No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Renal Non-Clear Cell Carcinoma (nccRCC) needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Cabbage and Bamboo should be eaten when undergoing Bevacizumab treatment for Renal Non-Clear Cell Carcinoma. On the same lines, avoid foods like Agave and Jicama with treatment of Bevacizumab for Renal Non-Clear Cell Carcinoma (nccRCC).
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Renal Non-Clear Cell Carcinoma.
What is Renal Non-Clear Cell Carcinoma?
Renal Non-Clear Cell Carcinoma refers to a heterogeneous group of cancers that develops in the kidney. The incidence rate of Renal Cell Carcinoma is 3 to 15 per 100,000 people per year, and 25% of the Renal Cell Carcinoma are of Non-Clear Cell type. This cancer is commonly diagnosed in people who are above 45 years of age, however, it can occur in people of any age.
Renal Non-Clear Cell Carcinoma has prevalence of certain genetic changes. Some of the genes such as MUC16, TP53, MET, and KMT2C are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Renal Non-Clear Cell Carcinoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Renal Non-Clear Cell Carcinoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Renal Non-Clear Cell Carcinoma (nccRCC) genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Renal Non-Clear Cell Carcinoma (nccRCC) nutrition may have to be redesigned.
Why Eating Right Matters for Renal Non-Clear Cell Carcinoma?
In Renal Non-Clear Cell Carcinoma, activation or inhibition of some of the biochemical pathways including Wnt Beta Catenin Signaling, MAPK Signaling, MYC Signaling, Epithelial To Mesenchymal Transition, RAS-RAF Signaling, Focal Adhesion, PI3K-AKT-MTOR Signaling, Oxidative Stress, Hypoxia, Cell Cycle, Small Molecule Transport, Growth Factor Signaling and Amino Acid Metabolism plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Renal Non-Clear Cell Carcinoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Bevacizumab treatment for Renal Non-Clear Cell Carcinoma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Renal Non-Clear Cell Carcinoma considering only one specific treatment- Bevacizumab.
Foods to Avoid with Bevacizumab treatment
Agave : Agave contains active ingredients such as Retinol and others. Retinol interferes with the impact of Bevacizumab in Renal Non-Clear Cell Carcinoma by activating a specific biological process called Focal Adhesion. Hence, avoid foods like Agave with Bevacizumab treatment for Renal Non-Clear Cell Carcinoma (nccRCC) .
Jicama : Jicama contains active ingredients such as Folic Acid, Vitamin C, Retinol and others. Folic Acid interferes with the impact of Bevacizumab in Renal Non-Clear Cell Carcinoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, avoid foods like Jicama with Bevacizumab treatment for Renal Non-Clear Cell Carcinoma (nccRCC).
Foods to Eat with Bevacizumab treatment
Cabbage : Cabbage contains active ingredients like Benzyl Isothiocyanate, Crocetin, Brassinin. Intake of Benzyl Isothiocyanate along with Bevacizumab treatment for Renal Non-Clear Cell Carcinoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Cabbage hence should be eaten with Bevacizumab treatment for Renal Non-Clear Cell Carcinoma. (Ji-Fan Lin et al, Int J Oncol., 2019; Sara Ramezani et al, Apoptosis., 2017)
Bamboo : Bamboo contains active ingredients like Beta-sitosterol, Linolenic Acid, Citric Acid. Intake of Beta-sitosterol along with Bevacizumab treatment for Renal Non-Clear Cell Carcinoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Bamboo hence should be eaten with Bevacizumab treatment for Renal Non-Clear Cell Carcinoma. (Song Hyo Sook et al, Phytother Res., 2014; Sara Ramezani et al, Apoptosis., 2017)
Should I take this Nutritional Supplement with Bevacizumab treatment?
Black Seed : Black Seed has no known reported CYP (drug metabolizing enzyme) interactions with Bevacizumab treatment. Black Seed supports the Bevacizumab treatment for Renal Non-Clear Cell Carcinoma by decreasing the biochemical pathways or processes such as Angiogenesis, Chemokine Signaling, Extracellular Matrix Remodeling, Epithelial to Mesenchymal Transition, MAPK Signaling, Focal Adhesion, Cytokine Signaling, MYC Signaling, Notch Signaling, PI3K-AKT-MTOR Signaling, TGFB Signaling, Cytoskeletal Dynamics, WNT Beta Catenin Signaling and Cancer Epigenetics.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Renal Non-Clear Cell Carcinoma?
In the initial stages, most cancers including Renal Non-Clear Cell Carcinoma may not cause any signs or symptoms. However, as the disease progresses, Renal Non-Clear Cell Carcinoma may start showing symptoms.
Following are some of the signs and symptoms that may be caused by Renal Non-Clear Cell Carcinoma.
- Lower back pain on one side
- Blood in the urine
- Unexplained Weight loss
- Lump on the side or lower back
- Weakness and Fatigue
- Unsubsiding Fever
- Lack of appetite
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Renal Non-Clear Cell Carcinoma.
What are the Treatment Options for Renal Non-Clear Cell Carcinoma?
The treatment for Renal Non-Clear Cell Carcinoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, and whether the cancer was just diagnosed or had come back. The treatment options for Renal Non-Clear Cell Carcinoma include:
- Radiation Therapy
- Targeted Therapy
As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for this cancer.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Renal Non-Clear Cell Carcinoma.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.