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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

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Which Foods and Supplements to Avoid for MSI-H+ Cholangiocarcinoma?

Nov 18, 2021

Estimated reading time: 6 minutes
Home » Blogs » Which Foods and Supplements to Avoid for MSI-H+ Cholangiocarcinoma?

Highlights

No two cancers are the same and neither should your nutrition be. When diagnosed with cancer or at risk of cancer – one immediate question is “What Should I Eat Differently Starting Now?” and “Which Supplements Should I Take and Avoid”. The answer is “It Depends”. It depends on which genetic mutations your tests identified. It depends on which cancer, which ongoing treatments and supplements. It depends on your age, weight, height, lifestyle, allergies and habits. The answer to “What Should I Eat Differently” and “Which Supplements Should I Take and Avoid” for MSI-H+ Cholangiocarcinoma also requires understanding of how the food and supplements included in your diet manipulate the molecular pathways which are relevant for cancer and interactions with your treatment.

Internet search to find answers will never be personalized to your cancer type such as MSI-H+ Cholangiocarcinoma and lifestyle conditions. Cancers are driven by biochemical pathways and therefore the answers to nutrition questions have to be based on molecular science irrespective of whether one understands it or not.  

For example foods like Tomato and Beetroot are recommended when undergoing Checkpoint PDL1 treatment for MSI-H+ Cholangiocarcinoma. Similarly Ginseng supplements are recommended with Checkpoint PDL1 treatment for MSI-H+ Cholangiocarcinoma. So always personalize your nutrition to your cancer gene mutations and other factors.



What is MSI-H+ Cholangiocarcinoma?

MSI-H+ Cholangiocarcinoma is one of the different subtypes of Cholangiocarcinoma. “MSI-high”, or “MSI-H” in MSI-H+ Cholangiocarcinoma stands for microsatellite instability-high, which means there’s a lot of instability in the tumor. You can visit NIH for information on the prevalence of genetic mutations across cancers. (Reference: Steven N Hart et al, Hum Mutat,. 2020)

Diet for MSI-H+ Cholangiocarcinoma

Why Are Some Foods Recommended in the Diet for MSI-H+ Cholangiocarcinoma?

Foods and Supplements contain different active ingredients which manipulate different molecular pathways relevant to cancers such as MSI-H+ Cholangiocarcinoma. Genetic mutations and cancer conditions cause specific molecular pathways to become disrupted. Hence, those foods and supplements are recommended which do not disrupt those molecular pathways further and instead reverse the disruption. For MSI-H+ Cholangiocarcinoma, cancer pathway or processes like Dendritic Cell Maturation, CD8 T-cell Activation, Noncoding RNA Signaling, Mismatch Repair, Natural Killer Cell Activation, Oncogenic Cancer Epigenetics, MYC Signaling, DNA Repair, WNT Beta Catenin Signaling, Macrophage M2, T-Regulatory Cell Differentiation, Myeloid-derived Suppressor Cells, PI3K-AKT-MTOR Signaling, Suppressive Histone Methylation, Antigen Presentation, Immune Checkpoints, JAK-STAT Signaling, MAPK Signaling, Growth Factor Signaling and Angiogenesis get disrupted. Choose those foods and supplements which contain active ingredients which cancel the molecular pathways disruption. Those supplements which interact with the treatments and disrupt the cancer molecular pathways further should be avoided.

The nutrition/diet for cancer such as MSI-H+ Cholangiocarcinoma depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. 

Example Foods to Eat with Checkpoint PDL1 treatment for MSI-H+ Cholangiocarcinoma

Foods and Supplements to take and avoid for MSI-H+ Cholangiocarcinoma

Recommended Foods

Tomato: Tomato contains active ingredients like Glucaric Acid, Citric Acid and Lupeol. For MSI-H+ Cholangiocarcinoma, along with other pathways, PI3K-AKT-MTOR Signaling is also disrupted and drives the cancer. Glucaric Acid manipulates the molecular pathways like PI3K-AKT-MTOR Signaling so as to cancel the disruption. Hence, foods like Tomato are recommended along with treatment Checkpoint PDL1 for MSI-H+ Cholangiocarcinoma.

