Acid, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Oncogenic Cancer Epigenetics, Suppressive Histone Methylation and PI3K-AKT-MTOR Signaling. Gamma-linolenic Acid has biological action on biochemical pathways Cytokine Signaling, Hypoxia and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Granulosa Cell Tumor due to abnormalities in genes FOXL2 and SMAD3 – Foods like Currant are recommended compared to Muskmelon. This is because the active ingredients Vitamin A and Folic Acid in Muskmelon further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Gamma-linolenic Acid contained in Currant together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CURRANT IS RECOMMENDED OVER MUSKMELON FOR REDUCING THE GENETIC RISK OF GRANULOSA CELL TUMOR DUE TO GENES FOXL2 AND SMAD3
Eat more nuts, Pine Nut or Acorn?
The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Oleic Acid, Linolenic Acid, Vitamin A among others. While the active ingredients contained in Acorn are Quercetin, Vitamin C, Beta-sitosterol, Gallic Acid, Vitamin B3 and others.
Beta-sitosterol can manipulate biochemical pathways Cytokine Signaling, Oncogenic Cancer Epigenetics and Hypoxia. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Beta-carotene has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Granulosa Cell Tumor due to abnormalities in genes FOXL2 and SMAD3 – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Vitamin A and Beta-carotene in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF GRANULOSA CELL TUMOR DUE TO GENES FOXL2 AND SMAD3
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Granulosa Cell Tumor by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
- Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway.
- Gallic acid, a phenolic compound, exerts anti-angiogenic effects via the PTEN/AKT/HIF-1α/VEGF signaling pathway in ovarian cancer cells.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Synthesis and structure-activity relationship analysis of caffeic acid amides as selective matrix metalloproteinase inhibitors.
- Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells.
- Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Gamma-linolenic acid inhibits hepatic PAI-1 expression by inhibiting p38 MAPK-dependent activator protein and mitochondria-mediated apoptosis pathway.
- Sequential protooncogene expression in regenerating kidney following acute renal injury.
- Polyol pathway mediates iron-induced oxidative injury in ischemic-reperfused rat heart.
- Research progress on the anticancer effects of vitamin K2.
- β-carotene Inhibits Expression of c-Myc and Cyclin E in Helicobacter pylori-infected Gastric Epithelial Cells.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.