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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

For which cancer is Pummelo beneficial for?

Apr 14, 2022

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Highlights

Nutrition is the single most effective tool which cancer patients can control for managing cancers like Testicular Germ Cell Tumors or Relapsed Refractory Multiple Myeloma – hence it is important to identify those Foods and Supplements which are scientifically recommended for you. A frequently asked question is if foods like Pummelo are beneficial for cancer and along with which treatments? There is a mis-conception that all plant-based foods are good for all cancers and all of them are equal in terms of their benefits or their lack of. The reality is that some plant-based foods will be better than others for a specific type of cancer, treatments and other conditions. So Pummelo benefits will vary and the answer is contextual.

For example, grapefruit with certain medications is not recommended. Also spinach with some blood thinning medications can cause adverse interactions and hence intake should be reduced. For cancer, nutrition which includes food and supplements are important decisions which need to be made.

So are there types of cancer where Pummelo has more benefits? Yes! Pummelo is beneficial for Relapsed Refractory Multiple Myeloma patients taking Lenalidomide treatment. But has adverse interactions for Testicular Germ Cell Tumors patients on Ifosfamide treatment.

For Relapsed Refractory Multiple Myeloma along with Lenalidomide – biochemical pathways like Vitamin D Signaling, P53 Signaling, Amino Acid Metabolism (Glutamine Metabolism), Hypoxia (HIF1 Signaling) and MYC Signaling are potential drivers of the disease. Pummelo has active ingredients which can manipulate these biochemical pathways to reduce the disease drivers and hence are scientifically beneficial. But for Testicular Germ Cell Tumors along with Ifosfamide – biochemical pathways like DNA Repair (Base Excision Repair), Oxidative Stress, DNA Repair (Homology Directed Repair), Cell Cycle (Proliferation) and DNA Repair (Global Genome Nucleotide Excision Repair) are potential drivers of the disease. Pummelo has active ingredients which can increase disease drivers like DNA Repair (Base Excision Repair), Oxidative Stress, DNA Repair (Homology Directed Repair), Cell Cycle (Proliferation) and DNA Repair (Global Genome Nucleotide Excision Repair) and hence intake should be reduced.

Similarly, eating Pummelo can have scientific benefits for healthy individuals who have a gene mutation in FLT3 which suggests potential risk of cancer. This is because of biochemical pathways PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), MAPK Signaling, RAS-RAF Signaling (RAS Signaling) and JAK-STAT Signaling. But reduce intake of Pummelo when at genetic risk of cancer due to mutation of gene ASXL1 due to its manipulation of biochemical pathways Oncogenic Cancer Epigenetics (CpG Methylation) and Suppressive Histone Methylation (Histone 3 Lysine 27 Methylation) causing cancer drivers to increase.

The takeaway being – for Testicular Germ Cell Tumors, Relapsed Refractory Multiple Myeloma and other cancers individual conditions can influence if foods like Pummelo are recommended or not. As conditions like ongoing treatments, supplements, habits and other conditions change; the nutrition plan must be re-designed and personalized. Whether Testicular Germ Cell Tumors or Relapsed Refractory Multiple Myeloma or other cancer types -, current treatments and supplements, age, gender, weight, height, lifestyle and genetic conditions are also key decision factors for creating a personalized nutrition plan.



Why is the choice of foods important for cancer?

Foods like Pummelo typically contain more than one active ingredient at varying concentrations. Each of these active ingredients like Naringenin has a unique molecular biological mechanism of action. Cancer like most diseases is driven by specific biochemical pathways and molecular interventions of the pathway can be beneficial or create adverse interactions. Hence for Testicular Germ Cell Tumors, Relapsed Refractory Multiple Myeloma and other cancers there is a need to personalize which foods and supplements to take and regularly evaluate if foods like Pummelo are recommended or not.

Pummelo for Relapsed Refractory Multiple Myeloma taking Lenalidomide Pummelo for Testicular Germ Cell Tumors with Ifosfamide treatment

So some of the example questions one may have related to Pummelo can be: Is Pummelo beneficial for me? Should I eat it when at genetic cancer risk due to mutation of gene ASXL1? Should I eat Pummelo when a mutation of a gene FLT3 is identified? Should I eat Pummelo when diagnosed with Testicular Germ Cell Tumors? Should I eat Pummelo when diagnosed with Relapsed Refractory Multiple Myeloma? Should I eat Pummelo when on Ifosfamide treatment? Should I continue eating Pummelo if my treatment changes from Ifosfamide to Lenalidomide? Are the implications of taking Pummelo in Relapsed Refractory Multiple Myeloma the same as Testicular Germ Cell Tumors? And so on.

Pummelo and cancer

Pummelo, (Citrus maxima), also spelled pomelo, also called shaddock, is a citrus tree of the family Rutaceae, grown for its large sweet fruits.

