Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Osteoblastic Osteosarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Osteoblastic Osteosarcoma because of NBN and DICER1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Osteoblastic Osteosarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Grapefruit” or “Include fruit Raspberry in my diet” or “Should I reduce consumption of vegetable Swiss Chard” or “Can I take Caffeine and Alpha Lipoic Acid supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO OSTEOBLASTIC OSTEOSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Osteoblastic Osteosarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR OSTEOBLASTIC OSTEOSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Osteoblastic Osteosarcoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Osteoblastic Osteosarcoma from cBioPortal. The patients enrolled in the studies for Osteoblastic Osteosarcoma are in ages between 57 to 57 with an average age of 57. 52.2% of males and 47.8% of females were the distribution of gender in these clinical studies. From a patient sample size of 15; the top genes with mutations and other abnormalities for Osteoblastic Osteosarcoma include genes NBN, DICER1, EGFR, EPHA7 and GATA2. The occurrence frequency distribution for these genes respectively is 13.3%, 6.7%, 6.7%, 6.7% and 6.7%. These tumor genetic details of Osteoblastic Osteosarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Osteoblastic Osteosarcoma.
Significance of Nutrition for Osteoblastic Osteosarcoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Osteoblastic Osteosarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Grapefruit includes active ingredients Linoleic Acid, Oleic Acid, Naringin, Linolenic Acid, Naringenin and others. And Raspberry contains active ingredients Resveratrol, Ellagic Acid, Vitamin C, Quercetin, Gallic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Osteoblastic Osteosarcoma, activation or inhibition of selected biochemical pathways like Cytoskeletal Dynamics, Focal Adhesion, PI3K-AKT-MTOR Signaling, Inositol Phosphate Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Osteoblastic Osteosarcoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR OSTEOBLASTIC OSTEOSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Osteoblastic Osteosarcoma undergoing chemotherapy treatment
In Osteoblastic Osteosarcoma – the genes NBN, DICER1, EGFR, EPHA7 and GATA2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Osteoblastic Osteosarcoma are Cytoskeletal Dynamics, Focal Adhesion, DNA Repair and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cytoskeletal Dynamics, Focal Adhesion, DNA Repair so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Adzuki Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Genistein, Beta-sitosterol, Linoleic Acid, Oleic Acid among others. While the active ingredients contained in Adzuki Bean are Genistein, Glucaric Acid, Isoliquiritigenin, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Oxidative Stress and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, Oxidative Stress and PI3K-AKT-MTOR Signaling.
Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Isoliquiritigenin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Osteoblastic Osteosarcoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Adzuki Bean. This is because the active ingredients Genistein and Isoliquiritigenin in Adzuki Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER ADZUKI BEAN FOR OSTEOBLASTIC OSTEOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Cabbage or Swiss Chard?
Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Benzyl Isothiocyanate, Beta-sitosterol, Indole-3-carbinol, Vitamin C, Quercetin among others. While the active ingredients contained in Swiss Chard are Caffeic Acid, Ferulic Acid, P-coumaric Acid, Melatonin, Vitamin A and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, Oxidative Stress and PI3K-AKT-MTOR Signaling. Glucaric Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways Focal Adhesion. P-coumaric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Osteoblastic Osteosarcoma with chemotherapy Radiation – Foods like Cabbage are recommended compared to Swiss Chard. This is because the active ingredients Vitamin A and P-coumaric Acid in Swiss Chard interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CABBAGE IS RECOMMENDED OVER SWISS CHARD FOR OSTEOBLASTIC OSTEOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Raspberry or Grapefruit?
Fruits are an important part of many diets. The active ingredients contained in Raspberry are Resveratrol, Ellagic Acid, Vitamin C, Quercetin, Gallic Acid among others. While the active ingredients contained in Grapefruit are Linoleic Acid, Oleic Acid, Naringin, Linolenic Acid, Naringenin and others.
Ellagic Acid can manipulate biochemical pathways Oxidative Stress, PI3K-AKT-MTOR Signaling and Focal Adhesion. Vitamin C has biological action on biochemical pathways MYC Signaling, Oxidative Stress and PI3K-AKT-MTOR Signaling.
Naringin can manipulate biochemical pathways Oxidative Stress. Naringenin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Osteoblastic Osteosarcoma with chemotherapy Radiation – Foods like Raspberry are recommended compared to Grapefruit. This is because the active ingredients Naringin and Naringenin in Grapefruit interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and Vitamin C contained in Raspberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: RASPBERRY IS RECOMMENDED OVER GRAPEFRUIT FOR OSTEOBLASTIC OSTEOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Almond or Pumpkin Seeds?
