Foods for Atypical Teratoid Rhabdoid Tumor!

Introduction

Foods for Atypical Teratoid Rhabdoid Tumor should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Atypical teratoid rhabdoid tumor (ATRT) is a rare and aggressive tumor most commonly found in the brain, particularly in children. Radiology plays a crucial role in diagnosing and monitoring ATRT, while pathology outlines provide important insights into the characteristics and features of this tumor. Survival rates for ATRT vary depending on various factors, including the age of the patient and the extent of the tumor. Accurate coding using the ICD-10 system ensures proper documentation of ATRT in medical records. Symptoms of ATRT can include headaches, nausea, changes in behavior, and neurological deficits. Prognosis for ATRT is generally poor, especially in advanced cases. Treatment options for ATRT typically include surgery, chemotherapy, and radiation therapy. The precise treatment approach varies depending on the individual case and may involve additional therapies such as targeted or immunotherapy. It is important to diagnose and treat ATRT promptly, as early intervention might improve outcomes. Understanding the radiographic features and interpreting MRI scans aid in the diagnosis and management of ATRT. Awareness of ATRT in adults and newborns is important, as the tumor can occur outside the typical pediatric age range. Ongoing research and collaborations through platforms like Radiopaedia continue to contribute to the understanding and treatment of ATRT. Recognizing the signs and symptoms of this aggressive tumor is essential for early detection and initiating appropriate treatment. Overall, comprehensive management and continued advancements in treatment modalities provide hope for individuals affected by ATRT.

For Atypical Teratoid Rhabdoid Tumor does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Atypical Teratoid Rhabdoid Tumor does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Atypical Teratoid Rhabdoid Tumor?

For example does it matter if vegetable Giant Butterbur is consumed more compared to Welsh Onion? Does it make any difference if fruit Pummelo is preferred over Black Mulberry? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Gram Bean over Yardlong Bean. And if what I eat matters – then how does one identify foods which are recommended for Atypical Teratoid Rhabdoid Tumor and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Atypical Teratoid Rhabdoid Tumor!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Quercetin, Curcumin, Apigenin, Phloretin, Genistein. And Black Mulberry contains active ingredients Quercetin, Curcumin, Apigenin, Morusin, Phloretin and possibly others.

A common mistake made when deciding and choosing foods to eat for Atypical Teratoid Rhabdoid Tumor – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Atypical Teratoid Rhabdoid Tumor.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Atypical Teratoid Rhabdoid Tumor?

Personalized nutrition for cancers like Atypical Teratoid Rhabdoid Tumor consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Atypical Teratoid Rhabdoid Tumor biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Atypical Teratoid Rhabdoid Tumor

All cancers like Atypical Teratoid Rhabdoid Tumor can be characterized by a unique set of biochemical pathways – the signature pathways of Atypical Teratoid Rhabdoid Tumor. Biochemical pathways like DNA Repair, Hypoxia, MAPK Signaling, Post Translation Modification are part of the signature definition of Atypical Teratoid Rhabdoid Tumor. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Atypical Teratoid Rhabdoid Tumor need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Atypical Teratoid Rhabdoid Tumor when taking cancer treatment Temozolomide, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

SMARCB1, SETD2, CIT, MUC4 and COL6A6 are the top ranked reported genes for Atypical Teratoid Rhabdoid Tumor. SMARCB1 is reported in 17.5 % of the representative patients across all clinical trials. And SETD2 is reported in 7.5 %. The combined population patient data cover ages from 2 to 17. 56.6 % of the patient data are identified as men. The Atypical Teratoid Rhabdoid Tumor biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Atypical Teratoid Rhabdoid Tumor

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GIANT BUTTERBUR or WELSH ONION?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Phloretin, Genistein, Formononetin. These active ingredients manipulate various biochemical pathways like JAK-STAT Signaling, Cell Cycle, Epithelial to Mesenchymal Transition and P53 Signaling and others. Giant Butterbur is recommended for Atypical Teratoid Rhabdoid Tumor when ongoing cancer treatment is Temozolomide. This is because Giant Butterbur modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Temozolomide.

Some of the active ingredients or bioactives in vegetable Welsh Onion are Curcumin, Phloretin, Genistein, Formononetin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and DNA Repair and others. Welsh Onion is not recommended for Atypical Teratoid Rhabdoid Tumor when ongoing cancer treatment is Temozolomide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER WELSH ONION FOR Atypical Teratoid Rhabdoid Tumor AND TREATMENT Temozolomide.

