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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

For which cancer is Ajwain beneficial for?

Mar 31, 2022

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Highlights

Nutrition is the single most effective tool which cancer patients can control for managing cancers like Chronic myeloid leukaemia or Monoclonal gammopathy of undetermined significance – hence it is important to identify those Foods and Supplements which are scientifically recommended for you. A frequently asked question is if foods like Ajwain are beneficial for cancer and along with which treatments? There is a mis-conception that all plant-based foods are good for all cancers and all of them are equal in terms of their benefits or their lack of. The reality is that some plant-based foods will be better than others for a specific type of cancer, treatments and other conditions. So Ajwain benefits will vary and the answer is contextual.

For example, grapefruit with certain medications is not recommended. Also spinach with some blood thinning medications can cause adverse interactions and hence intake should be reduced. For cancer, nutrition which includes food and supplements are important decisions which need to be made.

So are there types of cancer where Ajwain has more benefits? Yes! Ajwain is beneficial for Monoclonal gammopathy of undetermined significance patients taking Lenalidomide treatment. But has adverse interactions for Chronic myeloid leukaemia patients on Imatinib treatment.

For Monoclonal gammopathy of undetermined significance along with Lenalidomide – biochemical pathways like PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), NFKB Signaling, Hypoxia (HIF1 Signaling), P53 Signaling and WNT Betacatenin Signaling are potential drivers of the disease. Ajwain has active ingredients which can manipulate these biochemical pathways to reduce the disease drivers and hence are scientifically beneficial. But for Chronic myeloid leukaemia along with Imatinib – biochemical pathways like Oxidative Stress, Noncoding RNA Signaling (LncRNA Signaling), MYC Signaling, TGFB Signaling (TGFBR Signaling) and Cell Cycle (Mitotic Cell Cycle) are potential drivers of the disease. Ajwain has active ingredients which can increase disease drivers like Oxidative Stress, Noncoding RNA Signaling (LncRNA Signaling), MYC Signaling, TGFB Signaling (TGFBR Signaling) and Cell Cycle (Mitotic Cell Cycle) and hence intake should be reduced.

Similarly, eating Ajwain can have scientific benefits for healthy individuals who have a gene mutation in CDKN2A which suggests potential risk of cancer. This is because of biochemical pathways P53 Signaling, MAPK Signaling, Cell Cycle (Proliferation), DNA Repair (Global Genome Nucleotide Excision Repair) and Stem Cell Signaling. But reduce intake of Ajwain when at genetic risk of cancer due to mutation of gene POLH due to its manipulation of biochemical pathways DNA Repair (Translesion Synthesis), Angiogenesis, MAPK Signaling, DNA Repair (Global Genome Nucleotide Excision Repair) and Stem Cell Signaling causing cancer drivers to increase.

The takeaway being – for Chronic myeloid leukaemia, Monoclonal gammopathy of undetermined significance and other cancers individual conditions can influence if foods like Ajwain are recommended or not. As conditions like ongoing treatments, supplements, habits and other conditions change; the nutrition plan must be re-designed and personalized. Whether Chronic myeloid leukaemia or Monoclonal gammopathy of undetermined significance or other cancer types -, current treatments and supplements, age, gender, weight, height, lifestyle and genetic conditions are also key decision factors for creating a personalized nutrition plan.



Why is the choice of foods important for cancer?

Foods like Ajwain typically contain more than one active ingredient at varying concentrations. Each of these active ingredients like Stigmasterol has a unique molecular biological mechanism of action. Cancer like most diseases is driven by specific biochemical pathways and molecular interventions of the pathway can be beneficial or create adverse interactions. Hence for Chronic myeloid leukaemia, Monoclonal gammopathy of undetermined significance and other cancers there is a need to personalize which foods and supplements to take and regularly evaluate if foods like Ajwain are recommended or not.

Ajwain for Monoclonal gammopathy of undetermined significance taking Lenalidomide treatment and ajwain for Chronic myeloid leukaemia along with Imatinib treatment

So some of the example questions one may have related to Ajwain can be: Is Ajwain beneficial for me? Should I eat it when at genetic cancer risk due to mutation of gene POLH? Should I eat Ajwain when a mutation of a gene CDKN2A is identified? Should I eat Ajwain when diagnosed with Chronic myeloid leukaemia? Should I eat Ajwain when diagnosed with Monoclonal gammopathy of undetermined significance? Should I eat Ajwain when on Imatinib treatment? Should I continue eating Ajwain if my treatment changes from Imatinib to Lenalidomide? Are the implications of taking Ajwain in Monoclonal gammopathy of undetermined significance the same as Chronic myeloid leukaemia? And so on.

Ajwain and cancer

Ajwain, ajowan or Trachyspermum ammi also known as ajowan caraway, thymol seeds is an annual herb in the family Apiaceae. Both the leaves and the seed-like fruit (often mistakenly called seeds) of the plant are consumed by humans. There is little high-quality clinical evidence that ajwain has anti-disease properties in humans. Ajwain is used in traditional medicine practices, such as Ayurveda, in herbal blends in the belief it can treat various disorders. There is no evidence or regulatory approval that oral use of ajwain in herbal blends is effective or safe.

