No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Endometrial Carcinoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Aloe Vera and Bamboo should be eaten when undergoing Anastrozole treatment for Endometrial Carcinoma. On the same lines, avoid foods like Acorn and Buttermilk with treatment of Anastrozole for Endometrial Carcinoma. Similarly, Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Anastrozole treatment and hence should be avoided.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Endometrial Carcinoma.
What is Endometrial Carcinoma?
Endometrial Carcinoma is a cancer that develops in the uterus. The incidence rate of this cancer is only 28.1 per 1 lakh women per year. This cancer is commonly diagnosed in women who are about 60 years of age, however, it can occur in people of any age. It is more commonly found in White women as compared to women in the Black population, however, the latter is more likely to die from this cancer.
Endometrial Carcinoma has prevalence of certain genetic changes. Some of the genes such as PTEN, PIK3CA, ARID1A, and TP53 are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Endometrial Carcinoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Endometrial Carcinoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Endometrial Carcinoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Endometrial Carcinoma nutrition may have to be redesigned.
Why Eating Right Matters for Endometrial Carcinoma?
In Endometrial Carcinoma, activation or inhibition of some of the biochemical pathways including MYC Signaling, Amino Acid Metabolism, MAPK Signaling, Hypoxia, Small Molecule Transport, Cell Cycle, HIPPO Signaling, P53 Signaling, NFKB Signaling, Vitamin D Signaling, PI3K-AKT-MTOR Signaling, Oxidative Stress, Angiogenesis, Growth Factor Signaling, Vitamin Metabolism and Epithelial To Mesenchymal Transition plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Endometrial Carcinoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Anastrozole treatment for Endometrial Carcinoma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Endometrial Carcinoma considering only one specific treatment- Anastrozole.
Foods to Avoid with Anastrozole treatment
Acorn : Acorn contains active ingredients such as Folic Acid, Retinol and others. Folic Acid interferes with the impact of Anastrozole in Endometrial Carcinoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, avoid foods like Acorn with Anastrozole treatment for Endometrial Carcinoma. (2566606, 2566606, 24663045, 22484466, 27382432)
Buttermilk : Buttermilk contains active ingredients such as Myristic Acid, Lauric Acid, Vitamin D3 and others. Myristic Acid interferes with the impact of Anastrozole in Endometrial Carcinoma by activating a specific biochemical pathway called MAPK Signaling. Hence, avoid foods like Buttermilk with Anastrozole treatment for Endometrial Carcinoma.
Foods to Eat with Anastrozole treatment
Aloe Vera : Aloe Vera contains active ingredients like Barbaloin, Acemannan, Lupeol. Intake of Barbaloin along with Anastrozole treatment for Endometrial Carcinoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Aloe Vera hence should be eaten with Anastrozole treatment for Endometrial Carcinoma. (Kangfeng Jiang et al, Int Immunopharmacol., 2018; Andrea Cavazzoni et al, Cancer Lett., 2012; Felicia Roncolato et al, Cochrane Database Syst Rev., 2019)
Bamboo : Bamboo contains active ingredients like Beta-sitosterol, Vitamin C, Oleic Acid. Intake of Beta-sitosterol along with Anastrozole treatment for Endometrial Carcinoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Bamboo hence should be eaten with Anastrozole treatment for Endometrial Carcinoma. (Zhang-Qi Cao et al, Front Pharmacol., 2019, Andrea Cavazzoni et al, Cancer Lett., 2012; Felicia Roncolato et al, Cochrane Database Syst Rev., 2019)
Should I take this Nutritional Supplement with Anastrozole treatment?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Anastrozole treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Anastrozole treatment efficacy in Endometrial Carcinoma. (Ahmed A Albassam et al, Saudi Pharm J., 2018; Landry K Kamdem et al, Br J Clin Pharmacol., 2010)
What are the Symptoms of Endometrial Carcinoma?
In the initial stages, most cancers including Endometrial Carcinoma may not cause any signs or symptoms. However, as the disease progresses, Endometrial Carcinoma may start showing symptoms.
Following are some of the signs and symptoms that may be caused by Endometrial Carcinoma.
- Bleeding from the vagina post menopause
- Pelvic pain
- Abnormal bleeding in between periods
- Unexpected weight loss
- Pain during intercourse
- Painful urination
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Endometrial Carcinoma.
What are the Treatment Options for Endometrial Carcinoma?
The treatment for Endometrial Carcinoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Endometrial Carcinoma include:
- Radiation therapy
- Hormone therapy
- Targeted drug therapy
Surgery to remove the uterus, fallopian tubes and ovaries is the most common treatment regimen for Endometrial Carcinoma. As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Endometrial Carcinoma.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Endometrial Carcinoma.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.