Beetroot: Beetroot contains active ingredients like Vitamin E, Citric Acid and Linoleic Acid. For MSI-H+ Cholangiocarcinoma, along with other pathways, PI3K-AKT-MTOR Signaling is also disrupted and drives the cancer. Vitamin E manipulates the molecular pathways like PI3K-AKT-MTOR Signaling so as to cancel the disruption. Hence, foods like Beetroot are recommended along with treatment Checkpoint PDL1 for MSI-H+ Cholangiocarcinoma.

Reduce Intake of These Foods

Agave:  Agave contains active ingredients like Retinol. For MSI-H+ Cholangiocarcinoma, along with other pathways, Antigen Presentation is also disrupted and drives the cancer. Retinol manipulates the molecular pathways like Antigen Presentation so as to disrupt them further. Hence avoid or reduce the intake of foods like Agave when undergoing Checkpoint PDL1 treatment for MSI-H+ Cholangiocarcinoma.

Towel Gourd:  Towel Gourd contains active ingredients like Linoleic Acid, Vitamin C and Retinol. For MSI-H+ Cholangiocarcinoma, along with other pathways, Angiogenesis is also disrupted and drives the cancer. Linoleic Acid manipulates the molecular pathways like Angiogenesis so as to disrupt them further. Hence avoid or reduce the intake of foods like Towel Gourd when undergoing Checkpoint PDL1 treatment for MSI-H+ Cholangiocarcinoma.

For MSI H+ Cholangiocarcinoma avoid these foods and supplements!

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Which Supplements To Avoid with Checkpoint PDL1 treatment for MSI-H+ Cholangiocarcinoma?

Unlike foods, supplements are high concentrations of active ingredients and hence important to understand the interactions with Checkpoint PDL1 treatment for MSI-H+ Cholangiocarcinoma.

Vitamin B2: For MSI-H+ Cholangiocarcinoma, along with other pathways, Natural Killer Cell Activation and CD8 T-cell Activation are also disrupted and drive the cancer. Vitamin B2 manipulates the molecular pathways like Natural Killer Cell Activation and CD8 T-cell Activation so as to disrupt them further. Hence avoid Vitamin B2 supplements when undergoing Checkpoint PDL1 treatment for MSI-H+ Cholangiocarcinoma.

Flaxseed: Flaxseed contains active ingredients Apigenin, Beta-sitosterol and Chlorogenic Acid. For MSI-H+ Cholangiocarcinoma, along with other pathways, Dendritic Cell Maturation and Natural Killer Cell Activation are also disrupted and drive the cancer. Apigenin manipulates the molecular pathways like Dendritic Cell Maturation and Natural Killer Cell Activation so as to disrupt them further. Hence avoid Flaxseed supplements when undergoing Checkpoint PDL1 treatment for MSI-H+ Cholangiocarcinoma.

Should I take this Nutritional Supplement with Checkpoint PDL1 treatment for MSI-H+ Cholangiocarcinoma?

Ginseng:  Ginseng contains active ingredients Casticin, Ginsenoside Rb1 and Ginsenoside Rb2. For MSI-H+ Cholangiocarcinoma, along with other pathways, Dendritic Cell Maturation and Antigen Presentation are also disrupted and drive the cancer. Casticin manipulates the molecular pathways like Dendritic Cell Maturation and Antigen Presentation so as to cancel these disruptions. Hence Ginseng supplements are recommended with Checkpoint PDL1 treatment for MSI-H+ Cholangiocarcinoma.

Curcumin:  For MSI-H+ Cholangiocarcinoma, along with other pathways, Dendritic Cell Maturation and Natural Killer Cell Activation are also disrupted and drive the cancer. Curcumin manipulates the molecular pathways like Dendritic Cell Maturation and Natural Killer Cell Activation so as to cancel these disruptions.  Hence Curcumin supplements are recommended with Checkpoint PDL1 treatment for MSI-H+ Cholangiocarcinoma.

In Conclusion

Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as MSI-H+ Cholangiocarcinoma.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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