Ajwain contains many active ingredients like Stigmasterol, Chlorogenic Acid, Linolenic Acid, Oleic Acid, Beta-sitosterol and many other Bioactives at different concentrations. The molecular pathways which are regulated by Ajwain include Oxidative Stress, PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), NFKB Signaling, DNA Repair (Translesion Synthesis), P53 Signaling and many others. These cellular pathways directly or indirectly influence cancer molecular endpoints like growth, spread and death. Because of this biological relationship – for cancer, choosing foods like Ajwain and supplements is an important decision to be made. And not necessarily the same food choices are scientifically best for all individuals.

Include Ajwain in my nutrition?

The answer to the question “Which Foods to Eat” and “Which Foods to Reduce Intake of” is dependent on multiple factors. Just like the same treatment does not work for every cancer patient, based on individual context the Ajwain may have scientific benefits or have adverse interactions. Along with which cancer – the ongoing treatments, supplements, lifestyle habits, height, weight, allergies and food preferences are all factors influencing answers to the question.

1. Any benefits of Ajwain for Chronic myeloid leukaemia with Imatinib treatment?

Chronic myeloid leukaemia is known to have mutations in gene like BCR-ABL1, RUNX1 and ASXL1 and others which together cause biochemical pathway changes in Oxidative Stress, Noncoding RNA Signaling (LncRNA Signaling), MYC Signaling, TGFB Signaling (TGFBR Signaling) and Cell Cycle (Mitotic Cell Cycle). A cancer treatment like Imatinib has molecular action on a unique set of biochemical pathways . The treatment intent is to have a good overlap with the cancer driving pathways and reduce the disease drivers. In such conditions foods which can scientifically cancel out the treatment effect by reducing the overlap between the cancer driving pathways and treatment are candidates for reducing intake of or completely avoid. For example – in the case of Chronic myeloid leukaemia and treatment Imatinib – Ajwain is not recommended. Ajwain impacts pathways or processes like Oxidative Stress which can negate the effects of the treatment.

2. Any benefits of Ajwain for Monoclonal gammopathy of undetermined significance with Lenalidomide treatment?

Monoclonal gammopathy of undetermined significance is defined and driven by specific genetic mutations like LATS2, ZMYM2 and CDK8 leading to biochemical pathway changes in PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), NFKB Signaling, Hypoxia (HIF1 Signaling), P53 Signaling and WNT Betacatenin Signaling. Also treatments like Lenalidomide have molecular action on a unique set of biochemical pathways. Ajwain should be considered for Monoclonal gammopathy of undetermined significance while on Lenalidomide treatment. Ajwain impacts pathways or processes like PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling) and NFKB Signaling which can either reduce drivers of Monoclonal gammopathy of undetermined significance and/or improve Lenalidomide treatment effect.

For Which Cancer Is Ajwain Beneficial For?

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Any benefits of Ajwain for gene POLH associated cancer genetic risk?

Many companies offer gene panel tests for evaluating genetic risk to different cancers. These panels cover genes like POLH and many others associated with high prevalence cancers of breast, ovary, uterus, prostate and gastrointestinal system and others. The intent of the genetic testing of POLH is for diagnosis and/or to find out any potential risk factors for cancer. POLH mutation causes biochemical pathways or processes like DNA Repair (Translesion Synthesis), Angiogenesis, MAPK Signaling, DNA Repair (Global Genome Nucleotide Excision Repair) and Stem Cell Signaling to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like DNA Repair (Translesion Synthesis), Angiogenesis, MAPK Signaling, DNA Repair (Global Genome Nucleotide Excision Repair) and Stem Cell Signaling. Intake of foods like Ajwain should be reduced when there is a mutation of POLH for risk of Skin cancer. Ajwain impacts pathways or processes like DNA Repair (Translesion Synthesis) and creates adverse effects with POLH mutation.

4. Any benefits of Ajwain for gene CDKN2A associated cancer genetic risk?

CDKN2A is also one of many genes available in panels for cancer risk testing. CDKN2A mutation causes biochemical pathways or processes like P53 Signaling, MAPK Signaling, Cell Cycle (Proliferation), DNA Repair (Global Genome Nucleotide Excision Repair) and Stem Cell Signaling to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like P53 Signaling, MAPK Signaling, Cell Cycle (Proliferation), DNA Repair (Global Genome Nucleotide Excision Repair) and Stem Cell Signaling. Intake of foods like Ajwain should be considered when Skin cancer and Head and Neck Squamous Cell Carcinoma risk is identified due to gene CDKN2A mutation. Ajwain impacts biochemical pathways or processes like P53 Signaling and MAPK Signaling associated with genetic risk to CDKN2A mutation.

* Other Factors Included Like BMI, Lifestyle Habits, Treatments

In Conclusion

Personalized nutrition planning for cancer can inform if foods like Ajwain are recommended or not. Nutrition is the single most effective tool which cancer patients can control and nutrition decisions are dependent on questions like “Is Ajwain beneficial for me?”

The addon personalized nutrition planning for cancer is a software approach based on molecular science. The addon approach supports cancers like Chronic myeloid leukaemia, Monoclonal gammopathy of undetermined significance and others along with commonly reported genomic group clusters.

To get your personalized nutrition plan – enter details like cancer indication (example Chronic myeloid leukaemia, name of current cancer and non-cancer treatments; habits and lifestyle conditions.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


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