Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Anaplastic Medulloblastoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Anaplastic Medulloblastoma because of WNK2 and SMO gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Anaplastic Medulloblastoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Peach” or “Include fruit Apple in my diet” or “Should I reduce consumption of vegetable Celery” or “Can I take Lavender and Curcumin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ANAPLASTIC MEDULLOBLASTOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Anaplastic Medulloblastoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR ANAPLASTIC MEDULLOBLASTOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Anaplastic Medulloblastoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Anaplastic Medulloblastoma from cBioPortal. The patients enrolled in the studies for Anaplastic Medulloblastoma are in ages between 1 to 86 with an average age of 6. 52.7% of males and 47.3% of females were the distribution of gender in these clinical studies. From a patient sample size of 203; the top genes with mutations and other abnormalities for Anaplastic Medulloblastoma include genes WNK2, SMO, PPM1D, PTCH1 and TP53. The occurrence frequency distribution for these genes respectively is 4.3%, 4.3%, 4.3%, 4.3% and 4.3%. These tumor genetic details of Anaplastic Medulloblastoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Anaplastic Medulloblastoma.
Significance of Nutrition for Anaplastic Medulloblastoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Anaplastic Medulloblastoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Peach includes active ingredients Modified Citrus Pectin, Glucaric Acid, Fisetin, Oleic Acid, Beta-sitosterol and others. And Apple contains active ingredients Modified Citrus Pectin, Phloretin, Glucaric Acid, Fisetin, Maslinic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Anaplastic Medulloblastoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Cell Cycle, PI3K-AKT-MTOR Signaling, Chromatin Remodeling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Anaplastic Medulloblastoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ANAPLASTIC MEDULLOBLASTOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Anaplastic Medulloblastoma undergoing chemotherapy treatment
In Anaplastic Medulloblastoma – the genes WNK2, SMO, PPM1D, PTCH1 and TP53 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Anaplastic Medulloblastoma are RAS-RAF Signaling, Cell Cycle, MAPK Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Cell Cycle, MAPK Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Lupeol, Genistein, Oleic Acid, Beta-sitosterol among others. While the active ingredients contained in Pigeon Pea are Genistein, Oleic Acid, Vitamin C, Linolenic Acid, Linoleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Cell Cycle and MYC Signaling. Vitamin C has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Oxidative Stress.
Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Linolenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Anaplastic Medulloblastoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Linolenic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR ANAPLASTIC MEDULLOBLASTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Jicama or Celery?
Vegetables are an important part of many diets. The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Celery are Apigenin, Quercetin, Angelicin, Glucaric Acid, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling. Beta-carotene has biological action on biochemical pathways NFKB Signaling, DNA Repair and PI3K-AKT-MTOR Signaling.
Luteolin can manipulate biochemical pathways MYC Signaling and Oxidative Stress. Cynaroside has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Anaplastic Medulloblastoma with chemotherapy Radiation – Foods like Jicama are recommended compared to Celery. This is because the active ingredients Luteolin and Cynaroside in Celery interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-carotene contained in Jicama support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER CELERY FOR ANAPLASTIC MEDULLOBLASTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Apple or Peach?
Fruits are an important part of many diets. The active ingredients contained in Apple are Modified Citrus Pectin, Phloretin, Glucaric Acid, Fisetin, Maslinic Acid among others. While the active ingredients contained in Peach are Modified Citrus Pectin, Glucaric Acid, Fisetin, Oleic Acid, Beta-sitosterol and others.
Glucaric Acid can manipulate biochemical pathways NFKB Signaling, Cell Cycle and MYC Signaling. Modified Citrus Pectin has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.
Citric Acid can manipulate biochemical pathways Oxidative Stress. Fisetin has biological action on biochemical pathways MYC Signaling and Oxidative Stress. And so on.
When treating Anaplastic Medulloblastoma with chemotherapy Radiation – Foods like Apple are recommended compared to Peach. This is because the active ingredients Citric Acid and Fisetin in Peach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Modified Citrus Pectin contained in Apple support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: APPLE IS RECOMMENDED OVER PEACH FOR ANAPLASTIC MEDULLOBLASTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Oleic Acid, Beta-sitosterol, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Ferulic Acid, Oleic Acid, Beta-sitosterol and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Cell Cycle and MYC Signaling. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and NFKB Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Anaplastic Medulloblastoma with chemotherapy Radiation – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Quercetin and Citric Acid in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR ANAPLASTIC MEDULLOBLASTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Anaplastic Medulloblastoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. WNK2 and SMO are two genes whose abnormalities are risk factors for Anaplastic Medulloblastoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Anaplastic Medulloblastoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Anaplastic Medulloblastoma gene WNK2 has causative impact on biological pathways like Small Molecule Transport. And SMO has a causative impact on biological pathways like GNAI Signaling and G-protein-coupled Receptor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like WNK2 and SMO should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes WNK2 and SMO should be avoided.
Eat more pulses, Mung Bean or Soy Bean?
