Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Cancer Of Unknown Primary when undergoing chemotherapy or when you determine you have a genetic risk for developing Cancer Of Unknown Primary because of ERBB2 and BLM gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Cancer Of Unknown Primary which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Pummelo” or “Include fruit Feijoa in my diet” or “Should I reduce consumption of vegetable Beetroot” or “Can I take Dim and Birch supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO CANCER OF UNKNOWN PRIMARY, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Cancer Of Unknown Primary is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR CANCER OF UNKNOWN PRIMARY, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Cancer Of Unknown Primary
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Cancer Of Unknown Primary from cBioPortal. The patients enrolled in the studies for Cancer Of Unknown Primary are in ages between 12 to 73 with an average age of 68. 42.3% of males and 57.7% of females were the distribution of gender in these clinical studies. From a patient sample size of 262; the top genes with mutations and other abnormalities for Cancer Of Unknown Primary include genes ERBB2, KMT2C, BLM, IGF1 and IL7R. The occurrence frequency distribution for these genes respectively is 12.5%, 8.3%, 4.2%, 4.2% and 4.2%. These tumor genetic details of Cancer Of Unknown Primary are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Cancer Of Unknown Primary.
Significance of Nutrition for Cancer Of Unknown Primary
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Cancer Of Unknown Primary. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Pummelo includes active ingredients Naringin, Naringenin, Beta-sitosterol, Hesperetin, Vitamin C and others. And Feijoa contains active ingredients Lycopene, Vitamin C, Casuarinin, Folic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Cancer Of Unknown Primary, activation or inhibition of selected biochemical pathways like DNA Repair, Angiogenesis, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Cancer Of Unknown Primary, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR CANCER OF UNKNOWN PRIMARY – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Cancer Of Unknown Primary undergoing chemotherapy treatment
In Cancer Of Unknown Primary – the genes ERBB2, KMT2C, BLM, IGF1 and IL7R have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Cancer Of Unknown Primary are DNA Repair, Angiogenesis, Hypoxia and others. Temozolomide is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers DNA Repair, Angiogenesis, Hypoxia so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Lima Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Delphinidin, Lupeol, Daidzein, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Lima Bean are Vitamin C, Oleic Acid, Genistein, Vitamin A, Linoleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Adherens junction. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle and MYC Signaling.
Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and Extracellular Matrix Remodelling. And so on.
When treating Cancer Of Unknown Primary with chemotherapy Temozolomide – Foods like Common Pea are recommended compared to Lima Bean. This is because the active ingredients Genistein and Vitamin A in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LIMA BEAN FOR CANCER OF UNKNOWN PRIMARY ON TREATMENT WITH CHEMOTHERAPY TEMOZOLOMIDE FOR SOME CONDITIONS.
Eat more vegetables, Cassava or Beetroot?
Vegetables are an important part of many diets. The active ingredients contained in Cassava are Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid, Vitamin A among others. While the active ingredients contained in Beetroot are Vitamin E, Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and Growth Factor Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Cell Cycle and MYC Signaling.
Vitamin E can manipulate biochemical pathways Oxidative Stress. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and Extracellular Matrix Remodelling. And so on.
When treating Cancer Of Unknown Primary with chemotherapy Temozolomide – Foods like Cassava are recommended compared to Beetroot. This is because the active ingredients Vitamin E and Vitamin A in Beetroot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER BEETROOT FOR CANCER OF UNKNOWN PRIMARY ON TREATMENT WITH CHEMOTHERAPY TEMOZOLOMIDE FOR SOME CONDITIONS.
Eat more fruits, Feijoa or Pummelo?
Fruits are an important part of many diets. The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Pummelo are Naringin, Naringenin, Beta-sitosterol, Hesperetin, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and Growth Factor Signaling. Lycopene has biological action on biochemical pathways NFKB Signaling, JAK-STAT Signaling and Cell Cycle.
