addonfinal2

What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

5
(1)

Which 3 Foods to Avoid for Myeloproliferative Neoplasms (MPNs)?

Aug 12, 2021

Estimated reading time: 7 minutes
Home » Blogs » Which 3 Foods to Avoid for Myeloproliferative Neoplasms (MPNs)?

Highlights

No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Myeloproliferative Neoplasms (MPNs) needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.

Foods like Aloe Vera and Arrowroot should be eaten when undergoing Cyclophosphamide treatment for Myeloproliferative Neoplasms (MPNs). On the same lines, avoid foods like Acorn and Black-eyed Pea with treatment of Cyclophosphamide for Myeloproliferative Neoplasms (MPNs). Similarly, Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Cyclophosphamide treatment and hence should be avoided.

You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Myeloproliferative Neoplasms (MPNs).



What is Myeloproliferative Neoplasms (MPNs)?

Myeloproliferative Neoplasms (MPNs) is a group of diseases arising due to abnormally high production of red blood cells, white blood cells or platelets by the bone marrow. The most common MPNs include Polycythemia Vera (PV), Essential Thrombocythemia (ET), and Primary Myelofibrosis (PMF). The incidence rates of Polycythemia Vera (PV), Essential Thrombocythemia (ET), and Primary Myelofibrosis (PMF) are 0.84, 1.03, and 0.47 respectively per 1 lakh people per year. This cancer is commonly diagnosed in people above the age of 50 years, however, it can occur in people of any age. 

Symptoms, diet, treatment for Myeloproliferative Neoplasms MPNs

Myeloproliferative Neoplasms (MPNs) has prevalence of certain genetic changes. Some of the genes such as JAK2, CALR, TET2, and ASXL1 are known to have genetic abnormalities in this cancer resulting in a change of function. 

The genetic abnormalities found in Myeloproliferative Neoplasms (MPNs) can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Myeloproliferative Neoplasms (MPNs). Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Myeloproliferative Neoplasms (MPNs) genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing a diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Myeloproliferative Neoplasms (MPNs) nutrition may have to be redesigned.

Why Eating Right Matters for Myeloproliferative Neoplasms (MPNs)?

In Myeloproliferative Neoplasms (MPNs), activation or inhibition of some of the biochemical pathways including MAPK Signaling, MYC Signaling, Angiogenesis, Epithelial To Mesenchymal Transition, P53 Signaling, DNA Repair, Hypoxia, Cytokine Signaling, JAK-STAT Signaling and Hematopoiesis plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Myeloproliferative Neoplasms (MPNs), eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.

Example Foods to “Not Eat” and Eat with Cyclophosphamide treatment for Myeloproliferative Neoplasms (MPNs)

The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Myeloproliferative Neoplasms (MPNs) considering only one specific treatment – Cyclophosphamide.

Foods to eat and avoid for Myeloproliferative Neoplasms (MPNs)

Foods to Avoid

Acorn : Acorn contains active ingredients such as Folic Acid, Retinol and others. Folic Acid interferes with the impact of Cyclophosphamide in Myeloproliferative Neoplasms (MPNs) by activating a specific biochemical pathway called MYC Signaling. Hence, avoid foods like Acorn with Cyclophosphamide treatment for Myeloproliferative Neoplasms (MPNs). 

Black-eyed Pea : Black-eyed Pea contains active ingredients such as Genistein, Folic Acid, Retinol and others. Genistein interferes with the impact of Cyclophosphamide in Myeloproliferative Neoplasms (MPNs) by activating a specific biological process called DNA Repair. Hence, avoid foods like Black-eyed Pea with Cyclophosphamide treatment for Myeloproliferative Neoplasms (MPNs). 

Foods to Eat

Aloe Vera :  Aloe Vera contains active ingredients like Barbaloin, Acemannan and Chrysophanol. Intake of Barbaloin along with Cyclophosphamide treatment for Myeloproliferative Neoplasms (MPNs) causes a decrease  in a specific biochemical pathway which is called  MYC Signaling, and this is a very positive effect. Aloe Vera hence should be eaten with Cyclophosphamide treatment for Myeloproliferative Neoplasms (MPNs). (Qin Pan et al, Cancer Cell Int., 2013; Nalan Akyurek et al, Cancer., 2012; M Dolores Delgado et al, Clin Transl Oncol., 2013)

Arrowroot :  Arrowroot contains active ingredients like Beta-carotene, Vanillic Acid, Chlorogenic Acid. Intake of Beta-carotene along with Cyclophosphamide treatment for Myeloproliferative Neoplasms (MPNs) causes a decrease  in a specific biochemical pathway which is called  Angiogenesis, and this is a very positive effect.  Arrowroot hence should be eaten with Cyclophosphamide treatment for Myeloproliferative Neoplasms (MPNs). (C Guruvayoorappan and Girija Kuttan, Integr Cancer Ther., 2007; Michael Medinger and Jakob Passweg, Swiss Med Wkly., 2014)

Should I take this Nutritional Supplement for Myeloproliferative Neoplasms (MPNs)?

Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Cyclophosphamide treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Cyclophosphamide treatment efficacy in Myeloproliferative Neoplasms (MPNs). (Ahmed A Albassam et al, Saudi Pharm J., 2018; Pius S Fasinu et al, Front Oncol., 2019)

What are the Symptoms of Myeloproliferative Neoplasms (MPNs)?

In the initial stages, most cancers including Myeloproliferative Neoplasms (MPNs) may not cause any signs or symptoms. However, as the disease progresses, Myeloproliferative Neoplasms (MPNs) may start showing symptoms. 

Following are some of the signs and symptoms that may be caused by Myeloproliferative Neoplasms (MPNs).

  • Tiredness or fatigue
  • Breathlessness
  • Easy bruising or unusual bleeding
  • Frequent headaches
  • Frequent infections
  • Vision problems
  • Ringing in the ears

Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Myeloproliferative Neoplasms (MPNs).

Science of Right Personalized Nutrition for Cancer

What are the Treatment Options for Myeloproliferative Neoplasms (MPNs)?

The treatment for Myeloproliferative Neoplasms (MPNs) may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, and whether the cancer was just diagnosed or had come back. The treatment options for Myeloproliferative Neoplasms (MPNs) include:

  • Blood transfusions
  • Phlebotomy to remove excess red blood cells
  • Chemotherapy
  • Radiation therapy
  • Surgery (to remove enlarged spleen)
  • Immunotherapy
  • Targeted therapy
  • Stem cell transplant

As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Myeloproliferative Neoplasms (MPNs).

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Myeloproliferative Neoplasms (MPNs).

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


You can also read this in

How useful was this post?

Click on a star to rate it!

Average rating 5 / 5. Vote count: 1

No votes so far! Be the first to rate this post.

As you found this post useful...

Follow us on social media!

We are sorry that this post was not useful for you!

Let us improve this post!

Tell us how we can improve this post?