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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

For which cancer is Black Pepper beneficial for?

Apr 25, 2022

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Highlights

Nutrition is the single most effective tool which cancer patients can control for managing cancers like Ganglioglioma or Nasopharyngeal Cancer – hence it is important to identify those Foods and Supplements which are scientifically recommended for you. A frequently asked question is if foods like Black Pepper are beneficial for cancer and along with which treatments? There is a mis-conception that all plant-based foods are good for all cancers and all of them are equal in terms of their benefits or their lack of. The reality is that some plant-based foods will be better than others for a specific type of cancer, treatments and other conditions. So Black Pepper benefits will vary and the answer is contextual.

For example, grapefruit with certain medications is not recommended. Also spinach with some blood thinning medications can cause adverse interactions and hence intake should be reduced. For cancer, nutrition which includes food and supplements are important decisions which need to be made.

So are there types of cancer where Black Pepper has more benefits? Yes! Black Pepper is beneficial for Nasopharyngeal Cancer patients taking Vincristine treatment. But has adverse interactions for Ganglioglioma patients on Hydroxyurea treatment.

For Nasopharyngeal Cancer along with Vincristine – biochemical pathways like Apoptosis (Intrinsic Apoptosis), Adherens junction, Carbohydrate Metabolism (Glycolysis), NFKB Signaling and Notch Signaling (NOTCH1 Signaling) are potential drivers of the disease. Black Pepper has active ingredients which can manipulate these biochemical pathways to reduce the disease drivers and hence are scientifically beneficial. But for Ganglioglioma along with Hydroxyurea – biochemical pathways like DNA Repair (Homology Directed Repair), P53 Signaling, DNA Repair (Non-homologous end-joining), MYC Signaling and Cytokine Signaling (OSM Signaling) are potential drivers of the disease. Black Pepper has active ingredients which can increase disease drivers like DNA Repair (Homology Directed Repair), P53 Signaling, DNA Repair (Non-homologous end-joining), MYC Signaling and Cytokine Signaling (OSM Signaling) and hence intake should be reduced.

Similarly, eating Black Pepper can have scientific benefits for healthy individuals who have a gene mutation in SMAD4 which suggests potential risk of cancer. This is because of biochemical pathways Lipid Metabolism (Arachidonic Acid Metabolism), MAPK Signaling, Stem Cell Signaling, Growth Factor Signaling (EGFR Signaling) and MYC Signaling. But reduce intake of Black Pepper when at genetic risk of cancer due to mutation of gene ASXL1 due to its manipulation of biochemical pathways Oncogenic Cancer Epigenetics (CpG Methylation) and Suppressive Histone Methylation (Histone 3 Lysine 27 Methylation) causing cancer drivers to increase.

The takeaway being – for Ganglioglioma, Nasopharyngeal Cancer and other cancers individual conditions can influence if foods like Black Pepper are recommended or not. As conditions like ongoing treatments, supplements, habits and other conditions change; the nutrition plan must be re-designed and personalized. Whether Ganglioglioma or Nasopharyngeal Cancer or other cancer types -, current treatments and supplements, age, gender, weight, height, lifestyle and genetic conditions are also key decision factors for creating a personalized nutrition plan.



Why is the choice of foods important for cancer?

Foods like Black Pepper typically contain more than one active ingredient at varying concentrations. Each of these active ingredients like Piperine has a unique molecular biological mechanism of action. Cancer like most diseases is driven by specific biochemical pathways and molecular interventions of the pathway can be beneficial or create adverse interactions. Hence for Ganglioglioma, Nasopharyngeal Cancer and other cancers there is a need to personalize which foods and supplements to take and regularly evaluate if foods like Black Pepper are recommended or not.

Black Pepper for Nasopharyngeal Cancer taking Vincristine Black Pepper for Ganglioglioma with Hydroxyurea treatment

So some of the example questions one may have related to Black Pepper can be: Is Black Pepper beneficial for me? Should I eat it when at genetic cancer risk due to mutation of gene ASXL1? Should I eat Black Pepper when a mutation of a gene SMAD4 is identified? Should I eat Black Pepper when diagnosed with Ganglioglioma? Should I eat Black Pepper when diagnosed with Nasopharyngeal Cancer? Should I eat Black Pepper when on Hydroxyurea treatment? Should I continue eating Black Pepper if my treatment changes from Hydroxyurea to Vincristine? Are the implications of taking Black Pepper in Nasopharyngeal Cancer the same as Ganglioglioma? And so on.

Black Pepper and cancer

Black pepper (Piper nigrum) is a flowering vine in the family Piperaceae, cultivated for its fruit, known as a peppercorn, which is usually dried and used as a spice and seasoning. Black pepper is produced from the still-green, unripe drupe of the pepper plant.

Black Pepper contains many active ingredients like Piperine, Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A and many other Bioactives at different concentrations. The molecular pathways which are regulated by Black Pepper include DNA Repair (Homology Directed Repair), Apoptosis (Intrinsic Apoptosis), Adherens junction, Oncogenic Cancer Epigenetics (CpG Methylation), Suppressive Histone Methylation (Histone 3 Lysine 27 Methylation) and many others. These cellular pathways directly or indirectly influence cancer molecular endpoints like growth, spread and death. Because of this biological relationship – for cancer, choosing foods like Black Pepper and supplements is an important decision to be made. And not necessarily the same food choices are scientifically best for all individuals.

