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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

For which cancer is Milk Thistle beneficial for?

Apr 2, 2022

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Highlights

Nutrition is the single most effective tool which cancer patients can control for managing cancers like Myeloproliferative Neoplasms or Mycosis fungoides – hence it is important to identify those Foods and Supplements which are scientifically recommended for you. A frequently asked question is if foods like Milk Thistle are beneficial for cancer and along with which treatments? There is a mis-conception that all plant-based foods are good for all cancers and all of them are equal in terms of their benefits or their lack of. The reality is that some plant-based foods will be better than others for a specific type of cancer, treatments and other conditions. So Milk Thistle benefits will vary and the answer is contextual.

For example, grapefruit with certain medications is not recommended. Also spinach with some blood thinning medications can cause adverse interactions and hence intake should be reduced. For cancer, nutrition which includes food and supplements are important decisions which need to be made.

So are there types of cancer where Milk Thistle has more benefits? Yes! Milk Thistle is beneficial for Mycosis fungoides patients taking Romidepsin treatment. But has adverse interactions for Myeloproliferative Neoplasms patients on Decitabine treatment.

For Mycosis fungoides along with Romidepsin – biochemical pathways like Cell Cycle Checkpoints (G1S Checkpoint), Cell Cycle (Mitotic Cell Cycle), DNA Repair (Homology Directed Repair), DNA Repair (Base Excision Repair) and Cell Cycle (Proliferation) are potential drivers of the disease. Milk Thistle has active ingredients which can manipulate these biochemical pathways to reduce the disease drivers and hence are scientifically beneficial. But for Myeloproliferative Neoplasms along with Decitabine – biochemical pathways like Angiogenesis, Epithelial to Mesenchymal Transition, Hypoxia (HIF1 Signaling), Apoptosis (Intrinsic Apoptosis) and Oncogenic Histone Methylation (Histone 3 Lysine 36 Methylation) are potential drivers of the disease. Milk Thistle has active ingredients which can increase disease drivers like Angiogenesis, Epithelial to Mesenchymal Transition, Hypoxia (HIF1 Signaling), Apoptosis (Intrinsic Apoptosis) and Oncogenic Histone Methylation (Histone 3 Lysine 36 Methylation) and hence intake should be reduced.

Similarly, eating Milk Thistle can have scientific benefits for healthy individuals who have a gene mutation in CDKN2A which suggests potential risk of cancer. This is because of biochemical pathways P53 Signaling, Cell Cycle (Mitotic Cell Cycle), Cell Cycle (Proliferation), DNA Repair (Global Genome Nucleotide Excision Repair) and Stem Cell Signaling. But reduce intake of Milk Thistle when at genetic risk of cancer due to mutation of gene CREBBP due to its manipulation of biochemical pathways Histone/Protein Acetylation causing cancer drivers to increase.

The takeaway being – for Myeloproliferative Neoplasms, Mycosis fungoides and other cancers individual conditions can influence if foods like Milk Thistle are recommended or not. As conditions like ongoing treatments, supplements, habits and other conditions change; the nutrition plan must be re-designed and personalized. Whether Myeloproliferative Neoplasms or Mycosis fungoides or other cancer types -, current treatments and supplements, age, gender, weight, height, lifestyle and genetic conditions are also key decision factors for creating a personalized nutrition plan.



Why is the choice of foods important for cancer?

Foods like Milk Thistle typically contain more than one active ingredient at varying concentrations. Each of these active ingredients like Linoleic Acid has a unique molecular biological mechanism of action. Cancer like most diseases is driven by specific biochemical pathways and molecular interventions of the pathway can be beneficial or create adverse interactions. Hence for Myeloproliferative Neoplasms, Mycosis fungoides and other cancers there is a need to personalize which foods and supplements to take and regularly evaluate if foods like Milk Thistle are recommended or not.

Milk Thistle for Mycosis fungoides taking Romidepsin treatment and milk thistle for  Myeloproliferative Neoplasms along with Decitabine treatment

So some of the example questions one may have related to Milk Thistle can be: Is Milk Thistle beneficial for me? Should I eat it when at genetic cancer risk due to mutation of gene CREBBP? Should I eat Milk Thistle when a mutation of a gene CDKN2A is identified? Should I eat Milk Thistle when diagnosed with Myeloproliferative Neoplasms? Should I eat Milk Thistle when diagnosed with Mycosis fungoides? Should I eat Milk Thistle when on Decitabine treatment? Should I continue eating Milk Thistle if my treatment changes from Decitabine to Romidepsin? Are the implications of taking Milk Thistle in Mycosis fungoides the same as Myeloproliferative Neoplasms? And so on.

Milk Thistle and cancer

Milk thistle is a widely-consumed botanical used for an array of purported health benefits. The primary extract of milk thistle is termed silymarin, a complex mixture that contains a number of structurally-related flavonolignans, the flavonoid, taxifolin, and a number of other constituents.

