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What Foods are Recommended for Cancer?
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Foods for Uterine Sarcoma!

Aug 2, 2023

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Introduction

Foods for Uterine Sarcoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Uterine sarcoma is a rare type of cancer that forms in the muscles and supporting tissues of the uterus. Recognizing the symptoms of uterine sarcoma early is crucial for timely diagnosis and treatment. These symptoms, however, can often be nonspecific, making radiology and ultrasound essential tools in the diagnostic process, as they help distinguish uterine sarcoma from benign conditions like fibroids, as seen in uterine sarcoma vs fibroid ultrasound comparisons. The diagnosis of uterine sarcoma, as outlined in its pathology outlines and confirmed through various imaging techniques, is crucial for staging the cancer and planning the appropriate treatment.

The staging of uterine sarcoma, which typically follows specific guidelines, is vital in assessing the extent of the disease and potential metastasis. Treatment for uterine sarcoma often involves a combination of surgery, chemotherapy, and radiation, tailored to the individual’s specific type of sarcoma and stage of the disease. Uterine sarcoma treatment guidelines emphasize the importance of a multidisciplinary approach for optimal outcomes. Various types of uterine sarcomas exist, each with unique characteristics and risk factors that influence the treatment strategy.

The prognosis for uterine sarcoma, including the survival rate, varies depending on factors like the cancer stage at diagnosis and the response to treatment. While uterine sarcoma can be aggressive and difficult to treat, advancements in medical treatments have improved the potential for successful management. The question of whether uterine sarcoma can be cured depends on these various factors, and ongoing research continues to explore more effective ways to treat this challenging condition. The ICD-10 classification is used for medical coding and insurance purposes, ensuring that patients receive appropriate care and treatment coverage.



For Uterine Sarcoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Uterine Sarcoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Uterine Sarcoma?

For example does it matter if vegetable Brussel Sprouts is consumed more compared to Mexican Groundcherry? Does it make any difference if fruit Pummelo is preferred over Pomegranate? Also if similar choices are made for nuts/seeds like Common Walnut over Chestnut and for pulses like Black-eyed Pea over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Uterine Sarcoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Uterine Sarcoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Uterine Sarcoma can be characterized by a unique set of biochemical pathways - the signature pathways of Uterine Sarcoma. Biochemical pathways like Epithelial to Mesenchymal Transition, MAPK Signaling, PI3K-AKT-MTOR Signaling, Chromatin Remodeling are part of the signature definition of Uterine Sarcoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Curcumin, Lycopene, Naringin, Lupeol, Apigenin. And Pomegranate contains active ingredients Curcumin, Ellagic Acid, Naringin, Lupeol, Apigenin and possibly others.

A common mistake made when deciding and choosing foods to eat for Uterine Sarcoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Uterine Sarcoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Uterine Sarcoma?

Personalized nutrition for cancers like Uterine Sarcoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Uterine Sarcoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Uterine Sarcoma

All cancers like Uterine Sarcoma can be characterized by a unique set of biochemical pathways – the signature pathways of Uterine Sarcoma. Biochemical pathways like Epithelial to Mesenchymal Transition, MAPK Signaling, PI3K-AKT-MTOR Signaling, Chromatin Remodeling are part of the signature definition of Uterine Sarcoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Uterine Sarcoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Uterine Sarcoma when taking cancer treatment Valrubicin, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

DICER1, ARID1A, NF2, IRF4 and INSR are the top ranked reported genes for Uterine Sarcoma. DICER1 is reported in 30.0 % of the representative patients across all clinical trials. And ARID1A is reported in 20.0 %. The combined population patient data cover ages from to . 0.0 % of the patient data are identified as men. The Uterine Sarcoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Uterine Sarcoma!

Food and Supplements for Uterine Sarcoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable BRUSSEL SPROUTS or MEXICAN GROUNDCHERRY?

