Nutritional supplements like Carvacrol have many health benefits and are being widely used by cancer patients and those at-genetic-risk of cancer. But, is it safe to take Carvacrol supplements for all types of cancer and without considering any ongoing treatments and other lifestyle conditions? A common belief but only a myth is that anything natural can only benefit me or do no harm. As one example, the use of grapefruit with certain medications is not recommended. Another example, the use of spinach with some blood thinning medications can cause adverse interactions and should be avoided. For cancer, nutrition which includes the food and natural supplements has been shown to influence outcomes. Hence a frequently asked question by cancer patients to dieticians and doctors is “What Should I eat and What Should I Avoid?”.
Taking nutritional Carvacrol supplements can benefit cancer patients with Stomach Adenocarcinoma on Oxaliplatin treatment. But avoid Carvacrol supplements if on Cyclophosphamide treatment for Chronic Myeloid Leukemia. Similarly, taking nutritional supplement Carvacrol can benefit healthy individuals who are at genetic risk of cancer due to mutation of gene TP53. But avoid taking nutritional supplement Carvacrol when at genetic risk of cancer due to mutation of gene TERT.
The takeaway being – your individual context will influence your decision if nutritional supplement Carvacrol is safe or not. And also that this decision needs to be constantly revisited as conditions change. Conditions like cancer type, current ongoing treatments and supplements, age, gender, weight, height, lifestyle and any genetic mutations identified matter. So a legitimate question for you to ask for any recommendation of food and natural supplement is how it is related to your individual context.
Nutritional supplements – vitamins, herbs, minerals, probiotics, and other specialty categories are increasing. Supplements are high concentrations of active ingredients which are also found in different foods. The difference being foods contain more than one active ingredient at lower diffused concentrations. Remember that each of these ingredients has its own science and biological mechanism at molecular level – hence choose the right combination of supplements like Carvacrol based on individual context and conditions.
So the question is should you take the supplement Carvacrol? Should you take it when at genetic risk of cancer for mutation of gene TERT? Should you take it when at genetic risk of cancer for mutation of gene TP53? Should you take it when diagnosed with Chronic Myeloid Leukemia? Should you take Carvacrol supplement when diagnosed with Stomach Adenocarcinoma? Should you take it when on Cyclophosphamide treatment? Should you continue taking Carvacrol supplements if you change your treatment from Cyclophosphamide to Oxaliplatin? So a general explanation like – it is natural or it increases immunity may not be acceptable and sufficient for choosing Carvacrol.
Cancer remains an unsolved problem statement. The improved availability of personalized treatments and monitoring of cancer via blood and saliva have been significant factors to improve outcomes. The earlier the intervention – the better the influence on outcome. Genetic testing has the potential to assess cancer risk and susceptibility early. But besides regular monitoring in most cases there are no therapeutic intervention options available. After diagnosis with cancer such as Chronic Myeloid Leukemia or Stomach Adenocarcinoma, the treatments get personalized to tumor genomics and factors like staging of disease, age and gender. During cancer remission (after treatment cycle is complete) – monitoring is used for assessment of any relapse and accordingly decide next steps. A large majority of cancer patients and those at-risk do take nutritional supplements like Carvacrol.
So the question is that are all genetic mutation risks and types of cancers to be considered as one when deciding the use of Carvacrol? Are the biochemical pathway implications of genetic risk for cancer due to mutation of gene TERT the same as due to mutation of gene TP53? Are the implications of taking Carvacrol supplements in Chronic Myeloid Leukemia the same as Stomach Adenocarcinoma? Is it one and the same if you are on treatment with Cyclophosphamide or on Oxaliplatin?
Carvacrol – A Nutritional Supplement
Carvacrol is a phenolic compound found in essential oils of various plants. Carvacrol is considered to have antimicrobial, antioxidant, and anticancer activities. (Mehdi Sharifi-Rad et al, Phytother Res., 2018) It may also have neuroprotective effects and may help reduce alcohol induced liver toxicity. (Imran Khan et al, Food Chem Toxicol., 2019; Fatemeh Zare Mehrjerdi et al, Naunyn Schmiedebergs Arch Pharmacol., 2020)
Carvacrol is an active ingredient found in various food items. Corn, Black Seed, Oregano oil, Bergamot and Marjoram contain Carvacrol at different concentration levels along with other active ingredients. The molecular pathways which are regulated by Carvacrol include Vitamin Metabolism, Extracellular Matrix Remodelling, Apoptosis, Cell Cycle Checkpoints and RUNX Signaling. These cellular pathways directly or indirectly regulate specific cancer molecular endpoints like growth, spread and death. Because of this biological regulation – for cancer nutrition, the right choice of supplements like Carvacrol individually or in combination is an important decision to be made. When making decisions on the use of supplement Carvacrol for cancer – do consider all these factors and explanations. Because just as true for cancer treatments – Carvacrol use cannot be a one-size-fits-all decision for all types of cancers.
