Nutritional supplements like Pycnogenol have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Pycnogenol supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Pycnogenol supplements can benefit cancer patients with Relapsed Refractory Diffuse Large B-Cell Lymphoma (DLBCL- Relapsed Refractory) on Prednisone treatment. But avoid Pycnogenol supplements if on Ifosfamide treatment for Seminoma. Similarly, taking nutritional supplement Pycnogenol can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene MLH1. But avoid taking nutritional supplement Pycnogenol when at genetic risk of cancer due to mutation of gene TERT.
The takeaway being – your individual context will influence your decision if nutritional supplement Pycnogenol is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Pycnogenol based on individual context and conditions.
So the question is should you take the supplement Pycnogenol? Should you take it when at genetic risk of cancer for mutation of gene TERT? Should you take it when at genetic risk of cancer for mutation of gene MLH1? Should you take it when diagnosed with Seminoma? Should you take Pycnogenol supplements when diagnosed with Relapsed Refractory Diffuse Large B-Cell Lymphoma (DLBCL- Relapsed Refractory)? Should you take it when on Ifosfamide treatment? Should you continue taking Pycnogenol supplements if you change your treatment from Ifosfamide to Prednisone? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Pycnogenol.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Seminoma or Relapsed Refractory Diffuse Large B-Cell Lymphoma (DLBCL- Relapsed Refractory), the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Pycnogenol.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Pycnogenol? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene TERT the same as due to mutation of gene MLH1? Are the implications of taking Pycnogenol supplements in Seminoma same as Relapsed Refractory Diffuse Large B-Cell Lymphoma (DLBCL- Relapsed Refractory)? Is it one and the same if you are on treatment with Ifosfamide or on Prednisone?
Pycnogenol – A Nutritional Supplement
Pycnogenol is the US registered trademark name for an extract derived from French maritime pine bark (Pinus pinaster). It has antioxidant and anti-inflammatory properties and is hence used as a dietary supplement for various health conditions. Following are some of the potential health benefits of Pycnogenol:
- May help with wound healing (G Blazsó et al, Phytother Res., 2004)
- May help reduce risk of cardiovascular diseases (Roberta Luzzi et al, Minerva Ginecol., 2017)
- May help reduce skin aging (A Marini et al, Skin Pharmacol Physiol., 2012)
- May help relieve symptoms related to Attention Deficit/Hyperactivity Disorder (ADHD) (Jana Trebatická et al, Eur Child Adolesc Psychiatry., 2006)
- May be beneficial for reducing Metabolic Syndrome and Related Disorders (Om P Gulati, Phytother Res., 2015)
The molecular pathways which are regulated by Pycnogenol include Apoptosis, MYC Signaling and PI3K-AKT-MTOR Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Pycnogenol individually or in combination is an important decision to be made. When making decisions on the use of supplement Pycnogenol for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Pycnogenol use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Pycnogenol Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Pycnogenol for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Pycnogenol may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Pycnogenol should be avoided or not and why.
1. Will Pycnogenol Supplements benefit Cancer Patients with Seminoma undergoing Ifosfamide treatment?
Seminoma is characterized and driven by specific genetic mutations like KIT and KRAS leading to specific biochemical pathway changes. A cancer treatment like Ifosfamide works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Pycnogenol should be avoided for Seminoma along with treatment of Ifosfamide. Pycnogenol impacts specific pathways which either promote drivers of the disease and/or nullify the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Pycnogenol Supplements benefit Cancer Patients with Relapsed Refractory Diffuse Large B-Cell Lymphoma (DLBCL- Relapsed Refractory) undergoing Prednisone Treatment?
Relapsed Refractory Diffuse Large B-Cell Lymphoma (DLBCL- Relapsed Refractory) is characterized and driven by specific genetic mutations like CREBBP and KMT2D leading to specific biochemical pathway changes. A cancer treatment like Prednisone works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Pycnogenol supplements should be considered for Relapsed Refractory Diffuse Large B-Cell Lymphoma (DLBCL- Relapsed Refractory) along with treatment Prednisone. Pycnogenol supplements impact specific pathways which either obstruct drivers of DLBCL (Relapsed Refractory) and/or improve Prednisone treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Pycnogenol Supplements Safe for Healthy Individuals with TERT Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. TERT is one of the genes generally available in panels for cancer risk testing.
TERT mutation causes biochemical pathways/processes like Apoptosis, RUNX Signaling, Stem Cell Signaling, Cell Cycle Checkpoints and JAK-STAT Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Pycnogenol should be avoided when the genetic panel identifies mutation of TERT for Hematological Cancer. Pycnogenol impacts pathways/processes like Apoptosis and RUNX Signaling and creates adverse effects with TERT and related conditions.
4. Are Pycnogenol Supplements Safe for Healthy Individuals with MLH1 Mutation Associated Genetic Risk?
MLH1 is one of the genes available in panels for cancer risk testing. MLH1 mutation causes biochemical pathways/processes like MYC Signaling, PI3K-AKT-MTOR Signaling, Stem Cell Signaling, Lipid Metabolism and P53 Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Pycnogenol supplements when the genetic panel identifies mutation in MLH1 for Ovarian Cancer and Colon Cancer. Pycnogenol impacts pathways/processes like MYC Signaling and PI3K-AKT-MTOR Signaling and creates a supportive effect in those with MLH1 mutation and related conditions.
* Other Factors are also included like BMI, Treatments, Lifestyle Habits
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Pycnogenol, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.