No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Adrenocortical Carcinoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Ajwain and Aloe Vera should be eaten when undergoing Cisplatin treatment for Adrenocortical Carcinoma. On the same lines, avoid foods like Bilberry and Blueberry with treatment of Cisplatin for Adrenocortical Carcinoma.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Adrenocortical Carcinoma.
What is Adrenocortical Carcinoma?
Adrenocortical Carcinoma is a rare cancer that develops from the outer layer of the adrenal gland. The incidence rate of this cancer is only 4-12 cases per 10 lakh people per year. This cancer is commonly diagnosed in people who are about 40-50 years of age, however, it can occur in people of any age. It is more commonly found in females as compared to males.
Adrenocortical Carcinoma has prevalence of certain genetic changes. Some of the genes such as TP53, CTNNB1, MUC16, and PCDH15 are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Adrenocortical Carcinoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Adrenocortical Carcinoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Adrenocortical Carcinoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Adrenocortical Carcinoma nutrition may have to be redesigned.
Why Eating Right Matters for Adrenocortical Carcinoma?
In Adrenocortical Carcinoma, activation or inhibition of some of the biochemical pathways including WNT Beta Catenin Signaling, MYC Signaling, Epithelial To Mesenchymal Transition, MAPK Signaling, Hypoxia, Cell Cycle Checkpoints, Cancer Epigenetics, Small Molecule Transport, Focal Adhesion, P53 Signaling, NFKB Signaling, Vitamin D Signaling, Nutrient Sensing, PI3K-AKT-MTOR Signaling, Oxidative Stress, Amino Acid Metabolism, Apoptosis and Angiogenesis plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Adrenocortical Carcinoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Cisplatin treatment for Adrenocortical Carcinoma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Adrenocortical Carcinoma considering only one specific treatment- Cisplatin.
Foods to Avoid with Cisplatin treatment
Bilberry : Bilberry contains active ingredients such as Resveratrol, Asperuloside, Caffeic Acid and others. Resveratrol interferes with the impact of Cisplatin in Adrenocortical Carcinoma by blocking a specific biochemical pathway called P53 Signaling. Hence, avoid foods like Bilberry with Cisplatin treatment for Adrenocortical Carcinoma.
Blueberry : Blueberry contains active ingredients such as Pelargonidin, Vitamin C, Cianidanol and others. Pelargonidin interferes with the impact of Cisplatin in Adrenocortical Carcinoma by activating a specific biochemical pathway called NFKB Signaling. Hence, avoid foods like Blueberry with Cisplatin treatment for Adrenocortical Carcinoma.
Foods to Eat with Cisplatin treatment
Ajwain : Ajwain contains active ingredients like Chlorogenic Acid, Stigmasterol and Oleic Acid. Intake of Chlorogenic Acid along with Cisplatin treatment for Adrenocortical Carcinoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Ajwain hence should be eaten with Cisplatin treatment for Adrenocortical Carcinoma. (Xiaokang Wang et al, J Pharm Pharmacol., 2019; Lei Duan et al, Cancer Biol Ther., 2014)
Aloe Vera : Aloe Vera contains active ingredients like Lupeol, Acemannan and Barbaloin. Intake of Lupeol along with Cisplatin treatment for Adrenocortical Carcinoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Aloe Vera hence should be eaten with Cisplatin treatment for Adrenocortical Carcinoma. (Lingli Zhang et al, Eur J Pharmacol., 2015; Lei Duan et al, Cancer Biol Ther., 2014)
Should I take this Nutritional Supplement with Cisplatin treatment?
Vitamin C : Vitamin C has no known reported CYP (drug metabolizing enzyme) interactions with Doxorubicin treatment. Vitamin C supports the Doxorubicin treatment for Adrenocortical Carcinoma by decreasing the biochemical pathways such as Angiogenesis, Cancer Epigenetics, WNT Beta Catenin Signaling, Epithelial to Mesenchymal Transition, MAPK Signaling, Hypoxia, PI3K-AKT-MTOR Signaling, MYC Signaling, Amino Acid Metabolism and increasing pathways like Nutrient sensing, Cell Cycle Checkpoints, Apoptosis, Oxidative Stress, P53 Signaling, Vitamin D Signaling.
What are the Symptoms of Adrenocortical Carcinoma?
In the initial stages, most cancers including Adrenocortical Carcinoma may not cause any signs or symptoms. However, as the disease progresses, Adrenocortical Carcinoma may start showing symptoms.
Following are some of the signs and symptoms that may be caused by Adrenocortical Carcinoma.
- Stomach or Back Pain
- Feeling of fullness in the abdomen
- Lump in the abdomen
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Adrenocortical Carcinoma.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
What are the Treatment Options for Adrenocortical Carcinoma?
The treatment for Adrenocortical Carcinoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, and whether the cancer was just diagnosed or had come back. The treatment options for Adrenocortical Carcinoma include:
- Radiation Therapy
As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Adrenocortical Carcinoma.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Adrenocortical Carcinoma.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.