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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Ocular Melanoma!

Jul 26, 2023

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Introduction

Foods for Ocular Melanoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Ocular melanoma, a rare but serious form of eye cancer, presents distinct challenges in diagnosis and treatment. Photos of ocular melanoma reveal its physical manifestation, aiding in early detection. The ICD-10 classification provides a standardized coding for diagnosis and insurance purposes. In radiology, imaging techniques are crucial for identifying and assessing the extent of the tumor. The survival rate and prognosis of ocular melanoma can vary, influenced by factors like the types of ocular melanoma and the stage at diagnosis. Treatment options range from radiation treatment, which is commonly used, to emerging therapies being explored in clinical trials. The definition and pathology outlines of ocular melanoma are critical for understanding its nature and development. Research continues to delve into aspects like ocular melanoma genetics and the potential hereditary nature of the disease. Immunotherapy and new treatment methods for ocular melanoma are subjects of ongoing study, offering hope for more effective management. The importance of early diagnosis cannot be overstated, as malignant ocular melanoma can lead to significant complications. Patients and healthcare providers often turn to resources like PowerPoint presentations (PPT) to educate themselves about this condition, emphasizing the need for continuous learning and advancements in ocular melanoma treatment.



For Ocular Melanoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Ocular Melanoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Ocular Melanoma?

For example does it matter if vegetable Giant Butterbur is consumed more compared to Chicory? Does it make any difference if fruit Pummelo is preferred over Red Raspberry? Also if similar choices are made for nuts/seeds like Common Hazelnut over European Chestnut and for pulses like Black-eyed Pea over Yardlong Bean. And if what I eat matters – then how does one identify foods which are recommended for Ocular Melanoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Ocular Melanoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Ocular Melanoma can be characterized by a unique set of biochemical pathways - the signature pathways of Ocular Melanoma. Biochemical pathways like RAS-RAF Signaling, mRNA Splicing, G-protein-coupled Receptor Signaling, Platelet aggregation are part of the signature definition of Ocular Melanoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Quercetin, Formononetin, Curcumin, Daidzein, Phloretin. And Red Raspberry contains active ingredients Quercetin, Ellagic Acid, Formononetin, Curcumin, Daidzein and possibly others.

A common mistake made when deciding and choosing foods to eat for Ocular Melanoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Ocular Melanoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Ocular Melanoma?

Personalized nutrition for cancers like Ocular Melanoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Ocular Melanoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Ocular Melanoma

All cancers like Ocular Melanoma can be characterized by a unique set of biochemical pathways – the signature pathways of Ocular Melanoma. Biochemical pathways like RAS-RAF Signaling, mRNA Splicing, G-protein-coupled Receptor Signaling, Platelet aggregation are part of the signature definition of Ocular Melanoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Ocular Melanoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Ocular Melanoma when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

GNAQ, GNA11, SF3B1, BAP1 and EIF1AX are the top ranked reported genes for Ocular Melanoma. GNAQ is reported in 30.3 % of the representative patients across all clinical trials. And GNA11 is reported in 27.3 %. The combined population patient data cover ages from to . 52.0 % of the patient data are identified as men. The Ocular Melanoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Ocular Melanoma !

Food and Supplements for Ocular Melanoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GIANT BUTTERBUR or CHICORY?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Formononetin, Curcumin, Daidzein, Phloretin, Lupeol. These active ingredients manipulate various biochemical pathways like Cell Cycle, Angiogenesis, Cell Survival and MYC Signaling and others. Giant Butterbur is recommended for Ocular Melanoma when ongoing cancer treatment is Radiation. This is because Giant Butterbur modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Chicory are Quercetin, Formononetin, Curcumin, Daidzein, Phloretin. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Focal Adhesion and PI3K-AKT-MTOR Signaling and others. Chicory is not recommended for Ocular Melanoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER CHICORY FOR Ocular Melanoma AND TREATMENT Radiation.

Choose Fruit RED RASPBERRY or PUMMELO?