Nuts are an important part of many diets. The active ingredients contained in Almond are Beta-sitosterol, Linoleic Acid, Oleic Acid, Vitamin E, Quercetin among others. While the active ingredients contained in Pumpkin Seeds are Beta-sitosterol, Linoleic Acid, Oleic Acid, Stigmasterol, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Oxidative Stress and PI3K-AKT-MTOR Signaling. Vitamin E has biological action on biochemical pathways DNA Repair, MYC Signaling and PI3K-AKT-MTOR Signaling.
Gamma-linolenic Acid can manipulate biochemical pathways Oxidative Stress. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Osteoblastic Osteosarcoma with chemotherapy Radiation – Foods like Almond are recommended compared to Pumpkin Seeds. This is because the active ingredients Gamma-linolenic Acid and Lecithin in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER PUMPKIN SEEDS FOR OSTEOBLASTIC OSTEOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Osteoblastic Osteosarcoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NBN and DICER1 are two genes whose abnormalities are risk factors for Osteoblastic Osteosarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Osteoblastic Osteosarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Osteoblastic Osteosarcoma gene NBN has causative impact on biological pathways like DNA Repair and Cell Cycle Checkpoints. And DICER1 has a causative impact on biological pathways like NFKB Signaling and Apoptosis. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NBN and DICER1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NBN and DICER1 should be avoided.
Eat more pulses, Scarlet Bean or Fava Bean?
The active ingredients contained in Scarlet Bean are Genistein, Oleic Acid, Vitamin C, Linolenic Acid, Beta-sitosterol among others. While the active ingredients contained in Fava Bean are Genistein, Cianidanol, Daidzein, Quercetin, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Quercetin can manipulate biochemical pathways DNA Repair. Ferulic Acid has biological action on biochemical pathways Growth Factor Signaling and DNA Repair. And so on.
For genetic risk of Osteoblastic Osteosarcoma due to abnormalities in genes NBN and DICER1 – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Quercetin and Ferulic Acid in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF OSTEOBLASTIC OSTEOSARCOMA DUE TO GENES NBN AND DICER1
Eat more vegetables, Jicama or Celery?
The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Celery are Apigenin, Quercetin, Oleic Acid, Vitamin C, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Vitamin B3 has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and Apoptosis.
Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Osteoblastic Osteosarcoma due to abnormalities in genes NBN and DICER1 – Foods like Jicama are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF OSTEOBLASTIC OSTEOSARCOMA DUE TO GENES NBN AND DICER1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Mulberry or Date?
The active ingredients contained in Mulberry are Resveratrol, Morusin, Deoxynojirimycin among others. While the active ingredients contained in Date are Apigenin, Protocatechuic Acid, Lupeol, Quercetin, Oleic Acid and others.
Morusin can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Deoxynojirimycin has biological action on biochemical pathways Apoptosis.
Quercetin can manipulate biochemical pathways DNA Repair. Ferulic Acid has biological action on biochemical pathways Growth Factor Signaling and DNA Repair. And so on.
For genetic risk of Osteoblastic Osteosarcoma due to abnormalities in genes NBN and DICER1 – Foods like Mulberry are recommended compared to Date. This is because the active ingredients Quercetin and Ferulic Acid in Date further promote the effects of genes on the biochemical pathways. While the active ingredients Morusin and Deoxynojirimycin contained in Mulberry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MULBERRY IS RECOMMENDED OVER DATE FOR REDUCING THE GENETIC RISK OF OSTEOBLASTIC OSTEOSARCOMA DUE TO GENES NBN AND DICER1
Eat more nuts, Pine Nut or Peanut?
The active ingredients contained in Pine Nut are Vitamin E, Oleic Acid, Linolenic Acid, Beta-sitosterol, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Quercetin, Oleic Acid, Gamma-linolenic Acid, Vitamin C and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Cell Cycle Checkpoints.
Quercetin can manipulate biochemical pathways DNA Repair. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Osteoblastic Osteosarcoma due to abnormalities in genes NBN and DICER1 – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Quercetin and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF OSTEOBLASTIC OSTEOSARCOMA DUE TO GENES NBN AND DICER1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Osteoblastic Osteosarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.