No two cancers are the same and neither should your nutrition be. The most commonly asked question to dieticians and oncologists globally is “What Should I Eat?”. The answer is “It Depends”. It depends on the type of cancer, current treatment and supplements being taken, age, gender, BMI, lifestyle and any genetic information available. In short – the answer to “What Should I Eat” for Wilms Tumor needs to be personalized to minimize adverse interactions between nutrition (from foods/diet) and treatment, and to improve symptoms.
Foods like Tomato and Arugula should be eaten when undergoing Doxorubicin treatment for Wilms Tumor. On the other hand, for Wilms Tumor, Banana and Black Chokeberry should be eaten with treatment of Vincristine. On the same lines, avoid foods like Swiss Chard with treatment of Doxorubicin for Wilms Tumor. If the treatment is Vincristine, then avoid Lotus.
Black Seed contains an active ingredient called Thymoquinone. Thymoquinone has CYP (drug metabolizing enzyme) interactions with Doxorubicin and Vincristine treatment and hence should be avoided.
You get the point – your nutrition needs to be personalized and it needs to be re-evaluated as soon as any of the conditions change. Create and follow a nutrition plan personalized to you to minimize adverse interactions of nutrition for cancers like Wilms Tumor.
What is Wilms Tumor?
Wilms Tumor is a rare type of kidney cancer. The incidence rate of this cancer is only 0.76 per 1 lakh people per year in the United States under 15 years of age. This cancer is commonly diagnosed in children who are about 3-4 years of age, however, it can occur in people of any age. It is more commonly found in children of Black population than White population.
Wilms Tumor has prevalence of certain genetic changes. Some of the genes such as TP53, CTNNB1, CDK11A, and DROSHA are known to have genetic abnormalities in this cancer resulting in a change of function.
The genetic abnormalities found in Wilms Tumor can influence specific biochemical pathways to drive these cancer cells to aggressive growth and survive the ongoing treatment. In addition, lifestyle conditions or habits like smoking, alcohol consumption and BMI (Body Mass Index) can have a big influence on the response to your physician prescribed treatments for Wilms Tumor. Numerous studies have consistently shown that your nutrition/diet – both food and nutritional supplements can adversely affect the treatment or be supportive or play no role. Hence, the triangulation of Wilms Tumor genomics, planned or ongoing therapies and lifestyle need to be thoroughly considered to make decisions on what foods and supplements to consider and avoid while designing diet/nutrition plan. Also, it is important to note that when any of these conditions change, like treatment or lifestyle or cancer diagnosis – it may impact the nutrition and the nutrition/diet plan for Wilms Tumor nutrition may have to be redesigned.
Why Eating Right Matters for Wilms Tumor?
In Wilms Tumor, activation or inhibition of some of the biochemical pathways including Adherens Junction, MAPK Signaling, WNT Beta Catenin Signaling, MYC Signaling, Epithelial To Mesenchymal Transition, Cell Cycle Checkpoints, RAS-RAF Signaling, Apoptosis, PI3K-AKT-MTOR Signaling and Carbohydrate Metabolism plays an important role in driving the disease. All foods and nutritional supplements contain active ingredients which have a specific molecular action on different biochemical pathways. Hence, while the intake of certain foods and nutritional supplements as part of the diet may support a specific treatment of Wilms Tumor, eating few other foods and supplements may lead to adverse interactions with the treatment or may increase the cancer progression.
Example Foods to “Not Eat” and Eat with Doxorubicin treatment for Wilms Tumor
The nutrition for cancer always depends on the type of cancer, treatments and supplements being taken (if any), age, gender, BMI, lifestyle and any genetic information available. Here we show changes in nutrition/diet for Wilms Tumor considering only the treatment changes.
Foods to Avoid
Swiss Chard : Swiss Chard contains active ingredients such as Folic Acid, Retinol, Kaempferol and others. Folic Acid interferes with the impact of Doxorubicin in Wilms Tumor by activating a specific biochemical pathway called MYC Signaling. Hence, avoid foods like Swiss Chard with Doxorubicin treatment for Wilms Tumor.
