Nutrition is the single most effective tool which cancer patients can control for managing cancers like Testicular Germ Cell Tumors or Poems Syndrome – hence it is important to identify those Foods and Supplements which are scientifically recommended for you. A frequently asked question is if foods like Canola are beneficial for cancer and along with which treatments? There is a mis-conception that all plant-based foods are good for all cancers and all of them are equal in terms of their benefits or their lack of. The reality is that some plant-based foods will be better than others for a specific type of cancer, treatments and other conditions. So Canola benefits will vary and the answer is contextual.
For example, grapefruit with certain medications is not recommended. Also spinach with some blood thinning medications can cause adverse interactions and hence intake should be reduced. For cancer, nutrition which includes food and supplements are important decisions which need to be made.
So are there types of cancer where Canola has more benefits? Yes! Canola is beneficial for Poems Syndrome patients taking Thalidomide treatment. But has adverse interactions for Testicular Germ Cell Tumors patients on Ifosfamide treatment.
For Poems Syndrome along with Thalidomide – biochemical pathways like P53 Signaling, Cell Cycle (Mitotic Cell Cycle), NFKB Signaling, Hypoxia (HIF1 Signaling) and Notch Signaling (NOTCH1 Signaling) are potential drivers of the disease. Canola has active ingredients which can manipulate these biochemical pathways to reduce the disease drivers and hence are scientifically beneficial. But for Testicular Germ Cell Tumors along with Ifosfamide – biochemical pathways like Oxidative Stress, DNA Repair (Homology Directed Repair), DNA Repair (Base Excision Repair), Cell Cycle (Proliferation) and DNA Repair (Global Genome Nucleotide Excision Repair) are potential drivers of the disease. Canola has active ingredients which can increase disease drivers like Oxidative Stress, DNA Repair (Homology Directed Repair), DNA Repair (Base Excision Repair), Cell Cycle (Proliferation) and DNA Repair (Global Genome Nucleotide Excision Repair) and hence intake should be reduced.
Similarly, eating Canola can have scientific benefits for healthy individuals who have a gene mutation in FLT3 which suggests potential risk of cancer. This is because of biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), RAS-RAF Signaling (RAS Signaling) and JAK-STAT Signaling. But reduce intake of Canola when at genetic risk of cancer due to mutation of gene CREBBP due to its manipulation of biochemical pathways Histone/Protein Acetylation causing cancer drivers to increase.
The takeaway being – for Testicular Germ Cell Tumors, Poems Syndrome and other cancers individual conditions can influence if foods like Canola are recommended or not. As conditions like ongoing treatments, supplements, habits and other conditions change; the nutrition plan must be re-designed and personalized. Whether Testicular Germ Cell Tumors or Poems Syndrome or other cancer types -, current treatments and supplements, age, gender, weight, height, lifestyle and genetic conditions are also key decision factors for creating a personalized nutrition plan.
Why is the choice of foods important for cancer?
Foods like Canola typically contain more than one active ingredient at varying concentrations. Each of these active ingredients like Linolenic Acid has a unique molecular biological mechanism of action. Cancer like most diseases is driven by specific biochemical pathways and molecular interventions of the pathway can be beneficial or create adverse interactions. Hence for Testicular Germ Cell Tumors, Poems Syndrome and other cancers there is a need to personalize which foods and supplements to take and regularly evaluate if foods like Canola are recommended or not.
So some of the example questions one may have related to Canola can be: Is Canola beneficial for me? Should I eat it when at genetic cancer risk due to mutation of gene CREBBP? Should I eat Canola when a mutation of a gene FLT3 is identified? Should I eat Canola when diagnosed with Testicular Germ Cell Tumors? Should I eat Canola when diagnosed with Poems Syndrome? Should I eat Canola when on Ifosfamide treatment? Should I continue eating Canola if my treatment changes from Ifosfamide to Thalidomide? Are the implications of taking Canola in Poems Syndrome the same as Testicular Germ Cell Tumors? And so on.
Canola and cancer
Canola is a crop from which seeds are harvested and crushed to produce canola oil. Following are some of the potential health benefits of canola oil:
- May help reduce cholesterol (A Chisholm et al, Nutr Metab Cardiovasc Dis., 2005)
- May improve insulin sensitivity (Lin Lin et al, Nutr Rev., 2013)
- May help reduce cardiovascular risk (Mojgan Amiri et al, Nutr Metab Cardiovasc Dis., 2020)
Canola contains many active ingredients like Linolenic Acid, Beta-sitosterol, Oleic Acid, Isorhamnetin, Kaempferol and many other Bioactives at different concentrations. The molecular pathways which are regulated by Canola include Oxidative Stress, P53 Signaling, Cell Cycle (Mitotic Cell Cycle), Histone/Protein Acetylation, MAPK Signaling and many others. These cellular pathways directly or indirectly influence cancer molecular endpoints like growth, spread and death. Because of this biological relationship – for cancer, choosing foods like Canola and supplements is an important decision to be made. And not necessarily the same food choices are scientifically best for all individuals.
