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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

For which cancer is Sage beneficial for?

Apr 20, 2022

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Highlights

Nutrition is the single most effective tool which cancer patients can control for managing cancers like Pilocytic astrocytoma or Rosai-Dorfman disease – hence it is important to identify those Foods and Supplements which are scientifically recommended for you. A frequently asked question is if foods like Sage are beneficial for cancer and along with which treatments? There is a mis-conception that all plant-based foods are good for all cancers and all of them are equal in terms of their benefits or their lack of. The reality is that some plant-based foods will be better than others for a specific type of cancer, treatments and other conditions. So Sage benefits will vary and the answer is contextual.

For example, grapefruit with certain medications is not recommended. Also spinach with some blood thinning medications can cause adverse interactions and hence intake should be reduced. For cancer, nutrition which includes food and supplements are important decisions which need to be made.

So are there types of cancer where Sage has more benefits? Yes! Sage is beneficial for Rosai-Dorfman disease patients taking Cladribine treatment. But has adverse interactions for Pilocytic astrocytoma patients on Radiation treatment.

For Rosai-Dorfman disease along with Cladribine – biochemical pathways like MAPK Signaling (ERK Signaling), MYC Signaling, PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), MAPK Signaling and RAS-RAF Signaling (RAF Signaling) are potential drivers of the disease. Sage has active ingredients which can manipulate these biochemical pathways to reduce the disease drivers and hence are scientifically beneficial. But for Pilocytic astrocytoma along with Radiation – biochemical pathways like MYC Signaling, MAPK Signaling (ERK Signaling), PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling) and RAS-RAF Signaling (RAS Signaling) are potential drivers of the disease. Sage has active ingredients which can increase disease drivers like MYC Signaling, MAPK Signaling (ERK Signaling), PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling) and RAS-RAF Signaling (RAS Signaling) and hence intake should be reduced.

Similarly, eating Sage can have scientific benefits for healthy individuals who have a gene mutation in CDKN2A which suggests potential risk of cancer. This is because of biochemical pathways P53 Signaling, Cell Cycle (Proliferation), DNA Repair (Global Genome Nucleotide Excision Repair), Stem Cell Signaling and MAPK Signaling. But reduce intake of Sage when at genetic risk of cancer due to mutation of gene WT1 due to its manipulation of biochemical pathways Angiogenesis, Endoplasmic Reticulum Stress, Stem Cell Signaling, Growth Factor Signaling (FGFR Signaling) and Angiogenesis (VEGF Signaling) causing cancer drivers to increase.

The takeaway being – for Pilocytic astrocytoma, Rosai-Dorfman disease and other cancers individual conditions can influence if foods like Sage are recommended or not. As conditions like ongoing treatments, supplements, habits and other conditions change; the nutrition plan must be re-designed and personalized. Whether Pilocytic astrocytoma or Rosai-Dorfman disease or other cancer types -, current treatments and supplements, age, gender, weight, height, lifestyle and genetic conditions are also key decision factors for creating a personalized nutrition plan.



Why is the choice of foods important for cancer?

Foods like Sage typically contain more than one active ingredient at varying concentrations. Each of these active ingredients like Luteolin has a unique molecular biological mechanism of action. Cancer like most diseases is driven by specific biochemical pathways and molecular interventions of the pathway can be beneficial or create adverse interactions. Hence for Pilocytic astrocytoma, Rosai-Dorfman disease and other cancers there is a need to personalize which foods and supplements to take and regularly evaluate if foods like Sage are recommended or not.

Sage for Rosai-Dorfman disease taking Cladribine Sage for Pilocytic astrocytoma with Radiation treatment

So some of the example questions one may have related to Sage can be: Is Sage beneficial for me? Should I eat it when at genetic cancer risk due to mutation of gene WT1? Should I eat Sage when a mutation of a gene CDKN2A is identified? Should I eat Sage when diagnosed with Pilocytic astrocytoma? Should I eat Sage when diagnosed with Rosai-Dorfman disease? Should I eat Sage when on Radiation treatment? Should I continue eating Sage if my treatment changes from Radiation to Cladribine? Are the implications of taking Sage in Rosai-Dorfman disease the same as Pilocytic astrocytoma? And so on.

Sage and cancer

Genus Salvia, commonly known as sage, is the largest genus in the Lamiaceae family. It comprises many species traditionally used as brain-enhancing tonics. In vitro and animal studies have confirmed that several Salvia species contain a large array of active compounds that may enhance cognitive activity and protect against neurodegenerative disease.

Sage contains many active ingredients like Luteolin, D-limonene, Linoleic Acid, Beta-sitosterol, Caffeic Acid and many other Bioactives at different concentrations. The molecular pathways which are regulated by Sage include MYC Signaling, MAPK Signaling (ERK Signaling), Angiogenesis, Endoplasmic Reticulum Stress, P53 Signaling and many others. These cellular pathways directly or indirectly influence cancer molecular endpoints like growth, spread and death. Because of this biological relationship – for cancer, choosing foods like Sage and supplements is an important decision to be made. And not necessarily the same food choices are scientifically best for all individuals.