Vegetable Brussel Sprouts contains many active ingredients or bioactives such as Curcumin, Lupeol, Phloretin, Beta-sitosterol, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling and others. Brussel Sprouts is recommended for Uterine Sarcoma when ongoing cancer treatment is Valrubicin. This is because Brussel Sprouts modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Valrubicin.

Some of the active ingredients or bioactives in vegetable Mexican Groundcherry are Curcumin, Lupeol, Apigenin, Phloretin, Myricetin. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Mexican Groundcherry is not recommended for Uterine Sarcoma when ongoing cancer treatment is Valrubicin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE BRUSSEL SPROUTS IS RECOMMENDED OVER MEXICAN GROUNDCHERRY FOR Uterine Sarcoma AND TREATMENT Valrubicin.

Choose Fruit POMEGRANATE or PUMMELO?

Fruit Pomegranate contains many active ingredients or bioactives such as Curcumin, Ellagic Acid, Naringin, Lupeol, Apigenin. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition, MAPK Signaling and PI3K-AKT-MTOR Signaling and others. Pomegranate is recommended for Uterine Sarcoma when ongoing cancer treatment is Valrubicin. This is because Pomegranate modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Valrubicin.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Lycopene, Naringin, Lupeol, Apigenin. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition and WNT Beta Catenin Signaling and others. Pummelo is not recommended for Uterine Sarcoma when ongoing cancer treatment is Valrubicin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT POMEGRANATE IS RECOMMENDED OVER PUMMELO FOR Uterine Sarcoma AND TREATMENT Valrubicin.

Choose Nut COMMON WALNUT or CHESTNUT?

Common Walnut contains many active ingredients or bioactives such as Curcumin, Ellagic Acid, Lupeol, Phloretin, Betulinic Acid. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition, MAPK Signaling and PI3K-AKT-MTOR Signaling and others. Common Walnut is recommended for Uterine Sarcoma when ongoing cancer treatment is Valrubicin. This is because Common Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Valrubicin.

Some of the active ingredients or bioactives in Chestnut are Curcumin, Lycopene, Ellagic Acid, Lupeol, Apigenin. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition and WNT Beta Catenin Signaling and others. Chestnut is not recommended for Uterine Sarcoma when ongoing cancer treatment is Valrubicin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

COMMON WALNUT IS RECOMMENDED OVER CHESTNUT FOR Uterine Sarcoma AND TREATMENT Valrubicin.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Uterine Sarcoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or ROMAINE LETTUCE?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, WNT Beta Catenin Signaling and MYC Signaling and others. Giant Butterbur is recommended for risk of Uterine Sarcoma when associated genetic risk is ARID1A. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Romaine Lettuce are Curcumin, Apigenin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition, P53 Signaling and Insulin Signaling and others. Romaine Lettuce is not recommended when risk of Uterine Sarcoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER ROMAINE LETTUCE FOR ARID1A GENETIC RISK OF CANCER.

Choose Fruit JAVA PLUM or APPLE?

Fruit Java Plum contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, WNT Beta Catenin Signaling and MYC Signaling and others. Java Plum is recommended for risk of Uterine Sarcoma when associated genetic risk is ARID1A. This is because Java Plum increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Apple are Curcumin, Apigenin, Lupeol, Beta-sitosterol, Daidzein. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition, Insulin Signaling and Cytoskeletal Dynamics and others. Apple is not recommended when risk of Uterine Sarcoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

FRUIT JAVA PLUM IS RECOMMENDED OVER APPLE FOR ARID1A GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or FLAXSEED?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling and Insulin Signaling and others. Butternut is recommended for risk of Uterine Sarcoma when associated genetic risk is ARID1A. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Flaxseed are Curcumin, Apigenin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition, Insulin Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling and others. Flaxseed is not recommended when risk of Uterine Sarcoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER FLAXSEED FOR ARID1A GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Uterine Sarcoma. Uterine Sarcoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Uterine Sarcoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Brussel Sprouts contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Uterine Sarcoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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