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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

For which cancer is Apple beneficial for?

Mar 8, 2022

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Highlights

Nutrition is the single most effective tool which cancer patients can control for managing cancers like Chronic myeloid leukaemia or Juvenile Myelomonocytic Leukemia – hence it is important to identify those Foods and Supplements which are scientifically recommended for you. A frequently asked question is if foods like Apple are beneficial for cancer and along with which treatments? There is a mis-conception that all plant-based foods are good for all cancers and all of them are equal in terms of their benefits or their lack of. The reality is that some plant-based foods will be better than others for a specific type of cancer, treatments and other conditions. So Apple benefits will vary and the answer is contextual.

For example, grapefruit with certain medications is not recommended. Also spinach with some blood thinning medications can cause adverse interactions and hence intake should be reduced. For cancer, nutrition which includes food and supplements are important decisions which need to be made. 

So are there types of cancer where Apple has more benefits? Yes!  Apple is beneficial for Juvenile Myelomonocytic Leukemia patients taking Trametinib treatment. But has adverse interactions for Chronic myeloid leukaemia patients on Pazopanib treatment.

For Juvenile Myelomonocytic Leukemia along with Trametinib – biochemical pathways like PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), MAPK Signaling (ERK Signaling), MYC Signaling, RAS-RAF Signaling (RAS Signaling) and JAK-STAT Signaling are potential drivers of the disease. Apple has active ingredients which can manipulate these biochemical pathways to reduce the disease drivers and hence are scientifically  beneficial. But for Chronic myeloid leukaemia along with Pazopanib – biochemical pathways like MYC Signaling, Oxidative Stress, Growth Factor Signaling (FGFR Signaling), TGFB Signaling (TGFBR Signaling) and Chemokine Signaling are potential drivers of the disease. Apple has active ingredients which can increase disease drivers like MYC Signaling, Oxidative Stress, Growth Factor Signaling (FGFR Signaling), TGFB Signaling (TGFBR Signaling) and Chemokine Signaling and hence intake should be reduced.

Similarly, eating Apple can have scientific benefits for healthy individuals who have a gene mutation in ERBB2 which suggests potential risk of cancer. This is  because of biochemical pathways PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), Growth Factor Signaling (PTK6 Signaling) and Growth Factor Signaling (ERBB2 Signaling).  But reduce intake of Apple when at genetic risk of cancer due to mutation of gene ATM due to its manipulation of biochemical pathways Angiogenesis, Estrogen Signaling, DNA Repair (Homology Directed Repair), Stem Cell Signaling and DNA Repair (ATM Signaling) causing cancer drivers to increase.

The takeaway being – for  Chronic myeloid leukaemia, Juvenile Myelomonocytic Leukemia and other cancers individual conditions can influence if foods like Apple are recommended or not. As conditions like ongoing treatments, supplements, habits and other conditions change; the nutrition plan must be re-designed and personalized. Whether Chronic myeloid leukaemia or Juvenile Myelomonocytic Leukemia or other cancer types  -, current treatments and supplements, age, gender, weight, height, lifestyle and genetic conditions are also key decision factors for creating a personalized nutrition plan.




Why is the choice of foods important for cancer?

Foods like Apple typically contain more than one active ingredient at varying concentrations. Each of these active ingredients like Fisetin has a unique molecular biological mechanism of action. Cancer like most diseases is driven by specific biochemical pathways and molecular interventions of the pathway can be beneficial or create adverse interactions. Hence for Chronic myeloid leukaemia, Juvenile Myelomonocytic Leukemia and other cancers there is a need to personalize which foods and supplements to take and regularly evaluate if foods like Apple are recommended or not.

Apple for cancer treatment and genetic risks

So some of the example questions one may have related to Apple can be: Is Apple beneficial for me? Should I eat it when at genetic cancer risk due to mutation of gene ATM? Should I eat Apple when a mutation of a gene ERBB2 is identified? Should I eat Apple when diagnosed with Chronic myeloid leukaemia? Should I eat Apple when diagnosed with Juvenile Myelomonocytic Leukemia? Should I eat Apple when on Pazopanib treatment? Should I continue eating Apple if my treatment changes from Pazopanib to Trametinib? Are the implications of taking Apple in Juvenile Myelomonocytic Leukemia the same as Chronic myeloid leukaemia? And so on.

Apple and cancer

Apples are one of the most popular fruits. Apples are a good source of fiber and vitamin C.These substances help neutralize free radicals. Free radicals are reactive molecules that can build up as a result of natural processes and environmental pressures.

They also contain polyphenols, which may have numerous health benefits.

Apple contains many active ingredients like Fisetin, Glucaric Acid, Epicatechin, Caffeic Acid, Chlorogenic Acid and many other Bioactives at different concentrations. The molecular pathways which are regulated by Apple include MYC Signaling, Oxidative Stress, PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), MAPK Signaling (ERK Signaling), Angiogenesis and many others. These cellular pathways directly or indirectly influence cancer molecular endpoints like growth, spread and death. Because of this biological relationship – for cancer, choosing foods like Apple and supplements is an important decision to be made. And not necessarily the same food choices are scientifically best for all individuals.