Include Black Pepper in my nutrition?

The answer to the question “Which Foods to Eat” and “Which Foods to Reduce Intake of” is dependent on multiple factors. Just like the same treatment does not work for every cancer patient, based on individual context the Black Pepper may have scientific benefits or have adverse interactions. Along with which cancer – the ongoing treatments, supplements, lifestyle habits, height, weight, allergies and food preferences are all factors influencing answers to the question.

1. Any benefits of Black Pepper for Ganglioglioma with Hydroxyurea treatment?

Ganglioglioma is known to have mutations in gene like BRAF, EME1 and TERT and others which together cause biochemical pathway changes in DNA Repair (Homology Directed Repair), P53 Signaling, DNA Repair (Non-homologous end-joining), MYC Signaling and Cytokine Signaling (OSM Signaling). A cancer treatment like Hydroxyurea has molecular action on a unique set of biochemical pathways . The treatment intent is to have a good overlap with the cancer driving pathways and reduce the disease drivers. In such conditions foods which can scientifically cancel out the treatment effect by reducing the overlap between the cancer driving pathways and treatment are candidates for reducing intake of or completely avoid. For example – in the case of Ganglioglioma and treatment Hydroxyurea – Black Pepper is not recommended. Black Pepper impacts pathways or processes like DNA Repair (Homology Directed Repair) which can negate the effects of the treatment.

2. Any benefits of Black Pepper for Nasopharyngeal Cancer with Vincristine treatment?

Nasopharyngeal Cancer is defined and driven by specific genetic mutations like TP53, TTN and SYNE1 leading to biochemical pathway changes in Apoptosis (Intrinsic Apoptosis), Adherens junction, Carbohydrate Metabolism (Glycolysis), NFKB Signaling and Notch Signaling (NOTCH1 Signaling). Also treatments like Vincristine have molecular action on a unique set of biochemical pathways. Black Pepper should be considered for Nasopharyngeal Cancer while on Vincristine treatment. Black Pepper impacts pathways or processes like Apoptosis (Intrinsic Apoptosis) and Adherens junction which can either reduce drivers of Nasopharyngeal Cancer and/or improve Vincristine treatment effect.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Any benefits of Black Pepper for gene ASXL1 associated cancer genetic risk?

Many companies offer gene panel tests for evaluating genetic risk to different cancers. These panels cover genes like ASXL1 and many others associated with high prevalence cancers of breast, ovary, uterus, prostate and gastrointestinal system and others. The intent of the genetic testing of ASXL1 is for diagnosis and/or to find out any potential risk factors for cancer. ASXL1 mutation causes biochemical pathways or processes like Oncogenic Cancer Epigenetics (CpG Methylation) and Suppressive Histone Methylation (Histone 3 Lysine 27 Methylation) to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like Oncogenic Cancer Epigenetics (CpG Methylation) and Suppressive Histone Methylation (Histone 3 Lysine 27 Methylation). Intake of foods like Black Pepper should be reduced when there is a mutation of ASXL1 for risk of Chronic myelomonocytic leukemia and Myelodysplastic Syndrome. Black Pepper impacts pathways or processes like Oncogenic Cancer Epigenetics (CpG Methylation) and Suppressive Histone Methylation (Histone 3 Lysine 27 Methylation) and creates adverse effects with ASXL1 mutation.

4. Any benefits of Black Pepper for gene SMAD4 associated cancer genetic risk?

SMAD4 is also one of many genes available in panels for cancer risk testing. SMAD4 mutation causes biochemical pathways or processes like Lipid Metabolism (Arachidonic Acid Metabolism), MAPK Signaling, Stem Cell Signaling, Growth Factor Signaling (EGFR Signaling) and MYC Signaling to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like Lipid Metabolism (Arachidonic Acid Metabolism), MAPK Signaling, Stem Cell Signaling, Growth Factor Signaling (EGFR Signaling) and MYC Signaling. Intake of foods like Black Pepper should be considered when Colon cancer and Gallbladder Cancer risk is identified due to gene SMAD4 mutation. Black Pepper impacts biochemical pathways or processes like Lipid Metabolism (Arachidonic Acid Metabolism) and MAPK Signaling associated with genetic risk to SMAD4 mutation.

* Other Factors Included Like BMI, Lifestyle Habits, Treatments

In Conclusion

Personalized nutrition planning for cancer can inform if foods like Black Pepper are recommended or not. Nutrition is the single most effective tool which cancer patients can control and nutrition decisions are dependent on questions like “Is Black Pepper beneficial for me?”

The addon personalized nutrition planning for cancer is a software approach based on molecular science. The addon approach supports cancers like Ganglioglioma, Nasopharyngeal Cancer and others along with commonly reported genomic group clusters.

To get your personalized nutrition plan – enter details like cancer indication (example Ganglioglioma, name of current cancer and non-cancer treatments; habits and lifestyle conditions.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


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