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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

For which cancer is Squashberry beneficial for?

Mar 21, 2022

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Highlights

Nutrition is the single most effective tool which cancer patients can control for managing cancers like Pineoblastoma or Endometrial Carcinoma – hence it is important to identify those Foods and Supplements which are scientifically recommended for you. A frequently asked question is if foods like Squashberry are beneficial for cancer and along with which treatments? There is a mis-conception that all plant-based foods are good for all cancers and all of them are equal in terms of their benefits or their lack of. The reality is that some plant-based foods will be better than others for a specific type of cancer, treatments and other conditions. So Squashberry benefits will vary and the answer is contextual.

For example, grapefruit with certain medications is not recommended. Also spinach with some blood thinning medications can cause adverse interactions and hence intake should be reduced. For cancer, nutrition which includes food and supplements are important decisions which need to be made.

So are there types of cancer where Squashberry has more benefits? Yes! Squashberry is beneficial for Endometrial Carcinoma patients taking Cyclophosphamide treatment. But has adverse interactions for Pineoblastoma patients on Etoposide treatment.

For Endometrial Carcinoma along with Cyclophosphamide – biochemical pathways like Vitamin D Signaling, Oxidative Stress, DNA Repair (Homology Directed Repair), DNA Repair (Base Excision Repair) and DNA Repair (Global Genome Nucleotide Excision Repair) are potential drivers of the disease. Squashberry has active ingredients which can manipulate these biochemical pathways to reduce the disease drivers and hence are scientifically beneficial. But for Pineoblastoma along with Etoposide – biochemical pathways like PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), DNA Repair (Homology Directed Repair), Notch Signaling (NOTCH1 Signaling), DNA Repair (Non-homologous end-joining) and RUNX Signaling (RUNX3 Signaling) are potential drivers of the disease. Squashberry has active ingredients which can increase disease drivers like PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), DNA Repair (Homology Directed Repair), Notch Signaling (NOTCH1 Signaling), DNA Repair (Non-homologous end-joining) and RUNX Signaling (RUNX3 Signaling) and hence intake should be reduced.

Similarly, eating Squashberry can have scientific benefits for healthy individuals who have a gene mutation in BRCA1 which suggests potential risk of cancer. This is because of biochemical pathways Androgen Signaling, Estrogen Signaling, DNA Repair (Homology Directed Repair), Stem Cell Signaling and P53 Signaling. But reduce intake of Squashberry when at genetic risk of cancer due to mutation of gene ASXL1 due to its manipulation of biochemical pathways Oncogenic Cancer Epigenetics (CpG Methylation) and Suppressive Histone Methylation (Histone 3 Lysine 27 Methylation) causing cancer drivers to increase.

The takeaway being – for Pineoblastoma, Endometrial Carcinoma and other cancers individual conditions can influence if foods like Squashberry are recommended or not. As conditions like ongoing treatments, supplements, habits and other conditions change; the nutrition plan must be re-designed and personalized. Whether Pineoblastoma or Endometrial Carcinoma or other cancer types -, current treatments and supplements, age, gender, weight, height, lifestyle and genetic conditions are also key decision factors for creating a personalized nutrition plan.



Why is the choice of foods important for cancer?

Foods like Squashberry typically contain more than one active ingredient at varying concentrations. Each of these active ingredients like Vitamin A has a unique molecular biological mechanism of action. Cancer like most diseases is driven by specific biochemical pathways and molecular interventions of the pathway can be beneficial or create adverse interactions. Hence for Pineoblastoma, Endometrial Carcinoma and other cancers there is a need to personalize which foods and supplements to take and regularly evaluate if foods like Squashberry are recommended or not.

Squahberry for Endometrial Carcinoma taking Cyclophosphamide treatment and squashberry for Pineoblastoma along with Etoposide treatment

So some of the example questions one may have related to Squashberry can be: Is Squashberry beneficial for me? Should I eat it when at genetic cancer risk due to mutation of gene ASXL1? Should I eat Squashberry when a mutation of a gene BRCA1 is identified? Should I eat Squashberry when diagnosed with Pineoblastoma? Should I eat Squashberry when diagnosed with Endometrial Carcinoma? Should I eat Squashberry when on Etoposide treatment? Should I continue eating Squashberry if my treatment changes from Etoposide to Cyclophosphamide? Are the implications of taking Squashberry in Endometrial Carcinoma the same as Pineoblastoma? And so on.

Squashberry and cancer

Squashberry (Viburnum edule). Similar to the highbush cranberry or mooseberry in other parts of North America, this berry is part of the Caprifoliaceae (Honeysuckle family).Squashberry bark was often chewed and juice swallowed to cure such ailments as lung colds. The Haida Indians considered these berries food for supernatural beings.

