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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Upper Tract Urothelial Carcinoma!

Aug 1, 2023

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Introduction

Foods for Upper Tract Urothelial Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Upper tract urothelial carcinoma, a type of cancer affecting the lining of the urinary system’s upper tract, requires meticulous attention in terms of diagnosis, staging, and treatment. The ICD-10 classification aids in its standardized documentation. Staging of the disease is crucial for determining prognosis and guiding treatment, which typically involves surgery and may include chemotherapy or immunotherapy, depending on the cancer’s advancement. Guidelines from authoritative bodies like the AUA (American Urological Association), NCCN (National Comprehensive Cancer Network), and EAU (European Association of Urology) provide comprehensive directives for the management of upper tract urothelial carcinoma. These guidelines also encompass follow-up and surveillance strategies post-treatment to monitor for recurrence. The prognosis and survival rates for upper tract urothelial carcinoma vary, with outcomes dependent on the stage at diagnosis and the effectiveness of the treatment. Diagnosis involves a combination of clinical assessment and radiological investigations, with symptoms like hematuria and pain prompting initial evaluation. Understanding upper tract urothelial cell carcinoma’s clinical presentation and adhering to recommended guidelines for its management are pivotal in enhancing patient care and improving outcomes.



For Upper Tract Urothelial Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Upper Tract Urothelial Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Upper Tract Urothelial Carcinoma?

For example does it matter if vegetable Kai-lan is consumed more compared to Sunburst Squash (pattypan Squash)? Does it make any difference if fruit Grapefruit is preferred over Sweet Rowanberry? Also if similar choices are made for nuts/seeds like Chia over Japanese Walnut and for pulses like Yellow Wax Bean over Pigeon Pea. And if what I eat matters – then how does one identify foods which are recommended for Upper Tract Urothelial Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Upper Tract Urothelial Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Upper Tract Urothelial Carcinoma can be characterized by a unique set of biochemical pathways - the signature pathways of Upper Tract Urothelial Carcinoma. Biochemical pathways like Vitamin Metabolism, Cell Cycle, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Upper Tract Urothelial Carcinoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Grapefruit contains active ingredients Luteolin, Phloretin, Lupeol, Bergapten, Eugenol. And Sweet Rowanberry contains active ingredients Quercetin, Luteolin, Apigenin, Phloretin, Caffeine and possibly others.

A common mistake made when deciding and choosing foods to eat for Upper Tract Urothelial Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Upper Tract Urothelial Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Upper Tract Urothelial Carcinoma?

Personalized nutrition for cancers like Upper Tract Urothelial Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Upper Tract Urothelial Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Upper Tract Urothelial Carcinoma

All cancers like Upper Tract Urothelial Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Upper Tract Urothelial Carcinoma. Biochemical pathways like Vitamin Metabolism, Cell Cycle, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Upper Tract Urothelial Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Upper Tract Urothelial Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Upper Tract Urothelial Carcinoma when taking cancer treatment Ifosfamide, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

FGFR3, KMT2D, KDM6A, TERT and KMT2C are the top ranked reported genes for Upper Tract Urothelial Carcinoma. FGFR3 is reported in 10.2 % of the representative patients across all clinical trials. And KMT2D is reported in 7.6 %. The combined population patient data cover ages from 38 to 88. 64.9 % of the patient data are identified as men. The Upper Tract Urothelial Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Upper Tract Urothelial Carcinoma!

Food and Supplements for Upper Tract Urothelial Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable KAI-LAN or SUNBURST SQUASH (PATTYPAN SQUASH)?

Vegetable Kai-lan contains many active ingredients or bioactives such as Quercetin, Apigenin, Phloretin, Caffeine, Lupeol. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle, Epithelial to Mesenchymal Transition and Cell Cycle Checkpoints and others. Kai-lan is recommended for Upper Tract Urothelial Carcinoma when ongoing cancer treatment is Ifosfamide. This is because Kai-lan modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Ifosfamide.

Some of the active ingredients or bioactives in vegetable Sunburst Squash (pattypan Squash) are Luteolin, Apigenin, Myricetin, Phloretin, Lupeol. These active ingredients manipulate various biochemical pathways like DNA Repair, Epithelial to Mesenchymal Transition and Oxidative Stress and others. Sunburst Squash (pattypan Squash) is not recommended for Upper Tract Urothelial Carcinoma when ongoing cancer treatment is Ifosfamide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE KAI-LAN IS RECOMMENDED OVER SUNBURST SQUASH (PATTYPAN SQUASH) FOR Upper Tract Urothelial Carcinoma AND TREATMENT Ifosfamide.