The active ingredients contained in Mung Bean are Quercetin, Linolenic Acid, Vitexin, Stigmasterol, Vitamin C among others. While the active ingredients contained in Soy Bean are Quercetin, Daidzein, Lupeol, Vitamin E, Linolenic Acid and others.
Vitexin can manipulate biochemical pathways NFKB Signaling, Apoptosis and MYC Signaling. Stigmasterol has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and Apoptosis.
Lecithin can manipulate biochemical pathways MYC Signaling and NFKB Signaling. Aescin has biological action on biochemical pathways Cell Cycle Checkpoints. And so on.
For genetic risk of Anaplastic Medulloblastoma due to abnormalities in genes WNK2 and SMO – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Lecithin and Aescin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitexin and Stigmasterol contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF ANAPLASTIC MEDULLOBLASTOMA DUE TO GENES WNK2 AND SMO
Eat more vegetables, Arrowroot or Carob?
The active ingredients contained in Arrowroot are Quercetin, Protocatechuic Acid, Vitamin C, Beta-carotene, Chlorogenic Acid among others. While the active ingredients contained in Carob are Quercetin, Palmitic Acid, Gallic Acid, Myricetin, Phloroglucinol and others.
Protocatechuic Acid can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Cell Cycle Checkpoints. Vitamin C has biological action on biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints.
Palmitic Acid can manipulate biochemical pathways NFKB Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.
For genetic risk of Anaplastic Medulloblastoma due to abnormalities in genes WNK2 and SMO – Foods like Arrowroot are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Folic Acid in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Protocatechuic Acid and Vitamin C contained in Arrowroot together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF ANAPLASTIC MEDULLOBLASTOMA DUE TO GENES WNK2 AND SMO
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Date or Cherry?
The active ingredients contained in Date are Apigenin, Quercetin, Lupeol, Protocatechuic Acid, Linolenic Acid among others. While the active ingredients contained in Cherry are Quercetin, Linolenic Acid, Beta-sitosterol, Vitamin C, Isorhamnetin and others.
Apigenin can manipulate biochemical pathways NFKB Signaling, Apoptosis and MYC Signaling. Lupeol has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and NFKB Signaling.
Shikimic Acid can manipulate biochemical pathways NFKB Signaling and Cell Cycle Checkpoints. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Anaplastic Medulloblastoma due to abnormalities in genes WNK2 and SMO – Foods like Date are recommended compared to Cherry. This is because the active ingredients Shikimic Acid and Chrysin in Cherry further promote the effects of genes on the biochemical pathways. While the active ingredients Apigenin and Lupeol contained in Date together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: DATE IS RECOMMENDED OVER CHERRY FOR REDUCING THE GENETIC RISK OF ANAPLASTIC MEDULLOBLASTOMA DUE TO GENES WNK2 AND SMO
Eat more nuts, Almond or Brazil Nut?
The active ingredients contained in Almond are Quercetin, Vitamin E, Linolenic Acid, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Cell Cycle Checkpoints. Vitamin E has biological action on biochemical pathways Apoptosis, MYC Signaling and NFKB Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling and NFKB Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, Apoptosis and MYC Signaling. And so on.
For genetic risk of Anaplastic Medulloblastoma due to abnormalities in genes WNK2 and SMO – Foods like Almond are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF ANAPLASTIC MEDULLOBLASTOMA DUE TO GENES WNK2 AND SMO
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Anaplastic Medulloblastoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pancan Pcawg 2020
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- BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
- Alpha-linolenic acid confers protection on mice renal cells against cisplatin-induced nephrotoxicity.
- Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
- Modified citrus pectin ameliorates myocardial fibrosis and inflammation via suppressing galectin-3 and TLR4/MyD88/NF-κB signaling pathway.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- The effect of Pasteurella haemolytica cytotoxin on bovine polymorphonuclear leukocytes can be attenuated by beta-adrenoceptor antagonists.
- Luteoloside attenuates neuroinflammation in focal cerebral ischemia in rats via regulation of the PPARγ/Nrf2/NF-κB signaling pathway.
- Research progress on the anticancer effects of vitamin K2.
- Small-molecule inhibitors of NADPH oxidase 4.
- The natural flavonoid glycoside vitexin displays preclinical antitumor activity by suppressing NF-κB signaling in nasopharyngeal carcinoma.
- Stigmasterol isolated from marine microalgae Navicula incerta induces apoptosis in human hepatoma HepG2 cells.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells–A SAR study.
- Isotretinoin in the treatment of systemic sclerosis.
- Shikimic acid promotes estrogen receptor(ER)-positive breast cancer cells proliferation via activation of NF-κB signaling.
- Protocatechuic acid inhibits the growth of ovarian cancer cells by inducing apoptosis and autophagy.
- Quercetin protects against obesity-induced skeletal muscle inflammation and atrophy.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- Pectin – Wikipedia
- Pectin and Pectin-Based Composite Materials: Beyond Food Texture.
- Fisetin: a dietary antioxidant for health promotion.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- HyperFoods/food_compound_original.csv at master · warcraft12321/HyperFoods · GitHub
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.