Foods for Acquired Idiopathic Sideroblastic Anemia!

Introduction 

Foods for Acquired Idiopathic Sideroblastic Anemia should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetic, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task. 

For Acquired Idiopathic Sideroblastic Anemia does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Acquired Idiopathic Sideroblastic Anemia does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Acquired Idiopathic Sideroblastic Anemia?

For example does it matter if vegetable Giant Butterbur is consumed more compared to Swede? Does it make any difference if fruit Pummelo is preferred over Lemon? Also if similar choices are made for nuts/seeds like Almond over European Chestnut and for pulses like Moth Bean over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Acquired Idiopathic Sideroblastic Anemia and is it the same answer for everyone with the same diagnosis or genetic risk? 

Yes! Foods you eat matters for Acquired Idiopathic Sideroblastic Anemia!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.  

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually. 

For example Pummelo contains active ingredients Apigenin, Lycopene, Curcumin, Daidzein, Lupeol. And Lemon contains active ingredients D-limonene, Curcumin, Daidzein, Lupeol, Naringin and possibly others. 

A common mistake made when deciding and choosing foods to eat for Acquired Idiopathic Sideroblastic Anemia – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Acquired Idiopathic Sideroblastic Anemia. 

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Acquired Idiopathic Sideroblastic Anemia?

Personalized nutrition for cancers like Acquired Idiopathic Sideroblastic Anemia consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Acquired Idiopathic Sideroblastic Anemia biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE  NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE,  CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Acquired Idiopathic Sideroblastic Anemia

All cancers like Acquired Idiopathic Sideroblastic Anemia can be characterized by a unique set of biochemical pathways – the signature pathways of Acquired Idiopathic Sideroblastic Anemia. Biochemical pathways like Amino Acid Metabolism, MAPK Signaling, Oncogenic Cancer Epigenetics, mRNA Splicing are part of the signature definition of Acquired Idiopathic Sideroblastic Anemia. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Acquired Idiopathic Sideroblastic Anemia need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Acquired Idiopathic Sideroblastic Anemia when taking cancer treatment Capecitabine, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations. 

SF3B1, TET2, DNMT3A, EP300 and ASXL1 are the top ranked reported genes for Acquired Idiopathic Sideroblastic Anemia. SF3B1 is reported in 31.0 % of the representative patients across all clinical trials. And TET2 is reported in 30.7 %. The Acquired Idiopathic Sideroblastic Anemia biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Acquired Idiopathic Sideroblastic Anemia

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.  

Choose Vegetable GIANT BUTTERBUR or SWEDE?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Lycopene, Curcumin, Daidzein, Lupeol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, MYC Signaling, PI3K-AKT-MTOR Signaling and Amino Acid Metabolism and others. Giant Butterbur is recommended for Acquired Idiopathic Sideroblastic Anemia when ongoing cancer treatment is Capecitabine. This is because Giant Butterbur modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Capecitabine.

Some of the active ingredients or bioactives in vegetable Swede are Apigenin, Curcumin, Daidzein, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like DNA Repair and PI3K-AKT-MTOR Signaling and others. Swede is not recommended for Acquired Idiopathic Sideroblastic Anemia when ongoing cancer treatment is Capecitabine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER SWEDE FOR Acquired Idiopathic Sideroblastic Anemia AND TREATMENT Capecitabine.

Choose Fruit LEMON or PUMMELO?

Fruit Lemon contains many active ingredients or bioactives such as D-limonene, Curcumin, Daidzein, Lupeol, Naringin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, MYC Signaling, Amino Acid Metabolism and Hypoxia and others. Lemon is recommended for Acquired Idiopathic Sideroblastic Anemia when ongoing cancer treatment is Capecitabine. This is because Lemon modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Capecitabine.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Lycopene, Curcumin, Daidzein, Lupeol. These active ingredients manipulate various biochemical pathways like DNA Repair and Amino Acid Metabolism and others. Pummelo is not recommended for Acquired Idiopathic Sideroblastic Anemia when ongoing cancer treatment is Capecitabine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT LEMON IS RECOMMENDED OVER PUMMELO FOR Acquired Idiopathic Sideroblastic Anemia AND TREATMENT Capecitabine.

Choose NUT ALMOND or EUROPEAN CHESTNUT?