Foods to Eat
Tomato : Tomato contains active ingredients like Glucaric Acid, Rutin and Quercitrin. Intake of Glucaric Acid along with Doxorubicin treatment for Wilms Tumor causes a decrease in a specific biochemical pathway which is called MYC Signaling, and this is a very positive effect. Tomato hence should be eaten with Doxorubicin treatment for Wilms Tumor. (Jiabin Liu et al, Ann Transl Med., 2019)
Arugula : Arugula contains active ingredients like Erysolin, Kaempferol and Esculin. Intake of Erysolin along with Doxorubicin treatment for Wilms Tumor causes a decrease in a specific biochemical pathway which is called MYC Signaling, and this is a very positive effect. Arugula hence should be eaten with Doxorubicin treatment for Wilms Tumor. (Avani R Vyas et al, J Cell Biochem., 2016; Jiabin Liu et al, Ann Transl Med., 2019)
Should I take this Nutritional Supplement for Wilms Tumor?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Doxorubicin treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Doxorubicin treatment efficacy in Wilms Tumor. (Ahmed A Albassam et al, Saudi Pharm J., 2018; Jun-Shik Choi et al, Arch Pharm Res., 2011)
Example Foods to “Not Eat” and Eat with Vincristine treatment for Wilms Tumor
Foods to Avoid
Lotus : Lotus contains active ingredients such as Oleic Acid, Fisetin, Linolenic Acid and others. Oleic Acid interferes with the impact of Vincristine in Wilms Tumor by activating a specific biological process called Epithelial to Mesenchymal Transition. Hence, avoid foods like Lotus with Vincristine treatment for Wilms Tumor.
Foods to Eat
Banana : Banana contains active ingredients like Linolenic Acid, Retinol and Citric Acid. Intake of Linolenic Acid along with Vincristine treatment for Wilms Tumor causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Banana, hence should be eaten with Vincristine treatment for Wilms Tumor. (Shih-Chung Wang et al, Biochem Pharmacol., 2020; Vivek Subbiah et al, PLoS One., 2013)
Black Chokeberry : Black Chokeberry contains active ingredients like Caffeic Acid, Hyperoside and Isorhamnetin. Intake of Caffeic Acid along with Vincristine treatment for Wilms Tumor causes a decrease in a specific biochemical pathway which is called PI3K-AKT-MTOR Signaling, and this is a very positive effect. Black Chokeberry hence should be eaten with Vincristine treatment for Wilms Tumor. (Kartick C Pramanik et al, Carcinogenesis., 2013; Vivek Subbiah et al, PLoS One., 2013)
Should I take this Nutritional Supplement for Wilms Tumor?
Black Seed : Black Seed nutritional supplements contain active ingredients such as Thymoquinone which have CYP3A4 interactions with Vincristine treatment, and hence should not be used. Also, Black Seed supplement does not show benefit on other biochemical pathways that could improve the Vincristine treatment efficacy in Wilms Tumor. (Ahmed A Albassam et al, Saudi Pharm J., 2018; Pius S Fasinu et al, Front Oncol., 2019)
What are the Symptoms of Wilms Tumor?
In the initial stages, most cancers including Wilms Tumor may not cause any signs or symptoms. However, as the disease progresses, Wilms Tumor may start showing symptoms.
Following are some of the signs and symptoms that may be caused by Wilms Tumor.
- A smooth lump in the abdomen
- Swelling in the stomach
- Stomach pain
- Nausea or vomiting or both
- Loss of appetite
- Shortness of breath
- High blood pressure
- Blood in the urine
Though many of these symptoms may also be caused by various other health conditions, consult your doctor if you experience these symptoms to rule out the possible chances of Wilms Tumor.
What are the Treatment Options for Wilms Tumor?
The treatment for Wilms Tumor may be decided based on different factors including the stage and extent of spread of the cancer, cancer characteristics, symptoms, whether tumour is present in one or both of the patient’s kidneys, patient’s general health and medical history, whether the cancer can be removed completely by surgery and whether the cancer was just diagnosed or had come back. The treatment options for Wilms Tumor include:
- Radiation Therapy
Surgery or surgery followed by radiation is the most common treatment regimen for Wilms Tumor. Radiotherapy and Chemotherapy help to shrink the tumor. As part of the diet, avoid including those foods and supplements that may adversely interact with the treatments for Wilms Tumor.
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition/diet which includes food and nutritional supplements is an effective tool which is controlled by you, while facing cancer such as Wilms Tumor.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.