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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

For which cancer is Roselle beneficial for?

Apr 19, 2022

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Highlights

Nutrition is the single most effective tool which cancer patients can control for managing cancers like Pancreatic Neuroendocrine Tumor or Acute Lymphoid Leukemia – hence it is important to identify those Foods and Supplements which are scientifically recommended for you. A frequently asked question is if foods like Roselle are beneficial for cancer and along with which treatments? There is a mis-conception that all plant-based foods are good for all cancers and all of them are equal in terms of their benefits or their lack of. The reality is that some plant-based foods will be better than others for a specific type of cancer, treatments and other conditions. So Roselle benefits will vary and the answer is contextual.

For example, grapefruit with certain medications is not recommended. Also spinach with some blood thinning medications can cause adverse interactions and hence intake should be reduced. For cancer, nutrition which includes food and supplements are important decisions which need to be made.

So are there types of cancer where Roselle has more benefits? Yes! Roselle is beneficial for Acute Lymphoid Leukemia patients taking Vincristine treatment. But has adverse interactions for Pancreatic Neuroendocrine Tumor patients on Sunitinib treatment.

For Acute Lymphoid Leukemia along with Vincristine – biochemical pathways like Apoptosis (Intrinsic Apoptosis), Cell Cycle (Mitotic Cell Cycle), PI3K-AKT-MTOR Signaling (MTOR Signaling), MAPK Signaling and WNT Betacatenin Signaling are potential drivers of the disease. Roselle has active ingredients which can manipulate these biochemical pathways to reduce the disease drivers and hence are scientifically beneficial. But for Pancreatic Neuroendocrine Tumor along with Sunitinib – biochemical pathways like Angiogenesis, Chemokine Signaling, Cytoskeletal Dynamics (CDC42 Signaling), Notch Signaling (NOTCH1 Signaling) and PI3K-AKT-MTOR Signaling (MTOR Signaling) are potential drivers of the disease. Roselle has active ingredients which can increase disease drivers like Angiogenesis, Chemokine Signaling, Cytoskeletal Dynamics (CDC42 Signaling), Notch Signaling (NOTCH1 Signaling) and PI3K-AKT-MTOR Signaling (MTOR Signaling) and hence intake should be reduced.

Similarly, eating Roselle can have scientific benefits for healthy individuals who have a gene mutation in CDKN2A which suggests potential risk of cancer. This is because of biochemical pathways P53 Signaling, Cell Cycle (Mitotic Cell Cycle), Cell Cycle (Proliferation), DNA Repair (Global Genome Nucleotide Excision Repair) and Stem Cell Signaling. But reduce intake of Roselle when at genetic risk of cancer due to mutation of gene ASXL1 due to its manipulation of biochemical pathways Oncogenic Cancer Epigenetics (CpG Methylation) and Suppressive Histone Methylation (Histone 3 Lysine 27 Methylation) causing cancer drivers to increase.

The takeaway being – for Pancreatic Neuroendocrine Tumor, Acute Lymphoid Leukemia and other cancers individual conditions can influence if foods like Roselle are recommended or not. As conditions like ongoing treatments, supplements, habits and other conditions change; the nutrition plan must be re-designed and personalized. Whether Pancreatic Neuroendocrine Tumor or Acute Lymphoid Leukemia or other cancer types -, current treatments and supplements, age, gender, weight, height, lifestyle and genetic conditions are also key decision factors for creating a personalized nutrition plan.



Why is the choice of foods important for cancer?

Foods like Roselle typically contain more than one active ingredient at varying concentrations. Each of these active ingredients like Linoleic Acid has a unique molecular biological mechanism of action. Cancer like most diseases is driven by specific biochemical pathways and molecular interventions of the pathway can be beneficial or create adverse interactions. Hence for Pancreatic Neuroendocrine Tumor, Acute Lymphoid Leukemia and other cancers there is a need to personalize which foods and supplements to take and regularly evaluate if foods like Roselle are recommended or not.

Roselle for Acute Lymphoid Leukemia taking Vincristine Roselle for Pancreatic Neuroendocrine Tumor with Sunitinib treatment

So some of the example questions one may have related to Roselle can be: Is Roselle beneficial for me? Should I eat it when at genetic cancer risk due to mutation of gene ASXL1? Should I eat Roselle when a mutation of a gene CDKN2A is identified? Should I eat Roselle when diagnosed with Pancreatic Neuroendocrine Tumor? Should I eat Roselle when diagnosed with Acute Lymphoid Leukemia? Should I eat Roselle when on Sunitinib treatment? Should I continue eating Roselle if my treatment changes from Sunitinib to Vincristine? Are the implications of taking Roselle in Acute Lymphoid Leukemia the same as Pancreatic Neuroendocrine Tumor? And so on.

Roselle and cancer

Roselle (Hibiscus sabdariffa) is a functional food with potential health benefits, consumed either as a hot or cold beverage. To ensure quality control of its various products, accurate measurement of active metabolites is warranted. 

Roselle contains many active ingredients like Linoleic Acid, Vitamin E, Vitamin C, Beta-sitosterol, Citric Acid and many other Bioactives at different concentrations. The molecular pathways which are regulated by Roselle include Angiogenesis, Chemokine Signaling, Apoptosis (Intrinsic Apoptosis), Cell Cycle (Mitotic Cell Cycle), Oncogenic Cancer Epigenetics (CpG Methylation) and many others. These cellular pathways directly or indirectly influence cancer molecular endpoints like growth, spread and death. Because of this biological relationship – for cancer, choosing foods like Roselle and supplements is an important decision to be made. And not necessarily the same food choices are scientifically best for all individuals.

