Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Anaplastic Oligodendroglioma when undergoing chemotherapy or when you determine you have a genetic risk for developing Anaplastic Oligodendroglioma because of HLA-A and PTCH1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Anaplastic Oligodendroglioma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Pummelo” or “Include fruit Raspberry in my diet” or “Should I reduce consumption of vegetable Lotus” or “Can I take Birch and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ANAPLASTIC OLIGODENDROGLIOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Anaplastic Oligodendroglioma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR ANAPLASTIC OLIGODENDROGLIOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Anaplastic Oligodendroglioma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Anaplastic Oligodendroglioma from cBioPortal. The patients enrolled in the studies for Anaplastic Oligodendroglioma are in ages between 19 to 81 with an average age of 45. 51.1% of males and 48.9% of females were the distribution of gender in these clinical studies. From a patient sample size of 103; the top genes with mutations and other abnormalities for Anaplastic Oligodendroglioma include genes HLA-A, PTCH1, IDH1, TERT and ARID2. The occurrence frequency distribution for these genes respectively is 4.3%, 4.3%, 4.3%, 4.3% and 4.3%. These tumor genetic details of Anaplastic Oligodendroglioma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Anaplastic Oligodendroglioma.
Significance of Nutrition for Anaplastic Oligodendroglioma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Anaplastic Oligodendroglioma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Pummelo includes active ingredients Oleic Acid, Beta-sitosterol, Naringin, Naringenin, Vitamin C and others. And Raspberry contains active ingredients Quercetin, Ellagic Acid, Resveratrol, Gallic Acid, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Anaplastic Oligodendroglioma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Anaplastic Oligodendroglioma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ANAPLASTIC OLIGODENDROGLIOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Anaplastic Oligodendroglioma undergoing chemotherapy treatment
In Anaplastic Oligodendroglioma – the genes HLA-A, PTCH1, IDH1, TERT and ARID2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Anaplastic Oligodendroglioma are RAS-RAF Signaling, mRNA Splicing, Cell Cycle and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, mRNA Splicing, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Lima Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Delphinidin, Oleic Acid, Beta-sitosterol among others. While the active ingredients contained in Lima Bean are Oleic Acid, Vitamin C, Genistein, Vitamin A, Linoleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Microtubule Dynamics. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling.
Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Vitamin A has biological action on biochemical pathways TGFB Signaling and Extracellular Matrix Remodelling. And so on.
When treating Anaplastic Oligodendroglioma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Lima Bean. This is because the active ingredients Genistein and Vitamin A in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LIMA BEAN FOR ANAPLASTIC OLIGODENDROGLIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Jicama or Lotus?
Vegetables are an important part of many diets. The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Lotus are Quercetin, Oleic Acid, Beta-sitosterol, Vitamin C, Kaempferol and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and MYC Signaling. Beta-carotene has biological action on biochemical pathways NFKB Signaling, Microtubule Dynamics and DNA Repair.
Citric Acid can manipulate biochemical pathways Oxidative Stress. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Anaplastic Oligodendroglioma with chemotherapy Radiation – Foods like Jicama are recommended compared to Lotus. This is because the active ingredients Citric Acid and Quercetin in Lotus interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-carotene contained in Jicama support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER LOTUS FOR ANAPLASTIC OLIGODENDROGLIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Raspberry or Pummelo?
Fruits are an important part of many diets. The active ingredients contained in Raspberry are Quercetin, Ellagic Acid, Resveratrol, Gallic Acid, Vitamin C among others. While the active ingredients contained in Pummelo are Oleic Acid, Beta-sitosterol, Naringin, Naringenin, Vitamin C and others.
Ellagic Acid can manipulate biochemical pathways NFKB Signaling, Extracellular Matrix Remodelling and DNA Repair. Vitamin C has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and MYC Signaling.
Naringin can manipulate biochemical pathways Oxidative Stress. Naringenin has biological action on biochemical pathways DNA Repair and Oxidative Stress. And so on.
