Foods for Ameloblastoma!

Introduction

Foods for Ameloblastoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Ameloblastoma is a rare type of tumor that usually develops in the jaw, particularly the mandible. Pathology outlines provide valuable information about the characteristics and features of ameloblastoma, aiding in accurate diagnosis. Radiology plays a crucial role in visualizing and assessing ameloblastoma tumors. Treatment for ameloblastoma typically involves surgical removal of the tumor, often requiring careful reconstruction of the affected area. Different types of ameloblastoma exist, each with unique features and treatment considerations. Understanding the clinical and radiographic features of ameloblastoma is essential for proper diagnosis and management. Ameloblastoma is not considered cancerous, although it can be locally aggressive and invade surrounding tissues. Management of ameloblastoma often requires a multidisciplinary approach involving oral and maxillofacial surgeons, dental experts, and pathology specialists. The Braf gene mutation has been associated with some cases of ameloblastoma, leading to potential targeted therapies. Early detection and appropriate management are essential for controlling the growth and preventing recurrence of ameloblastoma. Providing information about the definition, features, and treatment options for ameloblastoma through platforms such as seminars and PowerPoint presentations helps educate both professionals and the general public. Overall, a comprehensive understanding of ameloblastoma and its specific characteristics aids in proper diagnosis, treatment, and patient management.

For Ameloblastoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Ameloblastoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Ameloblastoma?

For example does it matter if vegetable Burdock is consumed more compared to Napa Cabbage? Does it make any difference if fruit Pummelo is preferred over Lemon? Also if similar choices are made for nuts/seeds like Walnut over European Chestnut and for pulses like Black-eyed Pea over Pigeon Pea. And if what I eat matters – then how does one identify foods which are recommended for Ameloblastoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Ameloblastoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Quercetin, Lycopene, Protocatechuic Acid, Lupeol, Apigenin. And Lemon contains active ingredients D-limonene, Linalool, Nobiletin, Protocatechuic Acid, Lupeol and possibly others.

A common mistake made when deciding and choosing foods to eat for Ameloblastoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Ameloblastoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Ameloblastoma?

Personalized nutrition for cancers like Ameloblastoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Ameloblastoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Ameloblastoma

All cancers like Ameloblastoma can be characterized by a unique set of biochemical pathways – the signature pathways of Ameloblastoma. Biochemical pathways like RAS-RAF Signaling, Cell Cycle, MAPK Signaling, PI3K-AKT-MTOR Signaling are part of the signature definition of Ameloblastoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Ameloblastoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Ameloblastoma when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

BRAF, SMO, PIK3CA, PTEN and CDKN2A are the top ranked reported genes for Ameloblastoma. BRAF is reported in 55.0 % of the representative patients across all clinical trials. And SMO is reported in 13.0 %. The combined population patient data cover ages from to . % of the patient data are identified as men. The Ameloblastoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Ameloblastoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable BURDOCK or NAPA CABBAGE?

Vegetable Burdock contains many active ingredients or bioactives such as Protocatechuic Acid, Lupeol, Apigenin, Daidzein, Myricetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, PI3K-AKT-MTOR Signaling, MAPK Signaling and MYC Signaling and others. Burdock is recommended for Ameloblastoma when ongoing cancer treatment is Radiation. This is because Burdock modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Napa Cabbage are Protocatechuic Acid, Lupeol, Daidzein, Phloretin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Cell Cycle, PI3K-AKT-MTOR Signaling and MYC Signaling and others. Napa Cabbage is not recommended for Ameloblastoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE BURDOCK IS RECOMMENDED OVER NAPA CABBAGE FOR Ameloblastoma AND TREATMENT Radiation.

Choose Fruit LEMON or PUMMELO?