Include Roselle in my nutrition?

The answer to the question “Which Foods to Eat” and “Which Foods to Reduce Intake of” is dependent on multiple factors. Just like the same treatment does not work for every cancer patient, based on individual context the Roselle may have scientific benefits or have adverse interactions. Along with which cancer – the ongoing treatments, supplements, lifestyle habits, height, weight, allergies and food preferences are all factors influencing answers to the question.

1. Any benefits of Roselle for Pancreatic Neuroendocrine Tumor with Sunitinib treatment?

Pancreatic Neuroendocrine Tumor is known to have mutations in gene like MEN1, DAXX and ATRX and others which together cause biochemical pathway changes in Angiogenesis, Chemokine Signaling, Cytoskeletal Dynamics (CDC42 Signaling), Notch Signaling (NOTCH1 Signaling) and PI3K-AKT-MTOR Signaling (MTOR Signaling). A cancer treatment like Sunitinib has molecular action on a unique set of biochemical pathways . The treatment intent is to have a good overlap with the cancer driving pathways and reduce the disease drivers. In such conditions foods which can scientifically cancel out the treatment effect by reducing the overlap between the cancer driving pathways and treatment are candidates for reducing intake of or completely avoid. For example – in the case of Pancreatic Neuroendocrine Tumor and treatment Sunitinib – Roselle is not recommended. Roselle impacts pathways or processes like Angiogenesis and Chemokine Signaling which can negate the effects of the treatment.

2. Any benefits of Roselle for Acute Lymphoid Leukemia with Vincristine treatment?

Acute Lymphoid Leukemia is defined and driven by specific genetic mutations like NRAS, KRAS and CREBBP leading to biochemical pathway changes in Apoptosis (Intrinsic Apoptosis), Cell Cycle (Mitotic Cell Cycle), PI3K-AKT-MTOR Signaling (MTOR Signaling), MAPK Signaling and WNT Betacatenin Signaling. Also treatments like Vincristine have molecular action on a unique set of biochemical pathways. Roselle should be considered for Acute Lymphoid Leukemia while on Vincristine treatment. Roselle impacts pathways or processes like Apoptosis (Intrinsic Apoptosis) and Cell Cycle (Mitotic Cell Cycle) which can either reduce drivers of Acute Lymphoid Leukemia and/or improve Vincristine treatment effect.

For Which Cancer Is Roselle Beneficial For?

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Any benefits of Roselle for gene ASXL1 associated cancer genetic risk?

Many companies offer gene panel tests for evaluating genetic risk to different cancers. These panels cover genes like ASXL1 and many others associated with high prevalence cancers of breast, ovary, uterus, prostate and gastrointestinal system and others. The intent of the genetic testing of ASXL1 is for diagnosis and/or to find out any potential risk factors for cancer. ASXL1 mutation causes biochemical pathways or processes like Oncogenic Cancer Epigenetics (CpG Methylation) and Suppressive Histone Methylation (Histone 3 Lysine 27 Methylation) to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like Oncogenic Cancer Epigenetics (CpG Methylation) and Suppressive Histone Methylation (Histone 3 Lysine 27 Methylation). Intake of foods like Roselle should be reduced when there is a mutation of ASXL1 for risk of Chronic myelomonocytic leukemia and Myelodysplastic Syndrome. Roselle impacts pathways or processes like Oncogenic Cancer Epigenetics (CpG Methylation) and Suppressive Histone Methylation (Histone 3 Lysine 27 Methylation) and creates adverse effects with ASXL1 mutation.

4. Any benefits of Roselle for gene CDKN2A associated cancer genetic risk?

CDKN2A is also one of many genes available in panels for cancer risk testing. CDKN2A mutation causes biochemical pathways or processes like P53 Signaling, Cell Cycle (Mitotic Cell Cycle), Cell Cycle (Proliferation), DNA Repair (Global Genome Nucleotide Excision Repair) and Stem Cell Signaling to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like P53 Signaling, Cell Cycle (Mitotic Cell Cycle), Cell Cycle (Proliferation), DNA Repair (Global Genome Nucleotide Excision Repair) and Stem Cell Signaling. Intake of foods like Roselle should be considered when Skin cancer and Head and Neck Squamous Cell Carcinoma risk is identified due to gene CDKN2A mutation. Roselle impacts biochemical pathways or processes like P53 Signaling and Cell Cycle (Mitotic Cell Cycle) associated with genetic risk to CDKN2A mutation.

* Other Factors Included Like BMI, Lifestyle Habits, Treatments

In Conclusion

Personalized nutrition planning for cancer can inform if foods like Roselle are recommended or not. Nutrition is the single most effective tool which cancer patients can control and nutrition decisions are dependent on questions like “Is Roselle beneficial for me?”

The addon personalized nutrition planning for cancer is a software approach based on molecular science. The addon approach supports cancers like Pancreatic Neuroendocrine Tumor, Acute Lymphoid Leukemia and others along with commonly reported genomic group clusters.

To get your personalized nutrition plan – enter details like cancer indication (example Pancreatic Neuroendocrine Tumor, name of current cancer and non-cancer treatments; habits and lifestyle conditions.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


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