Which Foods are Recommended for Ameloblastoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Ameloblastoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Ameloblastoma because of BRAF and SMO gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Ameloblastoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Kumquat” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Amaranth” or “Can I take D-limonene and Lavender supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO AMELOBLASTOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Ameloblastoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR AMELOBLASTOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Ameloblastoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Ameloblastoma from cBioPortal. The top genes with mutations and other abnormalities for Ameloblastoma include genes BRAF, SMO, PIK3CA, PTEN and CDKN2A. The occurrence frequency distribution for these genes respectively is 55.0%, 13.0%, 8.0%, 8.0% and 6.0%. These tumor genetic details of Ameloblastoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Ameloblastoma.

Ameloblastoma is a rare, benign (noncancerous) tumor that develops most often in the jaw. Ameloblastoma begins in the cells that form the protective enamel lining our teeth. The most common type of ameloblastoma is aggressive and it forms a large tumor growing into the jawbone. Ameloblastoma is most often diagnosed in adults between ages 30- 60 years, and it can occur in children and young adults also. The rate of incidence has a higher male predominance and higher in black versus white population. It often causes no symptoms but may include pain and a lump or swelling in the jaw. If left untreated, the tumor can grow very large and distort the shape of the jaw and lower face and shift teeth out of position. Ameloblastoma tumor rarely becomes malignant and metastasizes. Treatment of ameloblastoma includes surgery, radiation therapy, prosthetics to fix the damage to teeth and structures in the mouth, and supportive care, along with the right nutrition (foods and supplements) to enhance well-being of the patient. (Ref: https://www.ncbi.nlm.nih.gov/books/NBK545165/; https://www.mayoclinic.org/diseases-conditions/ameloblastoma/symptoms-causes/syc-20351278 )

Significance of Nutrition for Ameloblastoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Ameloblastoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Kumquat includes active ingredients Apigenin, Naringenin, Vitamin C, Oleic Acid, Linolenic Acid and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Ameloblastoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Cell Cycle, MAPK Signaling, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Ameloblastoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR AMELOBLASTOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Ameloblastoma undergoing chemotherapy treatment

In Ameloblastoma – the genes BRAF, SMO, PIK3CA, PTEN and CDKN2A have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Ameloblastoma are RAS-RAF Signaling, Cell Cycle, MAPK Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Cell Cycle, MAPK Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Hyacinth Bean?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Glucaric Acid, Genistein, Vitamin C, Oleic Acid among others. While the active ingredients contained in Hyacinth Bean are Genistein, Vitamin C, Palmitic Acid, Myristic Acid, Folic Acid and others.

Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and MYC Signaling. Glucaric Acid has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.

Palmitic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and MAPK Signaling. Myristic Acid has biological action on biochemical pathways Cell Cycle, RAS-RAF Signaling and MYC Signaling. And so on.

When treating Ameloblastoma with chemotherapy Radiation – Foods like Mung Bean are recommended compared to Hyacinth Bean. This is because the active ingredients Palmitic Acid and Myristic Acid in Hyacinth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Glucaric Acid contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER HYACINTH BEAN FOR AMELOBLASTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Arugula or Amaranth?

Vegetables are an important part of many diets. The active ingredients contained in Arugula are Vitamin A, Esculin, Kaempferol, Vitamin K, Erysolin among others. While the active ingredients contained in Amaranth are Beta-sitosterol, Vitamin C, Oleic Acid, Isoquercitrin, Linolenic Acid and others.

Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and MYC Signaling. Kaempferol has biological action on biochemical pathways RAS-RAF Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle.

Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Ameloblastoma with chemotherapy Radiation – Foods like Arugula are recommended compared to Amaranth. This is because the active ingredients Oleic Acid and Linoleic Acid in Amaranth interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Kaempferol contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER AMARANTH FOR AMELOBLASTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Partridgeberry or Kumquat?

Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Kumquat are Apigenin, Naringenin, Vitamin C, Oleic Acid, Linolenic Acid and others.

Resveratrol can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and Cell Cycle. Beta-sitosterol has biological action on biochemical pathways Epithelial to Mesenchymal Transition, PI3K-AKT-MTOR Signaling and Cell Cycle.