Fruit Lemon contains many active ingredients or bioactives such as D-limonene, Linalool, Nobiletin, Protocatechuic Acid, Lupeol. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition, Cell Cycle, PI3K-AKT-MTOR Signaling and MAPK Signaling and others. Lemon is recommended for Ameloblastoma when ongoing cancer treatment is Radiation. This is because Lemon modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Lycopene, Protocatechuic Acid, Lupeol, Apigenin. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition and others. Pummelo is not recommended for Ameloblastoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT LEMON IS RECOMMENDED OVER PUMMELO FOR Ameloblastoma AND TREATMENT Radiation.

Choose Nut WALNUT or EUROPEAN CHESTNUT?

Walnut contains many active ingredients or bioactives such as D-limonene, Ellagic Acid, Protocatechuic Acid, Lupeol, Apigenin. These active ingredients manipulate various biochemical pathways like Cell Cycle, PI3K-AKT-MTOR Signaling, MAPK Signaling and MYC Signaling and others. Walnut is recommended for Ameloblastoma when ongoing cancer treatment is Radiation. This is because Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in European Chestnut are Ellagic Acid, Quercetin, Protocatechuic Acid, Lupeol, Apigenin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and Epithelial to Mesenchymal Transition and others. European Chestnut is not recommended for Ameloblastoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

WALNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Ameloblastoma AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Ameloblastoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable WILD CARROT or WHITE CABBAGE?

Vegetable Wild Carrot contains many active ingredients or bioactives such as Apigenin, Quercetin, Curcumin, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like Angiogenesis, Inositol Phosphate Signaling, RAS-RAF Signaling and Cell Cycle and others. Wild Carrot is recommended for risk of Ameloblastoma when associated genetic risk is BRAF. This is because Wild Carrot increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable White Cabbage are Quercetin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Cell Cycle and Insulin Signaling and others. White Cabbage is not recommended when risk of Ameloblastoma when associated genetic risk is BRAF because it increases the signature pathways of it.

VEGETABLE WILD CARROT IS RECOMMENDED OVER WHITE CABBAGE FOR BRAF GENETIC RISK OF CANCER.

Choose Fruit EVERGREEN BLACKBERRY or SUMMER GRAPE?

Fruit Evergreen Blackberry contains many active ingredients or bioactives such as Ellagic Acid, Myricetin, Linalool, Eugenol, Methyleugenol. These active ingredients manipulate various biochemical pathways like Inositol Phosphate Signaling, RAS-RAF Signaling, Cell Cycle and Insulin Signaling and others. Evergreen Blackberry is recommended for risk of Ameloblastoma when associated genetic risk is BRAF. This is because Evergreen Blackberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Summer Grape are Apigenin, Curcumin, Myricetin, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and Insulin Signaling and others. Summer Grape is not recommended when risk of Ameloblastoma when associated genetic risk is BRAF because it increases the signature pathways of it.

FRUIT EVERGREEN BLACKBERRY IS RECOMMENDED OVER SUMMER GRAPE FOR BRAF GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or BRAZIL NUT?

Common Hazelnut contains many active ingredients or bioactives such as Quercetin, Curcumin, Myricetin, Lupeol, Lycopene. These active ingredients manipulate various biochemical pathways like Inositol Phosphate Signaling, Cell Cycle, PI3K-AKT-MTOR Signaling and P53 Signaling and others. Common Hazelnut is recommended for risk of Ameloblastoma when associated genetic risk is BRAF. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Brazil Nut are Ellagic Acid, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling and others. Brazil Nut is not recommended when risk of Ameloblastoma when associated genetic risk is BRAF because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER BRAZIL NUT FOR BRAF GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Ameloblastoma. Ameloblastoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Ameloblastoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Burdock contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Ameloblastoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
• Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
• Chlorogenic-induced inhibition of non-small cancer cells occurs through regulation of histone deacetylase 6.
• Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents.
• The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review).
• New concepts in phospholipase D signaling in inflammation and cancer.
• Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2.
• https://www.ncbi.nlm.nih.gov/books/NBK545165
• https://www.mayoclinic.org/diseases-conditions/ameloblastoma/symptoms-causes/syc-20351278