Milk Thistle contains many active ingredients like Linoleic Acid, Silibinin, Oleic Acid, Vitamin E and many other Bioactives at different concentrations. The molecular pathways which are regulated by Milk Thistle include Angiogenesis, Epithelial to Mesenchymal Transition, Cell Cycle Checkpoints (G1S Checkpoint), Cell Cycle (Mitotic Cell Cycle), Histone/Protein Acetylation and many others. These cellular pathways directly or indirectly influence cancer molecular endpoints like growth, spread and death. Because of this biological relationship – for cancer, choosing foods like Milk Thistle and supplements is an important decision to be made. And not necessarily the same food choices are scientifically best for all individuals.

Include Milk Thistle in my nutrition?

The answer to the question “Which Foods to Eat” and “Which Foods to Reduce Intake of” is dependent on multiple factors. Just like the same treatment does not work for every cancer patient, based on individual context the Milk Thistle may have scientific benefits or have adverse interactions. Along with which cancer – the ongoing treatments, supplements, lifestyle habits, height, weight, allergies and food preferences are all factors influencing answers to the question.

1. Any benefits of Milk Thistle for Myeloproliferative Neoplasms with Decitabine treatment?

Myeloproliferative Neoplasms is known to have mutations in gene like JAK2, CALR and TET2 and others which together cause biochemical pathway changes in Angiogenesis, Epithelial to Mesenchymal Transition, Hypoxia (HIF1 Signaling), Apoptosis (Intrinsic Apoptosis) and Oncogenic Histone Methylation (Histone 3 Lysine 36 Methylation). A cancer treatment like Decitabine has molecular action on a unique set of biochemical pathways . The treatment intent is to have a good overlap with the cancer driving pathways and reduce the disease drivers. In such conditions foods which can scientifically cancel out the treatment effect by reducing the overlap between the cancer driving pathways and treatment are candidates for reducing intake of or completely avoid. For example – in the case of Myeloproliferative Neoplasms and treatment Decitabine – Milk Thistle is not recommended. Milk Thistle impacts pathways or processes like Angiogenesis and Epithelial to Mesenchymal Transition which can negate the effects of the treatment.

2. Any benefits of Milk Thistle for Mycosis fungoides with Romidepsin treatment?

Mycosis fungoides is defined and driven by specific genetic mutations like FAT1, MGAM and KMT2D leading to biochemical pathway changes in Cell Cycle Checkpoints (G1S Checkpoint), Cell Cycle (Mitotic Cell Cycle), DNA Repair (Homology Directed Repair), DNA Repair (Base Excision Repair) and Cell Cycle (Proliferation). Also treatments like Romidepsin have molecular action on a unique set of biochemical pathways. Milk Thistle should be considered for Mycosis fungoides while on Romidepsin treatment. Milk Thistle impacts pathways or processes like Cell Cycle Checkpoints (G1S Checkpoint) and Cell Cycle (Mitotic Cell Cycle) which can either reduce drivers of Mycosis fungoides and/or improve Romidepsin treatment effect.

For Which Cancer Is Milk Thistle Beneficial For?

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Any benefits of Milk Thistle for gene CREBBP associated cancer genetic risk?

Many companies offer gene panel tests for evaluating genetic risk to different cancers. These panels cover genes like CREBBP and many others associated with high prevalence cancers of breast, ovary, uterus, prostate and gastrointestinal system and others. The intent of the genetic testing of CREBBP is for diagnosis and/or to find out any potential risk factors for cancer. CREBBP mutation causes biochemical pathways or processes like Histone/Protein Acetylation to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like Histone/Protein Acetylation. Intake of foods like Milk Thistle should be reduced when there is a mutation of CREBBP for risk of Follicular Lymphoma and Non-Hodgkin Lymphoma. Milk Thistle impacts pathways or processes like Histone/Protein Acetylation and creates adverse effects with CREBBP mutation.

4. Any benefits of Milk Thistle for gene CDKN2A associated cancer genetic risk?

CDKN2A is also one of many genes available in panels for cancer risk testing. CDKN2A mutation causes biochemical pathways or processes like P53 Signaling, Cell Cycle (Mitotic Cell Cycle), Cell Cycle (Proliferation), DNA Repair (Global Genome Nucleotide Excision Repair) and Stem Cell Signaling to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like P53 Signaling, Cell Cycle (Mitotic Cell Cycle), Cell Cycle (Proliferation), DNA Repair (Global Genome Nucleotide Excision Repair) and Stem Cell Signaling. Intake of foods like Milk Thistle should be considered when Skin cancer and Head and Neck Squamous Cell Carcinoma risk is identified due to gene CDKN2A mutation. Milk Thistle impacts biochemical pathways or processes like P53 Signaling and Cell Cycle (Mitotic Cell Cycle) associated with genetic risk to CDKN2A mutation.

* Other Factors Included Like BMI, Lifestyle Habits, Treatments

In Conclusion

Personalized nutrition planning for cancer can inform if foods like Milk Thistle are recommended or not. Nutrition is the single most effective tool which cancer patients can control and nutrition decisions are dependent on questions like “Is Milk Thistle beneficial for me?”

The addon personalized nutrition planning for cancer is a software approach based on molecular science. The addon approach supports cancers like Myeloproliferative Neoplasms, Mycosis fungoides and others along with commonly reported genomic group clusters.

To get your personalized nutrition plan – enter details like cancer indication (example Myeloproliferative Neoplasms, name of current cancer and non-cancer treatments; habits and lifestyle conditions.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

sample-report

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


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