Choosing Carvacrol Supplements for Your Cancer
The reason there is no easy way to answer the question “When should I avoid Carvacrol for Cancer” is because “It Depends!”. Just like the same treatment does not work for every cancer patient, based on your individual context the Carvacrol may be harmful or safe. Along with which cancer and associated genetics – the ongoing treatments, supplements, lifestyle habits, BMI and allergies are all factors deciding if Carvacrol should be avoided or not and why.
1. Will Carvacrol Supplements benefit Cancer Patients with Chronic Myeloid Leukemia undergoing Cyclophosphamide treatment?
Chronic Myeloid Leukemia is characterized and driven by specific genetic mutations like BCR-ABL1 and RUNX1 leading to biochemical pathway changes in Vitamin Metabolism, Growth Factor Signaling, Cancer Epigenetics and RUNX Signaling. A cancer treatment like Cyclophosphamide works through a specific pathway mechanism of action. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach which is effective. In such a condition any food or nutritional supplement which has a contrary effect to the treatment or reduces the overlap should be avoided. As an example, Carvacrol should be avoided for Chronic Myeloid Leukemia along with treatment of Cyclophosphamide. Carvacrol impacts pathways/processes like Vitamin Metabolism which either promote drivers of the disease and/or nullify the treatment effect. Some of the factors which should be considered when choosing nutrition are type of cancer, treatments and supplements being taken currently (if any), age, gender, BMI, lifestyle and any genetic mutation information (if available).
2. Will Carvacrol Supplements benefit cancer Patients with Stomach Adenocarcinoma undergoing Oxaliplatin Treatment?
Stomach Adenocarcinoma is characterized and driven by specific genetic mutations like TP53 and MUC16 leading to biochemical pathway changes in Extracellular Matrix Remodelling, RUNX Signaling, PI3K-AKT-MTOR Signaling, Small Molecule Transport and MAPK Signaling. A cancer treatment like Oxaliplatin works through specific pathway mechanisms. The goal is to have a good overlap between the treatment and cancer driving pathways for a personalized approach. In such a condition any food or nutritional supplement which has a compatible effect to the treatment or reduces the overlap should be considered. As an example, Carvacrol supplements should be considered for Stomach Adenocarcinoma along with treatment Oxaliplatin. Carvacrol supplement impacts pathways/processes like Extracellular Matrix Remodelling and RUNX Signaling which either obstruct drivers of Stomach Adenocarcinoma and/or improve Oxaliplatin treatment effect.
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
3. Are Carvacrol Supplements Safe for Healthy Individuals with TERT Mutation Associated Genetic Risk?
Different companies offer panels of genes to be tested for assessing genetic risk to different cancers. These panels cover genes associated with cancers of the breast, ovary, uterus, prostate, and gastrointestinal system and others. Genetic testing of these genes may confirm a diagnosis and help guide treatment and management decisions. Identification of a disease-causing variant may also guide testing and diagnosis of at-risk relatives. TERT is one of the genes generally available in panels for cancer risk testing.
TERT mutation causes biochemical pathways/processes like Apoptosis, RUNX Signaling, Stem Cell Signaling, Cell Cycle Checkpoints and JAK-STAT Signaling to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Carvacrol should be avoided when the genetic panel identifies mutation of TERT for Hematological Cancer. Carvacrol impacts pathways/processes like Apoptosis and RUNX Signaling and creates adverse effects with TERT and related conditions.
4. Are Carvacrol Supplements Safe for Healthy Individuals with TP53 Mutation Associated Genetic Risk?
TP53 is one of the genes available in panels for cancer risk testing. TP53 mutation causes biochemical pathways/processes like Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling, Stem Cell Signaling, TGFB Signaling and Autophagy to get impacted. These pathways are direct or indirect drivers of cancer molecular endpoints. Consider taking Carvacrol supplements when the genetic panel identifies mutation in TP53 for Breast Cancer and Lung Cancer. Carvacrol supplement impacts pathways/processes like Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling and creates a supportive effect in those with TP53 mutation and related conditions.
* Other Factors are also included like BMI, Treatments, Lifestyle Habits
The two most important things to remember are that cancer treatments and nutrition are never the same for everyone. Nutrition which includes food and nutritional supplements like Carvacrol, is an effective tool which can be controlled by you, while facing cancer.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.
Cancer patients often have to deal with different chemotherapy side effects which affect their quality of life and look out for alternative therapies for cancer. Taking the right nutrition and supplements based on scientific considerations (avoiding guesswork and random selection) is the best natural remedy for cancer and treatment related side-effects.