Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Breast Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Breast Carcinoma because of BRCA1 and CDH1 gene mutations – a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Breast Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Nance in my diet” or “Should I reduce consumption of vegetable Cauliflower” or “Can I take Thunder God and Neem Extract supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO BREAST CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Breast Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR BREAST CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Breast Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK. (Reference https://www.cbioportal.org/about).
Following key highlights are derived from clinical data for Breast Carcinoma from cBioPortal. The patients enrolled in the studies for Breast Carcinoma are in ages between 15 to 97 with an average age of 57. 0.6% of males and 99.4% of females were the distribution of gender in these clinical studies. From a patient sample size of 5470; the top genes with mutations and other abnormalities for Breast Carcinoma include genes TP53, PIK3CA, MUC16, RYR1 and MAP3K1. The occurrence frequency distribution for these genes respectively is 2.2%, 1.7%, 0.6%, 0.5% and 0.5%. These tumor genetic details of Breast Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Breast Carcinoma.
Significance of Nutrition for Breast Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Breast Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Cranberry includes active ingredients Quercetin, Ellagic Acid, Resveratrol, Myricetin, Vitamin C and others. And Nance contains active ingredients Vitamin C, Betulin, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Breast Carcinoma, activation or inhibition of selected biochemical pathways like Oncogenic Cancer Epigenetics, Chromatin Remodeling, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Breast Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR BREAST CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Breast Carcinoma with chemotherapy
In Breast Carcinoma – the genes TP53, PIK3CA, MUC16, RYR1 and MAP3K1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Breast Carcinoma are Oncogenic Cancer Epigenetics, Chromatin Remodeling, MAPK Signaling and others. Doxorubicin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Oncogenic Cancer Epigenetics, Chromatin Remodeling, MAPK Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Beta-sitosterol, Lupeol, Daidzein, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Vitamin C, Oleic Acid, Genistein, Linoleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, Oxidative Stress and Vitamin D Signaling. Vitamin C has biological action on biochemical pathways Oncogenic Cancer Epigenetics, WNT Beta Catenin Signaling and MAPK Signaling.
Genistein can manipulate biochemical pathways Oxidative Stress, Estrogen Signaling and DNA Repair. Linolenic Acid has biological action on biochemical pathways Vitamin D Signaling and Oxidative Stress. And so on.
When treating Breast Carcinoma with chemotherapy Doxorubicin – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Linolenic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR BREAST CARCINOMA WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more vegetables, Cabbage or Cauliflower?
Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Quercetin, Benzyl Isothiocyanate, Beta-sitosterol, Sulforaphane, Vitamin C among others. While the active ingredients contained in Cauliflower are Beta-sitosterol, Sulforaphane, Linolenic Acid, Vitamin C, Brassinin and others.
Vitamin C can manipulate biochemical pathways Oncogenic Cancer Epigenetics, WNT Beta Catenin Signaling and Cell Cycle Checkpoints. Glucaric Acid has biological action on biochemical pathways Estrogen Signaling, Inflammation and MAPK Signaling.
Brassinin can manipulate biochemical pathways Oxidative Stress. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Breast Carcinoma with chemotherapy Doxorubicin – Foods like Cabbage are recommended compared to Cauliflower. This is because the active ingredients Brassinin and Citric Acid in Cauliflower interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CABBAGE IS RECOMMENDED OVER CAULIFLOWER FOR BREAST CARCINOMA WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more fruits, Nance or Cranberry?
Fruits are an important part of many diets. The active ingredients contained in Nance are Vitamin C, Betulin, Vitamin A among others. While the active ingredients contained in Cranberry are Quercetin, Ellagic Acid, Resveratrol, Myricetin, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Oncogenic Cancer Epigenetics, WNT Beta Catenin Signaling and Cell Cycle Checkpoints. Betulin has biological action on biochemical pathways Oxidative Stress, MAPK Signaling and Hypoxia.