Fruit Red Raspberry contains many active ingredients or bioactives such as Quercetin, Ellagic Acid, Formononetin, Curcumin, Daidzein. These active ingredients manipulate various biochemical pathways like DNA Repair, Cell Cycle, Angiogenesis and MAPK Signaling and others. Red Raspberry is recommended for Ocular Melanoma when ongoing cancer treatment is Radiation. This is because Red Raspberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Formononetin, Curcumin, Daidzein, Phloretin. These active ingredients manipulate various biochemical pathways like DNA Repair and Oxidative Stress and others. Pummelo is not recommended for Ocular Melanoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RED RASPBERRY IS RECOMMENDED OVER PUMMELO FOR Ocular Melanoma AND TREATMENT Radiation.

Choose Nut COMMON HAZELNUT or EUROPEAN CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Quercetin, Formononetin, Curcumin, Daidzein, Phloretin. These active ingredients manipulate various biochemical pathways like Cell Cycle, TGFB Signaling, Angiogenesis and DNA Repair and others. Common Hazelnut is recommended for Ocular Melanoma when ongoing cancer treatment is Radiation. This is because Common Hazelnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in European Chestnut are Quercetin, Ellagic Acid, Formononetin, Curcumin, Daidzein. These active ingredients manipulate various biochemical pathways like Oxidative Stress and others. European Chestnut is not recommended for Ocular Melanoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

COMMON HAZELNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Ocular Melanoma AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Ocular Melanoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable WILD LEEK or MOUNTAIN YAM?

Vegetable Wild Leek contains many active ingredients or bioactives such as Protocatechuic Acid, Apigenin, Curcumin, Delphinidin, Vitamin C. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Oncogenic Cancer Epigenetics and MYC Signaling and others. Wild Leek is recommended for risk of Ocular Melanoma when associated genetic risk is BAP1. This is because Wild Leek increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Mountain Yam are Lycopene, Protocatechuic Acid, Apigenin, Curcumin, Delphinidin. These active ingredients manipulate various biochemical pathways like G-protein-coupled Receptor Signaling and others. Mountain Yam is not recommended when risk of Ocular Melanoma when associated genetic risk is BAP1 because it increases the signature pathways of it.

VEGETABLE WILD LEEK IS RECOMMENDED OVER MOUNTAIN YAM FOR BAP1 GENETIC RISK OF CANCER.

Choose Fruit SOURSOP or BAYBERRY?

Fruit Soursop contains many active ingredients or bioactives such as Protocatechuic Acid, Apigenin, Curcumin, Emodin, Delphinidin. These active ingredients manipulate various biochemical pathways like Phospholipase Signaling, G-protein-coupled Receptor Signaling and MYC Signaling and others. Soursop is recommended for risk of Ocular Melanoma when associated genetic risk is BAP1. This is because Soursop increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Bayberry are Lycopene, Protocatechuic Acid, Apigenin, Curcumin, Delphinidin. These active ingredients manipulate various biochemical pathways like G-protein-coupled Receptor Signaling and others. Bayberry is not recommended when risk of Ocular Melanoma when associated genetic risk is BAP1 because it increases the signature pathways of it.

FRUIT SOURSOP IS RECOMMENDED OVER BAYBERRY FOR BAP1 GENETIC RISK OF CANCER.

Choose Nut HAZELNUT or HICKORY NUT?

Hazelnut contains many active ingredients or bioactives such as Protocatechuic Acid, Apigenin, Curcumin, Delphinidin, Lupeol. These active ingredients manipulate various biochemical pathways like MAPK Signaling and MYC Signaling and others. Hazelnut is recommended for risk of Ocular Melanoma when associated genetic risk is BAP1. This is because Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Hickory Nut are Lycopene, Protocatechuic Acid, Apigenin, Curcumin, Delphinidin. These active ingredients manipulate various biochemical pathways like G-protein-coupled Receptor Signaling and others. Hickory Nut is not recommended when risk of Ocular Melanoma when associated genetic risk is BAP1 because it increases the signature pathways of it.

HAZELNUT IS RECOMMENDED OVER HICKORY NUT FOR BAP1 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Ocular Melanoma. Ocular Melanoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Ocular Melanoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Giant Butterbur contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Ocular Melanoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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