Nutrition is the single most effective tool which cancer patients can control for managing cancers like Seminoma or Juvenile Myelomonocytic Leukemia – hence it is important to identify those Foods and Supplements which are scientifically recommended for you. A frequently asked question is if foods like Cinnamon are beneficial for cancer and along with which treatments? There is a mis-conception that all plant-based foods are good for all cancers and all of them are equal in terms of their benefits or their lack of. The reality is that some plant-based foods will be better than others for a specific type of cancer, treatments and other conditions. So Cinnamon benefits will vary and the answer is contextual.
For example, grapefruit with certain medications is not recommended. Also spinach with some blood thinning medications can cause adverse interactions and hence intake should be reduced. For cancer, nutrition which includes food and supplements are important decisions which need to be made.
So are there types of cancer where Cinnamon has more benefits? Yes! Cinnamon is beneficial for Juvenile Myelomonocytic Leukemia patients taking Trametinib treatment. But has adverse interactions for Seminoma patients on Ifosfamide treatment.
For Juvenile Myelomonocytic Leukemia along with Trametinib – biochemical pathways like MYC Signaling, MAPK Signaling (ERK Signaling), PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), RAS-RAF Signaling (RAS Signaling) and JAK-STAT Signaling are potential drivers of the disease. Cinnamon has active ingredients which can manipulate these biochemical pathways to reduce the disease drivers and hence are scientifically beneficial. But for Seminoma along with Ifosfamide – biochemical pathways like Oxidative Stress, DNA Repair (Homology Directed Repair), Cell Cycle (Proliferation), DNA Repair (Global Genome Nucleotide Excision Repair) and P53 Signaling are potential drivers of the disease. Cinnamon has active ingredients which can increase disease drivers like Oxidative Stress, DNA Repair (Homology Directed Repair), Cell Cycle (Proliferation), DNA Repair (Global Genome Nucleotide Excision Repair) and P53 Signaling and hence intake should be reduced.
Similarly, eating Cinnamon can have scientific benefits for healthy individuals who have a gene mutation in NRAS which suggests potential risk of cancer. This is because of biochemical pathways MYC Signaling, MAPK Signaling (ERK Signaling) and RAS-RAF Signaling (RAS Signaling). But reduce intake of Cinnamon when at genetic risk of cancer due to mutation of gene CREBBP due to its manipulation of biochemical pathways Histone/Protein Acetylation causing cancer drivers to increase.
The takeaway being – for Seminoma, Juvenile Myelomonocytic Leukemia and other cancers individual conditions can influence if foods like Cinnamon are recommended or not. As conditions like ongoing treatments, supplements, habits and other conditions change; the nutrition plan must be re-designed and personalized. Whether Seminoma or Juvenile Myelomonocytic Leukemia or other cancer types -, current treatments and supplements, age, gender, weight, height, lifestyle and genetic conditions are also key decision factors for creating a personalized nutrition plan.
Why is the choice of foods important for cancer?
Foods like Cinnamon typically contain more than one active ingredient at varying concentrations. Each of these active ingredients like Cinnamaldehyde has a unique molecular biological mechanism of action. Cancer like most diseases is driven by specific biochemical pathways and molecular interventions of the pathway can be beneficial or create adverse interactions. Hence for Seminoma, Juvenile Myelomonocytic Leukemia and other cancers there is a need to personalize which foods and supplements to take and regularly evaluate if foods like Cinnamon are recommended or not.
So some of the example questions one may have related to Cinnamon can be: Is Cinnamon beneficial for me? Should I eat it when at genetic cancer risk due to mutation of gene CREBBP? Should I eat Cinnamon when a mutation of a gene NRAS is identified? Should I eat Cinnamon when diagnosed with Seminoma? Should I eat Cinnamon when diagnosed with Juvenile Myelomonocytic Leukemia? Should I eat Cinnamon when on Ifosfamide treatment? Should I continue eating Cinnamon if my treatment changes from Ifosfamide to Trametinib? Are the implications of taking Cinnamon in Juvenile Myelomonocytic Leukemia the same as Seminoma? And so on.
Cinnamon and cancer
Cinnamon has been used as a spice and as traditional herbal medicine for centuries.They are excellent sources of antioxidants with their high content of phenolic compounds. It is evident that frequent consumption of spicy foods was also linked to a lower risk of death from cancer and ischemic heart and respiratory system diseases.
- Helps in lowering cholesterol. (Gruenwald, Joerg, Janine Freder, and Nicole Armbruester.Critical reviews in food science and nutrition 50.9 (2010): 822-834.)
- May help in lower risk of death from cancer and ischemic heart and respiratory system diseases. (Jiang, T. Alan.Journal of AOAC International 102.2 (2019): 395-411.)
