Nutrition is the single most effective tool which cancer patients can control for managing cancers like Ameloblastoma or Mycosis fungoides – hence it is important to identify those Foods and Supplements which are scientifically recommended for you. A frequently asked question is if foods like Elderberry are beneficial for cancer and along with which treatments? There is a mis-conception that all plant-based foods are good for all cancers and all of them are equal in terms of their benefits or their lack of. The reality is that some plant-based foods will be better than others for a specific type of cancer, treatments and other conditions. So Elderberry benefits will vary and the answer is contextual.
For example, grapefruit with certain medications is not recommended. Also spinach with some blood thinning medications can cause adverse interactions and hence intake should be reduced. For cancer, nutrition which includes food and supplements are important decisions which need to be made.
So are there types of cancer where Elderberry has more benefits? Yes! Elderberry is beneficial for Mycosis fungoides patients taking Romidepsin treatment. But has adverse interactions for Ameloblastoma patients on Radiation treatment.
For Mycosis fungoides along with Romidepsin – biochemical pathways like DNA Repair (Base Excision Repair), JAK-STAT Signaling, DNA Repair (Homology Directed Repair), Cell Cycle (Proliferation) and Stem Cell Signaling are potential drivers of the disease. Elderberry has active ingredients which can manipulate these biochemical pathways to reduce the disease drivers and hence are scientifically beneficial. But for Ameloblastoma along with Radiation – biochemical pathways like Epithelial to Mesenchymal Transition, Cell Cycle (Proliferation), RAS-RAF Signaling (RAS Signaling), MYC Signaling and PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling) are potential drivers of the disease. Elderberry has active ingredients which can increase disease drivers like Epithelial to Mesenchymal Transition, Cell Cycle (Proliferation), RAS-RAF Signaling (RAS Signaling), MYC Signaling and PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling) and hence intake should be reduced.
Similarly, eating Elderberry can have scientific benefits for healthy individuals who have a gene mutation in SMAD4 which suggests potential risk of cancer. This is because of biochemical pathways Lipid Metabolism (Arachidonic Acid Metabolism), MAPK Signaling, Stem Cell Signaling, Growth Factor Signaling (EGFR Signaling) and MYC Signaling. But reduce intake of Elderberry when at genetic risk of cancer due to mutation of gene CREBBP due to its manipulation of biochemical pathways Histone/Protein Acetylation causing cancer drivers to increase.
The takeaway being – for Ameloblastoma, Mycosis fungoides and other cancers individual conditions can influence if foods like Elderberry are recommended or not. As conditions like ongoing treatments, supplements, habits and other conditions change; the nutrition plan must be re-designed and personalized. Whether Ameloblastoma or Mycosis fungoides or other cancer types -, current treatments and supplements, age, gender, weight, height, lifestyle and genetic conditions are also key decision factors for creating a personalized nutrition plan.
Why is the choice of foods important for cancer?
Foods like Elderberry typically contain more than one active ingredient at varying concentrations. Each of these active ingredients like Oleic Acid has a unique molecular biological mechanism of action. Cancer like most diseases is driven by specific biochemical pathways and molecular interventions of the pathway can be beneficial or create adverse interactions. Hence for Ameloblastoma, Mycosis fungoides and other cancers there is a need to personalize which foods and supplements to take and regularly evaluate if foods like Elderberry are recommended or not.
So some of the example questions one may have related to Elderberry can be: Is Elderberry beneficial for me? Should I eat it when at genetic cancer risk due to mutation of gene CREBBP? Should I eat Elderberry when a mutation of a gene SMAD4 is identified? Should I eat Elderberry when diagnosed with Ameloblastoma? Should I eat Elderberry when diagnosed with Mycosis fungoides? Should I eat Elderberry when on Radiation treatment? Should I continue eating Elderberry if my treatment changes from Radiation to Romidepsin? Are the implications of taking Elderberry in Mycosis fungoides the same as Ameloblastoma? And so on.
Elderberry and cancer
Elderberries are small, black-purple berries produced by several varieties of the sambus tree, also known as the European elderberry or black elder. They are packed with nutrients and have many health benefits. Following are some of the potential health benefits of Elderberry:
- May have antiviral properties (Randall S Porter and Robert F Bode, Phytother Res., 2017)
- May support treatment for influenza (Z Zakay-Rones et al, J Int Med Res., Mar-Apr 2004)
- May have antibacterial, antidepressant, antiancer and hypoglycemic effects (Karolina Młynarczyk et al, J Funct Foods., 2018)
Elderberry contains many active ingredients like Oleic Acid, Rutin, Linolenic Acid, Betulinic Acid, Isorhamnetin and many other Bioactives at different concentrations. The molecular pathways which are regulated by Elderberry include Epithelial to Mesenchymal Transition, DNA Repair (Base Excision Repair), JAK-STAT Signaling, Histone/Protein Acetylation, Lipid Metabolism (Arachidonic Acid Metabolism) and many others. These cellular pathways directly or indirectly influence cancer molecular endpoints like growth, spread and death. Because of this biological relationship – for cancer, choosing foods like Elderberry and supplements is an important decision to be made. And not necessarily the same food choices are scientifically best for all individuals.