Squashberry contains many active ingredients like Vitamin A, Vitamin C and many other Bioactives at different concentrations. The molecular pathways which are regulated by Squashberry include PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), Vitamin D Signaling, Oxidative Stress, Oncogenic Cancer Epigenetics (CpG Methylation), Suppressive Histone Methylation (Histone 3 Lysine 27 Methylation) and many others. These cellular pathways directly or indirectly influence cancer molecular endpoints like growth, spread and death. Because of this biological relationship – for cancer, choosing foods like Squashberry and supplements is an important decision to be made. And not necessarily the same food choices are scientifically best for all individuals.

Include Squashberry in my nutrition?

The answer to the question “Which Foods to Eat” and “Which Foods to Reduce Intake of” is dependent on multiple factors. Just like the same treatment does not work for every cancer patient, based on individual context the Squashberry may have scientific benefits or have adverse interactions. Along with which cancer – the ongoing treatments, supplements, lifestyle habits, height, weight, allergies and food preferences are all factors influencing answers to the question.

1. Any benefits of Squashberry for Pineoblastoma with Etoposide treatment?

Pineoblastoma is known to have mutations in gene like ATR, ATM and CREBBP and others which together cause biochemical pathway changes in PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), DNA Repair (Homology Directed Repair), Notch Signaling (NOTCH1 Signaling), DNA Repair (Non-homologous end-joining) and RUNX Signaling (RUNX3 Signaling). A cancer treatment like Etoposide has molecular action on a unique set of biochemical pathways . The treatment intent is to have a good overlap with the cancer driving pathways and reduce the disease drivers. In such conditions foods which can scientifically cancel out the treatment effect by reducing the overlap between the cancer driving pathways and treatment are candidates for reducing intake of or completely avoid. For example – in the case of Pineoblastoma and treatment Etoposide – Squashberry is not recommended. Squashberry impacts pathways or processes like PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling) which can negate the effects of the treatment.

2. Any benefits of Squashberry for Endometrial Carcinoma with Cyclophosphamide treatment?

Endometrial Carcinoma is defined and driven by specific genetic mutations like PTEN, PIK3CA and ARID1A leading to biochemical pathway changes in Vitamin D Signaling, Oxidative Stress, DNA Repair (Homology Directed Repair), DNA Repair (Base Excision Repair) and DNA Repair (Global Genome Nucleotide Excision Repair). Also treatments like Cyclophosphamide have molecular action on a unique set of biochemical pathways. Squashberry should be considered for Endometrial Carcinoma while on Cyclophosphamide treatment. Squashberry impacts pathways or processes like Vitamin D Signaling and Oxidative Stress which can either reduce drivers of Endometrial Carcinoma and/or improve Cyclophosphamide treatment effect.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Any benefits of Squashberry for gene ASXL1 associated cancer genetic risk?

Many companies offer gene panel tests for evaluating genetic risk to different cancers. These panels cover genes like ASXL1 and many others associated with high prevalence cancers of breast, ovary, uterus, prostate and gastrointestinal system and others. The intent of the genetic testing of ASXL1 is for diagnosis and/or to find out any potential risk factors for cancer. ASXL1 mutation causes biochemical pathways or processes like Oncogenic Cancer Epigenetics (CpG Methylation) and Suppressive Histone Methylation (Histone 3 Lysine 27 Methylation) to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like Oncogenic Cancer Epigenetics (CpG Methylation) and Suppressive Histone Methylation (Histone 3 Lysine 27 Methylation). Intake of foods like Squashberry should be reduced when there is a mutation of ASXL1 for risk of Chronic myelomonocytic leukemia and Myelodysplastic Syndrome. Squashberry impacts pathways or processes like Oncogenic Cancer Epigenetics (CpG Methylation) and Suppressive Histone Methylation (Histone 3 Lysine 27 Methylation) and creates adverse effects with ASXL1 mutation.

4. Any benefits of Squashberry for gene BRCA1 associated cancer genetic risk?

BRCA1 is also one of many genes available in panels for cancer risk testing. BRCA1 mutation causes biochemical pathways or processes like Androgen Signaling, Estrogen Signaling, DNA Repair (Homology Directed Repair), Stem Cell Signaling and P53 Signaling to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like Androgen Signaling, Estrogen Signaling, DNA Repair (Homology Directed Repair), Stem Cell Signaling and P53 Signaling. Intake of foods like Squashberry should be considered when Ovarian cancer and Breast cancer risk is identified due to gene BRCA1 mutation. Squashberry impacts biochemical pathways or processes like Androgen Signaling and Estrogen Signaling associated with genetic risk to BRCA1 mutation.

* Other Factors Included Like BMI, Lifestyle Habits, Treatments

In Conclusion

Personalized nutrition planning for cancer can inform if foods like Squashberry are recommended or not. Nutrition is the single most effective tool which cancer patients can control and nutrition decisions are dependent on questions like “Is Squashberry beneficial for me?”

The addon personalized nutrition planning for cancer is a software approach based on molecular science. The addon approach supports cancers like Pineoblastoma, Endometrial Carcinoma and others along with commonly reported genomic group clusters.

To get your personalized nutrition plan – enter details like cancer indication (example Pineoblastoma, name of current cancer and non-cancer treatments; habits and lifestyle conditions.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


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