Pummelo contains many active ingredients like Naringenin, Naringin, Chlorogenic Acid, Beta-sitosterol, Citric Acid and many other Bioactives at different concentrations. The molecular pathways which are regulated by Pummelo include DNA Repair (Base Excision Repair), Oxidative Stress, Vitamin D Signaling, P53 Signaling, Oncogenic Cancer Epigenetics (CpG Methylation) and many others. These cellular pathways directly or indirectly influence cancer molecular endpoints like growth, spread and death. Because of this biological relationship – for cancer, choosing foods like Pummelo and supplements is an important decision to be made. And not necessarily the same food choices are scientifically best for all individuals.

Include Pummelo in my nutrition?

The answer to the question “Which Foods to Eat” and “Which Foods to Reduce Intake of” is dependent on multiple factors. Just like the same treatment does not work for every cancer patient, based on individual context the Pummelo may have scientific benefits or have adverse interactions. Along with which cancer – the ongoing treatments, supplements, lifestyle habits, height, weight, allergies and food preferences are all factors influencing answers to the question.

1. Any benefits of Pummelo for Testicular Germ Cell Tumors with Ifosfamide treatment?

Testicular Germ Cell Tumors is known to have mutations in gene like KIT, KRAS and PTMA and others which together cause biochemical pathway changes in DNA Repair (Base Excision Repair), Oxidative Stress, DNA Repair (Homology Directed Repair), Cell Cycle (Proliferation) and DNA Repair (Global Genome Nucleotide Excision Repair). A cancer treatment like Ifosfamide has molecular action on a unique set of biochemical pathways . The treatment intent is to have a good overlap with the cancer driving pathways and reduce the disease drivers. In such conditions foods which can scientifically cancel out the treatment effect by reducing the overlap between the cancer driving pathways and treatment are candidates for reducing intake of or completely avoid. For example – in the case of Testicular Germ Cell Tumors and treatment Ifosfamide – Pummelo is not recommended. Pummelo impacts pathways or processes like DNA Repair (Base Excision Repair) and Oxidative Stress which can negate the effects of the treatment.

2. Any benefits of Pummelo for Relapsed Refractory Multiple Myeloma with Lenalidomide treatment?

Relapsed Refractory Multiple Myeloma is defined and driven by specific genetic mutations like MCL1, CCND1 and MYC leading to biochemical pathway changes in Vitamin D Signaling, P53 Signaling, Amino Acid Metabolism (Glutamine Metabolism), Hypoxia (HIF1 Signaling) and MYC Signaling. Also treatments like Lenalidomide have molecular action on a unique set of biochemical pathways. Pummelo should be considered for Relapsed Refractory Multiple Myeloma while on Lenalidomide treatment. Pummelo impacts pathways or processes like Vitamin D Signaling and P53 Signaling which can either reduce drivers of Relapsed Refractory Multiple Myeloma and/or improve Lenalidomide treatment effect.

For Which Cancer Is Pummelo Beneficial For?

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Any benefits of Pummelo for gene ASXL1 associated cancer genetic risk?

Many companies offer gene panel tests for evaluating genetic risk to different cancers. These panels cover genes like ASXL1 and many others associated with high prevalence cancers of breast, ovary, uterus, prostate and gastrointestinal system and others. The intent of the genetic testing of ASXL1 is for diagnosis and/or to find out any potential risk factors for cancer. ASXL1 mutation causes biochemical pathways or processes like Oncogenic Cancer Epigenetics (CpG Methylation) and Suppressive Histone Methylation (Histone 3 Lysine 27 Methylation) to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like Oncogenic Cancer Epigenetics (CpG Methylation) and Suppressive Histone Methylation (Histone 3 Lysine 27 Methylation). Intake of foods like Pummelo should be reduced when there is a mutation of ASXL1 for risk of Chronic myelomonocytic leukemia and Myelodysplastic Syndrome. Pummelo impacts pathways or processes like Oncogenic Cancer Epigenetics (CpG Methylation) and creates adverse effects with ASXL1 mutation.

4. Any benefits of Pummelo for gene FLT3 associated cancer genetic risk?

FLT3 is also one of many genes available in panels for cancer risk testing. FLT3 mutation causes biochemical pathways or processes like PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), MAPK Signaling, RAS-RAF Signaling (RAS Signaling) and JAK-STAT Signaling to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), MAPK Signaling, RAS-RAF Signaling (RAS Signaling) and JAK-STAT Signaling. Intake of foods like Pummelo should be considered when Acute Myeloid Leukemia risk is identified due to gene FLT3 mutation. Pummelo impacts biochemical pathways or processes like PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling) and MAPK Signaling associated with genetic risk to FLT3 mutation.

* Other Factors Included Like BMI, Lifestyle Habits, Treatments

In Conclusion

Personalized nutrition planning for cancer can inform if foods like Pummelo are recommended or not. Nutrition is the single most effective tool which cancer patients can control and nutrition decisions are dependent on questions like “Is Pummelo beneficial for me?”

The addon personalized nutrition planning for cancer is a software approach based on molecular science. The addon approach supports cancers like Testicular Germ Cell Tumors, Relapsed Refractory Multiple Myeloma and others along with commonly reported genomic group clusters.

To get your personalized nutrition plan – enter details like cancer indication (example Testicular Germ Cell Tumors, name of current cancer and non-cancer treatments; habits and lifestyle conditions.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


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