Quercetin can manipulate biochemical pathways Oxidative Stress. Ellagic Acid has biological action on biochemical pathways WNT Beta Catenin Signaling, Cell Cycle Checkpoints and Vitamin D Signaling. And so on.
When treating Breast Carcinoma with chemotherapy Doxorubicin – Foods like Nance are recommended compared to Cranberry. This is because the active ingredients Quercetin and Ellagic Acid in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Betulin contained in Nance support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: NANCE IS RECOMMENDED OVER CRANBERRY FOR BREAST CARCINOMA WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Pumpkin Seeds?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Cianidanol, Vitamin E, Linolenic Acid, Oleic Acid, Delphinidin among others. While the active ingredients contained in Pumpkin Seeds are Beta-sitosterol, Linolenic Acid, Oleic Acid, Stigmasterol, Gamma-linolenic Acid and others.
Cianidanol can manipulate biochemical pathways Estrogen Signaling, DNA Repair and Cell Cycle Checkpoints. Vitamin E has biological action on biochemical pathways Vitamin D Signaling, Inflammation and MAPK Signaling.
Gamma-linolenic Acid can manipulate biochemical pathways Oxidative Stress and Vitamin D Signaling. Lecithin has biological action on biochemical pathways Inflammation, MAPK Signaling and Cytokine Signaling. And so on.
When treating Breast Carcinoma with chemotherapy Doxorubicin – Foods like Pecan Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Gamma-linolenic Acid and Lecithin in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Cianidanol and Vitamin E contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR BREAST CARCINOMA WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Breast Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. BRCA1 and CDH1 are two genes whose abnormalities are risk factors for Breast Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Breast Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Breast Carcinoma gene BRCA1 has causative impact on biological pathways like DNA Repair, Androgen Signaling and Cell Cycle. And CDH1 has a causative impact on biological pathways like WNT Beta Catenin Signaling, Epithelial to Mesenchymal Transition and Adherens junction. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like BRCA1 and CDH1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes BRCA1 and CDH1 should be avoided.
Eat more pulses, Common Bean or Lentils?
The active ingredients contained in Common Bean are Apigenin, Vitamin C, Linolenic Acid, Gamma-linolenic Acid, Kaempferol among others. While the active ingredients contained in Lentils are Beta-sitosterol, Isoliquiritigenin, Ellagic Acid, Daidzein, Vitamin C and others.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling, NFKB Signaling and Estrogen Signaling. Apigenin has biological action on biochemical pathways P53 Signaling, Adherens junction and Androgen Signaling.
Ellagic Acid can manipulate biochemical pathways WNT Beta Catenin Signaling, Epithelial to Mesenchymal Transition and MYC Signaling. Genistein has biological action on biochemical pathways Estrogen Signaling. And so on.
For genetic risk of Breast Carcinoma due to abnormalities in genes BRCA1 and CDH1 – Foods like Common Bean are recommended compared to Lentils. This is because the active ingredients Ellagic Acid and Genistein in Lentils further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin A and Apigenin contained in Common Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON BEAN IS RECOMMENDED OVER LENTILS FOR GENETIC RISK OF BREAST CARCINOMA DUE TO GENES BRCA1 AND CDH1
Eat more vegetables, Lettuce or Spinach?
The active ingredients contained in Lettuce are Quercetin, Caffeic Acid, Beta-sitosterol, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Spinach are Quercetin, Apigenin, Beta-sitosterol, Vitamin C, Linolenic Acid and others.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling, NFKB Signaling and Estrogen Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Quercetin can manipulate biochemical pathways DNA Repair. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition and NFKB Signaling. And so on.
For genetic risk of Breast Carcinoma due to abnormalities in genes BRCA1 and CDH1 – Foods like Lettuce are recommended compared to Spinach. This is because the active ingredients Quercetin and Oleic Acid in Spinach further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin A and Vitamin K contained in Lettuce together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: LETTUCE IS RECOMMENDED OVER SPINACH FOR GENETIC RISK OF BREAST CARCINOMA DUE TO GENES BRCA1 AND CDH1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Papaya or Gooseberry?
