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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

For which cancer is Safflower beneficial for?

Apr 11, 2022

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Highlights

Nutrition is the single most effective tool which cancer patients can control for managing cancers like Chronic myeloid leukaemia or Richter syndrome – hence it is important to identify those Foods and Supplements which are scientifically recommended for you. A frequently asked question is if foods like Safflower are beneficial for cancer and along with which treatments? There is a mis-conception that all plant-based foods are good for all cancers and all of them are equal in terms of their benefits or their lack of. The reality is that some plant-based foods will be better than others for a specific type of cancer, treatments and other conditions. So Safflower benefits will vary and the answer is contextual.

For example, grapefruit with certain medications is not recommended. Also spinach with some blood thinning medications can cause adverse interactions and hence intake should be reduced. For cancer, nutrition which includes food and supplements are important decisions which need to be made.

So are there types of cancer where Safflower has more benefits? Yes! Safflower is beneficial for Richter syndrome patients taking Doxorubicin treatment. But has adverse interactions for Chronic myeloid leukaemia patients on Imatinib treatment.

For Richter syndrome along with Doxorubicin – biochemical pathways like Apoptosis (Intrinsic Apoptosis), P53 Signaling, DNA Repair (Homology Directed Repair), DNA Repair (Base Excision Repair) and NFKB Signaling are potential drivers of the disease. Safflower has active ingredients which can manipulate these biochemical pathways to reduce the disease drivers and hence are scientifically beneficial. But for Chronic myeloid leukaemia along with Imatinib – biochemical pathways like Oxidative Stress, Noncoding RNA Signaling (LncRNA Signaling), MYC Signaling, TGFB Signaling (TGFBR Signaling) and Cell Cycle (Mitotic Cell Cycle) are potential drivers of the disease. Safflower has active ingredients which can increase disease drivers like Oxidative Stress, Noncoding RNA Signaling (LncRNA Signaling), MYC Signaling, TGFB Signaling (TGFBR Signaling) and Cell Cycle (Mitotic Cell Cycle) and hence intake should be reduced.

Similarly, eating Safflower can have scientific benefits for healthy individuals who have a gene mutation in FLT3 which suggests potential risk of cancer. This is because of biochemical pathways PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), RAS-RAF Signaling (RAS Signaling), MAPK Signaling and JAK-STAT Signaling. But reduce intake of Safflower when at genetic risk of cancer due to mutation of gene RB1 due to its manipulation of biochemical pathways Angiogenesis, Growth Factor Signaling (EGFR Signaling), Stem Cell Signaling and Oncogenic Cancer Epigenetics (CpG Methylation) causing cancer drivers to increase.

The takeaway being – for Chronic myeloid leukaemia, Richter syndrome and other cancers individual conditions can influence if foods like Safflower are recommended or not. As conditions like ongoing treatments, supplements, habits and other conditions change; the nutrition plan must be re-designed and personalized. Whether Chronic myeloid leukaemia or Richter syndrome or other cancer types -, current treatments and supplements, age, gender, weight, height, lifestyle and genetic conditions are also key decision factors for creating a personalized nutrition plan.



Why is the choice of foods important for cancer?

Foods like Safflower typically contain more than one active ingredient at varying concentrations. Each of these active ingredients like Stigmasterol has a unique molecular biological mechanism of action. Cancer like most diseases is driven by specific biochemical pathways and molecular interventions of the pathway can be beneficial or create adverse interactions. Hence for Chronic myeloid leukaemia, Richter syndrome and other cancers there is a need to personalize which foods and supplements to take and regularly evaluate if foods like Safflower are recommended or not.

Safflower for Richter syndrome taking Doxorubicin treatment and safflower for  Chronic myeloid leukaemia along with Imatinib treatment

So some of the example questions one may have related to Safflower can be: Is Safflower beneficial for me? Should I eat it when at genetic cancer risk due to mutation of gene RB1? Should I eat Safflower when a mutation of a gene FLT3 is identified? Should I eat Safflower when diagnosed with Chronic myeloid leukaemia? Should I eat Safflower when diagnosed with Richter syndrome? Should I eat Safflower when on Imatinib treatment? Should I continue eating Safflower if my treatment changes from Imatinib to Doxorubicin? Are the implications of taking Safflower in Richter syndrome the same as Chronic myeloid leukaemia? And so on.

Safflower and cancer

Safflower (Carthamus tinctorius L.) has long been grown as a crop due to its commercial utility as oil, animal feed, and pharmacologically significant secondary metabolites.Safflower contains numerous chemical components that possess many pharmacological activities. 

