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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

For which cancer is Gooseberry beneficial for?

Apr 26, 2022

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Highlights

Nutrition is the single most effective tool which cancer patients can control for managing cancers like Testicular Germ Cell Tumors or Rosai-Dorfman disease – hence it is important to identify those Foods and Supplements which are scientifically recommended for you. A frequently asked question is if foods like Gooseberry are beneficial for cancer and along with which treatments? There is a mis-conception that all plant-based foods are good for all cancers and all of them are equal in terms of their benefits or their lack of. The reality is that some plant-based foods will be better than others for a specific type of cancer, treatments and other conditions. So Gooseberry benefits will vary and the answer is contextual.

For example, grapefruit with certain medications is not recommended. Also spinach with some blood thinning medications can cause adverse interactions and hence intake should be reduced. For cancer, nutrition which includes food and supplements are important decisions which need to be made.

So are there types of cancer where Gooseberry has more benefits? Yes! Gooseberry is beneficial for Rosai-Dorfman disease patients taking Cladribine treatment. But has adverse interactions for Testicular Germ Cell Tumors patients on Ifosfamide treatment.

For Rosai-Dorfman disease along with Cladribine – biochemical pathways like MAPK Signaling, MYC Signaling, MAPK Signaling (ERK Signaling), PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling) and RAS-RAF Signaling (RAF Signaling) are potential drivers of the disease. Gooseberry has active ingredients which can manipulate these biochemical pathways to reduce the disease drivers and hence are scientifically beneficial. But for Testicular Germ Cell Tumors along with Ifosfamide – biochemical pathways like Oxidative Stress, DNA Repair (Homology Directed Repair), DNA Repair (Base Excision Repair), Cell Cycle (Proliferation) and DNA Repair (Global Genome Nucleotide Excision Repair) are potential drivers of the disease. Gooseberry has active ingredients which can increase disease drivers like Oxidative Stress, DNA Repair (Homology Directed Repair), DNA Repair (Base Excision Repair), Cell Cycle (Proliferation) and DNA Repair (Global Genome Nucleotide Excision Repair) and hence intake should be reduced.

Similarly, eating Gooseberry can have scientific benefits for healthy individuals who have a gene mutation in FLT3 which suggests potential risk of cancer. This is because of biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), RAS-RAF Signaling (RAS Signaling) and JAK-STAT Signaling. But reduce intake of Gooseberry when at genetic risk of cancer due to mutation of gene ASXL1 due to its manipulation of biochemical pathways Oncogenic Cancer Epigenetics (CpG Methylation) and Suppressive Histone Methylation (Histone 3 Lysine 27 Methylation) causing cancer drivers to increase.

The takeaway being – for Testicular Germ Cell Tumors, Rosai-Dorfman disease and other cancers individual conditions can influence if foods like Gooseberry are recommended or not. As conditions like ongoing treatments, supplements, habits and other conditions change; the nutrition plan must be re-designed and personalized. Whether Testicular Germ Cell Tumors or Rosai-Dorfman disease or other cancer types -, current treatments and supplements, age, gender, weight, height, lifestyle and genetic conditions are also key decision factors for creating a personalized nutrition plan.



Why is the choice of foods important for cancer?

Foods like Gooseberry typically contain more than one active ingredient at varying concentrations. Each of these active ingredients like Citric Acid has a unique molecular biological mechanism of action. Cancer like most diseases is driven by specific biochemical pathways and molecular interventions of the pathway can be beneficial or create adverse interactions. Hence for Testicular Germ Cell Tumors, Rosai-Dorfman disease and other cancers there is a need to personalize which foods and supplements to take and regularly evaluate if foods like Gooseberry are recommended or not.

Gooseberry for Rosai-Dorfman disease taking Cladribine Gooseberry for Testicular Germ Cell Tumors with Ifosfamide treatment

So some of the example questions one may have related to Gooseberry can be: Is Gooseberry beneficial for me? Should I eat it when at genetic cancer risk due to mutation of gene ASXL1? Should I eat Gooseberry when a mutation of a gene FLT3 is identified? Should I eat Gooseberry when diagnosed with Testicular Germ Cell Tumors? Should I eat Gooseberry when diagnosed with Rosai-Dorfman disease? Should I eat Gooseberry when on Ifosfamide treatment? Should I continue eating Gooseberry if my treatment changes from Ifosfamide to Cladribine? Are the implications of taking Gooseberry in Rosai-Dorfman disease the same as Testicular Germ Cell Tumors? And so on.

Gooseberry and cancer

Gooseberries are small, round fruits of Ribes (which also includes currants) as well as different other plants of similar appearance, with many health benefits. There are many varieties of gooseberries with colors varying from green to yellow/green, to yellow, or white, to pink, to red, to dark red, or purple. They are low in calories and rich in fiber. Following are some of the potential health benefits of gooseberries:

Gooseberry contains many active ingredients like Citric Acid, Gallic Acid, Beta-sitosterol, Linoleic Acid, Linolenic Acid and many other Bioactives at different concentrations. The molecular pathways which are regulated by Gooseberry include Oxidative Stress, MAPK Signaling, MYC Signaling, Oncogenic Cancer Epigenetics (CpG Methylation), PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling) and many others. These cellular pathways directly or indirectly influence cancer molecular endpoints like growth, spread and death. Because of this biological relationship – for cancer, choosing foods like Gooseberry and supplements is an important decision to be made. And not necessarily the same food choices are scientifically best for all individuals.

