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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

For which cancer is Agave beneficial for?

Apr 12, 2022

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Highlights

Nutrition is the single most effective tool which cancer patients can control for managing cancers like NTRK+ Cholangiocarcinoma or Bladder Urothelial Carcinoma – hence it is important to identify those Foods and Supplements which are scientifically recommended for you. A frequently asked question is if foods like Agave are beneficial for cancer and along with which treatments? There is a mis-conception that all plant-based foods are good for all cancers and all of them are equal in terms of their benefits or their lack of. The reality is that some plant-based foods will be better than others for a specific type of cancer, treatments and other conditions. So Agave benefits will vary and the answer is contextual.

For example, grapefruit with certain medications is not recommended. Also spinach with some blood thinning medications can cause adverse interactions and hence intake should be reduced. For cancer, nutrition which includes food and supplements are important decisions which need to be made.

So are there types of cancer where Agave has more benefits? Yes! Agave is beneficial for Bladder Urothelial Carcinoma patients taking Cisplatin treatment. But has adverse interactions for NTRK+ Cholangiocarcinoma patients on Entrectinib treatment.

For Bladder Urothelial Carcinoma along with Cisplatin – biochemical pathways like Cell Cycle Checkpoints (G1S Checkpoint), Apoptosis (Intrinsic Apoptosis), DNA Repair (Homology Directed Repair), DNA Repair (Global Genome Nucleotide Excision Repair) and WNT Betacatenin Signaling are potential drivers of the disease. Agave has active ingredients which can manipulate these biochemical pathways to reduce the disease drivers and hence are scientifically beneficial. But for NTRK+ Cholangiocarcinoma along with Entrectinib – biochemical pathways like MAPK Signaling (ERK Signaling), MAPK Signaling, Growth Factor Signaling (EGFR Signaling), MYC Signaling and PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling) are potential drivers of the disease. Agave has active ingredients which can increase disease drivers like MAPK Signaling (ERK Signaling), MAPK Signaling, Growth Factor Signaling (EGFR Signaling), MYC Signaling and PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling) and hence intake should be reduced.

Similarly, eating Agave can have scientific benefits for healthy individuals who have a gene mutation in CDH1 which suggests potential risk of cancer. This is because of biochemical pathways Adherens junction, WNT Betacatenin Signaling, Adherens junction (CDH1 Signaling), Stem Cell Signaling and Estrogen Signaling. But reduce intake of Agave when at genetic risk of cancer due to mutation of gene NOTCH1 due to its manipulation of biochemical pathways Notch Signaling (NOTCH1 Signaling) causing cancer drivers to increase.

The takeaway being – for NTRK+ Cholangiocarcinoma, Bladder Urothelial Carcinoma and other cancers individual conditions can influence if foods like Agave are recommended or not. As conditions like ongoing treatments, supplements, habits and other conditions change; the nutrition plan must be re-designed and personalized. Whether NTRK+ Cholangiocarcinoma or Bladder Urothelial Carcinoma or other cancer types -, current treatments and supplements, age, gender, weight, height, lifestyle and genetic conditions are also key decision factors for creating a personalized nutrition plan.



Why is the choice of foods important for cancer?

Foods like Agave typically contain more than one active ingredient at varying concentrations. Each of these active ingredients like Beta-carotene has a unique molecular biological mechanism of action. Cancer like most diseases is driven by specific biochemical pathways and molecular interventions of the pathway can be beneficial or create adverse interactions. Hence for NTRK+ Cholangiocarcinoma, Bladder Urothelial Carcinoma and other cancers there is a need to personalize which foods and supplements to take and regularly evaluate if foods like Agave are recommended or not.

Agave for Bladder Urothelial Carcinoma taking Cisplatin Agave for NTRK+ Cholangiocarcinoma with Entrectinib treatment

So some of the example questions one may have related to Agave can be: Is Agave beneficial for me? Should I eat it when at genetic cancer risk due to mutation of gene NOTCH1? Should I eat Agave when a mutation of a gene CDH1 is identified? Should I eat Agave when diagnosed with NTRK+ Cholangiocarcinoma? Should I eat Agave when diagnosed with Bladder Urothelial Carcinoma? Should I eat Agave when on Entrectinib treatment? Should I continue eating Agave if my treatment changes from Entrectinib to Cisplatin? Are the implications of taking Agave in Bladder Urothelial Carcinoma the same as NTRK+ Cholangiocarcinoma? And so on.

Agave and cancer

The agave is a succulent plant native to the Southern United States and Latin America. Agave nectar is generally used as an alternative to sugar. Following are some of the potential health benefits of Agave: 

Agave contains many active ingredients like Beta-carotene, Vitamin A and many other Bioactives at different concentrations. The molecular pathways which are regulated by Agave include MAPK Signaling (ERK Signaling), Cell Cycle Checkpoints (G1S Checkpoint), Apoptosis (Intrinsic Apoptosis), Notch Signaling (NOTCH1 Signaling), Adherens junction and many others. These cellular pathways directly or indirectly influence cancer molecular endpoints like growth, spread and death. Because of this biological relationship – for cancer, choosing foods like Agave and supplements is an important decision to be made. And not necessarily the same food choices are scientifically best for all individuals.