Apigenin can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Ameloblastoma with chemotherapy Radiation – Foods like Partridgeberry are recommended compared to Kumquat. This is because the active ingredients Apigenin and Oleic Acid in Kumquat interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER KUMQUAT FOR AMELOBLASTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Walnut?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Oleic Acid, Linolenic Acid, Vitamin A among others. While the active ingredients contained in Walnut are D-limonene, Ellagic Acid, Protocatechuic Acid, Quercetin, Betulinic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and MYC Signaling. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Cell Cycle.

Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition and MYC Signaling. Plumbagin has biological action on biochemical pathways MAPK Signaling and MYC Signaling. And so on.

When treating Ameloblastoma with chemotherapy Radiation – Foods like Pine Nut are recommended compared to Walnut. This is because the active ingredients Ellagic Acid and Plumbagin in Walnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER WALNUT FOR AMELOBLASTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Ameloblastoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. BRAF and SMO are two genes whose abnormalities are risk factors for Ameloblastoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Ameloblastoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Ameloblastoma gene BRAF has causative impact on biological pathways like RAS-RAF Signaling, MAPK Signaling and Antigen Presentation. And SMO has a causative impact on biological pathways like GNAI Signaling and G-protein-coupled Receptor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like BRAF and SMO should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes BRAF and SMO should be avoided.

Eat more pulses, Common Pea or Soy Bean?

The active ingredients contained in Common Pea are Lupeol, Vitamin C, Daidzein, Beta-sitosterol, Linolenic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Quercetin, Vitamin C, Vitamin E, Daidzein and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, Oncogenic Cancer Epigenetics and Apoptosis.

Lecithin can manipulate biochemical pathways MYC Signaling and RAS-RAF Signaling. Aescin has biological action on biochemical pathways Cell Cycle Checkpoints. And so on.

For genetic risk of Ameloblastoma due to abnormalities in genes BRAF and SMO – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Lecithin and Aescin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF AMELOBLASTOMA DUE TO GENES BRAF AND SMO

Eat more vegetables, Cassava or Radish?

The active ingredients contained in Cassava are Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Radish are Quercetin, Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, Oncogenic Cancer Epigenetics and Apoptosis.

Pelargonidin can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and RAS-RAF Signaling. And so on.

For genetic risk of Ameloblastoma due to abnormalities in genes BRAF and SMO – Foods like Cassava are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF AMELOBLASTOMA DUE TO GENES BRAF AND SMO

Eat more fruits, Lemon or Cranberry?

The active ingredients contained in Lemon are D-limonene, Modified Citrus Pectin, Vitamin C, Obacunone, Oleic Acid among others. While the active ingredients contained in Cranberry are Ellagic Acid, Quercetin, Hyperoside, Vitamin C, P-coumaric Acid and others.

D-limonene can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, Oncogenic Cancer Epigenetics and RAS-RAF Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

For genetic risk of Ameloblastoma due to abnormalities in genes BRAF and SMO – Foods like Lemon are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Myricetin in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Lemon together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: LEMON IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF AMELOBLASTOMA DUE TO GENES BRAF AND SMO

Eat more nuts, Pecan Nut or Peanut?

The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Oleic Acid, Cianidanol, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin C, Vitamin E, Beta-sitosterol, Rhamnetin and others.

Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Cianidanol has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and P53 Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling and RAS-RAF Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Ameloblastoma due to abnormalities in genes BRAF and SMO – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF AMELOBLASTOMA DUE TO GENES BRAF AND SMO

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Ameloblastoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Natural products as a gold mine for selective matrix metalloproteinases inhibitors.
• Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
• Targeting metastasis-initiating cells through the fatty acid receptor CD36.
• Sequence homology of surface membrane proteins of Babesia rodhaini.
• Forkhead proteins are critical for bone morphogenetic protein-2 regulation and anti-tumor activity of resveratrol.
• Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
• Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
• Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
• Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
• Flavonoids as receptor tyrosine kinase FLT3 inhibitors.
• Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells.
• Research progress on the anticancer effects of vitamin K2.
• Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
• The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
• The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
• D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
• Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
• Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
• Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
• Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol.
• HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
• Resveratrol, pterostilbene, and piceatannol in vaccinium berries.