addonfinal2
What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Adrenocortical Carcinoma?

Jul 23, 2023

4.5
(33)
Estimated reading time: 13 minutes
Home » Blogs » Foods for Adrenocortical Carcinoma?

Introduction

Foods for Adrenocortical Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Adrenocortical carcinoma is a rare form of cancer that originates in the outer layer of the adrenal glands, which are located on top of the kidneys. Pathology outlines play a crucial role in understanding the characteristics and features of adrenocortical carcinoma, aiding in accurate diagnosis. Symptoms of adrenocortical carcinoma can vary, but they may include abdominal pain, weight gain, hormonal imbalances, and high blood pressure. Radiology techniques are used to visualize and assess adrenocortical carcinoma tumors. The survival rate for adrenocortical carcinoma depends on various factors, including the stage at diagnosis. Metastasis, or the spread of the tumor to other parts of the body, greatly affects the prognosis. Accurate coding using the ICD-10 system ensures proper documentation of adrenocortical carcinoma in medical records. Treatment for adrenocortical carcinoma typically involves a combination of surgery, chemotherapy, and targeted therapies, guided by treatment guidelines. Clinical trials provide opportunities to explore new therapeutic approaches and improve outcomes for patients with adrenocortical carcinoma. In some cases, adrenocortical carcinoma can be hereditary, emphasizing the importance of genetic screening and counseling. Understanding the causes and risk factors associated with adrenocortical carcinoma is crucial for prevention and early detection. The incidence of adrenocortical carcinoma is relatively low, making comprehensive management and specialized care essential. It is important to stay informed about the latest research and advancements in order to provide the best possible treatment options and support to individuals with adrenocortical carcinoma.



For Adrenocortical Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Adrenocortical Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Adrenocortical Carcinoma?

For example does it matter if vegetable Giant Butterbur is consumed more compared to Malabar Spinach? Does it make any difference if fruit Grapefruit is preferred over Pitanga? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Black-eyed Pea over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Adrenocortical Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Adrenocortical Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Adrenocortical Carcinoma can be characterized by a unique set of biochemical pathways - the signature pathways of Adrenocortical Carcinoma. Biochemical pathways like Cell Cycle, Nucleotide Metabolism, Small Molecule Transport, Focal Adhesion are part of the signature definition of Adrenocortical Carcinoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Grapefruit contains active ingredients Curcumin, Isoliquiritigenin, Lycopene, Lupeol, Phloretin. And Pitanga contains active ingredients Curcumin, Apigenin, Quercetin, Isoliquiritigenin, Lycopene and possibly others.

A common mistake made when deciding and choosing foods to eat for Adrenocortical Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Adrenocortical Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Adrenocortical Carcinoma?

Personalized nutrition for cancers like Adrenocortical Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Adrenocortical Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Adrenocortical Carcinoma

All cancers like Adrenocortical Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Adrenocortical Carcinoma. Biochemical pathways like Cell Cycle, Nucleotide Metabolism, Small Molecule Transport, Focal Adhesion are part of the signature definition of Adrenocortical Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Adrenocortical Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Adrenocortical Carcinoma when taking cancer treatment Cisplatin, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

CTNNB1, MUC16, FAT4, MEN1 and KMT2B are the top ranked reported genes for Adrenocortical Carcinoma. CTNNB1 is reported in 12.3 % of the representative patients across all clinical trials. And MUC16 is reported in 12.3 %. The combined population patient data cover ages from 1 to 88. 35.7 % of the patient data are identified as men. The Adrenocortical Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Adrenocortical Carcinoma!

Food and Supplements for Adrenocortical Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GIANT BUTTERBUR or MALABAR SPINACH?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Isoliquiritigenin, Lycopene, Lupeol. These active ingredients manipulate various biochemical pathways like JAK-STAT Signaling, NFKB Signaling, Cell Cycle and Epithelial to Mesenchymal Transition and others. Giant Butterbur is recommended for Adrenocortical Carcinoma when ongoing cancer treatment is Cisplatin. This is because Giant Butterbur modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cisplatin.

Some of the active ingredients or bioactives in vegetable Malabar Spinach are Curcumin, Apigenin, Quercetin, Isoliquiritigenin, Lycopene. These active ingredients manipulate various biochemical pathways like Oxidative Stress, Epithelial to Mesenchymal Transition and DNA Repair and others. Malabar Spinach is not recommended for Adrenocortical Carcinoma when ongoing cancer treatment is Cisplatin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER MALABAR SPINACH FOR Adrenocortical Carcinoma AND TREATMENT Cisplatin.