Include Canola in my nutrition?
The answer to the question “Which Foods to Eat” and “Which Foods to Reduce Intake of” is dependent on multiple factors. Just like the same treatment does not work for every cancer patient, based on individual context the Canola may have scientific benefits or have adverse interactions. Along with which cancer – the ongoing treatments, supplements, lifestyle habits, height, weight, allergies and food preferences are all factors influencing answers to the question.
1. Any benefits of Canola for Testicular Germ Cell Tumors with Ifosfamide treatment?
Testicular Germ Cell Tumors is known to have mutations in gene like KIT, KRAS and PTMA and others which together cause biochemical pathway changes in Oxidative Stress, DNA Repair (Homology Directed Repair), DNA Repair (Base Excision Repair), Cell Cycle (Proliferation) and DNA Repair (Global Genome Nucleotide Excision Repair). A cancer treatment like Ifosfamide has molecular action on a unique set of biochemical pathways . The treatment intent is to have a good overlap with the cancer driving pathways and reduce the disease drivers. In such conditions foods which can scientifically cancel out the treatment effect by reducing the overlap between the cancer driving pathways and treatment are candidates for reducing intake of or completely avoid. For example – in the case of Testicular Germ Cell Tumors and treatment Ifosfamide – Canola is not recommended. Canola impacts pathways or processes like Oxidative Stress which can negate the effects of the treatment.
2. Any benefits of Canola for Poems Syndrome with Thalidomide treatment?
Poems Syndrome is defined and driven by specific genetic mutations like LATS2, ZMYM2 and CDK8 leading to biochemical pathway changes in P53 Signaling, Cell Cycle (Mitotic Cell Cycle), NFKB Signaling, Hypoxia (HIF1 Signaling) and Notch Signaling (NOTCH1 Signaling). Also treatments like Thalidomide have molecular action on a unique set of biochemical pathways. Canola should be considered for Poems Syndrome while on Thalidomide treatment. Canola impacts pathways or processes like P53 Signaling and Cell Cycle (Mitotic Cell Cycle) which can either reduce drivers of Poems Syndrome and/or improve Thalidomide treatment effect.
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3. Any benefits of Canola for gene CREBBP associated cancer genetic risk?
Many companies offer gene panel tests for evaluating genetic risk to different cancers. These panels cover genes like CREBBP and many others associated with high prevalence cancers of breast, ovary, uterus, prostate and gastrointestinal system and others. The intent of the genetic testing of CREBBP is for diagnosis and/or to find out any potential risk factors for cancer. CREBBP mutation causes biochemical pathways or processes like Histone/Protein Acetylation to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like Histone/Protein Acetylation. Intake of foods like Canola should be reduced when there is a mutation of CREBBP for risk of Follicular Lymphoma and Non-Hodgkin Lymphoma. Canola impacts pathways or processes like Histone/Protein Acetylation and creates adverse effects with CREBBP mutation.
4. Any benefits of Canola for gene FLT3 associated cancer genetic risk?
FLT3 is also one of many genes available in panels for cancer risk testing. FLT3 mutation causes biochemical pathways or processes like MAPK Signaling, PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), RAS-RAF Signaling (RAS Signaling) and JAK-STAT Signaling to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), RAS-RAF Signaling (RAS Signaling) and JAK-STAT Signaling. Intake of foods like Canola should be considered when Acute Myeloid Leukemia risk is identified due to gene FLT3 mutation. Canola impacts biochemical pathways or processes like MAPK Signaling and PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling) associated with genetic risk to FLT3 mutation.
* Other Factors Included Like BMI, Lifestyle Habits, Treatments
Personalized nutrition planning for cancer can inform if foods like Canola are recommended or not. Nutrition is the single most effective tool which cancer patients can control and nutrition decisions are dependent on questions like “Is Canola beneficial for me?”
The addon personalized nutrition planning for cancer is a software approach based on molecular science. The addon approach supports cancers like Testicular Germ Cell Tumors, Poems Syndrome and others along with commonly reported genomic group clusters.
To get your personalized nutrition plan – enter details like cancer indication (example Testicular Germ Cell Tumors, name of current cancer and non-cancer treatments; habits and lifestyle conditions.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.