The active ingredients contained in Papaya are Benzyl Isothiocyanate, Lycopene, Beta-sitosterol, Vitamin C, Linalool among others. While the active ingredients contained in Gooseberry are Beta-sitosterol, Vitamin C, Linolenic Acid, Modified Citrus Pectin, Oleic Acid and others.
Lycopene can manipulate biochemical pathways PI3K-AKT-MTOR Signaling, NFKB Signaling and Cholesterol Metabolism. Zeaxanthin has biological action on biochemical pathways P53 Signaling, Androgen Signaling and Angiogenesis.
Gallic Acid can manipulate biochemical pathways DNA Repair. Rutin has biological action on biochemical pathways WNT Beta Catenin Signaling and Estrogen Signaling. And so on.
For genetic risk of Breast Carcinoma due to abnormalities in genes BRCA1 and CDH1 – Foods like Papaya are recommended compared to Gooseberry. This is because the active ingredients Gallic Acid and Rutin in Gooseberry further promote the effects of genes on the biochemical pathways. While the active ingredients Lycopene and Zeaxanthin contained in Papaya together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PAPAYA IS RECOMMENDED OVER GOOSEBERRY FOR GENETIC RISK OF BREAST CARCINOMA DUE TO GENES BRCA1 AND CDH1
Eat more nuts, Pistachio or Peanut?
The active ingredients contained in Pistachio are Beta-sitosterol, Vitamin E, Resveratrol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Beta-sitosterol, Vitamin E, Vitamin C, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways PI3K-AKT-MTOR Signaling, NFKB Signaling and Estrogen Signaling. Vitamin E has biological action on biochemical pathways Cholesterol Metabolism, Growth Factor Signaling and P53 Signaling.
Quercetin can manipulate biochemical pathways DNA Repair. Lecithin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Angiogenesis. And so on.
For genetic risk of Breast Carcinoma due to abnormalities in genes BRCA1 and CDH1 – Foods like Pistachio are recommended compared to Peanut. This is because the active ingredients Quercetin and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER PEANUT FOR GENETIC RISK OF BREAST CARCINOMA DUE TO GENES BRCA1 AND CDH1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Breast Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Breast Msk 2018
- Pan-cancer analysis of whole genomes.
- β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling.
- Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
- Peroxisome proliferator-activated receptor gamma (PPARgamma ) as a molecular target for the soy phytoestrogen genistein.
- Alpha-linolenic acid confers protection on mice renal cells against cisplatin-induced nephrotoxicity.
- Trends in congenital heart disease in Dallas County births. 1971-1984.
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- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
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- Inhibitory effect of brassinin on TNF‑α‑induced vascular inflammation in human umbilical vein endothelial cells.
- (+)-Catechin inhibits tumour angiogenesis and regulates the production of nitric oxide and TNF-alpha in LPS-stimulated macrophages.
- Anti-IL-1 alpha autoantibodies in patients with rheumatic diseases and in healthy subjects.
- Research on Rett syndrome: strategy and preliminary results.
- New concepts in phospholipase D signaling in inflammation and cancer.
- Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
- Small-molecule inhibitors of NADPH oxidase 4.
- Can Lycopene Impact the Androgen Axis in Prostate Cancer?: A Systematic Review of Cell Culture and Animal Studies.
- Zeaxanthin inhibits hypoxia-induced VEGF secretion by RPE cells through decreased protein levels of hypoxia-inducible factors-1α.
- Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.
- Identification of Steroidogenic Components Derived From Gardenia jasminoides Ellis Potentially Useful for Treating Postmenopausal Syndrome.
- Research progress on the anticancer effects of vitamin K2.
- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- Pumpkin Seed Oil – National Nutrition Articles
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.