Include Agave in my nutrition?

The answer to the question “Which Foods to Eat” and “Which Foods to Reduce Intake of” is dependent on multiple factors. Just like the same treatment does not work for every cancer patient, based on individual context the Agave may have scientific benefits or have adverse interactions. Along with which cancer – the ongoing treatments, supplements, lifestyle habits, height, weight, allergies and food preferences are all factors influencing answers to the question.

1. Any benefits of Agave for NTRK+ Cholangiocarcinoma with Entrectinib treatment?

NTRK+ Cholangiocarcinoma is known to have mutations in gene like NTRK3, TP53 and ARID1A and others which together cause biochemical pathway changes in MAPK Signaling (ERK Signaling), MAPK Signaling, Growth Factor Signaling (EGFR Signaling), MYC Signaling and PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling). A cancer treatment like Entrectinib has molecular action on a unique set of biochemical pathways . The treatment intent is to have a good overlap with the cancer driving pathways and reduce the disease drivers. In such conditions foods which can scientifically cancel out the treatment effect by reducing the overlap between the cancer driving pathways and treatment are candidates for reducing intake of or completely avoid. For example – in the case of NTRK+ Cholangiocarcinoma and treatment Entrectinib – Agave is not recommended. Agave impacts pathways or processes like MAPK Signaling (ERK Signaling) which can negate the effects of the treatment.

2. Any benefits of Agave for Bladder Urothelial Carcinoma with Cisplatin treatment?

Bladder Urothelial Carcinoma is defined and driven by specific genetic mutations like TP53, MUC16 and KMT2D leading to biochemical pathway changes in Cell Cycle Checkpoints (G1S Checkpoint), Apoptosis (Intrinsic Apoptosis), DNA Repair (Homology Directed Repair), DNA Repair (Global Genome Nucleotide Excision Repair) and WNT Betacatenin Signaling. Also treatments like Cisplatin have molecular action on a unique set of biochemical pathways. Agave should be considered for Bladder Urothelial Carcinoma while on Cisplatin treatment. Agave impacts pathways or processes like Cell Cycle Checkpoints (G1S Checkpoint) and Apoptosis (Intrinsic Apoptosis) which can either reduce drivers of Bladder Urothelial Carcinoma and/or improve Cisplatin treatment effect.

For Which Cancer Is Agave Beneficial For?

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Any benefits of Agave for gene NOTCH1 associated cancer genetic risk?

Many companies offer gene panel tests for evaluating genetic risk to different cancers. These panels cover genes like NOTCH1 and many others associated with high prevalence cancers of breast, ovary, uterus, prostate and gastrointestinal system and others. The intent of the genetic testing of NOTCH1 is for diagnosis and/or to find out any potential risk factors for cancer. NOTCH1 mutation causes biochemical pathways or processes like Notch Signaling (NOTCH1 Signaling) to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like Notch Signaling (NOTCH1 Signaling). Intake of foods like Agave should be reduced when there is a mutation of NOTCH1 for risk of Chronic Lymphocytic Leukemia. Agave impacts pathways or processes like Notch Signaling (NOTCH1 Signaling) and creates adverse effects with NOTCH1 mutation.

4. Any benefits of Agave for gene CDH1 associated cancer genetic risk?

CDH1 is also one of many genes available in panels for cancer risk testing. CDH1 mutation causes biochemical pathways or processes like Adherens junction, WNT Betacatenin Signaling, Adherens junction (CDH1 Signaling), Stem Cell Signaling and Estrogen Signaling to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like Adherens junction, WNT Betacatenin Signaling, Adherens junction (CDH1 Signaling), Stem Cell Signaling and Estrogen Signaling. Intake of foods like Agave should be considered when Gastric cancer and Breast cancer risk is identified due to gene CDH1 mutation. Agave impacts biochemical pathways or processes like Adherens junction and WNT Betacatenin Signaling associated with genetic risk to CDH1 mutation.

* Other Factors Included Like BMI, Lifestyle Habits, Treatments

In Conclusion

Personalized nutrition planning for cancer can inform if foods like Agave are recommended or not. Nutrition is the single most effective tool which cancer patients can control and nutrition decisions are dependent on questions like “Is Agave beneficial for me?”

The addon personalized nutrition planning for cancer is a software approach based on molecular science. The addon approach supports cancers like NTRK+ Cholangiocarcinoma, Bladder Urothelial Carcinoma and others along with commonly reported genomic group clusters.

To get your personalized nutrition plan – enter details like cancer indication (example NTRK+ Cholangiocarcinoma, name of current cancer and non-cancer treatments; habits and lifestyle conditions.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


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