When treating Anaplastic Oligodendroglioma with chemotherapy Radiation – Foods like Raspberry are recommended compared to Pummelo. This is because the active ingredients Naringin and Naringenin in Pummelo interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Vitamin C contained in Raspberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: RASPBERRY IS RECOMMENDED OVER PUMMELO FOR ANAPLASTIC OLIGODENDROGLIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Oleic Acid, Beta-sitosterol, Linolenic Acid, Vitamin A among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Microtubule Dynamics. Vitamin K has biological action on biochemical pathways MYC Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways NFKB Signaling, JAK-STAT Signaling and MYC Signaling. Vitamin E has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Anaplastic Oligodendroglioma with chemotherapy Radiation – Foods like Pine Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Vitamin E in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER BRAZIL NUT FOR ANAPLASTIC OLIGODENDROGLIOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Anaplastic Oligodendroglioma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. HLA-A and PTCH1 are two genes whose abnormalities are risk factors for Anaplastic Oligodendroglioma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Anaplastic Oligodendroglioma can be used as a guide for coming up with a recommended personalized nutrition plan. For Anaplastic Oligodendroglioma gene HLA-A has causative impact on biological pathways like Interferon Signaling and Antigen Presentation. And PTCH1 has a causative impact on biological pathways like G-protein-coupled Receptor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like HLA-A and PTCH1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes HLA-A and PTCH1 should be avoided.
Eat more pulses, Scarlet Bean or Common Bean?
The active ingredients contained in Scarlet Bean are Genistein, Oleic Acid, Beta-sitosterol, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Genistein, Esculin, Oleic Acid, Vitamin C and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and Cell Cycle Checkpoints. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and MYC Signaling.
Ferulic Acid can manipulate biochemical pathways DNA Repair. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Anaplastic Oligodendroglioma due to abnormalities in genes HLA-A and PTCH1 – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Ferulic Acid and Pelargonidin in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF ANAPLASTIC OLIGODENDROGLIOMA DUE TO GENES HLA-A AND PTCH1
Eat more vegetables, Cassava or Jute?
The active ingredients contained in Cassava are Oleic Acid, Beta-sitosterol, Vitamin C, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Jute are Quercetin, Oleic Acid, Vitamin C, Kaempferol, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, MYC Signaling and Cell Cycle Checkpoints.
Quercetin can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways MYC Signaling, RAS-RAF Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Anaplastic Oligodendroglioma due to abnormalities in genes HLA-A and PTCH1 – Foods like Cassava are recommended compared to Jute. This is because the active ingredients Quercetin and Folic Acid in Jute further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER JUTE FOR REDUCING THE GENETIC RISK OF ANAPLASTIC OLIGODENDROGLIOMA DUE TO GENES HLA-A AND PTCH1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Grape or Huckleberry?
The active ingredients contained in Grape are Resveratrol, Lupeol, Oleic Acid, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Huckleberry are Resveratrol, Quercetin, Vitamin C, Caffeic Acid, Delphinidin and others.
Resveratrol can manipulate biochemical pathways DNA Repair, MYC Signaling and Cell Cycle Checkpoints. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and RAS-RAF Signaling.
Quercetin can manipulate biochemical pathways DNA Repair. Ferulic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Anaplastic Oligodendroglioma due to abnormalities in genes HLA-A and PTCH1 – Foods like Grape are recommended compared to Huckleberry. This is because the active ingredients Quercetin and Ferulic Acid in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Resveratrol and Vitamin C contained in Grape together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GRAPE IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF ANAPLASTIC OLIGODENDROGLIOMA DUE TO GENES HLA-A AND PTCH1
Eat more nuts, Pecan Nut or Acorn?
The active ingredients contained in Pecan Nut are Oleic Acid, Vitamin E, Cianidanol, Linolenic Acid, Delphinidin among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Vitamin B3, Quercitrin and others.
Cianidanol can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Delphinidin has biological action on biochemical pathways RAS-RAF Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.
Quercetin can manipulate biochemical pathways DNA Repair. Gallic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Anaplastic Oligodendroglioma due to abnormalities in genes HLA-A and PTCH1 – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Cianidanol and Delphinidin contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF ANAPLASTIC OLIGODENDROGLIOMA DUE TO GENES HLA-A AND PTCH1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Anaplastic Oligodendroglioma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.