Include Elderberry in my nutrition?
The answer to the question “Which Foods to Eat” and “Which Foods to Reduce Intake of” is dependent on multiple factors. Just like the same treatment does not work for every cancer patient, based on individual context the Elderberry may have scientific benefits or have adverse interactions. Along with which cancer – the ongoing treatments, supplements, lifestyle habits, height, weight, allergies and food preferences are all factors influencing answers to the question.
1. Any benefits of Elderberry for Ameloblastoma with Radiation treatment?
Ameloblastoma is known to have mutations in gene like BRAF, SMO and PIK3CA and others which together cause biochemical pathway changes in Epithelial to Mesenchymal Transition, Cell Cycle (Proliferation), RAS-RAF Signaling (RAS Signaling), MYC Signaling and PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling). A cancer treatment like Radiation has molecular action on a unique set of biochemical pathways . The treatment intent is to have a good overlap with the cancer driving pathways and reduce the disease drivers. In such conditions foods which can scientifically cancel out the treatment effect by reducing the overlap between the cancer driving pathways and treatment are candidates for reducing intake of or completely avoid. For example – in the case of Ameloblastoma and treatment Radiation – Elderberry is not recommended. Elderberry impacts pathways or processes like Epithelial to Mesenchymal Transition which can negate the effects of the treatment.
2. Any benefits of Elderberry for Mycosis fungoides with Romidepsin treatment?
Mycosis fungoides is defined and driven by specific genetic mutations like FAT1, MGAM and KMT2D leading to biochemical pathway changes in DNA Repair (Base Excision Repair), JAK-STAT Signaling, DNA Repair (Homology Directed Repair), Cell Cycle (Proliferation) and Stem Cell Signaling. Also treatments like Romidepsin have molecular action on a unique set of biochemical pathways. Elderberry should be considered for Mycosis fungoides while on Romidepsin treatment. Elderberry impacts pathways or processes like DNA Repair (Base Excision Repair) and JAK-STAT Signaling which can either reduce drivers of Mycosis fungoides and/or improve Romidepsin treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Any benefits of Elderberry for gene CREBBP associated cancer genetic risk?
Many companies offer gene panel tests for evaluating genetic risk to different cancers. These panels cover genes like CREBBP and many others associated with high prevalence cancers of breast, ovary, uterus, prostate and gastrointestinal system and others. The intent of the genetic testing of CREBBP is for diagnosis and/or to find out any potential risk factors for cancer. CREBBP mutation causes biochemical pathways or processes like Histone/Protein Acetylation to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like Histone/Protein Acetylation. Intake of foods like Elderberry should be reduced when there is a mutation of CREBBP for risk of Follicular Lymphoma and Non-Hodgkin Lymphoma. Elderberry impacts pathways or processes like Histone/Protein Acetylation and creates adverse effects with CREBBP mutation.
4. Any benefits of Elderberry for gene SMAD4 associated cancer genetic risk?
SMAD4 is also one of many genes available in panels for cancer risk testing. SMAD4 mutation causes biochemical pathways or processes like Lipid Metabolism (Arachidonic Acid Metabolism), MAPK Signaling, Stem Cell Signaling, Growth Factor Signaling (EGFR Signaling) and MYC Signaling to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like Lipid Metabolism (Arachidonic Acid Metabolism), MAPK Signaling, Stem Cell Signaling, Growth Factor Signaling (EGFR Signaling) and MYC Signaling. Intake of foods like Elderberry should be considered when Colon cancer and Gallbladder Cancer risk is identified due to gene SMAD4 mutation. Elderberry impacts biochemical pathways or processes like Lipid Metabolism (Arachidonic Acid Metabolism) and MAPK Signaling associated with genetic risk to SMAD4 mutation.
* Other Factors Included Like BMI, Lifestyle Habits, Treatments
Personalized nutrition planning for cancer can inform if foods like Elderberry are recommended or not. Nutrition is the single most effective tool which cancer patients can control and nutrition decisions are dependent on questions like “Is Elderberry beneficial for me?”
The addon personalized nutrition planning for cancer is a software approach based on molecular science. The addon approach supports cancers like Ameloblastoma, Mycosis fungoides and others along with commonly reported genomic group clusters.
To get your personalized nutrition plan – enter details like cancer indication (example Ameloblastoma, name of current cancer and non-cancer treatments; habits and lifestyle conditions.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.