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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Diffuse Glioma!

Aug 4, 2023

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Introduction

Foods for Diffuse Glioma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.



For Diffuse Glioma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Diffuse Glioma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Diffuse Glioma?

For example does it matter if vegetable Jute is consumed more compared to Turnip? Does it make any difference if fruit Pummelo is preferred over Red Raspberry? Also if similar choices are made for nuts/seeds like Almond over European Chestnut and for pulses like Black-eyed Pea over Common Bean. And if what I eat matters – then how does one identify foods which are recommended for Diffuse Glioma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Diffuse Glioma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Diffuse Glioma can be characterized by a unique set of biochemical pathways - the signature pathways of Diffuse Glioma. Biochemical pathways like DNA Repair, Direct Repair, PI3K-AKT-MTOR Signaling, Hypoxia are part of the signature definition of Diffuse Glioma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Caffeine, Curcumin, Daidzein, Isoliquiritigenin, Phloretin. And Red Raspberry contains active ingredients Ellagic Acid, Curcumin, Daidzein, Isoliquiritigenin, Phloretin and possibly others.

A common mistake made when deciding and choosing foods to eat for Diffuse Glioma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Diffuse Glioma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Diffuse Glioma?

Personalized nutrition for cancers like Diffuse Glioma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Diffuse Glioma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Diffuse Glioma

All cancers like Diffuse Glioma can be characterized by a unique set of biochemical pathways – the signature pathways of Diffuse Glioma. Biochemical pathways like DNA Repair, Direct Repair, PI3K-AKT-MTOR Signaling, Hypoxia are part of the signature definition of Diffuse Glioma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Diffuse Glioma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Diffuse Glioma when taking cancer treatment Procarbazine, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

IDH1, TP53, ATRX, PTEN and EGFR are the top ranked reported genes for Diffuse Glioma. IDH1 is reported in 50.1 % of the representative patients across all clinical trials. And TP53 is reported in 39.3 %. The combined population patient data cover ages from 10 to 89. 59.0 % of the patient data are identified as men. The Diffuse Glioma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Diffuse Glioma!

Food and Supplements for Diffuse Glioma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable JUTE or TURNIP?

Vegetable Jute contains many active ingredients or bioactives such as Curcumin, Daidzein, Isoliquiritigenin, Phloretin, Formononetin. These active ingredients manipulate various biochemical pathways like Oxidative Stress, NFKB Signaling and PI3K-AKT-MTOR Signaling and others. Jute is recommended for Diffuse Glioma when ongoing cancer treatment is Procarbazine. This is because Jute modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Procarbazine.

Some of the active ingredients or bioactives in vegetable Turnip are Ellagic Acid, Curcumin, Daidzein, Isoliquiritigenin, Phloretin. These active ingredients manipulate various biochemical pathways like DNA Repair and others. Turnip is not recommended for Diffuse Glioma when ongoing cancer treatment is Procarbazine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE JUTE IS RECOMMENDED OVER TURNIP FOR Diffuse Glioma AND TREATMENT Procarbazine.

Choose Fruit RED RASPBERRY or PUMMELO?

Fruit Red Raspberry contains many active ingredients or bioactives such as Ellagic Acid, Curcumin, Daidzein, Isoliquiritigenin, Phloretin. These active ingredients manipulate various biochemical pathways like NFKB Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling and Hypoxia and others. Red Raspberry is recommended for Diffuse Glioma when ongoing cancer treatment is Procarbazine. This is because Red Raspberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Procarbazine.

Some of the active ingredients or bioactives in fruit Pummelo are Caffeine, Curcumin, Daidzein, Isoliquiritigenin, Phloretin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and DNA Repair and others. Pummelo is not recommended for Diffuse Glioma when ongoing cancer treatment is Procarbazine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RED RASPBERRY IS RECOMMENDED OVER PUMMELO FOR Diffuse Glioma AND TREATMENT Procarbazine.

Choose Nut ALMOND or EUROPEAN CHESTNUT?

Almond contains many active ingredients or bioactives such as Curcumin, Daidzein, Isoliquiritigenin, Phloretin, Formononetin. These active ingredients manipulate various biochemical pathways like NFKB Signaling, Hedgehog Signaling, PI3K-AKT-MTOR Signaling and Hypoxia and others. Almond is recommended for Diffuse Glioma when ongoing cancer treatment is Procarbazine. This is because Almond modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Procarbazine.

Some of the active ingredients or bioactives in European Chestnut are Ellagic Acid, Myricetin, Curcumin, Daidzein, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and DNA Repair and others. European Chestnut is not recommended for Diffuse Glioma when ongoing cancer treatment is Procarbazine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

ALMOND IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Diffuse Glioma AND TREATMENT Procarbazine.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Diffuse Glioma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or SPINACH?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Catechol, Formononetin. These active ingredients manipulate various biochemical pathways like Apoptosis, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints and P53 Signaling and others. Giant Butterbur is recommended for risk of Diffuse Glioma when associated genetic risk is ATRX. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Spinach are Curcumin, Quercetin, Apigenin, Lupeol, Catechol. These active ingredients manipulate various biochemical pathways like Insulin Signaling and Oncogenic Cancer Epigenetics and others. Spinach is not recommended when risk of Diffuse Glioma when associated genetic risk is ATRX because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER SPINACH FOR ATRX GENETIC RISK OF CANCER.

Choose Fruit NANCE or ACEROLA?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Catechol, Formononetin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Hypoxia and P53 Signaling and others. Nance is recommended for risk of Diffuse Glioma when associated genetic risk is ATRX. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Acerola are Curcumin, Quercetin, Apigenin, Lupeol, Catechol. These active ingredients manipulate various biochemical pathways like Insulin Signaling and Oncogenic Cancer Epigenetics and others. Acerola is not recommended when risk of Diffuse Glioma when associated genetic risk is ATRX because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER ACEROLA FOR ATRX GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or BRAZIL NUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Catechol, Formononetin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Insulin Signaling and P53 Signaling and others. Butternut is recommended for risk of Diffuse Glioma when associated genetic risk is ATRX. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Brazil Nut are Curcumin, Ellagic Acid, Lupeol, Catechol, Formononetin. These active ingredients manipulate various biochemical pathways like Insulin Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling and others. Brazil Nut is not recommended when risk of Diffuse Glioma when associated genetic risk is ATRX because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER BRAZIL NUT FOR ATRX GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Diffuse Glioma. Diffuse Glioma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Diffuse Glioma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Jute contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Diffuse Glioma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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