Almond contains many active ingredients or bioactives such as Curcumin, Daidzein, Lupeol, Phloretin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like DNA Repair, MAPK Signaling, MYC Signaling and Amino Acid Metabolism and others. Almond is recommended for Acquired Idiopathic Sideroblastic Anemia when ongoing cancer treatment is Capecitabine. This is because Almond modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Capecitabine.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Ellagic Acid, Curcumin, Daidzein, Lupeol. These active ingredients manipulate various biochemical pathways like MYC Signaling and PI3K-AKT-MTOR Signaling and others. European Chestnut is not recommended for Acquired Idiopathic Sideroblastic Anemia when ongoing cancer treatment is Capecitabine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

ALMOND IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Acquired Idiopathic Sideroblastic Anemia AND TREATMENT Capecitabine.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Acquired Idiopathic Sideroblastic Anemia or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized. 

Choose Vegetable GREEN BELL PEPPER or MUSTARD SPINACH?

Vegetable Green Bell Pepper contains many active ingredients or bioactives such as Curcumin, Salicylic Acid, Resveratrol, Isoliquiritigenin, Psoralen. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics, MYC Signaling, WNT Beta Catenin Signaling and Suppressive Histone Methylation and others. Green Bell Pepper is recommended for risk of Acquired Idiopathic Sideroblastic Anemia when associated genetic risk is ASXL1. This is because Green Bell Pepper increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Mustard Spinach are Curcumin, Salicylic Acid, Isoliquiritigenin, Apigenin, Lycopene. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics, WNT Beta Catenin Signaling and G-protein-coupled Receptor Signaling and others. Mustard Spinach is not recommended when risk of Acquired Idiopathic Sideroblastic Anemia when associated genetic risk is ASXL1 because it increases the signature pathways of it.

VEGETABLE GREEN BELL PEPPER IS RECOMMENDED OVER MUSTARD SPINACH FOR ASXL1 GENETIC RISK OF CANCER.

Choose Fruit STRAWBERRY GUAVA or GRAPEFRUIT?

Fruit Strawberry Guava contains many active ingredients or bioactives such as Curcumin, Salicylic Acid, Isoliquiritigenin, Apigenin, Lycopene. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics, WNT Beta Catenin Signaling and G-protein-coupled Receptor Signaling and others. Strawberry Guava is recommended for risk of Acquired Idiopathic Sideroblastic Anemia when associated genetic risk is ASXL1. This is because Strawberry Guava increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Grapefruit are Curcumin, Isoliquiritigenin, Lycopene, Psoralen, Lupeol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and G-protein-coupled Receptor Signaling and others. Grapefruit is not recommended when risk of Acquired Idiopathic Sideroblastic Anemia when associated genetic risk is ASXL1 because it increases the signature pathways of it.

FRUIT STRAWBERRY GUAVA IS RECOMMENDED OVER GRAPEFRUIT FOR ASXL1 GENETIC RISK OF CANCER.

Choose Nut COMMON WALNUT or JAPANESE WALNUT?

Common Walnut contains many active ingredients or bioactives such as Curcumin, Salicylic Acid, Plumbagin, Isoliquiritigenin, Psoralen. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, TGFB Signaling and G-protein-coupled Receptor Signaling and others. Common Walnut is recommended for risk of Acquired Idiopathic Sideroblastic Anemia when associated genetic risk is ASXL1. This is because Common Walnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Japanese Walnut are Curcumin, Salicylic Acid, Isoliquiritigenin, Apigenin, Lycopene. These active ingredients manipulate various biochemical pathways like Oncogenic Cancer Epigenetics, WNT Beta Catenin Signaling and Sirtuin Signaling and others. Japanese Walnut is not recommended when risk of Acquired Idiopathic Sideroblastic Anemia when associated genetic risk is ASXL1 because it increases the signature pathways of it.

COMMON WALNUT IS RECOMMENDED OVER JAPANESE WALNUT FOR ASXL1 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Acquired Idiopathic Sideroblastic Anemia. Acquired Idiopathic Sideroblastic Anemia patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Acquired Idiopathic Sideroblastic Anemia, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Giant Butterbur contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Acquired Idiopathic Sideroblastic Anemia?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

1) Anti-tumour effects of beta-sitosterol are mediated by AMPK/PTEN/HSP90 axis in AGS human gastric adenocarcinoma cells and xenograft mouse models.

2) BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.

3) Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat.

4) D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.

5) Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.

6) Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity.

7) Isorhamnetin inhibited migration and invasion via suppression of Akt/ERK-mediated epithelial-to-mesenchymal transition (EMT) in A549 human non-small-cell lung cancer cells.