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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Burkitt Lymphoma!

Aug 4, 2023

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Introduction

Foods for Burkitt Lymphoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Burkitt lymphoma is an aggressive form of cancer that primarily affects the lymphatic system. It is characterized by rapidly dividing cancerous cells and progression in the bone marrow and central nervous system. The translocation of chromosomes, particularly 8 and 14, is a defining feature of Burkitt lymphoma. Epstein-Barr virus (EBV) infection is closely associated with Burkitt lymphoma in some cases. Symptoms of Burkitt lymphoma include nausea, vomiting, loss of apetite, abdominal pain, masses in the jaw, renal failure, headaches, visual impairment, night sweats, weight loss, fatigue, enlarged lymph nodes and possibly gastrointestinal bleeding or intestinal perforation. Treatment options for Burkitt lymphoma typically involve intensive chemotherapy regimens. Proper management of Burkitt lymphoma requires a multidisciplinary approach involving oncologists, hematologists, and other healthcare professionals. The survival rate for Burkitt lymphoma varies depending on factors such as the stage of the cancer and the patient’s overall health. The prognosis for about 90% of pediatric patients and 50-60% of adult patients is doo with long-term survival expected if the patient is quickly diagnosed and treated appropriately with chemotherapy.



For Burkitt Lymphoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Burkitt Lymphoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Burkitt Lymphoma?

For example does it matter if vegetable Celery Stalks is consumed more compared to Horned Melon? Does it make any difference if fruit Ohelo Berry is preferred over Red Raspberry? Also if similar choices are made for nuts/seeds like Common Hazelnut over Flaxseed and for pulses like Broad Bean over Adzuki Bean. And if what I eat matters – then how does one identify foods which are recommended for Burkitt Lymphoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Burkitt Lymphoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Burkitt Lymphoma can be characterized by a unique set of biochemical pathways - the signature pathways of Burkitt Lymphoma. Biochemical pathways like Apoptosis, Cell Cycle, PI3K-AKT-MTOR Signaling, Chromatin Remodeling are part of the signature definition of Burkitt Lymphoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Ohelo Berry contains active ingredients Apigenin, Curcumin, Lycopene, Lupeol, Phloretin. And Red Raspberry contains active ingredients Curcumin, Ellagic Acid, Quercetin, Lupeol, Phloretin and possibly others.

A common mistake made when deciding and choosing foods to eat for Burkitt Lymphoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Burkitt Lymphoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Burkitt Lymphoma?

Personalized nutrition for cancers like Burkitt Lymphoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Burkitt Lymphoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Burkitt Lymphoma

All cancers like Burkitt Lymphoma can be characterized by a unique set of biochemical pathways – the signature pathways of Burkitt Lymphoma. Biochemical pathways like Apoptosis, Cell Cycle, PI3K-AKT-MTOR Signaling, Chromatin Remodeling are part of the signature definition of Burkitt Lymphoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Burkitt Lymphoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Burkitt Lymphoma when taking cancer treatment Prednisone, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

MYC, ID3, TP53, CCND3 and SMARCA4 are the top ranked reported genes for Burkitt Lymphoma. MYC is reported in 41.1 % of the representative patients across all clinical trials. And ID3 is reported in 31.5 %. The combined population patient data cover ages from 4 to 18. 94.1 % of the patient data are identified as men. The Burkitt Lymphoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Burkitt Lymphoma!

Food and Supplements for Burkitt Lymphoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CELERY STALKS or HORNED MELON?

Vegetable Celery Stalks contains many active ingredients or bioactives such as Apigenin, Curcumin, Lycopene, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like NFKB Signaling, Cell Cycle, Notch Signaling and Apoptosis and others. Celery Stalks is recommended for Burkitt Lymphoma when ongoing cancer treatment is Prednisone. This is because Celery Stalks modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Prednisone.

Some of the active ingredients or bioactives in vegetable Horned Melon are Apigenin, Curcumin, Lycopene, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like TWEAK Signaling and others. Horned Melon is not recommended for Burkitt Lymphoma when ongoing cancer treatment is Prednisone because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CELERY STALKS IS RECOMMENDED OVER HORNED MELON FOR Burkitt Lymphoma AND TREATMENT Prednisone.

Choose Fruit RED RASPBERRY or OHELO BERRY?

Fruit Red Raspberry contains many active ingredients or bioactives such as Curcumin, Ellagic Acid, Quercetin, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like NFKB Signaling, Cell Cycle, MAPK Signaling and MYC Signaling and others. Red Raspberry is recommended for Burkitt Lymphoma when ongoing cancer treatment is Prednisone. This is because Red Raspberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Prednisone.

Some of the active ingredients or bioactives in fruit Ohelo Berry are Apigenin, Curcumin, Lycopene, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like TWEAK Signaling and others. Ohelo Berry is not recommended for Burkitt Lymphoma when ongoing cancer treatment is Prednisone because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RED RASPBERRY IS RECOMMENDED OVER OHELO BERRY FOR Burkitt Lymphoma AND TREATMENT Prednisone.

Choose Nut COMMON HAZELNUT or FLAXSEED?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Lycopene, Quercetin, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like NFKB Signaling, Cell Cycle, MAPK Signaling and Apoptosis and others. Common Hazelnut is recommended for Burkitt Lymphoma when ongoing cancer treatment is Prednisone. This is because Common Hazelnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Prednisone.

Some of the active ingredients or bioactives in Flaxseed are Apigenin, Curcumin, Lupeol, Phloretin, Daidzein. These active ingredients manipulate various biochemical pathways like MAPK Signaling, NFKB Signaling and TWEAK Signaling and others. Flaxseed is not recommended for Burkitt Lymphoma when ongoing cancer treatment is Prednisone because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

COMMON HAZELNUT IS RECOMMENDED OVER FLAXSEED FOR Burkitt Lymphoma AND TREATMENT Prednisone.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Burkitt Lymphoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or TURNIP?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Phloretin. These active ingredients manipulate various biochemical pathways like Cell Cycle, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints and Apoptosis and others. Giant Butterbur is recommended for risk of Burkitt Lymphoma when associated genetic risk is CCND3. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Turnip are Curcumin, Lupeol, Daidzein, Indole-3-carbinol, Ellagic Acid. These active ingredients manipulate various biochemical pathways like TGFB Signaling and MAPK Signaling and others. Turnip is not recommended when risk of Burkitt Lymphoma when associated genetic risk is CCND3 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER TURNIP FOR CCND3 GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Phloretin. These active ingredients manipulate various biochemical pathways like Cell Cycle, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints and Apoptosis and others. Nance is recommended for risk of Burkitt Lymphoma when associated genetic risk is CCND3. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Lupeol, Daidzein, Phloretin. These active ingredients manipulate various biochemical pathways like Amino Acid Metabolism, Cell Cycle Checkpoints and TGFB Signaling and others. Pummelo is not recommended when risk of Burkitt Lymphoma when associated genetic risk is CCND3 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR CCND3 GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or CHESTNUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Daidzein, Phloretin. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Stem Cell Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling and others. Butternut is recommended for risk of Burkitt Lymphoma when associated genetic risk is CCND3. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Apigenin, Curcumin, Lupeol, Daidzein, Ellagic Acid. These active ingredients manipulate various biochemical pathways like Amino Acid Metabolism, Cell Cycle Checkpoints and TGFB Signaling and others. Chestnut is not recommended when risk of Burkitt Lymphoma when associated genetic risk is CCND3 because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER CHESTNUT FOR CCND3 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Burkitt Lymphoma. Burkitt Lymphoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Burkitt Lymphoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Celery Stalks contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Burkitt Lymphoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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