Cinnamon contains many active ingredients like Cinnamaldehyde, Linalool, Salicylic Acid, Acetyleugenol, Caffeic Acid and many other Bioactives at different concentrations. The molecular pathways which are regulated by Cinnamon include Oxidative Stress, MYC Signaling, MAPK Signaling (ERK Signaling), Histone/Protein Acetylation and many others. These cellular pathways directly or indirectly influence cancer molecular endpoints like growth, spread and death. Because of this biological relationship – for cancer, choosing foods like Cinnamon and supplements is an important decision to be made. And not necessarily the same food choices are scientifically best for all individuals.
Include Cinnamon in my nutrition?
The answer to the question “Which Foods to Eat” and “Which Foods to Reduce Intake of” is dependent on multiple factors. Just like the same treatment does not work for every cancer patient, based on individual context the Cinnamon may have scientific benefits or have adverse interactions. Along with which cancer – the ongoing treatments, supplements, lifestyle habits, height, weight, allergies and food preferences are all factors influencing answers to the question.
1. Any benefits of Cinnamon for Seminoma with Ifosfamide treatment?
Seminoma is known to have mutations in gene like KIT, KRAS and NRAS and others which together cause biochemical pathway changes in Oxidative Stress, DNA Repair (Homology Directed Repair), Cell Cycle (Proliferation), DNA Repair (Global Genome Nucleotide Excision Repair) and P53 Signaling. A cancer treatment like Ifosfamide has molecular action on a unique set of biochemical pathways . The treatment intent is to have a good overlap with the cancer driving pathways and reduce the disease drivers. In such conditions foods which can scientifically cancel out the treatment effect by reducing the overlap between the cancer driving pathways and treatment are candidates for reducing intake of or completely avoid. For example – in the case of Seminoma and treatment Ifosfamide – Cinnamon is not recommended. Cinnamon impacts pathways or processes like Oxidative Stress which can negate the effects of the treatment.
2. Any benefits of Cinnamon for Juvenile Myelomonocytic Leukemia with Trametinib treatment?
Juvenile Myelomonocytic Leukemia is defined and driven by specific genetic mutations like PTPN11, NRAS and NF1 leading to biochemical pathway changes in MYC Signaling, MAPK Signaling (ERK Signaling), PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), RAS-RAF Signaling (RAS Signaling) and JAK-STAT Signaling. Also treatments like Trametinib have molecular action on a unique set of biochemical pathways. Cinnamon should be considered for Juvenile Myelomonocytic Leukemia while on Trametinib treatment. Cinnamon impacts pathways or processes like MYC Signaling and MAPK Signaling (ERK Signaling) which can either reduce drivers of Juvenile Myelomonocytic Leukemia and/or improve Trametinib treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Any benefits of Cinnamon for gene CREBBP associated cancer genetic risk?
Many companies offer gene panel tests for evaluating genetic risk to different cancers. These panels cover genes like CREBBP and many others associated with high prevalence cancers of breast, ovary, uterus, prostate and gastrointestinal system and others. The intent of the genetic testing of CREBBP is for diagnosis and/or to find out any potential risk factors for cancer. CREBBP mutation causes biochemical pathways or processes like Histone/Protein Acetylation to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like Histone/Protein Acetylation. Intake of foods like Cinnamon should be reduced when there is a mutation of CREBBP for risk of Follicular Lymphoma and Non-Hodgkin Lymphoma. Cinnamon impacts pathways or processes like Histone/Protein Acetylation and creates adverse effects with CREBBP mutation.
4. Any benefits of Cinnamon for gene NRAS associated cancer genetic risk?
NRAS is also one of many genes available in panels for cancer risk testing. NRAS mutation causes biochemical pathways or processes like MYC Signaling, MAPK Signaling (ERK Signaling) and RAS-RAF Signaling (RAS Signaling) to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like MYC Signaling, MAPK Signaling (ERK Signaling) and RAS-RAF Signaling (RAS Signaling). Intake of foods like Cinnamon should be considered when Acute Lymphoid Leukemia and Multiple Myeloma risk is identified due to gene NRAS mutation. Cinnamon impacts biochemical pathways or processes like MYC Signaling and MAPK Signaling (ERK Signaling) associated with genetic risk to NRAS mutation.
* Other Factors Included Like BMI, Lifestyle Habits, Treatments
Personalized nutrition planning for cancer can inform if foods like Cinnamon are recommended or not. Nutrition is the single most effective tool which cancer patients can control and nutrition decisions are dependent on questions like “Is Cinnamon beneficial for me?”
The addon personalized nutrition planning for cancer is a software approach based on molecular science. The addon approach supports cancers like Seminoma, Juvenile Myelomonocytic Leukemia and others along with commonly reported genomic group clusters.
To get your personalized nutrition plan – enter details like cancer indication (example Seminoma, name of current cancer and non-cancer treatments; habits and lifestyle conditions.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.