Include Gooseberry in my nutrition?

The answer to the question “Which Foods to Eat” and “Which Foods to Reduce Intake of” is dependent on multiple factors. Just like the same treatment does not work for every cancer patient, based on individual context the Gooseberry may have scientific benefits or have adverse interactions. Along with which cancer – the ongoing treatments, supplements, lifestyle habits, height, weight, allergies and food preferences are all factors influencing answers to the question.

1. Any benefits of Gooseberry for Testicular Germ Cell Tumors with Ifosfamide treatment?

Testicular Germ Cell Tumors is known to have mutations in gene like KIT, KRAS and PTMA and others which together cause biochemical pathway changes in Oxidative Stress, DNA Repair (Homology Directed Repair), DNA Repair (Base Excision Repair), Cell Cycle (Proliferation) and DNA Repair (Global Genome Nucleotide Excision Repair). A cancer treatment like Ifosfamide has molecular action on a unique set of biochemical pathways . The treatment intent is to have a good overlap with the cancer driving pathways and reduce the disease drivers. In such conditions foods which can scientifically cancel out the treatment effect by reducing the overlap between the cancer driving pathways and treatment are candidates for reducing intake of or completely avoid. For example – in the case of Testicular Germ Cell Tumors and treatment Ifosfamide – Gooseberry is not recommended. Gooseberry impacts pathways or processes like Oxidative Stress which can negate the effects of the treatment.

2. Any benefits of Gooseberry for Rosai-Dorfman disease with Cladribine treatment?

Rosai-Dorfman disease is defined and driven by specific genetic mutations like KRAS, MAP2K1 and BARD1 leading to biochemical pathway changes in MAPK Signaling, MYC Signaling, MAPK Signaling (ERK Signaling), PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling) and RAS-RAF Signaling (RAF Signaling). Also treatments like Cladribine have molecular action on a unique set of biochemical pathways. Gooseberry should be considered for Rosai-Dorfman disease while on Cladribine treatment. Gooseberry impacts pathways or processes like MAPK Signaling and MYC Signaling which can either reduce drivers of Rosai-Dorfman disease and/or improve Cladribine treatment effect.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Any benefits of Gooseberry for gene ASXL1 associated cancer genetic risk?

Many companies offer gene panel tests for evaluating genetic risk to different cancers. These panels cover genes like ASXL1 and many others associated with high prevalence cancers of breast, ovary, uterus, prostate and gastrointestinal system and others. The intent of the genetic testing of ASXL1 is for diagnosis and/or to find out any potential risk factors for cancer. ASXL1 mutation causes biochemical pathways or processes like Oncogenic Cancer Epigenetics (CpG Methylation) and Suppressive Histone Methylation (Histone 3 Lysine 27 Methylation) to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like Oncogenic Cancer Epigenetics (CpG Methylation) and Suppressive Histone Methylation (Histone 3 Lysine 27 Methylation). Intake of foods like Gooseberry should be reduced when there is a mutation of ASXL1 for risk of Chronic myelomonocytic leukemia and Myelodysplastic Syndrome. Gooseberry impacts pathways or processes like Oncogenic Cancer Epigenetics (CpG Methylation) and creates adverse effects with ASXL1 mutation.

4. Any benefits of Gooseberry for gene FLT3 associated cancer genetic risk?

FLT3 is also one of many genes available in panels for cancer risk testing. FLT3 mutation causes biochemical pathways or processes like MAPK Signaling, PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), RAS-RAF Signaling (RAS Signaling) and JAK-STAT Signaling to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), RAS-RAF Signaling (RAS Signaling) and JAK-STAT Signaling. Intake of foods like Gooseberry should be considered when Acute Myeloid Leukemia risk is identified due to gene FLT3 mutation. Gooseberry impacts biochemical pathways or processes like MAPK Signaling and PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling) associated with genetic risk to FLT3 mutation.

* Other Factors Included Like BMI, Lifestyle Habits, Treatments

In Conclusion

Personalized nutrition planning for cancer can inform if foods like Gooseberry are recommended or not. Nutrition is the single most effective tool which cancer patients can control and nutrition decisions are dependent on questions like “Is Gooseberry beneficial for me?”

The addon personalized nutrition planning for cancer is a software approach based on molecular science. The addon approach supports cancers like Testicular Germ Cell Tumors, Rosai-Dorfman disease and others along with commonly reported genomic group clusters.

To get your personalized nutrition plan – enter details like cancer indication (example Testicular Germ Cell Tumors, name of current cancer and non-cancer treatments; habits and lifestyle conditions.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


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