addonfinal2

What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

0
(0)

Which 3 Foods to Avoid for Hepatocellular Carcinoma?

Aug 12, 2021

Estimated reading time: 8 minutes
Home » Blogs » Which 3 Foods to Avoid for Hepatocellular Carcinoma?

Highlights

No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Hepatocellular Carcinoma (Liver Cancer) needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.

Foods like Ajwain and Aloe Vera should be eaten when undergoing Sorafenib treatment for Hepatocellular Carcinoma (Liver Cancer) . On the other hand, for Hepatocellular Carcinoma, Adzuki Bean and Apple should be eaten with treatment of Bevacizumab. On the same lines, avoid foods like Acorn and Carob with treatment of Sorafenib for Hepatocellular Carcinoma (Liver Cancer) . If the treatment is Bevacizumab, then avoid Agave and Black-eyed Pea.

Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Sorafenib treatment and hence should be avoided.

You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Hepatocellular Carcinoma.



What is Hepatocellular Carcinoma?

Hepatocellular Carcinoma is a cancer that develops in the liver. The incidence rate of this cancer is only 9.3 per 1 lakh people per year. This cancer is commonly diagnosed in people aged above 40 years, however, it can occur in people of any age. It is more commonly found in men as compared to women.

Symptoms, diet, treatment for rare cancer - Hepatocellular Carcinoma

Hepatocellular Carcinoma has prevalence of certain genetic changes. Some of the genes such as TP53, CTNNB1, MUC16, and ALB are known to have genetic abnormalities in this cancer resulting in a change of function. 

The genetic abnormalities found in Hepatocellular Carcinoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment.  In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Hepatocellular Carcinoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Hepatocellular Carcinoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Hepatocellular Carcinoma nutrition may have to be redesigned.

Why Eating Right Matters for Hepatocellular Carcinoma (Liver Cancer)?

In Hepatocellular Carcinoma, activation or inhibition of some of the biochemical pathways including Myc Signaling, TGFB Signaling, Cytoskeletal Dynamics, Angiogenesis, WNT Beta Catenin Signaling, MAPK Signaling, Small Molecule Transport, Cytokine Signaling, Notch Signaling, PI3K-AKT-MTOR Signaling, Cancer Epigenetics, Epithelial To Mesenchymal Transition, Extracellular Matrix Remodelling, Focal Adhesion and Chemokine Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Hepatocellular Carcinoma (Liver Cancer), eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.

Example Foods to “Not Eat” and Eat with Sorafenib treatment for Hepatocellular Carcinoma (Liver Cancer)

The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show changes in nutrition/diet for Hepatocellular Carcinoma considering only the treatment changes.

Foods to Avoid

Acorn : Acorn contains active ingredients such as Folic Acid, Retinol and others. Folic Acid interferes with the impact of Sorafenib in Hepatocellular Carcinoma by activating a specific biochemical pathway called MAPK Signaling. Hence, avoid foods like Acorn with Sorafenib treatment for Hepatocellular Carcinoma (Liver Cancer). 

Carob : Carob contains active ingredients such as Palmitic Acid, Folic Acid, Gallic Acid and others. Palmitic Acid interferes with the impact of Sorafenib in Hepatocellular Carcinoma by activating a specific biochemical pathway called MAPK Signaling. Hence, avoid foods like Carob with Sorafenib treatment for Hepatocellular Carcinoma (Liver Cancer). 

Foods to Eat

Ajwain :  Ajwain contains active ingredients like Stigmasterol, Beta-sitosterol and Linolenic Acid. Intake of Stigmasterol along with Sorafenib treatment for Hepatocellular Carcinoma causes a decrease  in a specific biochemical pathway which is called  MAPK Signaling, and this is a very positive effect.  Ajwain hence should be eaten with Sorafenib treatment for Hepatocellular Carcinoma. (Hyocheol Bae et al, Pharmaceutics., 2020; Hyuk Moon and Simon Weonsang Ro, Cancers (Basel)., 2021)

Aloe VeraAloe Vera contains active ingredients like Barbaloin, Acemannan and Lupeol. Intake of Barbaloin along with Sorafenib treatment for Hepatocellular Carcinoma causes a decrease  in a specific biochemical pathway which is called  MAPK Signaling, and this is a very positive effect.  Aloe Vera hence should be eaten with Sorafenib treatment for Hepatocellular Carcinoma. (Zhang Zhang et al, Oncol Rep., 2017; Hyuk Moon and Simon Weonsang Ro, Cancers (Basel)., 2021)

Should I take this Nutritional Supplement for Hepatocellular Carcinoma?

Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Sorafenib treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Sorafenib treatment efficacy in Hepatocellular Carcinoma. (Ahmed A Albassam et al, Saudi Pharm J., 2018; Sussan Ghassabian et al, Biochem Pharmacol., 2012)

Foods to eat and avoid for Hepatocellular carcinoma

Example Foods to “Not Eat” and Eat with Bevacizumab treatment for Hepatocellular Carcinoma (Liver Cancer)

Foods to Avoid

Agave : Agave contains active ingredients such as Retinol and others. Retinol interferes with the impact of Bevacizumab in Hepatocellular Carcinoma by activating a specific biochemical pathway called Focal Adhesion. Hence, avoid foods like Agave with Bevacizumab treatment for Hepatocellular Carcinoma. 

Black-eyed Pea : Black-eyed Pea contains active ingredients such as Retinol, Folic Acid, Genistein and others. Retinol interferes with the impact of Bevacizumab in Hepatocellular Carcinoma by activating a specific biochemical pathway called Focal Adhesion. Hence, avoid foods like Black-eyed Pea with Bevacizumab treatment for Hepatocellular Carcinoma. 

Foods to Eat

Adzuki Bean : Adzuki Bean contains active ingredients like Genistein, Folic Acid and Isoliquiritigenin. Intake of Genistein along with Bevacizumab treatment for Hepatocellular Carcinoma causes a decrease  in a specific biochemical pathway which is called  PI3K-AKT-MTOR Signaling, and this is a very positive effect. Adzuki Bean hence should be eaten with Bevacizumab treatment for Hepatocellular Carcinoma. (Pariyada Tanjak et al, Int J Oncol., 2018; Yan Gu et al, World J Gastroenterol., 2005)

Apple :  Apple contains active ingredients like Chlorogenic Acid, Rutin and Uvaol. Intake of Chlorogenic Acid along with Bevacizumab treatment for Hepatocellular Carcinoma causes a decrease  in a specific biochemical pathway which is called  PI3K-AKT-MTOR Signaling, and this is a very positive effect.  Apple hence should be eaten with Bevacizumab treatment for Hepatocellular Carcinoma. (Xiaokang Wang et al, J Pharm Pharmacol., 2019; Qian Zhou et al, Future Oncol., 2011)

Should I take this Nutritional Supplement for Hepatocellular Carcinoma?

Black Seed : Black Seed has no known reported CYP (drug metabolizing enzyme) interactions with Bevacizumab treatment. Black Seed supports the Bevacizumab treatment for Hepatocellular Carcinoma by decreasing the biochemical pathways/processes called Angiogenesis, Chemokine Signaling, Extracellular Matrix Remodelling, Epithelial to Mesenchymal Transition, MAPK Signaling, Focal Adhesion, Cytokine Signaling, MYC Signaling, Notch Signaling, PI3K-AKT-MTOR Signaling, TGFB Signaling, Cytoskeletal Dynamics, WNT Beta Catenin Signaling, Cancer Epigenetics. 

What are the Symptoms of Hepatocellular Carcinoma?

In the initial stages, for some patients, most cancers including Hepatocellular Carcinoma may not cause any signs or symptoms. However, as the disease progresses, Hepatocellular Carcinoma may start showing symptoms. Following are some of the signs and symptoms that may be caused by Hepatocellular Carcinoma.

  • Weakness and fatigue
  • Unintentional weight loss
  • Nausea and vomiting
  • Swelling in the stomach
  • Upper abdominal pain
  • Loss of appetite
  • Jaundice
  • White or pale stools

Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Hepatocellular Carcinoma.

Science of Right Personalized Nutrition for Cancer

What are the Treatment Options for Hepatocellular Carcinoma?

The treatment for Hepatocellular Carcinoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Hepatocellular Carcinoma include:

  • Surgery
  • Radiation Therapy
  • Targeted Therapy
  • Chemotherapy
  • Immunotherapy

As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Hepatocellular Carcinoma.

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Hepatocellular Carcinoma.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


You can also read this in

How useful was this post?

Click on a star to rate it!

Average rating 0 / 5. Vote count: 0

No votes so far! Be the first to rate this post.

As you found this post useful...

Follow us on social media!

We are sorry that this post was not useful for you!

Let us improve this post!

Tell us how we can improve this post?