Include Sage in my nutrition?

The answer to the question “Which Foods to Eat” and “Which Foods to Reduce Intake of” is dependent on multiple factors. Just like the same treatment does not work for every cancer patient, based on individual context the Sage may have scientific benefits or have adverse interactions. Along with which cancer – the ongoing treatments, supplements, lifestyle habits, height, weight, allergies and food preferences are all factors influencing answers to the question.

1. Any benefits of Sage for Pilocytic astrocytoma with Radiation treatment?

Pilocytic astrocytoma is known to have mutations in gene like KIAA1549-BRAF, BRAF and FGFR1 and others which together cause biochemical pathway changes in MYC Signaling, MAPK Signaling (ERK Signaling), PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling) and RAS-RAF Signaling (RAS Signaling). A cancer treatment like Radiation has molecular action on a unique set of biochemical pathways . The treatment intent is to have a good overlap with the cancer driving pathways and reduce the disease drivers. In such conditions foods which can scientifically cancel out the treatment effect by reducing the overlap between the cancer driving pathways and treatment are candidates for reducing intake of or completely avoid. For example – in the case of Pilocytic astrocytoma and treatment Radiation – Sage is not recommended. Sage impacts pathways or processes like MYC Signaling which can negate the effects of the treatment.

2. Any benefits of Sage for Rosai-Dorfman disease with Cladribine treatment?

Rosai-Dorfman disease is defined and driven by specific genetic mutations like KRAS, MAP2K1 and BARD1 leading to biochemical pathway changes in MAPK Signaling (ERK Signaling), MYC Signaling, PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), MAPK Signaling and RAS-RAF Signaling (RAF Signaling). Also treatments like Cladribine have molecular action on a unique set of biochemical pathways. Sage should be considered for Rosai-Dorfman disease while on Cladribine treatment. Sage impacts pathways or processes like MAPK Signaling (ERK Signaling) and MYC Signaling which can either reduce drivers of Rosai-Dorfman disease and/or improve Cladribine treatment effect.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Any benefits of Sage for gene WT1 associated cancer genetic risk?

Many companies offer gene panel tests for evaluating genetic risk to different cancers. These panels cover genes like WT1 and many others associated with high prevalence cancers of breast, ovary, uterus, prostate and gastrointestinal system and others. The intent of the genetic testing of WT1 is for diagnosis and/or to find out any potential risk factors for cancer. WT1 mutation causes biochemical pathways or processes like Angiogenesis, Endoplasmic Reticulum Stress, Stem Cell Signaling, Growth Factor Signaling (FGFR Signaling) and Angiogenesis (VEGF Signaling) to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like Angiogenesis, Endoplasmic Reticulum Stress, Stem Cell Signaling, Growth Factor Signaling (FGFR Signaling) and Angiogenesis (VEGF Signaling). Intake of foods like Sage should be reduced when there is a mutation of WT1 for risk of Kidney cancer. Sage impacts pathways or processes like Angiogenesis and Endoplasmic Reticulum Stress and creates adverse effects with WT1 mutation.

4. Any benefits of Sage for gene CDKN2A associated cancer genetic risk?

CDKN2A is also one of many genes available in panels for cancer risk testing. CDKN2A mutation causes biochemical pathways or processes like P53 Signaling, Cell Cycle (Proliferation), DNA Repair (Global Genome Nucleotide Excision Repair), Stem Cell Signaling and MAPK Signaling to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like P53 Signaling, Cell Cycle (Proliferation), DNA Repair (Global Genome Nucleotide Excision Repair), Stem Cell Signaling and MAPK Signaling. Intake of foods like Sage should be considered when Skin cancer and Head and Neck Squamous Cell Carcinoma risk is identified due to gene CDKN2A mutation. Sage impacts biochemical pathways or processes like P53 Signaling and Cell Cycle (Proliferation) associated with genetic risk to CDKN2A mutation.

* Other Factors Included Like BMI, Lifestyle Habits, Treatments

In Conclusion

Personalized nutrition planning for cancer can inform if foods like Sage are recommended or not. Nutrition is the single most effective tool which cancer patients can control and nutrition decisions are dependent on questions like “Is Sage beneficial for me?”

The addon personalized nutrition planning for cancer is a software approach based on molecular science. The addon approach supports cancers like Pilocytic astrocytoma, Rosai-Dorfman disease and others along with commonly reported genomic group clusters.

To get your personalized nutrition plan – enter details like cancer indication (example Pilocytic astrocytoma, name of current cancer and non-cancer treatments; habits and lifestyle conditions.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


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