No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Chronic Lymphocytic Leukemia needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Arrowroot and Asparagus should be eaten when undergoing Fludarabine treatment for Chronic Lymphocytic Leukemia. On the same lines, avoid foods like Adzuki Bean and Black-eyed Pea with treatment of Fludarabine for Chronic Lymphocytic Leukemia (CLL).
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Chronic Lymphocytic Leukemia.
What is Chronic Lymphocytic Leukemia?
Chronic Lymphocytic Leukemia is the cancer of the white blood cells, which develop from the lymphoid stem cells. The incidence rate of this cancer is only 4.9 per 1 lakh people per year. This cancer is commonly diagnosed in people who are about 70 years of age, however, it can occur in people of any age. It is slightly more commonly found in men as compared to women.
Chronic Lymphocytic Leukemia has prevalence of certain genetic changes. Some of the genes such as NOTCH1, SF3B1, ATM, and CHD2 are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Chronic Lymphocytic Leukemia can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Chronic Lymphocytic Leukemia. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Chronic Lymphocytic Leukemia (CLL) genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Chronic Lymphocytic Leukemia nutrition may have to be redesigned.
Why Eating Right Matters for Chronic Lymphocytic Leukemia?
In Chronic Lymphocytic Leukemia, activation or inhibition of some of the biochemical pathways including MYC Signaling, Amino Acid Metabolism, MAPK Signaling, Hypoxia, Small Molecule Transport, Cell Cycle, P53 Signaling, Notch Signaling, Vitamin D Signaling, PI3K-AKT-MTOR Signaling, Oxidative Stress, Angiogenesis, Growth Factor Signaling, Vitamin Metabolism and Epithelial To Mesenchymal Transition plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Chronic Lymphocytic Leukemia, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Fludarabine treatment for Chronic Lymphocytic Leukemia
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example for nutrition/diet for Chronic Lymphocytic Leukemia considering only one specific treatment-Fludarabine.
Foods to Avoid with Fludarabine treatment
Adzuki Bean : Adzuki Bean contains active ingredients such as Folic Acid, Genistein, Isoliquiritigenin and others. Folic Acid interferes with the impact of Fludarabine in Chronic Lymphocytic Leukemia by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, avoid foods like Adzuki Bean with Fludarabine treatment for Chronic Lymphocytic Leukemia (CLL).
Black-eyed Pea : Black-eyed Pea contains active ingredients such as Folic Acid, Genistein, Retinol and others. Folic Acid interferes with the impact of Fludarabine in Chronic Lymphocytic Leukemia by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, avoid foods like Black-eyed Pea with Fludarabine treatment for Chronic Lymphocytic Leukemia (CLL).
Foods to Eat with Fludarabine treatment
Arrowroot : Arrowroot contains active ingredients like Beta-carotene, Vitamin C and Quercetin. Intake of Beta-carotene along with Fludarabine treatment for Chronic Lymphocytic Leukemia causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Arrowroot hence should be eaten with Fludarabine treatment for Chronic Lymphocytic Leukemia. (G Sowmya Shree et al, Mol Cell Biochem., 2017; Etienne Moussay et al, Mol Cancer., 2010; Matthias Niedermeier et al, Blood., 2009)
Asparagus : Asparagus contains active ingredients like Isorhamnetin, Vitamin C and Quercetin. Intake of Isorhamnetin along with Fludarabine treatment for Chronic Lymphocytic Leukemia causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Asparagus hence should be eaten with Fludarabine treatment for Chronic Lymphocytic Leukemia. (Chuan Li et al, Mol Med Rep., 2014; Etienne Moussay et al, Mol Cancer., 2010; Matthias Niedermeier et al, Blood., 2009)
Should I take this Nutritional Supplement with Fludarabine treatment?
Black Seed : Black Seed has no known reported CYP (drug metabolizing enzyme) interactions with Fludarabine treatment. Black Seed supports the Fludarabine treatment for Chronic Lymphocytic Leukemia by decreasing the biochemical pathways such as Cell Survival, MAPK Signaling, MYC Signaling, Notch Signaling and PI3K-AKT-MTOR Signaling and increasing pathways like Cell Cycle Checkpoints, Apoptosis and RUNX Signaling.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Symptoms of Chronic Lymphocytic Leukemia?
In the initial stages, most cancers including Chronic Lymphocytic Leukemia may not cause any signs or symptoms. However, as the disease progresses, Chronic Lymphocytic Leukemia may start showing symptoms.
Following are some of the signs and symptoms that may be caused by Chronic Lymphocytic Leukemia.
- Frequent infections
- Pale skin
- Swollen glands in the neck, armpits or groin
- Swelling abdomen
- Easy bleeding and bruising
- Fever with a high temperature
- Night sweats
- Unintentional weight loss
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Chronic Lymphocytic Leukemia.
What are the Treatment Options for Chronic Lymphocytic Leukemia?
The treatment for Chronic Lymphocytic Leukemia may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, and whether the cancer was just diagnosed or had come back. The treatment options for Chronic Lymphocytic Leukemia include:
- Targeted drug therapy
- Bone marrow transplantation
As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Chronic Lymphocytic Leukemia (CLL).
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Chronic Lymphocytic Leukemia.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.