Choose Fruit SWEET ROWANBERRY or GRAPEFRUIT?

Fruit Sweet Rowanberry contains many active ingredients or bioactives such as Quercetin, Luteolin, Apigenin, Phloretin, Caffeine. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle, Epithelial to Mesenchymal Transition and Cell Cycle Checkpoints and others. Sweet Rowanberry is recommended for Upper Tract Urothelial Carcinoma when ongoing cancer treatment is Ifosfamide. This is because Sweet Rowanberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Ifosfamide.

Some of the active ingredients or bioactives in fruit Grapefruit are Luteolin, Phloretin, Lupeol, Bergapten, Eugenol. These active ingredients manipulate various biochemical pathways like DNA Repair and Oxidative Stress and others. Grapefruit is not recommended for Upper Tract Urothelial Carcinoma when ongoing cancer treatment is Ifosfamide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT SWEET ROWANBERRY IS RECOMMENDED OVER GRAPEFRUIT FOR Upper Tract Urothelial Carcinoma AND TREATMENT Ifosfamide.

Choose Nut CHIA or JAPANESE WALNUT?

Chia contains many active ingredients or bioactives such as Luteolin, Apigenin, Myricetin, Phloretin, Caffeine. These active ingredients manipulate various biochemical pathways like Cell Cycle, Epithelial to Mesenchymal Transition, DNA Repair and Vitamin Metabolism and others. Chia is recommended for Upper Tract Urothelial Carcinoma when ongoing cancer treatment is Ifosfamide. This is because Chia modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Ifosfamide.

Some of the active ingredients or bioactives in Japanese Walnut are Luteolin, Apigenin, Ellagic Acid, Myricetin, Phloretin. These active ingredients manipulate various biochemical pathways like DNA Repair, Epithelial to Mesenchymal Transition and Oxidative Stress and others. Japanese Walnut is not recommended for Upper Tract Urothelial Carcinoma when ongoing cancer treatment is Ifosfamide because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

CHIA IS RECOMMENDED OVER JAPANESE WALNUT FOR Upper Tract Urothelial Carcinoma AND TREATMENT Ifosfamide.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Upper Tract Urothelial Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable CAULIFLOWER or SPINACH?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Formononetin, Lupeol, Daidzein, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Apoptosis, P53 Signaling, MAPK Signaling and Cell Cycle Checkpoints and others. Cauliflower is recommended for risk of Upper Tract Urothelial Carcinoma when associated genetic risk is FGFR3. This is because Cauliflower increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Spinach are Apigenin, Curcumin, Quercetin, Myricetin, Formononetin. These active ingredients manipulate various biochemical pathways like MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling and others. Spinach is not recommended when risk of Upper Tract Urothelial Carcinoma when associated genetic risk is FGFR3 because it increases the signature pathways of it.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER SPINACH FOR FGFR3 GENETIC RISK OF CANCER.

Choose Fruit RED RASPBERRY or PUMMELO?

Fruit Red Raspberry contains many active ingredients or bioactives such as Curcumin, Ellagic Acid, Quercetin, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Apoptosis, P53 Signaling, MAPK Signaling and Cell Cycle Checkpoints and others. Red Raspberry is recommended for risk of Upper Tract Urothelial Carcinoma when associated genetic risk is FGFR3. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Quercetin, Formononetin, Lycopene. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints and MYC Signaling and others. Pummelo is not recommended when risk of Upper Tract Urothelial Carcinoma when associated genetic risk is FGFR3 because it increases the signature pathways of it.

FRUIT RED RASPBERRY IS RECOMMENDED OVER PUMMELO FOR FGFR3 GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Myricetin, Formononetin, Lycopene. These active ingredients manipulate various biochemical pathways like JAK-STAT Signaling, P53 Signaling, MAPK Signaling and Cell Cycle Checkpoints and others. Common Hazelnut is recommended for risk of Upper Tract Urothelial Carcinoma when associated genetic risk is FGFR3. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Apigenin, Curcumin, Ellagic Acid, Myricetin, Formononetin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints and MYC Signaling and others. Chestnut is not recommended when risk of Upper Tract Urothelial Carcinoma when associated genetic risk is FGFR3 because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR FGFR3 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Upper Tract Urothelial Carcinoma. Upper Tract Urothelial Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Upper Tract Urothelial Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Kai-lan contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Upper Tract Urothelial Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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