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What should I eat after Cancer Diagnosis?

is a very common question asked.​
Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

is a very common question asked. Choose food and supplements personalized to your cancer, genes, ongoing treatments and lifestyle.

Personalized cancer Nutrition Planning for only .

Personalized cancer Nutrition Planning for only​ .

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For Which Cancer Types Should I Avoid Alpha Lipoic Acid Supplement?

Aug 2, 2021

Estimated reading time: 9 minutes
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Highlights

Nutritional supplements like Alpha Lipoic Acid have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Alpha Lipoic Acid supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”. 

Taking nutritional Alpha Lipoic Acid supplements can benefit cancer patients with Endometrial Carcinoma on Cyclophosphamide treatment. But avoid Alpha Lipoic Acid supplements if on Cytarabine treatment for Myeloproliferative Neoplasms. Similarly, taking nutritional supplement Alpha Lipoic Acid can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene CDKN1B. But avoid taking nutritional supplement Alpha Lipoic Acid when at genetic risk of cancer due to mutation of gene TERT.

The takeaway being – your individual context will influence your decision if nutritional supplement Alpha Lipoic Acid is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context. 



Brief Overview

Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements  are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose  the right combination of supplements like Alpha Lipoic Acid based on individual context and conditions. 

Alpha Lipoic Acid Supplements for Cancer Treatment and Genetic Risk

So the question is should you take the supplement Alpha Lipoic Acid? Should you take it when at genetic risk of cancer for mutation of gene TERT? Should you take it when at genetic risk of cancer for mutation of gene CDKN1B? Should you take it when diagnosed with Myeloproliferative Neoplasms? Should you take Alpha Lipoic Acid supplement when diagnosed with Endometrial Carcinoma? Should you take it when on Cytarabine treatment? Should you continue taking Alpha Lipoic Acid supplement if you change your treatment from Cytarabine to Cyclophosphamide? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Alpha Lipoic Acid. 

Cancer

Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Myeloproliferative Neoplasms or Endometrial Carcinoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Alpha Lipoic Acid.

So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Alpha Lipoic Acid? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene TERT the same as due to mutation of gene CDKN1B? Are the implications of taking Alpha Lipoic Acid supplement in Myeloproliferative Neoplasms the same as Endometrial Carcinoma? Is it one and the same if you are on treatment with Cytarabine or on Cyclophosphamide? 

Alpha Lipoic Acid – A Nutritional Supplement

Alpha Lipoic Acid is an organic compound produced by plants, animals, and humans. It has antioxidant properties. It is produced by the human body at low amounts and is mostly obtained from diet, through foods such as meat, vegetables and fruits. Alpha Lipoic Acid is also available in the form of dietary supplements. Following are some of the potential health benefits of Alpha Lipoic Acid:

Alpha Lipoic Acid is an active ingredient found in various food items. Spinach, broccoli, tomatoes, yams, and rice bran contain Alpha Lipoic Acid at different concentration levels along with other active ingredients. The molecular pathways which are regulated by Alpha Lipoic Acid include Apoptosis, Stem Cell Signaling, Angiogenesis and Cell Cycle Checkpoints. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Alpha Lipoic Acid individually or in combination is an important decision to be made. When making decisions on the use of supplement Alpha Lipoic Acid for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Alpha Lipoic Acid use cannot be a one-size-fits-all decision for all types of cancers.

Choosing Alpha Lipoic Acid Supplements for Your Cancer

The reason there is no easy way to answer the question “When should I avoid Alpha Lipoic Acid for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Alpha Lipoic Acid may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Alpha Lipoic Acid should be avoided or not and why.

1. Will Alpha Lipoic Acid Supplements benefit Cancer Patients with Myeloproliferative Neoplasms undergoing Cytarabine treatment?

Myeloproliferative Neoplasms is characterized and driven by specific genetic mutations like JAK2 and CALR. A cancer treatment like Cytarabine works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Alpha Lipoic Acid should be avoided for Myeloproliferative Neoplasms along with treatment Cytarabine. Alpha Lipoic Acid impacts specific pathways which either promote drivers of the disease and/or nullify the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).

2. Will Alpha Lipoic Acid Supplements benefit Cancer Patients with Endometrial Carcinoma undergoing Cyclophosphamide Treatment?

Endometrial Carcinoma is characterized and driven by specific genetic mutations like PTEN and PIK3CA. A cancer treatment like Cyclophosphamide works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Alpha Lipoic Acid supplements should be considered for Endometrial Carcinoma along with treatment Cyclophosphamide. Alpha Lipoic Acid supplement impacts specific pathways which either obstruct drivers of Endometrial Carcinoma and/or improve Cyclophosphamide treatment effect. 

For Which Cancer to Avoid taking Supplement Alpha Lipoic Acid

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

3. Are Alpha Lipoic Acid Supplements Safe for Healthy Individuals with TERT Mutation Associated Genetic Risk?

Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. TERT is one of the genes generally available in panels for cancer risk testing. 

TERT mutation causes biochemical pathways/processes like Apoptosis, RUNX Signaling, Stem Cell Signaling, Cell Cycle Checkpoints and JAK-STAT Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Alpha Lipoic Acid should be avoided when the genetic panel identifies mutation of TERT for Hematological Cancer. Alpha Lipoic Acid impacts pathways/processes like Apoptosis and RUNX Signaling and creates adverse effects with TERT and related conditions.

4. Are Alpha Lipoic Acid Supplements Safe for Healthy Individuals with CDKN1B Mutation Associated Genetic Risk?

CDKN1B is one of the genes available in panels for cancer risk testing. CDKN1B mutation causes biochemical pathways/processes like Stem Cell Signaling, Cell Cycle Checkpoints, FOXO Signaling, PI3K-AKT-MTOR Signaling and Angiogenesis to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Alpha Lipoic Acid supplements when the genetic panel identifies mutation in CDKN1B for Neuroendocrine Cancer. Alpha Lipoic Acid impacts pathways/processes like Stem Cell Signaling and Cell Cycle Checkpoints and creates a supportive effect in those with CDKN1B mutation and related conditions.

Which Cancer Types to Avoid Alpha Lipoic Acid Supplement

* Other Factors are also included like BMI, Treatments, Lifestyle Habits

In Conclusion

The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Alpha Lipoic Acid, is an effective tool which can be controlled by you, while facing cancer.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.


Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.


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