Choose Fruit BLACK MULBERRY or PUMMELO?

Fruit Black Mulberry contains many active ingredients or bioactives such as Quercetin, Curcumin, Apigenin, Morusin, Phloretin. These active ingredients manipulate various biochemical pathways like JAK-STAT Signaling and Epithelial to Mesenchymal Transition and others. Black Mulberry is recommended for Atypical Teratoid Rhabdoid Tumor when ongoing cancer treatment is Temozolomide. This is because Black Mulberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Temozolomide.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Curcumin, Apigenin, Phloretin, Genistein. These active ingredients manipulate various biochemical pathways like Oxidative Stress and DNA Repair and others. Pummelo is not recommended for Atypical Teratoid Rhabdoid Tumor when ongoing cancer treatment is Temozolomide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT BLACK MULBERRY IS RECOMMENDED OVER PUMMELO FOR Atypical Teratoid Rhabdoid Tumor AND TREATMENT Temozolomide.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Phloretin, Genistein, Formononetin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, JAK-STAT Signaling, Epithelial to Mesenchymal Transition and P53 Signaling and others. Butternut is recommended for Atypical Teratoid Rhabdoid Tumor when ongoing cancer treatment is Temozolomide. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Temozolomide.

Some of the active ingredients or bioactives in European Chestnut are Quercetin, Curcumin, Ellagic Acid, Apigenin, Phloretin. These active ingredients manipulate various biochemical pathways like Oxidative Stress, Stem Cell Signaling and WNT Beta Catenin Signaling and others. European Chestnut is not recommended for Atypical Teratoid Rhabdoid Tumor when ongoing cancer treatment is Temozolomide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Atypical Teratoid Rhabdoid Tumor AND TREATMENT Temozolomide.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Atypical Teratoid Rhabdoid Tumor or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable CAULIFLOWER or GARLAND CHRYSANTHEMUM?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Lupeol, Daidzein, Formononetin, Delphinidin. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, Cell Cycle, PI3K-AKT-MTOR Signaling and Growth Factor Signaling and others. Cauliflower is recommended for risk of Atypical Teratoid Rhabdoid Tumor when associated genetic risk is CIT. This is because Cauliflower increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Garland Chrysanthemum are Apigenin, Curcumin, Lupeol, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like Oncogenic Histone Methylation and Focal Adhesion and others. Garland Chrysanthemum is not recommended when risk of Atypical Teratoid Rhabdoid Tumor when associated genetic risk is CIT because it increases the signature pathways of it.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER GARLAND CHRYSANTHEMUM FOR CIT GENETIC RISK OF CANCER.

Choose Fruit RED RASPBERRY or JUJUBE?

Fruit Red Raspberry contains many active ingredients or bioactives such as Curcumin, Ellagic Acid, Quercetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, Cell Cycle, PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints and others. Red Raspberry is recommended for risk of Atypical Teratoid Rhabdoid Tumor when associated genetic risk is CIT. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Jujube are Apigenin, Curcumin, Quercetin, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Small Molecule Transport, Extracellular Matrix Remodelling, Chromatin Remodeling and PI3K-AKT-MTOR Signaling and others. Jujube is not recommended when risk of Atypical Teratoid Rhabdoid Tumor when associated genetic risk is CIT because it increases the signature pathways of it.

FRUIT RED RASPBERRY IS RECOMMENDED OVER JUJUBE FOR CIT GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Lupeol, Daidzein, Lycopene. These active ingredients manipulate various biochemical pathways like RAS-RAF Signaling, Cell Cycle, PI3K-AKT-MTOR Signaling and P53 Signaling and others. Common Hazelnut is recommended for risk of Atypical Teratoid Rhabdoid Tumor when associated genetic risk is CIT. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Apigenin, Curcumin, Ellagic Acid, Lupeol, Daidzein. These active ingredients manipulate various biochemical pathways like Small Molecule Transport, Extracellular Matrix Remodelling and Focal Adhesion and others. Chestnut is not recommended when risk of Atypical Teratoid Rhabdoid Tumor when associated genetic risk is CIT because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR CIT GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Atypical Teratoid Rhabdoid Tumor. Atypical Teratoid Rhabdoid Tumor patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Atypical Teratoid Rhabdoid Tumor, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Giant Butterbur contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Atypical Teratoid Rhabdoid Tumor?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

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• https://www.cancer.gov/rare-brain-spine-tumor/tumors/atrt
• https://www.cancer.gov/types/brain/hp/child-cns-atrt-treatment-pdq