No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Esophageal Squamous Cell Carcinoma (ESCC) needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Allspice and Almond should be eaten when undergoing Capecitabine treatment for Esophageal Squamous Cell Carcinoma (ESCC). On the same lines, avoid foods like Adzuki Bean and Black-eyed Pea with treatment of Capecitabine for Esophageal Squamous Cell Carcinoma (ESCC).
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Esophageal Squamous Cell Carcinoma.
What is Esophageal Squamous Cell Carcinoma?
Esophageal Squamous Cell Carcinoma is a type of esophageal cancer that develops from the thin, flat cells lining the inside of the esophagus (squamous cells). The incidence rate of this cancer is only 1.9 per 1 lakh people per year. This cancer is commonly diagnosed in people who are about 60 to 70 years of age, however, it can occur in people of any age. It is more commonly found in men as compared to women.
Esophageal Squamous Cell Carcinoma has prevalence of certain genetic changes. Some of the genes such as TP53, CSMD3, KMT2D, and NFE2L2 are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Esophageal Squamous Cell Carcinoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Esophageal Squamous Cell Carcinoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Esophageal Squamous Cell Carcinoma (ESCC) genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Esophageal Squamous Cell Carcinoma (ESCC) nutrition may have to be redesigned.
Why Eating Right Matters for Esophageal Squamous Cell Carcinoma?
In Esophageal Squamous Cell Carcinoma, activation or inhibition of some of the biochemical pathways including Wnt Beta Catenin Signaling, Myc Signaling, MAPK Signaling, Hypoxia, Cell Cycle Checkpoints, Cell Cycle, P53 Signaling, Nutrient Sensing, PI3K-AKT-MTOR Signaling, Growth Factor Signaling, Apoptosis, Dna Repair and Epithelial To Mesenchymal Transition plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Esophageal Squamous Cell Carcinoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Capecitabine treatment for Esophageal Squamous Cell Carcinoma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Esophageal Squamous Cell Carcinoma considering only one specific treatment- Capecitabine.
Foods to Avoid
Adzuki Bean : Adzuki Bean contains active ingredients such as Folic Acid, Genistein, Isoliquiritigenin and others. Folic Acid interferes with the impact of Capecitabine in Esophageal Squamous Cell Carcinoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, avoid foods like Adzuki Bean with Capecitabine treatment for Esophageal Squamous Cell Carcinoma (ESCC).
Black-eyed Pea : Black-eyed Pea contains active ingredients such as Genistein, Folic Acid, Retinol and others. Genistein interferes with the impact of Capecitabine in Esophageal Squamous Cell Carcinoma by activating a specific biological process called DNA Repair. Hence, avoid foods like Black-eyed Pea with Capecitabine treatment for Esophageal Squamous Cell Carcinoma (ESCC).
Foods to Eat
Allspice : Allspice contains active ingredients like Eucalyptol, Vitamin C and Salicylic Acid. Intake of Eucalyptol along with Capecitabine treatment for Esophageal Squamous Cell Carcinoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Allspice hence should be eaten with Capecitabine treatment for Esophageal Squamous Cell Carcinoma. (Soichiro Murata et al, Oncol Rep., 2013; Soo Jung Lee et al, J Korean Med Sci., 2009)
Almond : Almond contains active ingredients like Geraniin, Salicylic Acid and Quercetin. Intake of Geraniin along with Capecitabine treatment for Esophageal Squamous Cell Carcinoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Almond hence should be eaten with Capecitabine treatment for Esophageal Squamous Cell Carcinoma. (Long-An Zhou et al, Anticancer Drugs., 2020; Soo Jung Lee et al, J Korean Med Sci., 2009)
Should I take this Nutritional Supplement for Esophageal Squamous Cell Carcinoma?
Black Seed : Black Seed has no known reported CYP (drug metabolizing enzyme) interactions with Capecitabine treatment. Black Seed supports the Capecitabine treatment for Esophageal Squamous Cell Carcinoma by decreasing the biochemical pathway(s) called MAPK Signaling, MYC Signaling, NFKB Signaling, PI3K-AKT-MTOR Signaling, DNA Repair.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Esophageal Squamous Cell Carcinoma (ESCC)?
In the initial stages, most cancers including Esophageal Squamous Cell Carcinoma (ESCC) may not cause any signs or symptoms. However, as the disease progresses, Esophageal Squamous Cell Carcinoma may start showing symptoms.
Following are some of the signs and symptoms that may be caused by Esophageal Squamous Cell Carcinoma (ESCC).
- Vomiting or coughing up blood
- Pain in the throat
- Persistent cough or Hoarseness
- Unintentional weight loss
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Esophageal Squamous Cell Carcinoma (ESCC).
What are the Treatment Options for Esophageal Squamous Cell Carcinoma (ESCC)?
The treatment for Esophageal Squamous Cell Carcinoma (ESCC) may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Esophageal Squamous Cell Carcinoma (ESCC) include:
- Radiation Therapy
- Targeted drug therapy
As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Esophageal Squamous Cell Carcinoma (ESCC).
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Esophageal Squamous Cell Carcinoma (ESCC).
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.