Naringin can manipulate biochemical pathways Oxidative Stress. Naringenin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Cancer Of Unknown Primary with chemotherapy Temozolomide – Foods like Feijoa are recommended compared to Pummelo. This is because the active ingredients Naringin and Naringenin in Pummelo interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Lycopene contained in Feijoa support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER PUMMELO FOR CANCER OF UNKNOWN PRIMARY ON TREATMENT WITH CHEMOTHERAPY TEMOZOLOMIDE FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid, Vitamin A among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Gallic Acid, Beta-carotene and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Adherens junction. Vitamin K has biological action on biochemical pathways MYC Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress. Gallic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Cancer Of Unknown Primary with chemotherapy Temozolomide – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR CANCER OF UNKNOWN PRIMARY ON TREATMENT WITH CHEMOTHERAPY TEMOZOLOMIDE FOR SOME CONDITIONS.
Foods for Genetic Risk of Cancer Of Unknown Primary
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ERBB2 and BLM are two genes whose abnormalities are risk factors for Cancer Of Unknown Primary. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Cancer Of Unknown Primary can be used as a guide for coming up with a recommended personalized nutrition plan. For Cancer Of Unknown Primary gene ERBB2 has causative impact on biological pathways like Growth Factor Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And BLM has a causative impact on biological pathways like DNA Repair, DNA Repair and Post Translation Modification. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ERBB2 and BLM should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ERBB2 and BLM should be avoided.
Eat more pulses, Scarlet Bean or Moth Bean?
The active ingredients contained in Scarlet Bean are Oleic Acid, Linolenic Acid, Beta-sitosterol, Vitamin C, Genistein among others. While the active ingredients contained in Moth Bean are Oleic Acid, Linolenic Acid, Beta-sitosterol, Stigmasterol, Linoleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
For genetic risk of Cancer Of Unknown Primary due to abnormalities in genes ERBB2 and BLM – Foods like Scarlet Bean are recommended compared to Moth Bean. This is because the active ingredients Vitamin A and Linoleic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF CANCER OF UNKNOWN PRIMARY DUE TO GENES ERBB2 AND BLM
Eat more vegetables, Jicama or Chayote?
The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Chayote are Oleic Acid, Linolenic Acid, Vitamin C, Linoleic Acid, Folic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Vitamin B3 has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Cancer Of Unknown Primary due to abnormalities in genes ERBB2 and BLM – Foods like Jicama are recommended compared to Chayote. This is because the active ingredients Linoleic Acid and Folic Acid in Chayote further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER CHAYOTE FOR REDUCING THE GENETIC RISK OF CANCER OF UNKNOWN PRIMARY DUE TO GENES ERBB2 AND BLM
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Kiwi or Peach?
The active ingredients contained in Kiwi are Quercetin, Vitamin C, Fisetin, Chlorogenic Acid, Vitamin A among others. While the active ingredients contained in Peach are Oleic Acid, Modified Citrus Pectin, Linolenic Acid, Beta-sitosterol, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Fisetin has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Growth Factor Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
For genetic risk of Cancer Of Unknown Primary due to abnormalities in genes ERBB2 and BLM – Foods like Kiwi are recommended compared to Peach. This is because the active ingredients Vitamin A and Linoleic Acid in Peach further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Fisetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: KIWI IS RECOMMENDED OVER PEACH FOR REDUCING THE GENETIC RISK OF CANCER OF UNKNOWN PRIMARY DUE TO GENES ERBB2 AND BLM
Eat more nuts, Pecan Nut or Peanut?
The active ingredients contained in Pecan Nut are Cianidanol, Delphinidin, Vitamin E, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Gamma-linolenic Acid, Oleic Acid, Linolenic Acid and others.
Cianidanol can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Delphinidin has biological action on biochemical pathways RAS-RAF Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Cancer Of Unknown Primary due to abnormalities in genes ERBB2 and BLM – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Cianidanol and Delphinidin contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF CANCER OF UNKNOWN PRIMARY DUE TO GENES ERBB2 AND BLM
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Cancer Of Unknown Primary by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Tmb Mskcc 2018
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- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Lycopene Inhibits Activation of Epidermal Growth Factor Receptor and Expression of Cyclooxygenase-2 in Gastric Cancer Cells.
- Palm tocotrienol exerted better antioxidant activities in bone than alpha-tocopherol.
- Research progress on the anticancer effects of vitamin K2.
- Small-molecule inhibitors of NADPH oxidase 4.
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- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
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- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Fisetin: a dietary antioxidant for health promotion.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.