No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Uterine Sarcoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Tomato and Bamboo should be eaten when undergoing Cisplatin treatment for Uterine Sarcoma. On the same lines, avoid foods like Yardlong Bean and Kale with treatment of Cisplatin for Uterine Sarcoma.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Uterine Sarcoma.
What is Uterine Sarcoma?
Uterine Sarcoma is a rare cancer that develops from the muscle and supporting tissues of the uterus. The incidence rate of this cancer is only 3–7 per 100,000 women per year in the United States. This cancer is commonly diagnosed in people who are about 51 years of age, however, it can occur in people of any age. It is more commonly found in African-American women as compared to White or Asian women.
Uterine Sarcoma has prevalence of certain genetic changes. Some of the genes such as TP53, ATRX, RB1, and MED12 are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Uterine Sarcoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Uterine Sarcoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Uterine Sarcoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Uterine Sarcoma nutrition may have to be redesigned.
Why Eating Right Matters for Uterine Sarcoma?
In Uterine Sarcoma, activation or inhibition of some of the biochemical pathways including Cell Cycle Checkpoints, WNT Beta Catenin Signaling, MAPK Signaling, MYC Signaling, Epithelial To Mesenchymal Transition, Cancer Epigenetics, P53 Signaling, Hypoxia, Apoptosis, Nutrient Sensing and PI3K-AKT-MTOR Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Uterine Sarcoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Cisplatin treatment for Uterine Sarcoma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show an example of nutrition/diet for Uterine Sarcoma considering only one specific treatment- Cisplatin.
Foods to Avoid
Yardlong Bean : Yardlong Bean contains active ingredients such as Folic Acid, Linolenic Acid, Retinol and others. Folic Acid interferes with the impact of Cisplatin in Uterine Sarcoma by activating a specific biochemical pathway called PI3K-AKT-MTOR Signaling. Hence, avoid foods like Yardlong Bean with Cisplatin treatment for Uterine Sarcoma.
Kale : Kale contains active ingredients such as Kaempferol, Linolenic Acid, Brassinin and others. Kaempferol interferes with the impact of Cisplatin in Uterine Sarcoma by activating a specific biochemical pathway called MYC Signaling. Hence, avoid foods like Kale with Cisplatin treatment for Uterine Sarcoma.
Foods to Eat
Tomato : Tomato contains active ingredients like Glucaric Acid, Rutin and Quercitrin. Intake of Glucaric Acid along with Cisplatin treatment for Uterine Sarcoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Tomato hence should be eaten with Cisplatin treatment for Uterine Sarcoma. (Prakash Tiwari et al, Biochimie., 2016; Tine Cuppens et al, Clin Cancer Res., 2017)
Bamboo : Bamboo contains active ingredients like Beta-sitosterol, Linolenic Acid and Citric Acid. Intake of Beta-sitosterol along with Cisplatin treatment for Uterine Sarcoma causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Bamboo hence should be eaten with Cisplatin treatment for Uterine Sarcoma. (Zhang-Qi Cao et al, Front Pharmacol., 2019; Tine Cuppens et al, Clin Cancer Res., 2017)
Should I take this Nutritional Supplement for Uterine Sarcoma?
Curcumin : Curcumin has no known reported CYP (drug metabolizing enzyme) interactions with Cisplatin treatment. Curcumin supports the Cisplatin treatment for Uterine Sarcoma by decreasing the biochemical pathways called Cell Survival, WNT Beta Catenin Signaling, Epithelial to Mesenchymal Transition, MAPK Signaling, DNA Repair, JAK-STAT Signaling, Cell Cycle, MYC Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling, and increasing pathways like Cell Cycle Checkpoints, P53 Signaling and RUNX Signaling.
What are the Symptoms of Uterine Sarcoma?
In the initial stages, most cancers including Uterine Sarcoma may not cause any signs or symptoms. However, as the disease progresses, Uterine Sarcoma may start showing symptoms.
Following are some of the signs and symptoms that may be caused by Uterine Sarcoma.
- Lump in the vagina
- Unusual bleeding from the vagina unrelated to menstrual periods
- Stomach pain
- Frequent urination
- Feeling full at all times
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Uterine Sarcoma.
What are the Treatment Options for Uterine Sarcoma?
The treatment for Uterine Sarcoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Uterine Sarcoma include:
- Radiation Therapy
- Hormone Therapy
Surgery or surgery followed by radiation is the most common treatment regimen for Uterine Sarcoma. Radiotherapy helps to shrink the tumor. In some cases, both radiotherapy and chemotherapy are given together. As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Uterine Sarcoma.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Uterine Sarcoma.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.