Choose Fruit PITANGA or GRAPEFRUIT?

Fruit Pitanga contains many active ingredients or bioactives such as Curcumin, Apigenin, Quercetin, Isoliquiritigenin, Lycopene. These active ingredients manipulate various biochemical pathways like Oxidative Stress, NFKB Signaling, Cell Cycle and Epithelial to Mesenchymal Transition and others. Pitanga is recommended for Adrenocortical Carcinoma when ongoing cancer treatment is Cisplatin. This is because Pitanga modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cisplatin.

Some of the active ingredients or bioactives in fruit Grapefruit are Curcumin, Isoliquiritigenin, Lycopene, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and others. Grapefruit is not recommended for Adrenocortical Carcinoma when ongoing cancer treatment is Cisplatin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT PITANGA IS RECOMMENDED OVER GRAPEFRUIT FOR Adrenocortical Carcinoma AND TREATMENT Cisplatin.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Isoliquiritigenin, Lycopene, Lupeol. These active ingredients manipulate various biochemical pathways like NFKB Signaling, JAK-STAT Signaling, Cell Cycle and Cell Cycle Checkpoints and others. Butternut is recommended for Adrenocortical Carcinoma when ongoing cancer treatment is Cisplatin. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cisplatin.

Some of the active ingredients or bioactives in European Chestnut are Curcumin, Apigenin, Quercetin, Ellagic Acid, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Oxidative Stress, Epithelial to Mesenchymal Transition and DNA Repair and others. European Chestnut is not recommended for Adrenocortical Carcinoma when ongoing cancer treatment is Cisplatin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Adrenocortical Carcinoma AND TREATMENT Cisplatin.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Adrenocortical Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable PEPPER (C. FRUTESCENS) or DAIKON RADISH?

Vegetable Pepper (c. Frutescens) contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Stem Cell Signaling, Epithelial to Mesenchymal Transition and Oncogenic Cancer Epigenetics and others. Pepper (c. Frutescens) is recommended for risk of Adrenocortical Carcinoma when associated genetic risk is CTNNB1. This is because Pepper (c. Frutescens) increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Daikon Radish are Curcumin, Apigenin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Vitamin D Signaling and DNA Repair and others. Daikon Radish is not recommended when risk of Adrenocortical Carcinoma when associated genetic risk is CTNNB1 because it increases the signature pathways of it.

VEGETABLE PEPPER (C. FRUTESCENS) IS RECOMMENDED OVER DAIKON RADISH FOR CTNNB1 GENETIC RISK OF CANCER.

Choose Fruit JAVA PLUM or PUMMELO?

Fruit Java Plum contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Stem Cell Signaling, Epithelial to Mesenchymal Transition and Oncogenic Cancer Epigenetics and others. Java Plum is recommended for risk of Adrenocortical Carcinoma when associated genetic risk is CTNNB1. This is because Java Plum increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Apigenin, Lupeol, Beta-sitosterol, Naringin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and DNA Repair and others. Pummelo is not recommended when risk of Adrenocortical Carcinoma when associated genetic risk is CTNNB1 because it increases the signature pathways of it.

FRUIT JAVA PLUM IS RECOMMENDED OVER PUMMELO FOR CTNNB1 GENETIC RISK OF CANCER.

Choose Nut CHIA or WALNUT?

Chia contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Epithelial to Mesenchymal Transition, Oncogenic Cancer Epigenetics and P53 Signaling and others. Chia is recommended for risk of Adrenocortical Carcinoma when associated genetic risk is CTNNB1. This is because Chia increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Walnut are Curcumin, Apigenin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like Vitamin D Signaling and Oncogenic Cancer Epigenetics and others. Walnut is not recommended when risk of Adrenocortical Carcinoma when associated genetic risk is CTNNB1 because it increases the signature pathways of it.

CHIA IS RECOMMENDED OVER WALNUT FOR CTNNB1 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Adrenocortical Carcinoma. Adrenocortical Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Adrenocortical Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Giant Butterbur contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Adrenocortical Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

You can also read this in

How useful was this post?

Click on a star to rate it!

Average rating 4.5 / 5. Vote count: 33

No votes so far! Be the first to rate this post.

As you found this post useful...

Follow us on social media!

We are sorry that this post was not useful for you!

Let us improve this post!

Tell us how we can improve this post?