Safflower contains many active ingredients like Stigmasterol, Beta-sitosterol, Linoleic Acid, Linolenic Acid, Oleic Acid and many other Bioactives at different concentrations. The molecular pathways which are regulated by Safflower include Oxidative Stress, Apoptosis (Intrinsic Apoptosis), P53 Signaling, Angiogenesis, Growth Factor Signaling (EGFR Signaling) and many others. These cellular pathways directly or indirectly influence cancer molecular endpoints like growth, spread and death. Because of this biological relationship – for cancer, choosing foods like Safflower and supplements is an important decision to be made. And not necessarily the same food choices are scientifically best for all individuals.

Include Safflower in my nutrition?

The answer to the question “Which Foods to Eat” and “Which Foods to Reduce Intake of” is dependent on multiple factors. Just like the same treatment does not work for every cancer patient, based on individual context the Safflower may have scientific benefits or have adverse interactions. Along with which cancer – the ongoing treatments, supplements, lifestyle habits, height, weight, allergies and food preferences are all factors influencing answers to the question.

1. Any benefits of Safflower for Chronic myeloid leukaemia with Imatinib treatment?

Chronic myeloid leukaemia is known to have mutations in gene like BCR-ABL1, RUNX1 and ASXL1 and others which together cause biochemical pathway changes in Oxidative Stress, Noncoding RNA Signaling (LncRNA Signaling), MYC Signaling, TGFB Signaling (TGFBR Signaling) and Cell Cycle (Mitotic Cell Cycle). A cancer treatment like Imatinib has molecular action on a unique set of biochemical pathways . The treatment intent is to have a good overlap with the cancer driving pathways and reduce the disease drivers. In such conditions foods which can scientifically cancel out the treatment effect by reducing the overlap between the cancer driving pathways and treatment are candidates for reducing intake of or completely avoid. For example – in the case of Chronic myeloid leukaemia and treatment Imatinib – Safflower is not recommended. Safflower impacts pathways or processes like Oxidative Stress which can negate the effects of the treatment.

2. Any benefits of Safflower for Richter syndrome with Doxorubicin treatment?

Richter syndrome is defined and driven by specific genetic mutations like MYC, TRAF3 and TP53 leading to biochemical pathway changes in Apoptosis (Intrinsic Apoptosis), P53 Signaling, DNA Repair (Homology Directed Repair), DNA Repair (Base Excision Repair) and NFKB Signaling. Also treatments like Doxorubicin have molecular action on a unique set of biochemical pathways. Safflower should be considered for Richter syndrome while on Doxorubicin treatment. Safflower impacts pathways or processes like Apoptosis (Intrinsic Apoptosis) and P53 Signaling which can either reduce drivers of Richter syndrome and/or improve Doxorubicin treatment effect.

For Which Cancer Is Safflower Beneficial For?

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Any benefits of Safflower for gene RB1 associated cancer genetic risk?

Many companies offer gene panel tests for evaluating genetic risk to different cancers. These panels cover genes like RB1 and many others associated with high prevalence cancers of breast, ovary, uterus, prostate and gastrointestinal system and others. The intent of the genetic testing of RB1 is for diagnosis and/or to find out any potential risk factors for cancer. RB1 mutation causes biochemical pathways or processes like Angiogenesis, Growth Factor Signaling (EGFR Signaling), Stem Cell Signaling and Oncogenic Cancer Epigenetics (CpG Methylation) to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like Angiogenesis, Growth Factor Signaling (EGFR Signaling), Stem Cell Signaling and Oncogenic Cancer Epigenetics (CpG Methylation). Intake of foods like Safflower should be reduced when there is a mutation of RB1 for risk of Brain cancer. Safflower impacts pathways or processes like Angiogenesis and Growth Factor Signaling (EGFR Signaling) and creates adverse effects with RB1 mutation.

4. Any benefits of Safflower for gene FLT3 associated cancer genetic risk?

FLT3 is also one of many genes available in panels for cancer risk testing. FLT3 mutation causes biochemical pathways or processes like PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), RAS-RAF Signaling (RAS Signaling), MAPK Signaling and JAK-STAT Signaling to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), RAS-RAF Signaling (RAS Signaling), MAPK Signaling and JAK-STAT Signaling. Intake of foods like Safflower should be considered when Acute Myeloid Leukemia risk is identified due to gene FLT3 mutation. Safflower impacts biochemical pathways or processes like PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling) associated with genetic risk to FLT3 mutation.

* Other Factors Included Like BMI, Lifestyle Habits, Treatments

In Conclusion

Personalized nutrition planning for cancer can inform if foods like Safflower are recommended or not. Nutrition is the single most effective tool which cancer patients can control and nutrition decisions are dependent on questions like “Is Safflower beneficial for me?”

The addon personalized nutrition planning for cancer is a software approach based on molecular science. The addon approach supports cancers like Chronic myeloid leukaemia, Richter syndrome and others along with commonly reported genomic group clusters.

To get your personalized nutrition plan – enter details like cancer indication (example Chronic myeloid leukaemia, name of current cancer and non-cancer treatments; habits and lifestyle conditions.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


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