Nutritional supplements like Agaricus Mushroom have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Agaricus Mushroom supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Agaricus Mushroom supplements can benefit Juvenile Myelomonocytic Leukemia patients on Trametinib cancer treatment. But avoid Agaricus Mushroom supplements if on Venetoclax treatment for Non-Hodgkin Lymphoma. Similarly, taking nutritional supplement Agaricus Mushroom can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene MAX. But avoid taking nutritional supplement Agaricus Mushroom when at genetic risk of cancer due to mutation of gene MRE11.
The takeaway being – your individual context will influence your decision if nutritional supplement Agaricus Mushroom is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Agaricus Mushroom based on individual context and conditions.
So the question is should you take the supplement Agaricus Mushroom? Should you take it when at genetic risk of cancer for mutation of gene MRE11? Should you take it when at genetic risk of cancer for mutation of gene MAX? Should you take it when diagnosed with Non-Hodgkin Lymphoma? Should you take Agaricus Mushroom supplements when diagnosed with Juvenile Myelomonocytic Leukemia? Should you take it when on Venetoclax treatment? Should you continue taking Agaricus Mushroom supplement if you change your treatment from Venetoclax to Trametinib? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Agaricus Mushroom.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Non-Hodgkin Lymphoma or Juvenile Myelomonocytic Leukemia, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Agaricus Mushroom.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Agaricus Mushroom? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene MRE11 the same as due to mutation of gene MAX? Are the implications of taking Agaricus Mushroom supplement in Non-Hodgkin Lymphoma the same as Juvenile Myelomonocytic Leukemia? Is it one and the same if you are on treatment Venetoclax or on Trametinib?
Agaricus Mushroom – A Nutritional Supplement
Agaricus blazei Murill, commonly known as Agaricus Mushroom or Agaricus blazei is an edible mushroom native to Brazil, but is also grown in China, Japan and the United States. It is considered to have antioxidant, anti-inflammatory and antimicrobial effects. Following are some of the purported uses/potential health benefits of Agaricus Mushrooms:
- May help reduce insulin resistance in Type 2 diabetes (Chung-Hua Hsu et al, J Altern Complement Med., Jan-Feb 2007)
- May help reduce Inflammatory Bowel Disease (D T Førland et al, Scand J Immunol., 2011)
- May help improve liver health (Chung-Hua Hsu et al, J Altern Complement Med., 2008)
Agaricus Mushroom supplements contain many active ingredients including Gallic acid, Caffeic acid, Myricetin, P-coumaric Acid, Linoleic Acid and Vitamin B3 at different concentration levels. The molecular pathways which are regulated by Agaricus Mushroom include Vitamin D Signaling, PI3K-AKT-MTOR Signaling, Estrogen Signaling, Stem Cell Signaling and Cell Cycle Checkpoints. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Agaricus Mushroom individually or in combination is an important decision to be made. When making decisions on the use of supplement Agaricus Mushroom for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Agaricus Mushroom use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Agaricus Mushroom Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Agaricus Mushroom for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Agaricus Mushroom may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Agaricus Mushroom should be avoided or not and why.
1. Will Agaricus Mushroom Supplements benefit Cancer Patients with Non-Hodgkin Lymphoma undergoing Venetoclax treatment?
Non-Hodgkin Lymphoma is characterized and driven by specific genetic mutations like KMT2D and CREBBP leading to biochemical pathway changes in Vitamin D Signaling, Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling, P53 Signaling and Cancer Epigenetics. A cancer treatment like Venetoclax works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Agaricus Mushroom should be avoided for Non-Hodgkin Lymphoma along with treatment Venetoclax. Agaricus Mushroom impacts pathways/processes like Vitamin D Signaling and Cell Cycle Checkpoints which either promote drivers of the disease and/or nullify the treatment effect. Additionally, Agaricus Mushroom supplements contain active ingredients like Gallic acid, Caffeic acid, Myricetin, Linoleic Acid and, Vitamin B3 which have CYP3A4/CYP3A5 (drug metabolizing enzyme) interactions with Venetoclax treatment and hence should be avoided by patients undergoing this treatment. (https://patents.google.com/patent/US7169763B2/en; Himanshu Rastogi and Snehasis Jana, Phytother Res., 2014; Yannan Li et al, Toxicol Lett., 2018; Melanie Z Sakatis et al, Chem Res Toxicol., 2012; Kevin J Freise et al, J Clin Pharmacol., 2017) Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Agaricus Mushroom Supplements benefit Juvenile Myelomonocytic Leukemia Patients undergoing Trametinib Cancer Treatment?
Juvenile Myelomonocytic Leukemia is characterized and driven by specific genetic mutations like PTPN11 and NRAS leading to biochemical pathway changes in PI3K-AKT-MTOR Signaling, RAS-RAF Signaling, JAK-STAT Signaling, MAPK Signaling and MYC Signaling. A cancer treatment like Trametinib works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Agaricus Mushroom supplements should be considered for Juvenile Myelomonocytic Leukemia along with treatment Trametinib. Agaricus Mushroom supplement impacts pathways/processes like PI3K-AKT-MTOR Signaling and RAS-RAF Signaling which either obstruct drivers of Juvenile Myelomonocytic Leukemia and/or improve Trametinib treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Agaricus Mushroom Supplements Safe for Healthy Individuals with MRE11 Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives.
MRE11 mutation causes biochemical pathways/processes like Estrogen Signaling, Growth Factor Signaling, Stem Cell Signaling, Interferon Signaling and Angiogenesis to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Agaricus Mushroom should be avoided when the genetic panel identifies mutation of MRE11 for Breast Cancer. Agaricus Mushroom impacts pathways/processes like Estrogen Signaling and Growth Factor Signaling and creates adverse effects with MRE11 and related conditions.
4. Are Agaricus Mushroom Supplements Safe for Healthy Individuals with MAX Mutation Associated Genetic Risk?
MAX is one of the genes available in panels for cancer risk testing. MAX mutation causes biochemical pathways/processes like Stem Cell Signaling, Angiogenesis, MYC Signaling, Cancer Epigenetics and Cell Cycle to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Agaricus Mushroom supplements when the genetic panel identifies mutation in MAX for Neuroendocrine Cancer. Agaricus Mushroom impacts pathways/processes like Stem Cell Signaling and Angiogenesis and creates a supportive effect in those with MAX mutation and related conditions.
* Other Factors are also included like BMI, Treatments, Lifestyle Habits
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Agaricus Mushroom, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.