No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Medulloblastoma needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Cabbage and Bitter Melon should be eaten when undergoing Temozolomide treatment for Medulloblastoma. On the other hand, for Medulloblastoma, Almond and Apricot should be eaten with treatment of Radiation. On the same lines, avoid foods like Yardlong Bean with treatment of Temozolomide for Medulloblastoma. If the treatment is Radiation, then avoid Chervil and Chili Pepper.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Medulloblastoma.
What is Medulloblastoma?
Medulloblastoma is a rare cancer that develops in the primary central nervous system (CNS) tumor. The incidence rate of this cancer is 1.5-2 cases per 1 lakh people per year. This cancer is commonly diagnosed in people who are 20 to 40 years of age, however, it can occur in people of any age. It is also common in children. It is more commonly found in White and Hispanic people and more often in males than females.
Medulloblastoma has prevalence of certain genetic changes. Some of the genes such as CTNNB1, DDX3X, PTCH1, and MGMT are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Medulloblastoma can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Medulloblastoma. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Medulloblastoma genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Medulloblastoma nutrition may have to be redesigned.
Why Eating Right Matters for Medulloblastoma?
In Medulloblastoma, activation or inhibition of some of the biochemical pathways including WNT Beta Catenin Signaling, MAPK Signaling, MYC Signaling, Adherens Junction, Epithelial To Mesenchymal Transition, RAS-RAF Signaling, Focal Adhesion, Cell Cycle, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Medulloblastoma, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Temozolomide treatment for Medulloblastoma
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show changes in nutrition/diet for Medulloblastoma considering only the treatment changes.
Foods to Avoid
Yardlong Bean : Yardlong Bean contains active ingredients such as Linoleic Acid, Linolenic Acid, Retinol and others. Linoleic Acid interferes with the impact of Temozolomide in Medulloblastoma by activating a specific biological process called Epithelial to Mesenchymal Transition. Hence, avoid foods like Yardlong Bean with Temozolomide treatment for Medulloblastoma.
Foods to Eat
Cabbage : Cabbage contains active ingredients like Benzyl Isothiocyanate, Crocetin and Brassinin. Intake of Benzyl Isothiocyanate along with Temozolomide treatment for Medulloblastoma causes a decrease in a specific biochemical pathway which is called Epithelial to Mesenchymal Transition, and this is a very positive effect. Cabbage hence should be eaten with Temozolomide treatment for Medulloblastoma. (Anuradha Sehrawat and Shivendra V. Singh, Cancer Prevention Research, 2011; Ran Gao et al, Oncol Lett., 2018)
Bitter Melon : Bitter Melon contains active ingredients like Acteoside, Linolenic Acid and Retinol. Intake of Acteoside along with Temozolomide treatment for Medulloblastoma causes a decrease in a specific biochemical pathway which is called Epithelial to Mesenchymal Transition, and this is a very positive effect. Bitter Melon hence should be eaten with Temozolomide treatment for Medulloblastoma. (Chun-Hsien Wu et al, Environ Toxicol., 2021; Ran Gao et al, Oncol Lett., 2018)
Should I take this Nutritional Supplement for Medulloblastoma?
Black Seed : Black Seed has no known reported CYP (drug metabolizing enzyme) interactions with Temozolomide treatment. Black Seed supports the Temozolomide treatment for Medulloblastoma by decreasing the biochemical pathways called Epithelial to Mesenchymal Transition, MAPK Signaling, Focal Adhesion, JAK-STAT Signaling, Cell Cycle, MYC Signaling, PI3K-AKT-MTOR Signaling and WNT Beta Catenin Signaling.
Example Foods to “Not Eat” and Eat with Radiation treatment for Medulloblastoma
Foods to Avoid
Chervil : Chervil contains active ingredients such as Folic Acid, Linolenic Acid, Retinol and others. Folic Acid interferes with the impact of Radiation in Medulloblastoma by activating a specific biochemical pathway called MYC Signaling. Hence, avoid foods like Chervil with Radiation treatment for Medulloblastoma.
Chili Pepper : Chili Pepper contains active ingredients such as Capsaicin, Dihydrocapsaicin, Linolenic Acid and others. Capsaicin interferes with the impact of Radiation in Medulloblastoma by activating a specific biochemical pathway called MYC Signaling. Hence, avoid foods like Chili Pepper with Radiation treatment for Medulloblastoma.
Foods to Eat
Almond : Almond contains active ingredients like Geraniin, Linolenic Acid and Citric Acid. Intake of Geraniin along with Radiation treatment for Medulloblastoma causes a decrease in a specific biochemical pathway which is called JAK-STAT Signaling, and this is a very positive effect. Almond hence should be eaten with Radiation treatment for Medulloblastoma. (Zhong Ren et al, Cytotechnology., 2017; Jia Wei et al, Curr Cancer Drug Targets., 2019)
Apricot : Apricot contains active ingredients like Epicatechin, Rutin and Linolenic Acid. Intake of Epicatechin along with Radiation treatment for Medulloblastoma causes a decrease in a specific biochemical pathway which is called MYC Signaling, and this is a very positive effect. Apricot hence should be eaten with Radiation treatment for Medulloblastoma. (L H Lu et al, Br J Pharmacol., 1998; Martine F Roussel and Giles W Robinson, Cold Spring Harb Perspect Med., 2013)
Should I take this Nutritional Supplement for Medulloblastoma?
Black Seed : Black Seed has no known reported CYP (drug metabolizing enzyme) interactions with Radiation treatment. Black Seed supports the Radiation treatment for Medulloblastoma by decreasing the biochemical pathways/processes called Epithelial to Mesenchymal Transition, MAPK Signaling, Focal Adhesion, JAK-STAT Signaling, MYC Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle and RAS-RAF Signaling.
What are the Symptoms of Medulloblastoma?
In the initial stages, most cancers including Medulloblastoma may not cause any signs or symptoms. However, as the disease progresses, Medulloblastoma may start showing symptoms.
Following are some of the signs and symptoms that may be caused by Medulloblastoma.
- Nausea and vomiting
- Irritability and behavioural changes
- Balance problems
- Problems in thinking ability
- Vision problems
- Hearing loss
- Weakness and fatigue
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Medulloblastoma.
What are the Treatment Options for Medulloblastoma?
The treatment for Medulloblastoma may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Medulloblastoma include:
- Radiation Therapy
Surgery is done to relieve fluid buildup in the brain and also to remove the medulloblastoma. Radiotherapy helps to shrink the tumor. The primary role of chemotherapy is to kill tumor cells. As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Medulloblastoma.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Medulloblastoma.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.