Include Apple in my nutrition?

The answer to the question “Which Foods to Eat” and “Which Foods to Reduce Intake of” is dependent on multiple factors. Just like the same treatment does not work for every cancer patient, based on individual context the Apple may have scientific benefits or have adverse interactions. Along with which cancer  – the ongoing treatments, supplements, lifestyle habits, height, weight, allergies and food preferences are all factors influencing answers to the question. 

1. Any benefits of Apple for Chronic myeloid leukaemia with Pazopanib treatment?

Chronic myeloid leukaemia is known to have mutations in gene like BCR-ABL1, RUNX1 and ASXL1 and others which together cause biochemical pathway changes in MYC Signaling, Oxidative Stress, Growth Factor Signaling (FGFR Signaling), TGFB Signaling (TGFBR Signaling) and Chemokine Signaling. A cancer treatment like Pazopanib has molecular action on a unique set of biochemical pathways . The treatment intent is to have a good overlap with the cancer driving pathways and reduce the disease drivers. In such conditions foods which can scientifically cancel out the treatment effect by reducing the overlap between the cancer driving pathways and treatment are candidates for reducing intake of or completely avoid. For example – in the case of Chronic myeloid leukaemia and treatment Pazopanib – Apple is not recommended. Apple impacts pathways or processes like MYC Signaling and Oxidative Stress which can negate the effects of the treatment. 

2. Any benefits of Apple for Juvenile Myelomonocytic Leukemia with Trametinib treatment?

Juvenile Myelomonocytic Leukemia is defined and driven by specific genetic mutations like PTPN11, NRAS and NF1 leading to biochemical pathway changes in PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), MAPK Signaling (ERK Signaling), MYC Signaling, RAS-RAF Signaling (RAS Signaling) and JAK-STAT Signaling. Also treatments like Trametinib have molecular action on a unique set of biochemical pathways. Apple should be considered for Juvenile Myelomonocytic Leukemia while on Trametinib treatment. Apple impacts pathways or processes like PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling) and MAPK Signaling (ERK Signaling) which can either reduce drivers of Juvenile Myelomonocytic Leukemia and/or improve Trametinib treatment effect.

For Which Cancer Is Apple Beneficial For?

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Any benefits of Apple for gene ATM associated cancer genetic risk?

Many companies offer gene panel tests for evaluating genetic risk to different cancers. These panels cover genes like ATM and many others associated with high prevalence cancers of breast, ovary, uterus, prostate and gastrointestinal system and others. The intent of the genetic testing of ATM is for diagnosis and/or to find out any potential risk factors for cancer. ATM mutation causes biochemical pathways or processes like Angiogenesis, Estrogen Signaling, DNA Repair (Homology Directed Repair), Stem Cell Signaling and DNA Repair (ATM Signaling) to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like Angiogenesis, Estrogen Signaling, DNA Repair (Homology Directed Repair), Stem Cell Signaling and DNA Repair (ATM Signaling). Intake of foods like Apple should be reduced when there is a mutation of ATM for risk of Chronic myelomonocytic leukemia and Mantle Cell Lymphoma. Apple impacts pathways or processes like Angiogenesis and Estrogen Signaling and creates adverse effects with ATM mutation.

4. Any benefits of Apple for gene ERBB2 associated cancer genetic risk? 

ERBB2 is also one of many genes available in panels for cancer risk testing. ERBB2 mutation causes biochemical pathways or processes like PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), Growth Factor Signaling (PTK6 Signaling) and Growth Factor Signaling (ERBB2 Signaling) to get impacted. Cancer molecular endpoints like apoptosis, proliferation and spread are impacted by pathways like PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling), Growth Factor Signaling (PTK6 Signaling) and Growth Factor Signaling (ERBB2 Signaling). Intake of foods like Apple should be considered when Esophageal Adenocarcinoma risk is identified due to gene ERBB2 mutation. Apple impacts biochemical pathways or processes like PI3K-AKT-MTOR Signaling (PI3K-AKT Signaling) associated with genetic risk to ERBB2 mutation.

* Other Factors Included Like BMI, Lifestyle Habits, Treatments

In Conclusion 

Personalized nutrition planning for cancer can inform if foods like Apple are recommended or not. Nutrition is the single most effective tool which cancer patients can control and nutrition decisions are dependent on questions  like “Is Apple beneficial for me?”

The addon personalized nutrition planning for cancer is a software approach based on molecular science. The addon approach supports cancers like Chronic myeloid leukaemia, Juvenile Myelomonocytic Leukemia and others along with commonly reported genomic group clusters. 

To get your personalized nutrition plan – enter details like cancer indication (example Chronic myeloid leukaemia, name of current cancer and non-cancer treatments; habits and lifestyle conditions.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


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